Best TWAS P=4.88e-08 · Best GWAS P=5.35e-08 conditioned to 0.0191
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Cells EBV-transformed lymphocytes | NUDT2 | 0.62 | 0.28 | enet | 47 | 0.60 | 3.9e-24 | -3.7 | -5.1 | 2.8e-07 | 0.12 | 0.87 | 0.09 | FALSE |
| 2 | GTEx | Pituitary | NUDT2 | 0.63 | 0.33 | lasso | 18 | 0.49 | 5.5e-14 | 3.7 | -5.2 | 2.2e-07 | 0.17 | 0.86 | 0.07 | FALSE |
| 3 | GTEx | Stomach | NUDT2 | 0.55 | 0.29 | enet | 23 | 0.56 | 2.0e-31 | -3.9 | -5.1 | 3.0e-07 | 0.18 | 0.86 | 0.09 | FALSE |
| 4 | YFS | Blood | UBE2R2 | 0.02 | 0.01 | lasso | 7 | 0.01 | 2.6e-03 | -5.2 | -5.2 | 2.0e-07 | 0.83 | 0.01 | 0.96 | FALSE |
| 5 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | UBE2R2 | 0.10 | 0.00 | enet | 13 | 0.02 | 4.0e-03 | -5.4 | 5.5 | 4.9e-08 | -0.78 | 0.01 | 0.93 | TRUE |
| 6 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | NUDT2 | 0.27 | 0.12 | blup | 36 | 0.25 | 4.5e-17 | 3.3 | -5.1 | 2.9e-07 | 0.13 | 0.02 | 0.34 | TRUE |
| 7 | The Cancer Genome Atlas | Uterine Corpus Endometrial Carcinoma | NUDT2 | 0.29 | 0.08 | blup | 36 | 0.23 | 5.2e-07 | 3.7 | -5.1 | 3.1e-07 | 0.15 | 0.00 | 0.14 | FALSE |