[Hub]/) : Traits : Lung FEV1/FVC ratio : ← →

chr11:71,339,667-74,335,121

Best TWAS P=7.48e-33 · Best GWAS P=4.53e-29 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
39	GTEx	Whole Blood	RP11-800A3.7	0.19	0.11	enet	10	0.12	2.0e-11	11.0	11.9	7.5e-33	0.85	0.00	1.00	TRUE
45	YFS	Blood	ARHGEF17	0.09	0.17	lasso	5	0.17	1.4e-53	11.2	11.1	1.7e-28	0.99	0.00	1.00	TRUE
35	GTEx	Whole Blood	FAM168A	0.06	0.04	lasso	3	0.02	4.6e-03	10.2	10.2	2.5e-24	0.92	0.29	0.58	TRUE
46	YFS	Blood	ATG16L2	0.01	0.00	blup	319	0.00	6.3e-02	6.3	9.4	6.3e-21	0.25	0.05	0.10	TRUE
47	YFS	Blood	STARD10	0.33	0.28	bslmm	322	0.37	4.8e-129	-6.0	-8.8	2.1e-18	-0.05	1.00	0.00	TRUE
19	GTEx	Esophagus Muscularis	STARD10	0.20	0.13	lasso	9	0.14	9.7e-09	-7.3	-8.6	5.8e-18	-0.02	0.20	0.80	TRUE
1	CommonMind	Brain Pre-frontal Cortex	ATG16L2	0.08	0.03	enet	13	0.05	1.7e-06	-7.9	7.8	4.9e-15	0.04	0.99	0.00	TRUE
6	GTEx	Adrenal Gland	ARAP1-AS1	0.16	-0.01	lasso	10	0.00	4.1e-01	-7.1	7.4	1.0e-13	0.02	0.03	0.39	TRUE
23	GTEx	Liver	CLPB	0.25	0.05	lasso	5	0.02	7.1e-02	6.9	7.4	1.1e-13	-0.03	0.04	0.16	TRUE
24	GTEx	Ovary	ATG16L2	0.69	-0.01	lasso	18	0.05	2.0e-02	5.3	7.2	5.3e-13	0.05	0.04	0.06	TRUE
2	CommonMind	Brain Pre-frontal Cortex	RELT	0.06	0.02	blup	318	0.04	4.1e-06	9.9	6.9	6.0e-12	0.71	0.03	0.95	TRUE
54	The Cancer Genome Atlas	Prostate Adenocarcinoma	PDE2A	0.06	0.01	lasso	5	0.01	4.4e-02	-5.1	-5.7	1.0e-08	0.07	0.09	0.08	TRUE
21	GTEx	Heart Atrial Appendage	RP11-707G14.1	0.09	0.01	enet	10	0.05	2.1e-03	4.8	5.3	1.3e-07	0.30	0.08	0.05	TRUE
40	METSIM	Adipose	PLEKHB1	0.06	0.01	blup	336	0.02	1.6e-03	-3.2	-5.3	1.3e-07	-0.11	0.56	0.02	TRUE
36	GTEx	Whole Blood	ARHGEF17	0.15	0.16	lasso	3	0.16	8.6e-15	11.0	11.3	1.2e-29	0.97	0.00	1.00	FALSE
43	ROSMAP	Brain Pre-frontal Cortex	FAM168A	0.03	0.02	bslmm	358	0.02	2.6e-03	10.2	-10.3	7.2e-25	-0.83	0.08	0.87	FALSE
55	The Cancer Genome Atlas	Stomach Adenocarcinoma	ARHGEF17	0.04	0.03	blup	54	0.02	1.2e-02	10.8	10.2	2.4e-24	0.91	0.01	0.86	FALSE
20	GTEx	Heart Atrial Appendage	STARD10	0.21	0.04	enet	23	0.05	4.1e-03	7.8	-8.7	2.5e-18	-0.03	0.01	0.98	FALSE
50	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	STARD10	0.03	0.01	blup	44	0.01	9.3e-03	-6.0	-8.5	2.8e-17	-0.05	0.02	0.41	FALSE
49	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	RELT	0.06	0.07	blup	35	0.08	3.5e-09	6.6	8.3	1.1e-16	0.78	0.88	0.12	FALSE
4	GTEx	Adipose Subcutaneous	STARD10	0.22	0.16	enet	16	0.17	6.7e-14	-6.0	-8.2	2.0e-16	-0.04	0.18	0.82	FALSE
33	GTEx	Spleen	RP11-809N8.4	0.33	0.03	lasso	4	0.03	5.5e-02	5.9	8.2	2.1e-16	0.77	0.02	0.70	FALSE
5	GTEx	Adipose Visceral Omentum	STARD10	0.12	0.09	enet	10	0.15	2.8e-08	-7.7	-7.8	5.1e-15	-0.03	0.02	0.98	FALSE
51	The Cancer Genome Atlas	Brain Lower Grade Glioma	STARD10	0.04	0.01	blup	45	0.02	2.1e-03	-6.0	-7.5	7.2e-14	-0.01	0.03	0.84	FALSE
10	GTEx	Artery Tibial	STARD10	0.19	0.10	enet	16	0.12	9.9e-10	-3.2	-7.4	2.0e-13	-0.03	0.23	0.77	FALSE
29	GTEx	Skin Not Sun Exposed Suprapubic	ARAP1-AS2	0.20	0.08	lasso	5	0.05	1.5e-03	5.5	7.3	2.9e-13	0.08	0.32	0.48	FALSE
38	GTEx	Whole Blood	RP11-809N8.4	0.08	0.06	lasso	2	0.04	6.5e-05	6.7	7.3	3.1e-13	0.70	0.62	0.30	FALSE
15	GTEx	Cells Transformed fibroblasts	STARD10	0.16	0.06	lasso	7	0.09	2.0e-07	-7.2	-7.2	8.6e-13	-0.01	0.06	0.94	FALSE
42	NTR	Blood	RELT	0.04	0.05	lasso	5	0.04	1.8e-13	6.2	7.1	1.1e-12	0.66	0.98	0.02	FALSE
30	GTEx	Skin Not Sun Exposed Suprapubic	ARAP1-AS1	0.14	0.13	lasso	4	0.07	9.1e-05	6.8	7.1	1.7e-12	0.06	0.69	0.25	FALSE
41	METSIM	Adipose	STARD10	0.08	0.04	blup	326	0.03	8.5e-06	-6.0	-7.0	3.3e-12	0.00	0.14	0.85	FALSE
37	GTEx	Whole Blood	STARD10	0.13	0.09	lasso	6	0.07	8.6e-07	-7.9	-6.9	5.7e-12	0.12	0.01	0.99	FALSE
22	GTEx	Heart Left Ventricle	STARD10	0.21	0.08	enet	24	0.07	1.6e-04	-7.7	-6.8	8.6e-12	-0.05	0.04	0.94	FALSE
56	The Cancer Genome Atlas	Thyroid Carcinoma	ATG16L2	0.08	0.10	enet	11	0.07	1.1e-07	-7.9	6.8	1.1e-11	0.01	0.00	1.00	FALSE
52	The Cancer Genome Atlas	Lung Adenocarcinoma	ATG16L2	0.02	0.01	blup	29	0.02	9.7e-04	-3.2	6.7	2.2e-11	-0.01	0.02	0.35	FALSE
28	GTEx	Skin Not Sun Exposed Suprapubic	ARAP1	0.24	0.20	lasso	4	0.16	3.6e-09	6.8	6.6	3.6e-11	0.07	0.95	0.05	FALSE
18	GTEx	Esophagus Mucosa	ARAP1-AS1	0.15	0.12	enet	7	0.13	4.1e-09	6.8	6.6	5.4e-11	0.09	0.96	0.04	FALSE
3	CommonMind	Brain Pre-frontal Cortex	STARD10	0.06	0.02	blup	349	0.02	1.7e-03	-3.2	-6.5	5.9e-11	0.02	0.11	0.83	FALSE
17	GTEx	Esophagus Mucosa	ARAP1-AS2	0.12	0.08	lasso	6	0.08	3.1e-06	6.8	6.4	1.2e-10	0.09	0.33	0.38	FALSE
16	GTEx	Esophagus Mucosa	ARAP1	0.27	0.25	lasso	5	0.26	2.6e-17	6.8	6.4	1.3e-10	0.07	0.96	0.04	FALSE
34	GTEx	Thyroid	STARD10	0.19	0.08	enet	18	0.13	2.4e-10	-3.2	-6.4	1.7e-10	-0.01	0.50	0.50	FALSE
11	GTEx	Brain Cerebellar Hemisphere	PDE2A	0.22	0.05	enet	17	0.10	1.3e-03	-4.3	-6.4	2.0e-10	0.01	0.01	0.92	FALSE
32	GTEx	Skin Sun Exposed Lower leg	ARAP1-AS1	0.18	0.07	lasso	7	0.06	1.0e-05	6.8	6.1	8.2e-10	0.08	0.83	0.03	FALSE
31	GTEx	Skin Sun Exposed Lower leg	ARAP1	0.21	0.13	lasso	7	0.13	1.2e-10	6.8	6.1	8.9e-10	0.08	0.96	0.04	FALSE
13	GTEx	Brain Hippocampus	STARD10	0.36	0.19	enet	16	0.27	5.1e-07	-3.2	-6.0	2.1e-09	-0.01	0.19	0.22	FALSE
9	GTEx	Artery Tibial	ARAP1	0.12	0.00	lasso	6	0.00	1.7e-01	5.0	-6.0	2.2e-09	-0.07	0.09	0.16	FALSE
12	GTEx	Brain Cerebellum	PDE2A	0.26	0.20	lasso	3	0.21	8.8e-07	-4.3	-5.9	2.8e-09	0.01	0.08	0.85	FALSE
26	GTEx	Pituitary	PDE2A	0.25	0.19	lasso	5	0.17	4.1e-05	5.8	5.9	4.9e-09	0.01	0.04	0.77	FALSE
48	The Cancer Genome Atlas	Breast Invasive Carcinoma	PDE2A	0.02	0.02	lasso	2	0.02	2.0e-04	5.8	-5.8	7.0e-09	-0.01	0.18	0.32	FALSE
27	GTEx	Pituitary	RP11-169D4.2	0.19	0.20	lasso	2	0.16	7.3e-05	5.8	5.7	1.4e-08	0.02	0.05	0.62	FALSE
7	GTEx	Artery Coronary	PAAF1	0.41	0.00	lasso	9	0.04	1.4e-02	-3.6	5.6	1.8e-08	0.34	0.04	0.11	FALSE
25	GTEx	Pituitary	ATG16L2	0.24	0.24	lasso	3	0.15	1.1e-04	-6.0	5.6	1.9e-08	0.03	0.20	0.05	FALSE
14	GTEx	Brain Hypothalamus	STARD10	0.22	0.08	lasso	7	0.09	4.0e-03	-7.2	-5.5	3.2e-08	-0.04	0.05	0.29	FALSE
8	GTEx	Artery Coronary	STARD10	0.26	0.08	enet	9	0.08	1.1e-03	-3.2	-5.5	4.0e-08	0.00	0.12	0.60	FALSE
44	YFS	Blood	ARAP1	0.02	0.01	lasso	1	0.01	2.3e-03	5.3	5.3	1.0e-07	0.00	0.10	0.23	FALSE
53	The Cancer Genome Atlas	Prostate Adenocarcinoma	FCHSD2	0.06	0.03	blup	74	0.01	2.8e-02	-7.3	-5.3	1.4e-07	-0.01	0.02	0.92	FALSE