Best TWAS P=1.63e-19 · Best GWAS P=3.26e-21 conditioned to 0.713
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Colon Transverse | SMUG1 | 0.23 | 0.06 | enet | 16 | 0.14 | 2.9e-07 | 3.3 | 5.5 | 4.3e-08 | -0.17 | 0.87 | 0.01 | FALSE |
| 2 | GTEx | Thyroid | RP11-834C11.4 | 0.19 | 0.10 | lasso | 3 | 0.10 | 5.3e-08 | -5.5 | -5.8 | 8.0e-09 | 0.20 | 0.96 | 0.00 | FALSE |
| 3 | YFS | Blood | PCBP2 | 0.01 | 0.02 | lasso | 4 | 0.01 | 2.2e-05 | 4.3 | -5.2 | 2.1e-07 | 0.08 | 0.01 | 0.89 | TRUE |
| 4 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | FLJ12825 | 0.34 | 0.18 | lasso | 5 | 0.24 | 1.6e-20 | 3.8 | -5.9 | 3.6e-09 | 0.33 | 1.00 | 0.00 | FALSE |
| 5 | The Cancer Genome Atlas | Breast Invasive Carcinoma | FLJ12825 | 0.32 | 0.29 | lasso | 5 | 0.32 | 1.7e-67 | -6.2 | -6.3 | 2.2e-10 | 0.28 | 1.00 | 0.00 | FALSE |
| 6 | The Cancer Genome Atlas | Breast Invasive Carcinoma | LOC100240734 | 0.05 | 0.05 | enet | 9 | 0.05 | 8.4e-11 | 6.0 | 6.2 | 7.4e-10 | -0.20 | 0.00 | 1.00 | FALSE |
| 7 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | FLJ12825 | 0.35 | 0.21 | lasso | 5 | 0.26 | 5.5e-13 | -6.2 | -6.2 | 7.4e-10 | 0.26 | 1.00 | 0.00 | FALSE |
| 8 | The Cancer Genome Atlas | Colon Adenocarcinoma | FLJ12825 | 0.26 | 0.13 | lasso | 5 | 0.19 | 2.9e-11 | -4.7 | -5.4 | 5.7e-08 | 0.28 | 0.99 | 0.00 | FALSE |
| 9 | The Cancer Genome Atlas | Esophageal Carcinoma | FLJ12825 | 0.12 | 0.05 | blup | 59 | 0.02 | 6.9e-02 | 4.6 | -8.2 | 1.6e-16 | 0.47 | 0.03 | 0.14 | FALSE |
| 10 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | FLJ12825 | 0.35 | 0.27 | lasso | 5 | 0.29 | 7.4e-33 | -6.2 | -6.3 | 3.6e-10 | 0.23 | 1.00 | 0.00 | FALSE |
| 11 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | HOXC5 | 0.02 | 0.00 | blup | 51 | 0.01 | 2.4e-02 | -8.4 | -7.2 | 8.3e-13 | 0.68 | 0.02 | 0.30 | FALSE |
| 12 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | FLJ12825 | 0.54 | 0.56 | enet | 12 | 0.57 | 2.5e-78 | -6.2 | -6.5 | 9.3e-11 | 0.28 | 1.00 | 0.00 | FALSE |
| 13 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | HOXC6 | 0.03 | 0.02 | blup | 50 | 0.03 | 3.9e-04 | -8.4 | 8.6 | 6.4e-18 | -0.80 | 0.06 | 0.73 | FALSE |
| 14 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | HOXC8 | 0.03 | 0.05 | enet | 5 | 0.04 | 2.4e-05 | -8.4 | 9.0 | 1.6e-19 | -0.82 | 0.10 | 0.80 | TRUE |
| 15 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | LOC100240734 | 0.11 | 0.10 | lasso | 4 | 0.09 | 4.2e-10 | 6.0 | 6.2 | 4.6e-10 | -0.24 | 0.00 | 1.00 | FALSE |
| 16 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | LOC100240735 | 0.03 | 0.01 | blup | 32 | 0.01 | 1.8e-02 | 2.6 | 5.5 | 4.7e-08 | -0.17 | 0.06 | 0.03 | FALSE |
| 17 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | FLJ12825 | 0.52 | 0.36 | lasso | 4 | 0.37 | 2.1e-22 | -6.2 | -6.2 | 4.7e-10 | 0.28 | 1.00 | 0.00 | FALSE |
| 18 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | LOC100240734 | 0.09 | 0.02 | enet | 8 | 0.04 | 1.6e-03 | 4.4 | 5.7 | 1.0e-08 | -0.14 | 0.02 | 0.54 | FALSE |
| 19 | The Cancer Genome Atlas | Lung Adenocarcinoma | FLJ12825 | 0.21 | 0.20 | lasso | 5 | 0.22 | 7.7e-25 | 3.8 | -5.4 | 7.3e-08 | 0.20 | 1.00 | 0.00 | FALSE |
| 20 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | FLJ12825 | 0.23 | 0.15 | enet | 14 | 0.21 | 1.7e-23 | -5.6 | -6.7 | 2.3e-11 | 0.28 | 1.00 | 0.00 | FALSE |
| 21 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | LOC100240734 | 0.05 | 0.03 | enet | 4 | 0.05 | 3.2e-04 | 5.6 | 6.8 | 1.3e-11 | -0.21 | 0.02 | 0.61 | FALSE |
| 22 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | FLJ12825 | 0.25 | 0.09 | lasso | 4 | 0.12 | 1.6e-05 | 5.0 | -5.8 | 6.6e-09 | 0.25 | 0.44 | 0.05 | FALSE |
| 23 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | FLJ12825 | 0.35 | 0.23 | lasso | 2 | 0.21 | 8.8e-09 | -6.2 | -6.4 | 2.1e-10 | 0.30 | 0.97 | 0.00 | FALSE |
| 24 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | LOC100240734 | 0.16 | 0.05 | enet | 8 | 0.08 | 4.9e-04 | 5.6 | 6.6 | 3.2e-11 | -0.17 | 0.02 | 0.87 | FALSE |
| 25 | The Cancer Genome Atlas | Prostate Adenocarcinoma | FLJ12825 | 0.47 | 0.24 | enet | 14 | 0.30 | 3.5e-31 | 3.8 | -5.8 | 8.0e-09 | 0.28 | 1.00 | 0.00 | FALSE |
| 26 | The Cancer Genome Atlas | Prostate Adenocarcinoma | LOC400043 | 0.08 | 0.02 | blup | 31 | 0.05 | 3.3e-06 | 3.6 | -5.5 | 3.2e-08 | 0.24 | 0.34 | 0.54 | FALSE |
| 27 | The Cancer Genome Atlas | Soft Tissue Sarcoma | FLJ12825 | 0.19 | 0.06 | enet | 7 | 0.11 | 3.9e-07 | -5.3 | -6.5 | 7.9e-11 | 0.36 | 0.98 | 0.00 | FALSE |
| 28 | The Cancer Genome Atlas | Stomach Adenocarcinoma | FLJ12825 | 0.18 | 0.11 | lasso | 3 | 0.16 | 1.4e-11 | 3.8 | -5.8 | 4.9e-09 | 0.20 | 1.00 | 0.00 | FALSE |
| 29 | The Cancer Genome Atlas | Stomach Adenocarcinoma | LOC100240734 | 0.06 | 0.01 | blup | 33 | 0.03 | 1.8e-03 | 4.4 | 6.6 | 4.6e-11 | -0.25 | 0.01 | 0.83 | FALSE |
| 30 | The Cancer Genome Atlas | Thyroid Carcinoma | LOC400043 | 0.15 | 0.00 | enet | 9 | 0.07 | 4.7e-07 | -6.2 | -7.0 | 3.0e-12 | 0.26 | 0.00 | 0.99 | TRUE |
| 31 | The Cancer Genome Atlas | Uterine Corpus Endometrial Carcinoma | FLJ12825 | 0.15 | 0.02 | lasso | 5 | 0.06 | 8.9e-03 | -8.5 | -8.9 | 5.3e-19 | 0.72 | 0.01 | 0.48 | FALSE |