TWAS
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Models
Genes
Traits
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Traits
:
Lung FEV1/FVC ratio
:
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chr8:70,854,206-72,277,458
Best TWAS P=2.95e-08 · Best GWAS P=1.61e-08 conditioned to 1
70.8M
71M
71.2M
71.4M
71.6M
71.8M
72M
72.2M
0
2
4
6
8
physical position
-log10 P
Conditional
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
3
ROSMAP
Brain Pre-frontal Cortex
LACTB2
0.05
0.07
lasso
3
0.08
6.3e-10
-5.6
-5.5
2.9e-08
0.96
0.02
0.98
TRUE
5
The Cancer Genome Atlas
Prostate Adenocarcinoma
LACTB2
0.03
0.02
lasso
3
0.02
6.1e-03
-5.5
-5.3
1.1e-07
0.99
0.01
0.92
FALSE
4
The Cancer Genome Atlas
Head and Neck Squamous Cell Carcinoma
LACTB2
0.03
0.03
lasso
1
0.03
1.7e-04
-5.2
-5.2
1.9e-07
0.99
0.01
0.89
FALSE
2
GTEx
Stomach
LACTB2
0.10
0.08
enet
21
0.04
3.4e-03
-5.6
-5.2
2.5e-07
0.96
0.04
0.96
FALSE
1
GTEx
Lung
LACTB2
0.05
0.03
lasso
6
0.02
1.4e-02
-5.5
-5.1
3.0e-07
0.89
0.05
0.91
FALSE