[Hub]/) : Traits : Lung FEV1/FVC ratio : ← →

chr12:53,136,542-55,276,396

Best TWAS P=1.63e-19 · Best GWAS P=3.26e-21 conditioned to 0.713

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
14	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	HOXC8	0.03	0.05	enet	5	0.04	2.4e-05	-8.4	9.0	1.6e-19	-0.82	0.10	0.80	TRUE
30	The Cancer Genome Atlas	Thyroid Carcinoma	LOC400043	0.15	0.00	enet	9	0.07	4.7e-07	-6.2	-7.0	3.0e-12	0.26	0.00	0.99	TRUE
3	YFS	Blood	PCBP2	0.01	0.02	lasso	4	0.01	2.2e-05	4.3	-5.2	2.1e-07	0.08	0.01	0.89	TRUE
31	The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	FLJ12825	0.15	0.02	lasso	5	0.06	8.9e-03	-8.5	-8.9	5.3e-19	0.72	0.01	0.48	FALSE
13	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	HOXC6	0.03	0.02	blup	50	0.03	3.9e-04	-8.4	8.6	6.4e-18	-0.80	0.06	0.73	FALSE
9	The Cancer Genome Atlas	Esophageal Carcinoma	FLJ12825	0.12	0.05	blup	59	0.02	6.9e-02	4.6	-8.2	1.6e-16	0.47	0.03	0.14	FALSE
11	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	HOXC5	0.02	0.00	blup	51	0.01	2.4e-02	-8.4	-7.2	8.3e-13	0.68	0.02	0.30	FALSE
21	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	LOC100240734	0.05	0.03	enet	4	0.05	3.2e-04	5.6	6.8	1.3e-11	-0.21	0.02	0.61	FALSE
20	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	FLJ12825	0.23	0.15	enet	14	0.21	1.7e-23	-5.6	-6.7	2.3e-11	0.28	1.00	0.00	FALSE
24	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	LOC100240734	0.16	0.05	enet	8	0.08	4.9e-04	5.6	6.6	3.2e-11	-0.17	0.02	0.87	FALSE
29	The Cancer Genome Atlas	Stomach Adenocarcinoma	LOC100240734	0.06	0.01	blup	33	0.03	1.8e-03	4.4	6.6	4.6e-11	-0.25	0.01	0.83	FALSE
27	The Cancer Genome Atlas	Soft Tissue Sarcoma	FLJ12825	0.19	0.06	enet	7	0.11	3.9e-07	-5.3	-6.5	7.9e-11	0.36	0.98	0.00	FALSE
12	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	FLJ12825	0.54	0.56	enet	12	0.57	2.5e-78	-6.2	-6.5	9.3e-11	0.28	1.00	0.00	FALSE
23	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	FLJ12825	0.35	0.23	lasso	2	0.21	8.8e-09	-6.2	-6.4	2.1e-10	0.30	0.97	0.00	FALSE
5	The Cancer Genome Atlas	Breast Invasive Carcinoma	FLJ12825	0.32	0.29	lasso	5	0.32	1.7e-67	-6.2	-6.3	2.2e-10	0.28	1.00	0.00	FALSE
10	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	FLJ12825	0.35	0.27	lasso	5	0.29	7.4e-33	-6.2	-6.3	3.6e-10	0.23	1.00	0.00	FALSE
15	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	LOC100240734	0.11	0.10	lasso	4	0.09	4.2e-10	6.0	6.2	4.6e-10	-0.24	0.00	1.00	FALSE
17	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	FLJ12825	0.52	0.36	lasso	4	0.37	2.1e-22	-6.2	-6.2	4.7e-10	0.28	1.00	0.00	FALSE
6	The Cancer Genome Atlas	Breast Invasive Carcinoma	LOC100240734	0.05	0.05	enet	9	0.05	8.4e-11	6.0	6.2	7.4e-10	-0.20	0.00	1.00	FALSE
7	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	FLJ12825	0.35	0.21	lasso	5	0.26	5.5e-13	-6.2	-6.2	7.4e-10	0.26	1.00	0.00	FALSE
4	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	FLJ12825	0.34	0.18	lasso	5	0.24	1.6e-20	3.8	-5.9	3.6e-09	0.33	1.00	0.00	FALSE
28	The Cancer Genome Atlas	Stomach Adenocarcinoma	FLJ12825	0.18	0.11	lasso	3	0.16	1.4e-11	3.8	-5.8	4.9e-09	0.20	1.00	0.00	FALSE
22	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	FLJ12825	0.25	0.09	lasso	4	0.12	1.6e-05	5.0	-5.8	6.6e-09	0.25	0.44	0.05	FALSE
2	GTEx	Thyroid	RP11-834C11.4	0.19	0.10	lasso	3	0.10	5.3e-08	-5.5	-5.8	8.0e-09	0.20	0.96	0.00	FALSE
25	The Cancer Genome Atlas	Prostate Adenocarcinoma	FLJ12825	0.47	0.24	enet	14	0.30	3.5e-31	3.8	-5.8	8.0e-09	0.28	1.00	0.00	FALSE
18	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	LOC100240734	0.09	0.02	enet	8	0.04	1.6e-03	4.4	5.7	1.0e-08	-0.14	0.02	0.54	FALSE
26	The Cancer Genome Atlas	Prostate Adenocarcinoma	LOC400043	0.08	0.02	blup	31	0.05	3.3e-06	3.6	-5.5	3.2e-08	0.24	0.34	0.54	FALSE
1	GTEx	Colon Transverse	SMUG1	0.23	0.06	enet	16	0.14	2.9e-07	3.3	5.5	4.3e-08	-0.17	0.87	0.01	FALSE
16	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	LOC100240735	0.03	0.01	blup	32	0.01	1.8e-02	2.6	5.5	4.7e-08	-0.17	0.06	0.03	FALSE
8	The Cancer Genome Atlas	Colon Adenocarcinoma	FLJ12825	0.26	0.13	lasso	5	0.19	2.9e-11	-4.7	-5.4	5.7e-08	0.28	0.99	0.00	FALSE
19	The Cancer Genome Atlas	Lung Adenocarcinoma	FLJ12825	0.21	0.20	lasso	5	0.22	7.7e-25	3.8	-5.4	7.3e-08	0.20	1.00	0.00	FALSE