TWAS
hub
About
Usage
Models
Genes
Traits
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Traits
:
Lung FEV1/FVC ratio
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chr12:403,545-2,299,048
Best TWAS P=2e-17 · Best GWAS P=2.66e-16 conditioned to 0.00919
0.5M
1M
1.5M
2M
0
5
10
15
physical position
-log10 P
Conditional
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
1
METSIM
Adipose
ERC1
0.08
0.05
enet
25
0.04
9.3e-07
7.1
8.5
2.0e-17
0.62
0.25
0.74
TRUE
4
The Cancer Genome Atlas
Stomach Adenocarcinoma
ERC1
0.12
0.00
blup
218
0.05
8.9e-05
3.9
7.0
2.3e-12
0.45
0.02
0.45
TRUE
3
The Cancer Genome Atlas
Kidney Renal Clear Cell Carcinoma
ERC1
0.10
0.02
blup
219
0.06
7.6e-07
3.8
6.8
7.5e-12
0.22
0.31
0.02
FALSE
2
The Cancer Genome Atlas
Breast Invasive Carcinoma
ERC1
0.03
0.03
lasso
3
0.03
2.2e-07
5.8
5.8
5.4e-09
0.08
0.99
0.00
FALSE