TWAS
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Traits
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Lung FEV1/FVC ratio
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chr12:14,575,459-16,190,627
Best TWAS P=3.27e-16 · Best GWAS P=2.77e-19 conditioned to 7.85e-05
14.6M
14.8M
15M
15.2M
15.4M
15.6M
15.8M
16M
16.2M
0
5
10
15
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
1
CommonMind
Brain Pre-frontal Cortex
RERG
0.11
0.07
lasso
2
0.08
1.4e-09
7.2
8.2
3.3e-16
-0.83
0.08
0.92
TRUE
2
ROSMAP
Brain Pre-frontal Cortex
RERG
0.22
0.10
enet
18
0.10
1.9e-12
7.2
5.5
3.2e-08
-0.69
0.69
0.31
FALSE