TWAS
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Usage
Models
Genes
Traits
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Traits
:
Lung FEV1/FVC ratio
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chr8:73,280,829-74,727,081
Best TWAS P=3.92e-10 · Best GWAS P=5.35e-09 conditioned to 0.757
73.2M
73.4M
73.6M
73.8M
74M
74.2M
74.4M
74.6M
74.8M
0
2
4
6
8
physical position
-log10 P
Conditional
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
1
GTEx
Lung
SBSPON
0.16
0.10
lasso
8
0.09
2.9e-07
5.8
-6.3
3.9e-10
-0.95
0.00
1.00
TRUE
2
The Cancer Genome Atlas
Brain Lower Grade Glioma
C8orf84
0.17
0.14
enet
16
0.15
6.3e-17
4.7
5.5
3.1e-08
0.66
0.28
0.72
FALSE