[Hub]/) : Traits : Lung FEV1/FVC ratio :

chr11:69,606,128-70,966,113

Best TWAS P=3.02e-10 · Best GWAS P=5.37e-11 conditioned to 9.31e-14

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 GTEx Artery Aorta CTTN 0.16 0.07 lasso 4 0.08 2.6e-05 -4.6 -5.9 3.8e-09 0.11 0.01 0.98 FALSE
2 GTEx Artery Tibial CTTN 0.18 0.08 enet 23 0.11 1.1e-08 -6.5 -6.1 1.4e-09 0.04 0.01 0.99 FALSE
3 The Cancer Genome Atlas Lung Adenocarcinoma CTTN 0.02 0.01 blup 32 0.02 3.8e-03 -3.9 -5.8 8.0e-09 0.13 0.01 0.71 FALSE
4 The Cancer Genome Atlas Prostate Adenocarcinoma CTTN 0.06 0.06 lasso 3 0.06 8.2e-07 -6.2 -6.3 3.0e-10 0.13 0.02 0.98 TRUE
5 The Cancer Genome Atlas Skin Cutaneous Melanoma PPFIA1 0.11 0.05 blup 69 0.05 1.7e-02 -6.2 5.8 5.7e-09 -0.04 0.02 0.41 FALSE
6 The Cancer Genome Atlas Thyroid Carcinoma CTTN 0.05 0.06 blup 32 0.04 3.5e-05 -6.3 -6.0 1.9e-09 0.12 0.01 0.99 FALSE