TWAS hub - CTTN

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adipose Subcutaneous	0.0720	0.0310	8.0e-03	0.007	NA	0.019	NA	0.015	7.4e-02	NA	9.4e-03	NA	1.8e-02
2	GTEx	Artery Aorta	0.1560	0.0530	3.8e-04	0.071	NA	0.073	NA	0.083	9.3e-05	NA	7.8e-05	NA	2.6e-05
3	GTEx	Artery Tibial	0.1845	0.0452	2.4e-07	0.080	NA	0.107	NA	0.097	7.3e-07	NA	1.1e-08	NA	4.8e-08
4	TCGA	Breast Invasive Carcinoma	0.0136	0.0084	4.7e-03	0.004	0.008	0.006	NA	0.009	4.2e-02	7.5e-03	2.1e-02	NA	3.8e-03
5	TCGA	Lung Adenocarcinoma	0.0181	0.0120	4.9e-03	0.011	0.017	0.008	NA	0.013	1.6e-02	3.8e-03	3.6e-02	NA	1.1e-02
6	TCGA	Prostate Adenocarcinoma	0.0642	0.0310	4.8e-07	0.062	0.049	0.051	NA	0.059	4.1e-07	7.1e-06	4.9e-06	NA	8.2e-07
7	TCGA	Thyroid Carcinoma	0.0450	0.0230	2.7e-06	0.058	0.045	0.039	NA	0.044	2.6e-06	3.5e-05	9.7e-05	NA	3.6e-05

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Lung FEV1/FVC ratio	6.1	30.8	39.7	-3.1	-5.9	-6.1	-5.1	-5.8	-6.3	-6.0
Pulse wave reflection index	5.8	7.1	11.2	-1.5	-2.7	-2.1	-2.5	-3.1	-2.9	-3.3
Mouth/teeth dental problems: Bleeding gums	5.1	6.6	10.5	-2.8	-3.2	-2.2	-1.0	-3.2	-2.4	-2.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	5.1	6.0	8.8	2.1	2.0	2.8	2.9	1.4	3.0	2.5
Had other major operations	4.7	5.7	7.3	2.2	2.5	2.7	2.3	2.1	2.2	2.6
Heart disease (siblings)	4.7	5.8	10.8	-1.8	-2.1	-2.3	-3.3	-1.3	-2.8	-2.8
Breastfed as a baby	4.2	5.2	7.3	-1.3	-2.7	-2.3	-2.4	-1.9	-2.4	-2.7
Breast cancer (self-reported)	3.9	4.6	10.2	0.7	2.9	1.5	0.6	3.2	2.2	2.4
Medication: Aspirin	3.6	4.8	8.0	-1.6	-2.7	-1.6	-1.4	-2.8	-2.3	-2.5
Crohns Disease (2012)	3.1	5.0	7.6	-1.6	-2.3	-1.7	-2.0	-2.6	-2.8	-2.4
Tinnitus: Yes, but not now, but have in the past	3.1	3.3	5.8	0.7	1.3	2.4	2.3	1.4	2.2	1.8
Medication: Paracetamol	3.1	5.1	7.2	-2.7	-2.3	-2.7	-2.6	-1.0	-1.7	-2.4
Angina (self-reported)	3.1	4.1	7.1	-1.7	-2.7	-2.1	-1.1	-2.2	-1.8	-2.2
Medication: Ibuprofen	3.1	3.7	6.3	0.6	2.1	1.5	1.9	2.1	2.5	2.2
Systolic blood pressure, automated reading	3.0	8.8	18.3	2.1	3.0	4.3	2.9	2.0	2.8	3.1
Angina	3.0	3.9	7.0	-1.6	-2.6	-2.0	-0.9	-2.4	-1.7	-2.2
Illnesses of father: Heart disease	3.0	4.1	5.7	-2.2	-1.8	-1.7	-2.0	-1.8	-2.4	-2.3
Mouth/teeth dental problems	2.9	4.4	7.6	2.8	1.7	1.6	1.7	2.3	2.3	2.1
Medication: Aspirin	2.8	3.7	7.2	-1.5	-2.5	-1.3	-0.8	-2.7	-1.9	-2.1
Medication: Simvastatin	2.4	3.5	6.2	-2.0	-2.5	-2.0	-0.4	-2.0	-1.6	-1.8
Worrier / anxious feelings	2.4	4.6	6.8	-2.5	-2.1	-2.6	-2.4	-0.9	-1.9	-2.2
Irritability	2.4	4.1	7.7	-1.0	-2.8	-2.4	-1.1	-2.2	-1.8	-2.2
Heart attack	2.3	3.0	6.9	-0.9	-2.6	-1.4	-0.9	-1.9	-1.3	-2.3
Ever had prostate specific antigen (PSA) test	2.2	2.6	6.6	0.1	-1.5	-1.1	-1.3	-2.6	-1.8	-1.8
Heart attack/myocardial infarction (self-reported)	2.2	2.9	6.9	-0.8	-2.6	-1.5	-0.9	-1.7	-1.2	-2.2
Coronary Artery Disease (CAD)	2.1	2.5	4.8	-0.5	-2.0	-1.1	-0.8	-2.2	-1.8	-1.9
Relative age voice broke	2.1	3.2	6.0	-2.5	-1.8	-1.1	-1.0	-2.1	-1.9	-1.7
Past tobacco smoking	2.1	3.9	8.8	0.4	1.5	2.0	3.0	1.0	2.5	2.1
Medication: Cholesterol lowering	2.1	3.3	5.9	-2.0	-2.4	-1.9	-1.1	-1.6	-1.6	-1.7
Diastolic blood pressure, automated reading	2.1	6.4	17.8	4.2	1.9	2.9	1.8	1.4	2.1	2.2
Average weekly spirits intake	1.9	2.4	5.3	-1.5	-1.5	-1.1	-0.7	-2.3	-1.7	-1.5
Age when periods started (menarche)	1.9	4.5	8.0	-1.6	-1.8	-2.8	-2.6	-1.2	-2.2	-2.1
Gout (self-reported)	1.9	2.6	4.9	-1.1	-2.0	-1.1	-0.9	-2.2	-1.8	-1.7
Medication: Ventolin 100micrograms inhaler	1.9	2.4	5.9	2.4	1.9	1.0	0.7	1.4	1.1	1.6
Medication: Omeprazole	1.9	2.3	3.6	1.7	1.1	1.8	1.9	1.0	1.6	1.3
Illness, injury, bereavement, stress in last 2 years	1.9	2.4	3.6	1.9	1.8	1.8	1.2	0.9	1.2	1.7
Waist Hip Ratio (WHR)	1.8	8.2	14.1	0.3	3.8	2.7	1.9	3.5	2.7	3.5
Systolic Blood Pressure	1.8	8.9	18.8	1.9	3.0	4.3	3.0	1.9	3.0	3.1
Fluid intelligence score	1.8	3.7	8.1	-1.6	-2.1	-1.2	-1.1	-2.9	-1.9	-2.1
Ever highly irritable/argumentative for 2 days	1.8	2.1	3.5	-0.3	1.4	1.9	1.4	1.5	1.6	1.7
Medication: Paracetamol	1.8	2.7	3.5	-1.9	-1.9	-1.7	-1.8	-0.9	-1.1	-1.9
Medication: Omeprazole (e.g. Zanprol)	1.8	2.1	2.9	1.6	1.0	1.6	1.7	1.1	1.7	1.2
Illnesses of siblings	1.7	2.5	3.7	1.6	1.6	0.9	1.1	1.8	1.9	1.7
Number of full brothers	1.7	2.2	3.0	-1.4	-1.5	-1.4	-1.4	-1.2	-1.7	-1.6
Medication for pain relief, constipation, heartburn	1.7	3.0	5.1	1.6	2.2	1.7	1.5	1.6	1.2	2.0
Smoking status: Previous	1.7	2.5	5.3	-0.3	-1.1	-1.6	-2.0	-1.2	-2.3	-1.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.7	3.6	5.4	-1.4	-1.7	-2.0	-1.3	-2.3	-2.3	-2.0
Average weekly champagne plus white wine intake	1.7	2.4	6.0	-1.6	-1.6	-1.0	-0.2	-2.5	-1.3	-1.6
Supplements: Fish oil (including cod liver oil)	1.7	2.2	6.3	-2.5	-1.6	-0.4	0.0	-1.9	-1.3	-1.2
Had menopause	1.6	2.0	2.6	-1.4	-1.2	-1.5	-1.6	-1.0	-1.6	-1.5
Pulse rate	1.6	2.8	5.0	1.5	1.4	0.9	1.1	2.2	2.1	1.9
Cholesterol lowering medication	1.6	2.4	4.2	-1.0	-2.1	-1.9	-0.3	-1.9	-1.4	-1.5
Hair/balding pattern: Pattern 2	1.5	2.0	5.1	1.5	1.5	0.8	-0.1	2.2	1.4	1.3
Pulse wave peak to peak time	1.5	1.8	2.9	0.5	1.5	1.1	1.4	1.4	1.4	1.7
Rheumatoid Arthritis	1.4	1.9	3.4	1.3	1.8	1.0	0.4	1.8	1.0	1.6
Neuroticism	1.4	3.4	5.3	-1.5	-2.0	-1.7	-2.3	-1.1	-1.8	-2.2
Medication: Ibuprofen (e.g. Nurofen)	1.4	1.7	3.4	0.3	1.2	1.1	1.7	1.1	1.8	1.4
Pulse wave Arterial Stiffness index	1.4	1.6	2.6	-0.5	-1.4	-0.9	-1.2	-1.4	-1.4	-1.6
Headache pain in last month	1.4	2.4	7.6	-2.8	-1.1	-1.3	-1.0	-1.3	-1.3	-1.5
Illnesses of father: High blood pressure	1.4	1.8	5.0	1.3	0.3	1.9	2.2	-0.9	0.5	1.0
Basal cell carcinoma (self-reported)	1.4	1.7	3.5	0.9	1.1	1.5	1.9	0.4	1.6	1.3
Irritable Bowel Disease (IBD)	1.3	3.2	4.0	-1.5	-2.0	-1.6	-1.6	-2.0	-1.8	-1.9
Frequency of depressed mood in last 2 weeks	1.3	1.8	3.1	-0.6	-1.8	-1.7	-1.3	-0.5	-1.1	-1.7
Depression (self-reported)	1.3	1.6	3.4	0.7	1.0	0.6	1.1	1.8	1.7	1.3
Mouth/teeth dental problems: Loose teeth	1.3	1.6	3.5	-1.1	-0.9	-0.9	-1.9	-0.6	-1.7	-1.2
Medication: Blood pressure	1.3	2.3	5.4	-0.1	-2.1	-0.9	-0.7	-2.3	-1.6	-1.6
Medication: Allopurinol	1.3	1.8	4.6	-0.6	-1.8	-0.9	-0.2	-2.1	-1.3	-1.2
Guilty feelings	1.3	1.9	4.9	-2.2	-1.4	-1.5	-1.2	-0.4	-0.8	-1.5
Neuroticism score	1.2	2.6	4.0	-1.5	-2.0	-1.9	-1.8	-0.6	-1.4	-1.8
Reason for reducing amount of alcohol drunk: Health precaution	1.2	1.4	2.6	-0.2	1.6	1.1	1.2	1.0	1.2	1.3
Mood swings	1.2	2.2	4.4	-1.3	-2.1	-1.4	-0.9	-1.2	-1.2	-1.8
Back pain experienced in last month	1.2	1.7	4.5	0.7	1.1	0.3	0.7	2.1	1.8	1.4
Pack years adult smoking proportion	1.1	1.6	2.8	1.1	0.7	1.4	1.4	1.2	1.7	1.3
Forced expiratory volume in 1-second (FEV1)	1.1	3.7	6.2	-1.0	-2.1	-1.7	-1.2	-2.5	-2.3	-2.2
Chronic bronchitis/emphysema (mother)	1.1	1.3	2.6	1.6	0.9	1.0	1.2	1.0	1.0	1.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.1	1.3	3.3	1.5	0.6	0.9	1.8	0.3	1.2	0.9
Ever smoked	1.1	1.9	6.2	0.0	-0.9	-1.2	-2.5	-0.1	-1.6	-1.4
Pack years of smoking	1.1	1.5	2.5	1.1	0.6	1.5	1.5	0.9	1.6	1.2
Crohns Disease (2017)	1.0	2.2	3.6	-1.1	-1.6	-1.2	-1.3	-1.9	-1.6	-1.5
Medication: Co-codamol	1.0	1.1	1.8	-0.1	1.0	0.9	1.3	0.9	1.3	1.4
Chronic bronchitis/emphysema (father)	1.0	1.2	2.1	1.4	1.2	0.4	0.5	1.4	0.9	1.1
Heel bone mineral density (BMD) T-score, automated (right)	1.0	2.4	3.6	-1.2	-1.7	-1.9	-1.8	-0.7	-1.5	-1.7
Medication: Ramipril	1.0	1.3	3.6	-0.1	-1.4	-0.9	-0.1	-1.9	-1.2	-1.1
Tense / ‘highly strung’	1.0	1.7	4.0	2.0	0.7	1.2	1.2	1.1	1.3	1.2
Birth weight	1.0	2.1	3.6	1.9	1.6	1.0	0.7	1.8	1.5	1.3
Commuting to job workplace: Walk	1.0	1.0	3.8	0.7	-0.3	1.3	1.9	-1.0	0.4	0.5
Medication for cholesterol	1.0	1.5	3.3	0.5	1.5	1.8	1.3	0.5	1.0	1.3
Fasting Glucose	0.9	1.1	2.2	1.5	0.9	1.3	0.6	0.9	0.9	0.8
Smoking Status	0.9	2.2	5.5	-1.1	-0.8	-1.8	-2.3	-0.1	-1.7	-1.2
Fed-up feelings	0.9	1.7	4.8	-0.5	-1.1	-1.5	-2.2	0.1	-1.0	-1.5
Stomach or abdominal pain in last month	0.9	1.2	2.2	0.4	1.1	0.4	0.8	1.4	1.4	1.5
Forced expiratory volume in 1-second (FEV1), Best measure	0.9	2.9	5.2	-0.1	-2.0	-1.6	-0.9	-2.3	-1.9	-2.1
Hair/balding pattern: Pattern 4	0.9	2.2	4.2	0.0	1.9	1.2	0.9	2.1	1.4	1.8
Chest pain or discomfort	0.9	1.3	3.3	-1.8	-1.0	-0.9	-1.0	-0.7	-1.0	-1.1
Family relationship satisfaction	0.9	1.1	1.6	-0.6	-0.7	-1.0	-1.3	-1.2	-1.1	-1.2
Loneliness, isolation	0.9	1.2	3.1	0.9	0.9	0.6	0.9	1.8	1.3	1.0
HbA1C	0.8	0.8	1.0	-0.9	1.0	0.9	0.7	0.9	0.9	0.9
Diabetes (mother)	0.8	1.1	3.1	0.3	1.1	1.0	0.1	1.8	0.9	1.1
Hayfever, allergic rhinitis or eczema	0.8	1.8	5.3	-1.2	-1.2	-0.8	-0.0	-2.3	-1.7	-1.0
High blood pressure (siblings)	0.8	1.1	3.4	-1.1	-1.3	0.1	0.5	-1.9	-0.9	-0.7
Forced expiratory volume in 1-second (FEV1), predicted	0.8	1.6	3.5	1.9	1.2	1.2	1.0	1.1	0.9	1.3
Long-standing illness, disability or infirmity	0.8	1.2	3.1	-1.8	-1.5	-1.4	-0.6	-0.4	-0.6	-0.9
Ever had bowel cancer screening	0.8	1.0	1.9	-1.4	-1.0	-1.0	-0.8	-1.0	-0.8	-0.9
Eye problems/disorders: Glaucoma	0.8	1.0	2.3	1.4	1.0	-0.1	-0.9	1.5	0.7	0.6
Pain type(s) experienced in last month: Hip pain	0.8	1.0	1.9	-1.0	0.5	0.6	1.1	1.3	1.4	0.8
Pain experienced in last month	0.8	1.3	3.3	1.8	1.5	1.4	0.2	0.5	0.3	1.1
Supplements: Calcium	0.8	0.9	1.6	-1.1	-0.6	-1.0	-0.1	-1.3	-1.1	-0.7
Allergy or Eczema	0.7	1.8	5.3	-1.5	-0.8	-0.3	-0.2	-2.3	-1.9	-1.0
Waist circumference	0.7	2.7	4.3	1.1	1.2	1.7	2.1	1.4	1.8	1.9
Number of live births	0.7	1.0	4.1	-0.2	0.1	-1.1	-2.0	0.7	-0.7	-0.6
Blood clot in the leg (DVT)	0.7	0.9	1.5	-1.1	-0.8	-1.2	-0.5	-0.9	-1.1	-0.9
Medication for cholesterol, blood pressure or diabetes	0.7	1.1	2.9	0.4	1.7	0.7	0.2	1.5	1.0	1.0
Medication: Amlodipine	0.7	1.0	2.9	-0.8	-1.2	-0.6	0.2	-1.7	-1.0	-0.9
Comparative body size at age 10	0.7	1.8	3.6	0.3	1.4	1.6	1.9	0.7	1.3	1.5
Health satisfaction	0.7	0.9	1.3	1.2	1.0	0.7	0.5	1.0	1.1	1.0
Heart disease (mother)	0.7	0.9	2.2	-1.5	-0.7	-0.0	-0.4	-1.3	-1.0	-0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.7	0.9	2.1	1.5	0.7	1.0	-0.3	1.2	0.9	0.4
Intelligence (Savage-Jansen 2018)	0.6	1.8	3.5	-0.6	-1.1	-1.0	-1.5	-1.6	-1.9	-1.4
Major Depression (MDD)	0.6	0.7	1.9	0.8	0.6	-0.4	0.2	1.1	1.4	0.7
Impedance of leg (right)	0.6	3.1	9.0	0.1	2.5	1.3	-0.1	3.0	1.2	1.7
Trunk fat percentage	0.6	2.5	4.0	0.8	1.6	1.5	1.4	1.8	1.6	2.0
Heel bone mineral density (BMD) T-score, automated (left)	0.6	1.3	2.5	-1.6	-1.3	-1.3	-1.1	-0.1	-0.9	-1.1
Serious illness, injury or assault to yourself	0.6	0.7	1.6	-1.3	-0.7	-0.8	-0.5	-0.8	-0.9	-0.9
Nervous feelings	0.6	1.0	2.2	0.9	0.5	0.7	0.7	1.5	1.5	1.0
Pain all over the body in last month	0.6	0.6	1.0	-0.3	0.5	0.5	0.9	1.0	1.0	0.9
Glaucoma (self-reported)	0.6	0.7	1.7	1.0	0.8	0.2	-0.7	1.3	0.7	0.6
Emphysema/chronic bronchitis	0.6	0.7	1.3	0.9	1.1	-0.0	0.4	1.1	0.7	0.8
Comparative height size at age 10	0.6	3.2	6.1	2.2	1.4	1.7	2.5	0.6	1.7	1.8
Number of full sisters	0.6	0.8	1.2	-1.1	1.0	0.7	0.5	1.1	0.7	0.8
Had major operations	0.6	0.7	2.5	-0.9	-0.6	-0.5	0.2	-1.6	-0.8	-0.5
Supplements: Vitamin C	0.6	0.7	1.8	0.9	0.6	0.2	0.5	1.3	0.9	0.8
Ever had stillbirth, spontaneous miscarriage or termination	0.6	0.7	2.2	1.2	0.6	-0.2	-0.5	1.5	0.5	0.5
Mouth/teeth dental problems: Mouth ulcers	0.6	1.0	1.4	-1.2	-0.9	-1.1	-1.1	-0.3	-0.7	-1.2
Osteoarthritis (self-reported)	0.6	0.8	1.8	-0.5	0.8	0.9	0.7	1.4	0.7	1.0
Illnesses of father: None of the above (group 1)	0.6	0.7	1.5	0.7	0.7	0.6	0.1	1.2	1.2	0.8
High cholesterol (Self-reported)	0.6	1.1	2.1	-0.1	-1.4	-1.5	-0.2	-1.3	-1.0	-0.9
Number of operations (self-reported)	0.6	0.9	2.7	1.0	0.5	1.1	1.7	-0.4	0.6	0.7
Fractured/broken bones in last 5 years	0.6	0.8	4.3	-2.1	-0.4	-0.5	0.5	-0.6	-0.1	-0.4
Ever depressed for a whole week	0.6	0.7	1.0	-1.0	-0.8	-0.7	-0.8	-0.7	-0.8	-0.9
Commuting to job workplace: Cycle	0.6	0.7	1.4	-0.2	-0.6	-0.9	-1.2	-0.6	-0.9	-1.0
Myopia	0.6	0.8	2.3	-0.7	-1.2	-0.7	0.1	-1.5	-0.5	-0.9
Deep venous thrombosis (DVT) (self-reported)	0.6	0.7	1.2	-1.1	-0.7	-1.1	-0.3	-0.8	-0.8	-0.8
Impedance of whole body	0.6	2.9	7.8	0.5	2.6	1.1	-0.2	2.8	1.2	1.7
Schizophrenia vs Biploar Disorder	0.5	0.6	1.1	-0.7	-0.8	-1.1	-0.9	-0.1	-0.8	-0.7
Alzheimer’s Disease (in father)	0.5	0.5	1.2	0.1	0.8	1.0	1.1	-0.2	0.3	0.9
Ulcerative Colitis (UC)	0.5	1.0	1.4	-0.9	-1.1	-1.2	-1.0	-0.9	-0.9	-0.9
Neuroticism (2016)	0.5	0.7	2.4	-1.6	-0.6	-1.1	-0.5	0.1	-0.4	-0.4
Blood Eosinophil Count	0.5	3.7	5.8	2.4	2.3	1.9	0.3	2.0	1.9	1.9
Heel T-Score	0.5	3.7	7.1	0.2	-2.7	-2.5	-2.0	-0.7	-1.7	-2.3
Respiratory disease	0.5	1.2	2.2	1.5	1.2	1.1	1.0	0.4	1.0	1.2
Relative age of first facial hair	0.5	1.0	1.7	-1.3	-0.8	-0.8	-0.8	-1.2	-1.1	-0.9
Ever used hormone-replacement therapy (HRT)	0.5	0.7	1.5	-0.6	1.2	0.7	0.1	1.1	0.7	0.8
Diverticular disease/diverticulitis (self-reported)	0.5	0.6	0.9	0.9	0.8	0.3	0.6	1.0	0.7	0.9
Frequency of tenseness / restlessness in last 2 weeks	0.5	0.7	1.8	1.0	-0.1	0.2	1.4	0.7	1.2	0.6
Impedance of arm (right)	0.5	2.3	5.3	1.0	2.3	0.8	-0.2	2.3	1.2	1.5
Father’s age at death	0.5	0.7	2.4	-1.6	-0.4	-0.3	-0.7	-0.7	-0.6	-0.7
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.8	2.6	-1.6	-0.1	-0.6	-1.1	1.2	0.1	-0.2
Hair/balding pattern: Pattern 3	0.5	0.7	1.7	-0.6	-0.7	-0.6	-0.6	-1.3	-1.0	-0.9
Happiness	0.5	0.6	2.5	-0.1	-0.6	-0.2	-0.2	-1.6	-0.6	-0.9
Body fat percentage	0.5	2.0	3.2	0.4	1.4	1.4	1.3	1.7	1.5	1.8
Leg fat percentage (right)	0.5	2.0	3.4	0.0	1.3	1.6	1.2	1.9	1.4	1.6
Wheeze or whistling in the chest in last year	0.5	0.9	1.7	-0.6	1.3	1.2	0.5	0.8	0.8	1.1
Eye problems/disorders: None of the above	0.5	0.5	0.9	0.6	0.6	0.8	0.9	0.5	0.8	0.8
Asthma (self-reported)	0.5	1.0	1.5	1.0	1.1	1.2	1.1	0.0	0.7	1.1
Miserableness	0.5	0.9	1.6	0.2	-1.3	-1.2	-1.2	0.3	-0.3	-1.2
Medication: Lisinopril	0.5	0.6	1.8	0.6	-1.2	-0.6	0.5	-1.4	-0.4	-0.5
Unable to work because of sickness or disability	0.5	0.7	2.2	0.5	1.0	-0.0	0.4	1.5	0.7	0.9
Neuroticism (Nagel 2018)	0.4	0.9	1.5	-1.2	-1.1	-0.8	-1.0	-0.5	-0.6	-1.2
Lung FVC	0.4	2.2	4.5	-1.9	-1.4	-0.7	-0.6	-2.1	-1.5	-1.6
Chronotype (morning person)	0.4	1.0	2.7	0.7	0.8	0.7	1.6	0.5	1.3	1.1
Hearing difficulty/problems: Yes	0.4	0.6	1.9	-1.4	-0.7	-0.1	0.3	-1.0	-0.7	-0.3
Other serious medical condition/disability diagnosed by doctor	0.4	0.5	1.6	-1.3	-0.8	-0.8	-0.3	-0.3	-0.4	-0.6
Ever had hysterectomy (womb removed)	0.4	0.5	0.9	0.7	1.0	0.9	0.3	0.6	0.5	0.7
Medication for hormone replacement therapy	0.4	0.5	1.8	-0.0	0.5	0.3	-0.3	1.3	0.8	0.6
Supplements: Zinc	0.4	0.5	1.1	0.3	-0.8	-0.8	0.1	-1.1	-0.6	-0.5
Townsend deprivation index at recruitment	0.4	0.5	1.8	0.6	-0.3	-0.5	-1.4	0.9	0.0	-0.5
Current tobacco smoking	0.4	0.7	2.4	-0.4	0.2	-0.8	-1.3	1.6	0.1	0.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.5	2.6	0.5	0.4	-0.2	-0.2	1.6	0.6	0.4
Bilateral oophorectomy (both ovaries removed)	0.4	0.5	1.4	0.2	0.6	0.8	0.0	1.2	0.9	0.5
Impedance of leg (left)	0.4	2.2	6.3	-0.2	2.3	0.9	-0.4	2.5	0.8	1.3
Trunk fat mass	0.4	1.7	2.7	0.9	1.0	1.3	1.4	1.3	1.4	1.6
Financial difficulties in last 2 years	0.4	0.5	2.7	-1.7	-0.4	-0.5	-0.1	0.4	0.1	-0.1
Asthma	0.4	0.8	1.3	0.9	1.1	1.1	0.9	-0.1	0.6	1.0
Prospective memory result	0.4	0.5	1.3	-0.4	-1.1	-0.8	0.5	-1.0	-0.3	-0.5
Impedance of arm (left)	0.4	1.8	4.1	0.7	2.0	1.0	0.0	1.9	1.1	1.4
Number of children fathered	0.4	0.5	1.0	-0.5	-0.8	-0.2	-0.1	-1.0	-0.9	-0.8
Suffer from ‘nerves’	0.4	0.6	2.0	-0.0	0.1	0.5	1.4	0.6	1.0	0.8
Knee pain experienced in last month	0.4	0.6	1.5	-1.2	-1.2	0.1	0.3	-0.8	-0.1	-0.9
Illnesses of siblings: Diabetes	0.4	0.5	2.0	-1.4	-0.8	0.2	0.3	-0.7	-0.1	-0.5
Arm fat percentage (left)	0.4	1.5	2.3	0.5	0.9	1.3	1.5	1.0	1.4	1.5
Handedness (chirality/laterality): Left-handed	0.4	0.5	1.3	0.2	1.1	0.6	0.5	0.6	0.6	0.9
Friendships satisfaction	0.4	0.6	1.0	-0.2	-0.4	-0.5	-1.0	-1.0	-0.6	-1.0
Qualifications: nursing, teaching	0.4	0.6	1.5	-1.2	-0.6	-0.6	0.0	-1.2	-0.5	-0.5
Eye problems/disorders: Cataract	0.4	0.4	1.0	-0.7	-0.6	-0.5	0.1	-1.0	-0.5	-0.7
Smoking status: Current	0.4	0.6	1.7	-0.7	-0.2	-1.0	-1.3	1.1	-0.2	-0.2
Wears glasses or contact lenses	0.4	0.5	1.0	-0.9	-0.1	-0.3	-0.7	-0.9	-1.0	-0.5
Medication: Atorvastatin	0.4	0.4	0.9	0.2	0.2	1.0	1.0	0.2	0.8	0.6
Leg fat percentage (left)	0.4	1.5	2.6	-0.2	1.2	1.3	1.1	1.6	1.2	1.5
Depressed Affect (Nagel 2018)	0.3	0.5	1.1	-0.4	-0.9	-0.7	-1.1	0.0	-0.4	-1.1
Verbal and Numeric Reasoning (VNR)	0.3	0.8	2.8	-0.1	-1.0	-0.3	-0.4	-1.7	-1.0	-0.9
Ovarian Cancer	0.3	0.5	1.7	1.0	-0.1	0.3	1.3	-0.3	0.5	0.4
Lupus	0.3	0.4	1.0	0.1	1.0	0.9	0.2	0.5	0.6	0.7
Blood White Count	0.3	2.5	7.3	-1.2	1.8	1.1	-0.2	2.7	1.4	1.6
Leg fat-free mass (left)	0.3	1.4	4.7	2.2	-0.1	0.7	1.6	0.2	1.0	0.9
Maternal smoking around birth	0.3	0.4	1.3	0.8	0.3	-0.3	-0.5	1.1	0.3	0.4
High blood pressure	0.3	0.9	3.1	0.2	-0.7	1.1	1.1	-1.8	-0.3	-0.2
High blood pressure (mother)	0.3	0.4	0.8	0.7	-0.4	0.6	0.9	-0.3	0.8	0.5
Alcohol usually taken with meals	0.3	0.5	2.0	-0.2	-0.3	0.4	1.0	-1.4	0.2	-0.3
Forced vital capacity (FVC)	0.3	1.2	1.8	-0.5	-1.2	-0.8	-0.9	-1.2	-1.4	-1.4
Diabetes (self-reported)	0.3	0.5	1.4	-1.2	-1.1	-0.3	0.3	-0.5	-0.7	-0.3
Arm fat percentage (right)	0.3	1.4	2.0	0.5	0.9	1.2	1.4	1.1	1.4	1.4
Qualifications: O levels/GCSEs or equivalent	0.3	0.4	1.1	0.8	-0.8	0.4	0.4	-1.1	-0.1	-0.4
Age at first live birth	0.3	0.5	2.2	0.2	-0.7	-0.4	0.3	-1.5	-0.6	-0.7
Qualifications: College or University degree	0.3	1.0	1.8	-0.4	-0.6	-1.1	-0.9	-1.4	-1.3	-1.2
Neck or shoulder pain in last month	0.3	0.4	0.7	-0.4	0.3	0.4	0.8	0.8	0.8	0.4
Medication: Seretide 50 evohaler	0.3	0.4	1.6	-1.3	-0.1	-0.6	-0.4	-0.2	-0.4	-0.5
Leg fat mass (right)	0.3	1.3	1.8	0.4	0.6	1.2	1.3	1.3	1.2	1.4
Hypertension (Self-reported)	0.3	0.8	3.3	0.1	-1.0	0.6	0.8	-1.8	-0.5	-0.4
Average weekly red wine intake	0.3	0.4	1.2	1.0	0.1	0.4	0.6	-1.1	-0.4	0.1
Mineral and other dietary supplements	0.3	0.5	0.9	0.9	0.7	-0.2	-0.9	1.0	0.1	0.4
Number of self-reported non-cancer illnesses	0.3	0.5	1.5	-0.6	-0.9	-0.5	-0.1	-1.2	-0.6	-0.6
Ever taken oral contraceptive pill	0.3	0.3	1.4	-1.2	-0.1	0.3	0.7	-0.4	0.1	0.2
Mother’s age at death	0.3	0.3	1.4	-0.5	-0.2	-0.0	-0.2	-1.2	-0.6	-0.5
Tinnitus: Yes, now most or all of the time	0.3	0.3	0.5	-0.2	-0.6	-0.6	-0.2	-0.7	-0.7	-0.7
Average weekly beer plus cider intake	0.3	0.4	0.8	-0.7	-0.4	-0.8	-0.9	0.7	-0.2	-0.5
Risk taking	0.3	0.4	1.6	0.1	0.5	-0.2	-0.6	1.3	0.7	0.3
Age started oral contraceptive pill	0.3	0.3	0.7	-0.3	-0.3	-0.8	-0.5	-0.6	-0.6	-0.6
Vascular/heart problems diagnosed by doctor	0.3	0.8	2.9	-0.1	1.1	-0.5	-0.7	1.7	0.6	0.5
Leg fat mass (left)	0.3	1.2	1.8	0.4	0.7	1.1	1.3	1.2	1.2	1.4
Depression (Nagel 2018)	0.2	0.3	0.6	-0.4	-0.7	-0.7	-0.5	-0.1	-0.4	-0.7
Schizophrenia (2018)	0.2	0.5	1.1	-1.1	0.6	-0.2	-0.8	1.0	0.0	0.3
Age at First Birth	0.2	0.3	0.6	-0.2	0.4	0.6	0.8	0.3	0.5	0.6
Body Mass Index (BMI) (2010)	0.2	0.3	0.9	0.9	-0.0	0.5	0.7	-0.0	0.6	0.1
Schizophrenia (2014)	0.2	0.5	1.3	-0.5	0.3	-0.9	-1.1	1.1	0.0	0.0
Blood Platelet Count	0.2	1.9	5.1	-1.1	1.9	0.4	-1.4	2.2	0.6	0.8
Height	0.2	4.1	16.8	4.1	1.5	1.4	1.7	0.7	1.0	1.8
Cardiovascular Disease	0.2	0.7	2.4	0.5	-1.1	0.3	0.9	-1.6	-0.5	-0.4
Eye problems/disorders: Diabetes related eye disease	0.2	0.3	0.7	-0.6	-0.2	-0.6	-0.4	-0.4	-0.9	-0.3
Vitamin and mineral supplements	0.2	0.2	0.6	0.8	-0.3	0.1	-0.5	-0.2	-0.5	-0.5
Medication: Metformin	0.2	0.3	1.2	-1.1	0.1	0.3	0.3	0.7	0.3	0.4
Diabetes (father)	0.2	0.2	0.5	-0.6	-0.1	0.3	0.6	-0.7	-0.4	0.0
Taking other prescription medications	0.2	0.4	1.4	-1.2	0.1	-0.8	-0.6	-0.1	-0.5	-0.0
Qualifications: CSEs or equivalent	0.2	0.2	1.1	-0.2	-0.1	0.4	1.0	-0.2	0.6	0.3
Multivitamins +/- minerals	0.2	0.3	1.3	-1.1	-0.1	-0.5	0.5	-0.4	0.2	0.1
Supplements: Glucosamine	0.2	0.2	0.5	-0.5	-0.7	-0.4	-0.0	-0.4	-0.0	-0.5
Leg predicted mass (left)	0.2	1.3	4.6	2.2	-0.2	0.7	1.5	0.1	0.9	0.8
Number of incorrect matches in round	0.2	0.3	1.2	-0.7	-0.2	0.5	0.3	-1.1	-0.2	-0.1
Hearing difficulty/problems with background noise	0.2	0.4	0.8	-0.9	-0.9	-0.1	0.2	-0.8	-0.3	-0.4
Allergy	0.2	0.4	1.7	0.4	0.2	0.1	-0.5	1.3	0.8	0.1
Weight	0.2	1.1	2.5	1.4	0.2	0.9	1.6	0.5	1.0	1.0
Alcohol intake versus 10 years previously	0.2	0.2	0.8	-0.9	-0.1	-0.2	-0.6	0.1	-0.7	-0.2
Noisy workplace	0.2	0.2	0.5	-0.6	-0.5	0.1	-0.7	0.7	-0.0	-0.1
Lung cancer (father)	0.2	0.3	0.7	0.3	0.4	-0.1	-0.7	0.8	0.4	0.3
Illnesses of mother	0.2	0.3	0.6	-0.6	0.4	-0.6	-0.7	0.7	-0.2	-0.1
Arm fat mass (right)	0.2	1.0	1.8	0.7	0.6	0.9	1.4	0.8	1.1	1.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.3	1.2	-0.2	-0.5	0.3	1.1	-0.0	0.7	0.1
Loud music exposure frequency	0.2	0.2	0.6	-0.8	-0.2	-0.5	-0.5	0.3	-0.3	-0.2
Forced vital capacity (FVC), Best measure	0.2	0.9	1.5	0.4	-1.2	-0.8	-0.5	-1.2	-1.0	-1.2
Worry too long after embarrassment	0.2	0.4	0.8	-0.5	-0.8	-0.2	-0.3	-0.9	-0.6	-0.6
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.3	0.9	-0.0	-0.4	-0.0	1.0	-0.6	0.5	0.3
Shortness of breath walking on level ground	0.2	0.3	0.8	0.9	0.1	0.1	-0.1	0.8	0.4	0.4
Migraine (self-reported)	0.2	0.3	0.9	-0.4	0.9	1.0	0.2	-0.2	0.2	0.3
Whole body fat mass	0.2	0.9	1.6	0.6	0.6	1.0	1.2	0.9	1.0	1.2
Age at last live birth	0.2	0.2	0.7	-0.2	-0.4	-0.4	-0.1	-0.8	-0.5	-0.5
Leg pain on walking	0.2	0.3	0.6	0.3	0.3	0.5	0.2	0.8	0.7	0.5
Commuting to job workplace: Car/motor vehicle	0.2	0.2	0.5	0.1	0.5	-0.6	-0.7	0.5	-0.5	0.1
Leg fat-free mass (right)	0.2	1.2	4.6	2.1	-0.3	0.5	1.5	-0.2	0.7	0.6
Diabetes diagnosed by doctor	0.2	0.3	1.1	-0.6	-0.4	0.3	1.1	0.4	0.1	0.4
Medication: Gliclazide	0.2	0.3	1.3	-0.3	-0.4	0.3	1.1	-0.5	0.2	0.2
Whole body water mass	0.2	0.9	3.6	1.9	-0.4	0.5	1.4	-0.3	0.5	0.4
Leg predicted mass (right)	0.2	1.2	4.6	2.1	-0.3	0.5	1.5	-0.2	0.7	0.6
Arm fat mass (left)	0.2	0.8	1.8	0.6	0.4	0.9	1.3	0.6	0.9	1.1
Alcohol drinker status: Never	0.2	0.2	0.7	0.8	-0.2	0.2	-0.5	0.4	0.4	-0.1
Basal metabolic rate	0.2	1.0	3.4	1.9	-0.2	0.7	1.4	-0.0	0.7	0.7
Alcohol drinker status: Previous	0.2	0.2	0.8	0.9	0.2	-0.0	0.1	0.7	0.4	0.3
Bipolar Disorder (2018)	0.1	0.2	0.8	0.5	-0.1	-0.9	-0.4	-0.1	-0.2	-0.2
Bipolar Disorder or Schizophrenia	0.1	0.3	0.7	-0.5	0.4	-0.7	-0.8	0.8	-0.1	0.1
Worry (Nagel 2018)	0.1	0.3	0.6	-0.7	-0.8	-0.5	-0.5	-0.0	-0.1	-0.5
Alzheimer’s Disease (in mother)	0.1	0.2	0.4	-0.2	-0.6	-0.3	0.2	-0.6	0.0	-0.5
Alzheimer’s Disease (including proxy)	0.1	0.1	0.6	0.2	0.3	0.3	0.8	-0.2	-0.0	0.3
Reaction Time	0.1	0.2	0.7	0.0	-0.8	-0.4	0.1	-0.5	-0.0	-0.6
Breast Cancer	0.1	0.3	0.6	0.5	0.7	0.5	0.4	0.6	0.5	0.5
Prostate Cancer	0.1	0.2	0.6	-0.1	-0.2	0.0	0.8	-0.7	0.3	0.0
HDL Cholesterol	0.1	0.2	0.5	-0.3	0.7	0.3	0.6	-0.1	0.6	0.6
LDL Cholesterol	0.1	0.2	0.3	0.2	0.3	0.5	0.4	0.5	0.4	0.4
Triglycerides	0.1	0.1	0.4	-0.1	-0.1	-0.2	-0.7	0.4	-0.6	-0.2
Type 2 Diabetes (T2D) (2012)	0.1	0.1	0.4	0.6	-0.1	0.5	-0.0	0.1	0.5	0.1
Blood Red Count	0.1	1.1	3.2	1.8	0.8	1.0	1.0	0.5	0.8	1.1
BMI	0.1	0.4	1.4	-0.0	-0.7	0.4	1.2	-0.7	0.2	-0.0
Hypothyroidism (self reported)	0.1	0.2	0.7	-0.1	0.8	0.6	0.2	0.1	0.3	0.4
Type 2 Diabetes (T2D) (2018)	0.1	0.1	0.4	-0.0	-0.6	0.0	0.6	0.2	-0.0	0.1
Hair Pigment	0.1	3.0	7.0	-2.4	-1.1	0.4	2.6	-2.6	-0.2	0.4
Tanning	0.1	1.1	2.0	0.5	-1.0	-1.2	-1.4	-0.5	-1.1	-1.1
Hand grip strength (left)	0.1	0.2	0.3	0.5	0.2	0.5	0.5	-0.6	-0.3	0.0
Number of treatments/medications taken	0.1	0.2	0.3	-0.6	-0.1	0.3	0.6	-0.5	0.2	0.2
Sensitivity / hurt feelings	0.1	0.2	0.6	-0.6	-0.8	-0.2	-0.5	0.0	-0.3	-0.4
Severe depression (siblings)	0.1	0.1	0.3	-0.3	-0.5	-0.5	0.1	-0.3	-0.1	-0.3
Hand grip strength (right)	0.1	0.3	0.6	0.8	-0.2	0.5	0.4	-0.7	-0.6	-0.2
Average weekly fortified wine intake	0.1	0.1	0.3	-0.5	0.5	0.1	0.1	0.3	0.1	0.3
Medication: Atenolol	0.1	0.1	0.3	-0.3	-0.5	-0.0	-0.2	-0.0	-0.0	-0.3
Medication: Levothyroxine sodium	0.1	0.2	0.7	0.8	0.5	0.0	-0.0	0.2	0.5	0.4
Sitting height	0.1	1.0	6.6	2.6	-0.0	0.3	0.2	0.3	0.2	0.1
Body mass index (BMI)	0.1	0.6	1.9	0.3	0.1	0.7	1.4	0.3	0.9	0.9
Ever unenthusiastic/disinterested for a whole week	0.1	0.2	0.5	0.0	-0.7	-0.6	-0.2	-0.3	-0.2	-0.5
Qualifications: None of the above	0.1	0.1	0.4	0.6	0.1	-0.1	0.3	0.5	0.3	0.5
Hayfever/allergic rhinitis (self-reported)	0.1	0.1	0.2	0.4	0.3	0.4	-0.1	-0.0	-0.2	0.3
Trunk fat-free mass	0.1	0.6	2.4	1.6	-0.5	0.4	1.1	-0.6	0.1	0.1
Hip circumference	0.1	0.6	1.6	0.7	0.1	0.7	1.3	0.5	0.9	0.9
Time employed in main current job	0.1	0.1	0.6	0.2	0.2	0.8	0.3	0.2	0.3	0.3
Falls in the last year	0.1	0.2	0.5	-0.3	-0.4	0.1	0.6	-0.7	-0.1	-0.3
Qualifications: A levels/AS levels or equivalent	0.1	0.2	0.7	0.6	-0.5	-0.4	0.2	-0.8	-0.1	-0.4
Serious illness, injury or assault of a close relative in last 2 years	0.1	0.2	0.3	0.5	0.5	0.3	-0.0	0.3	0.5	0.3
Mouth/teeth dental problems: Dentures	0.1	0.2	0.9	-0.0	-0.1	-0.6	-1.0	0.2	-0.5	-0.3
Medication: Lansoprazole	0.1	0.1	0.4	-0.7	-0.2	0.4	0.3	-0.4	0.3	-0.0
Trunk predicted mass	0.1	0.6	2.4	1.5	-0.5	0.5	1.1	-0.5	0.2	0.2
Standing height	0.1	1.1	6.4	2.5	0.4	0.6	0.5	0.4	0.2	0.5
Length of working week for main job	0.1	0.1	0.5	0.2	0.2	-0.3	0.1	0.7	0.3	0.4
Exposure to tobacco smoke at home	0.1	0.2	0.5	0.7	0.2	0.1	-0.2	0.6	0.1	0.3
Birth weight of first child	0.1	0.2	1.0	1.0	0.4	0.4	0.2	-0.4	0.0	0.2
Peak expiratory flow (PEF)	0.1	0.2	1.0	0.0	-0.0	-0.5	-0.3	-0.4	-1.0	-0.3
Hypothyroidism/myxoedema (self-reported)	0.1	0.3	0.8	0.2	-0.2	-0.4	-0.9	-0.4	-0.5	-0.6
Arm fat-free mass (right)	0.1	0.5	1.6	1.3	-0.5	0.4	1.1	-0.3	0.2	0.3
Exposure to tobacco smoke outside home	0.1	0.2	0.6	-0.2	-0.1	0.5	0.8	-0.0	0.5	0.2
Mean time to correctly identify matches	0.1	0.2	0.5	-0.6	-0.7	-0.4	0.2	-0.6	0.1	-0.5
Arm predicted mass (right)	0.1	0.6	1.6	1.3	-0.5	0.4	1.3	-0.5	0.2	0.3
Alcohol intake frequency.	0.1	0.2	0.6	0.7	-0.0	0.8	0.5	0.1	0.4	0.4
Overall health rating	0.1	0.3	1.0	-1.0	-0.4	-0.5	-0.1	0.6	0.5	0.0
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.1	0.4	-0.4	-0.2	0.0	-0.5	0.6	0.2	-0.0
Whole body fat-free mass	0.1	0.9	3.3	1.8	-0.4	0.5	1.3	-0.4	0.5	0.4
Osteoporosis (self-reported)	0.1	0.2	0.7	-0.4	-0.3	-0.8	0.4	-0.2	0.0	-0.1
Hearing aid user	0.1	0.2	0.5	0.4	-0.2	0.5	0.7	-0.0	0.2	0.2
Financial situation satisfaction	0.1	0.1	0.2	0.1	0.1	0.1	-0.5	0.4	0.3	0.2
Commuting to job workplace: Public transport	0.1	0.1	0.4	0.4	0.3	0.1	0.1	0.6	0.6	0.2
Medication: Blood pressure	0.1	0.3	0.7	0.6	-0.7	0.1	0.0	-0.8	-0.3	-0.4
Medication: Bendroflumethiazide	0.1	0.1	0.2	-0.3	-0.4	0.4	-0.2	-0.5	0.1	-0.1
Arm fat-free mass (left)	0.1	0.5	1.6	1.3	-0.4	0.5	1.2	-0.2	0.3	0.3
Arm predicted mass (left)	0.1	0.5	1.9	1.4	-0.3	0.3	1.1	-0.2	0.3	0.3
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Mean Putamen Volume	0.0	0.0	0.1	-0.2	-0.1	0.1	0.3	0.1	0.0	0.0
Primary Biliary Cirrhosis	0.0	0.1	0.3	-0.2	0.1	0.0	-0.6	0.2	-0.3	-0.0
Ulcerative Colitis	0.0	0.0	0.1	0.3	-0.1	-0.0	-0.3	-0.1	-0.2	-0.2
Pulse rate, automated reading	0.0	0.2	0.4	0.1	-0.4	-0.6	-0.4	0.5	0.3	-0.0

Hub : Genes

CTTN

Models

Trait associations