[Hub]/) : Traits : Lung FEV1/FVC ratio :

chr12:55,601,472-58,303,535

Best TWAS P=3e-30 · Best GWAS P=8.88e-30 conditioned to 1

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex RPS26 0.48 0.62 lasso 5 0.63 5.9e-99 -7.8 -7.8 6.0e-15 0.00 1.00 0.00 FALSE
2 CommonMind Brain Pre-frontal Cortex STAT6 0.11 0.08 lasso 3 0.11 9.1e-14 5.3 7.2 4.7e-13 0.52 0.98 0.02 FALSE
3 GTEx Artery Aorta SUOX 0.36 0.30 lasso 7 0.35 3.8e-20 -7.3 7.1 1.7e-12 0.00 0.99 0.01 FALSE
4 GTEx Artery Tibial LRP1 0.15 0.12 lasso 2 0.10 3.9e-08 11.3 -11.4 3.0e-30 -1.00 0.00 1.00 TRUE
5 GTEx Artery Tibial SUOX 0.18 0.14 enet 23 0.18 2.1e-14 -7.3 6.2 6.4e-10 0.00 0.77 0.23 FALSE
6 GTEx Artery Tibial STAT6 0.08 0.03 enet 4 0.02 1.3e-02 8.4 6.3 2.1e-10 0.61 0.23 0.24 FALSE
7 GTEx Artery Tibial RPS26 0.07 0.02 enet 5 0.01 3.5e-02 -7.8 -7.9 2.1e-15 0.00 0.06 0.78 FALSE
8 GTEx Brain Cerebellum SUOX 0.24 0.20 lasso 6 0.20 1.2e-06 -7.3 6.5 9.6e-11 0.02 0.37 0.37 FALSE
9 GTEx Brain Cortex SUOX 0.16 0.11 lasso 4 0.10 1.1e-03 -7.3 7.2 5.2e-13 0.02 0.04 0.61 FALSE
10 GTEx Brain Nucleus accumbens basal ganglia SUOX 0.18 0.08 lasso 4 0.10 1.1e-03 -7.3 6.0 2.6e-09 0.02 0.07 0.41 FALSE
11 GTEx Brain Putamen basal ganglia RP11-977G19.11 0.30 0.15 enet 33 0.20 1.5e-05 -8.0 5.5 3.9e-08 0.01 0.37 0.04 FALSE
12 GTEx Breast Mammary Tissue RPS26 0.29 0.05 enet 37 0.12 9.4e-07 -7.8 -8.0 1.2e-15 -0.06 0.70 0.28 FALSE
13 GTEx Breast Mammary Tissue (Female) RPS26 0.20 0.11 lasso 3 0.10 6.6e-04 -7.3 -8.1 7.1e-16 -0.05 0.05 0.17 FALSE
14 GTEx Cells Transformed fibroblasts RPS26 0.11 0.08 enet 15 0.09 3.4e-07 -7.5 -6.6 3.4e-11 -0.01 0.58 0.41 FALSE
15 GTEx Colon Sigmoid SUOX 0.23 0.18 lasso 4 0.15 7.9e-06 -7.3 7.3 2.3e-13 0.01 0.12 0.86 FALSE
16 GTEx Colon Transverse SUOX 0.24 0.22 enet 24 0.25 3.8e-12 -7.3 5.4 7.7e-08 0.05 0.89 0.10 FALSE
17 GTEx Esophagus Gastroesophageal Junction SUOX 0.20 0.16 lasso 5 0.19 2.7e-07 -7.3 7.7 1.2e-14 0.00 0.12 0.87 FALSE
18 GTEx Esophagus Gastroesophageal Junction WIBG 0.16 0.02 lasso 5 0.04 1.9e-02 1.4 6.2 4.5e-10 0.02 0.01 0.72 FALSE
19 GTEx Esophagus Muscularis SUOX 0.24 0.19 enet 16 0.15 2.3e-09 -7.3 7.2 5.4e-13 0.02 0.99 0.01 FALSE
20 GTEx Heart Atrial Appendage SUOX 0.09 0.10 enet 8 0.09 1.1e-04 -7.8 7.8 5.0e-15 0.01 0.09 0.76 FALSE
21 GTEx Lung SUOX 0.34 0.23 enet 38 0.26 4.6e-20 -7.3 5.9 3.1e-09 0.01 1.00 0.00 FALSE
22 GTEx Muscle Skeletal RAB5B 0.29 0.32 lasso 4 0.33 1.3e-33 -8.4 8.6 8.2e-18 0.00 0.61 0.39 FALSE
23 GTEx Muscle Skeletal SUOX 0.11 0.04 lasso 7 0.04 4.4e-05 -7.3 6.6 5.1e-11 0.02 0.34 0.56 FALSE
24 GTEx Muscle Skeletal AC034102.1 0.28 0.31 lasso 4 0.31 2.3e-31 -8.3 8.6 8.3e-18 0.00 0.52 0.48 FALSE
25 GTEx Nerve Tibial SUOX 0.34 0.30 enet 22 0.35 8.5e-26 -7.3 6.0 1.9e-09 0.01 1.00 0.00 FALSE
26 GTEx Nerve Tibial RPS26 0.12 0.09 enet 7 0.11 3.0e-08 -8.4 -7.3 3.8e-13 0.00 0.76 0.23 FALSE
27 GTEx Ovary SUOX 0.23 0.14 enet 12 0.21 8.4e-06 -7.3 6.2 4.5e-10 0.02 0.11 0.29 FALSE
28 GTEx Ovary RPS26 0.50 0.24 enet 25 0.22 5.0e-06 -7.6 -5.8 4.8e-09 0.00 0.37 0.52 FALSE
29 GTEx Pancreas SUOX 0.30 0.20 enet 23 0.30 3.5e-13 -7.3 5.5 4.0e-08 0.01 0.96 0.02 FALSE
30 GTEx Prostate SUOX 0.22 0.04 enet 11 0.05 2.3e-02 -7.3 8.7 2.6e-18 0.00 0.04 0.72 TRUE
31 GTEx Skin Not Sun Exposed Suprapubic SUOX 0.10 0.14 lasso 2 0.12 2.5e-07 -7.3 7.3 2.1e-13 0.02 0.26 0.71 FALSE
32 GTEx Skin Sun Exposed Lower leg SUOX 0.23 0.30 lasso 3 0.29 1.9e-24 -7.3 7.6 4.0e-14 0.02 1.00 0.00 FALSE
33 GTEx Spleen SUOX 0.34 0.31 enet 15 0.28 5.4e-08 -7.3 6.5 9.0e-11 0.07 0.29 0.48 FALSE
34 GTEx Stomach SUOX 0.15 0.17 enet 8 0.09 6.7e-05 -7.3 7.2 5.7e-13 0.01 0.79 0.12 FALSE
35 GTEx Stomach RPS26 0.16 0.08 enet 5 0.05 1.8e-03 -7.3 -7.4 1.6e-13 0.00 0.13 0.32 FALSE
36 GTEx Testis SUOX 0.27 0.18 lasso 14 0.18 1.4e-08 -7.3 7.6 2.3e-14 0.01 0.09 0.91 FALSE
37 GTEx Thyroid SUOX 0.37 0.40 lasso 7 0.38 5.4e-31 -7.3 7.3 2.0e-13 0.03 1.00 0.00 FALSE
38 GTEx Whole Blood SUOX 0.07 0.01 enet 20 0.02 1.1e-02 -7.8 7.5 9.0e-14 -0.02 0.01 0.97 FALSE
39 GTEx Whole Blood RPS26 0.05 0.05 lasso 1 0.05 3.4e-05 -7.3 -7.3 2.0e-13 -0.01 0.05 0.92 FALSE
40 METSIM Adipose IKZF4 0.04 0.04 enet 3 0.04 1.0e-06 -7.6 -7.6 2.2e-14 0.00 0.98 0.02 FALSE
41 METSIM Adipose RPS26 0.30 0.40 lasso 5 0.41 7.2e-66 -7.5 -7.7 1.2e-14 0.00 1.00 0.00 FALSE
42 METSIM Adipose STAT6 0.08 0.02 blup 343 0.03 5.0e-06 8.4 -6.2 5.1e-10 -0.53 0.42 0.55 FALSE
43 METSIM Adipose SUOX 0.04 0.01 blup 288 0.02 1.1e-03 -7.6 6.2 5.2e-10 -0.01 0.55 0.23 FALSE
44 YFS Blood SUOX 0.11 0.09 bslmm 269 0.09 3.4e-27 -7.3 7.5 7.7e-14 0.05 1.00 0.00 FALSE
45 The Cancer Genome Atlas Bladder Urothelial Carcinoma RPS26 0.14 0.22 lasso 2 0.23 4.8e-19 -7.5 -7.6 2.7e-14 0.00 0.94 0.06 FALSE
46 The Cancer Genome Atlas Breast Invasive Carcinoma RPS26 0.30 0.44 enet 10 0.45 5.2e-104 -7.8 -8.3 1.5e-16 0.00 0.99 0.01 FALSE
47 The Cancer Genome Atlas Cervical Squamous Cell Carcinoma RPS26 0.23 0.40 lasso 2 0.39 1.5e-20 -7.8 -8.1 7.8e-16 0.00 0.25 0.75 FALSE
48 The Cancer Genome Atlas Colon Adenocarcinoma RPS26 0.43 0.48 lasso 4 0.47 1.8e-30 -7.8 -8.2 3.2e-16 0.00 0.75 0.25 FALSE
49 The Cancer Genome Atlas Esophageal Carcinoma RPS26 0.19 0.13 lasso 5 0.11 2.4e-04 -7.8 -8.1 8.5e-16 0.00 0.01 0.98 FALSE
50 The Cancer Genome Atlas Glioblastoma Multiforme RPS26 0.41 0.38 enet 9 0.39 7.9e-13 -7.5 -7.8 4.7e-15 0.00 0.40 0.60 FALSE
51 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma RPS26 0.17 0.29 lasso 4 0.29 6.2e-33 -7.5 -7.8 6.7e-15 0.00 1.00 0.00 FALSE
52 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma RPS26 0.50 0.45 enet 13 0.52 1.4e-67 -7.5 -6.9 5.8e-12 -0.01 1.00 0.00 FALSE
53 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma RPS26 0.27 0.38 enet 8 0.40 5.0e-24 -7.8 -8.1 5.9e-16 0.00 0.99 0.01 FALSE
54 The Cancer Genome Atlas Brain Lower Grade Glioma ERBB3 0.07 0.02 blup 29 0.05 2.1e-06 -9.1 -7.0 2.5e-12 0.02 0.00 1.00 FALSE
55 The Cancer Genome Atlas Brain Lower Grade Glioma RPS26 0.31 0.53 enet 8 0.55 1.7e-74 -7.8 -7.9 3.2e-15 0.00 1.00 0.00 FALSE
56 The Cancer Genome Atlas Liver Hepatocellular Carcinoma RPS26 0.18 0.31 lasso 2 0.29 3.9e-14 -7.8 -7.7 1.1e-14 0.00 0.97 0.03 FALSE
57 The Cancer Genome Atlas Lung Adenocarcinoma RAB5B 0.03 0.02 enet 7 0.02 4.3e-03 -8.4 -8.4 3.8e-17 0.03 0.02 0.49 FALSE
58 The Cancer Genome Atlas Lung Adenocarcinoma RPS26 0.26 0.45 enet 9 0.47 3.6e-61 -7.8 -8.1 5.2e-16 0.00 1.00 0.00 FALSE
59 The Cancer Genome Atlas Lung Squamous Cell Carcinoma RPS26 0.22 0.31 lasso 3 0.31 1.6e-35 -7.8 -8.3 1.4e-16 0.00 0.98 0.02 FALSE
60 The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma RPS26 0.30 0.20 lasso 4 0.24 3.9e-16 -7.8 -8.6 6.5e-18 0.00 0.05 0.95 FALSE
61 The Cancer Genome Atlas Pancreatic Adenocarcinoma RPS26 0.36 0.44 lasso 7 0.42 2.4e-19 -7.5 -7.7 1.8e-14 0.00 0.99 0.01 FALSE
62 The Cancer Genome Atlas Pheochromocytoma and Paraganglioma RPS26 0.47 0.43 lasso 2 0.44 3.2e-19 -7.3 -7.6 2.7e-14 0.00 0.98 0.02 FALSE
63 The Cancer Genome Atlas Prostate Adenocarcinoma RPS26 0.33 0.52 enet 9 0.54 5.6e-66 -7.8 -8.1 5.6e-16 0.00 0.99 0.01 FALSE
64 The Cancer Genome Atlas Rectum Adenocarcinoma RPS26 0.24 0.18 lasso 2 0.20 1.9e-05 -7.8 -7.7 1.0e-14 0.00 0.05 0.57 FALSE
65 The Cancer Genome Atlas Soft Tissue Sarcoma RPS26 0.23 0.31 lasso 3 0.30 2.4e-18 -7.8 -7.9 2.6e-15 0.00 0.64 0.36 FALSE
66 The Cancer Genome Atlas Skin Cutaneous Melanoma RPS26 0.28 0.15 lasso 2 0.17 3.0e-05 -8.4 -8.3 1.2e-16 0.00 0.01 0.94 FALSE
67 The Cancer Genome Atlas Stomach Adenocarcinoma ERBB3 0.13 0.01 enet 12 0.03 1.9e-03 -7.5 5.7 1.4e-08 -0.02 0.01 0.27 FALSE
68 The Cancer Genome Atlas Stomach Adenocarcinoma RPS26 0.19 0.32 lasso 5 0.34 2.0e-25 -7.5 -7.8 4.9e-15 0.00 1.00 0.00 FALSE
69 The Cancer Genome Atlas Testicular Germ Cell Tumors RPS26 0.46 0.64 lasso 4 0.65 8.5e-30 -7.8 -8.1 5.6e-16 0.00 0.44 0.56 FALSE
70 The Cancer Genome Atlas Thyroid Carcinoma RPS26 0.33 0.51 enet 19 0.50 7.3e-56 -7.8 -7.4 1.5e-13 0.00 0.99 0.01 FALSE
71 The Cancer Genome Atlas Thyroid Carcinoma STAT6 0.04 0.01 blup 47 0.01 2.3e-02 9.1 7.2 4.8e-13 0.79 0.02 0.73 FALSE
72 The Cancer Genome Atlas Uterine Corpus Endometrial Carcinoma RPS26 0.17 0.19 lasso 4 0.18 1.3e-05 -7.8 -7.8 8.1e-15 0.00 0.02 0.97 FALSE