Best TWAS P=3e-30 · Best GWAS P=8.88e-30 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | RPS26 | 0.48 | 0.62 | lasso | 5 | 0.63 | 5.9e-99 | -7.8 | -7.8 | 6.0e-15 | 0.00 | 1.00 | 0.00 | FALSE |
| 2 | CommonMind | Brain Pre-frontal Cortex | STAT6 | 0.11 | 0.08 | lasso | 3 | 0.11 | 9.1e-14 | 5.3 | 7.2 | 4.7e-13 | 0.52 | 0.98 | 0.02 | FALSE |
| 3 | GTEx | Artery Aorta | SUOX | 0.36 | 0.30 | lasso | 7 | 0.35 | 3.8e-20 | -7.3 | 7.1 | 1.7e-12 | 0.00 | 0.99 | 0.01 | FALSE |
| 4 | GTEx | Artery Tibial | LRP1 | 0.15 | 0.12 | lasso | 2 | 0.10 | 3.9e-08 | 11.3 | -11.4 | 3.0e-30 | -1.00 | 0.00 | 1.00 | TRUE |
| 5 | GTEx | Artery Tibial | SUOX | 0.18 | 0.14 | enet | 23 | 0.18 | 2.1e-14 | -7.3 | 6.2 | 6.4e-10 | 0.00 | 0.77 | 0.23 | FALSE |
| 6 | GTEx | Artery Tibial | STAT6 | 0.08 | 0.03 | enet | 4 | 0.02 | 1.3e-02 | 8.4 | 6.3 | 2.1e-10 | 0.61 | 0.23 | 0.24 | FALSE |
| 7 | GTEx | Artery Tibial | RPS26 | 0.07 | 0.02 | enet | 5 | 0.01 | 3.5e-02 | -7.8 | -7.9 | 2.1e-15 | 0.00 | 0.06 | 0.78 | FALSE |
| 8 | GTEx | Brain Cerebellum | SUOX | 0.24 | 0.20 | lasso | 6 | 0.20 | 1.2e-06 | -7.3 | 6.5 | 9.6e-11 | 0.02 | 0.37 | 0.37 | FALSE |
| 9 | GTEx | Brain Cortex | SUOX | 0.16 | 0.11 | lasso | 4 | 0.10 | 1.1e-03 | -7.3 | 7.2 | 5.2e-13 | 0.02 | 0.04 | 0.61 | FALSE |
| 10 | GTEx | Brain Nucleus accumbens basal ganglia | SUOX | 0.18 | 0.08 | lasso | 4 | 0.10 | 1.1e-03 | -7.3 | 6.0 | 2.6e-09 | 0.02 | 0.07 | 0.41 | FALSE |
| 11 | GTEx | Brain Putamen basal ganglia | RP11-977G19.11 | 0.30 | 0.15 | enet | 33 | 0.20 | 1.5e-05 | -8.0 | 5.5 | 3.9e-08 | 0.01 | 0.37 | 0.04 | FALSE |
| 12 | GTEx | Breast Mammary Tissue | RPS26 | 0.29 | 0.05 | enet | 37 | 0.12 | 9.4e-07 | -7.8 | -8.0 | 1.2e-15 | -0.06 | 0.70 | 0.28 | FALSE |
| 13 | GTEx | Breast Mammary Tissue (Female) | RPS26 | 0.20 | 0.11 | lasso | 3 | 0.10 | 6.6e-04 | -7.3 | -8.1 | 7.1e-16 | -0.05 | 0.05 | 0.17 | FALSE |
| 14 | GTEx | Cells Transformed fibroblasts | RPS26 | 0.11 | 0.08 | enet | 15 | 0.09 | 3.4e-07 | -7.5 | -6.6 | 3.4e-11 | -0.01 | 0.58 | 0.41 | FALSE |
| 15 | GTEx | Colon Sigmoid | SUOX | 0.23 | 0.18 | lasso | 4 | 0.15 | 7.9e-06 | -7.3 | 7.3 | 2.3e-13 | 0.01 | 0.12 | 0.86 | FALSE |
| 16 | GTEx | Colon Transverse | SUOX | 0.24 | 0.22 | enet | 24 | 0.25 | 3.8e-12 | -7.3 | 5.4 | 7.7e-08 | 0.05 | 0.89 | 0.10 | FALSE |
| 17 | GTEx | Esophagus Gastroesophageal Junction | SUOX | 0.20 | 0.16 | lasso | 5 | 0.19 | 2.7e-07 | -7.3 | 7.7 | 1.2e-14 | 0.00 | 0.12 | 0.87 | FALSE |
| 18 | GTEx | Esophagus Gastroesophageal Junction | WIBG | 0.16 | 0.02 | lasso | 5 | 0.04 | 1.9e-02 | 1.4 | 6.2 | 4.5e-10 | 0.02 | 0.01 | 0.72 | FALSE |
| 19 | GTEx | Esophagus Muscularis | SUOX | 0.24 | 0.19 | enet | 16 | 0.15 | 2.3e-09 | -7.3 | 7.2 | 5.4e-13 | 0.02 | 0.99 | 0.01 | FALSE |
| 20 | GTEx | Heart Atrial Appendage | SUOX | 0.09 | 0.10 | enet | 8 | 0.09 | 1.1e-04 | -7.8 | 7.8 | 5.0e-15 | 0.01 | 0.09 | 0.76 | FALSE |
| 21 | GTEx | Lung | SUOX | 0.34 | 0.23 | enet | 38 | 0.26 | 4.6e-20 | -7.3 | 5.9 | 3.1e-09 | 0.01 | 1.00 | 0.00 | FALSE |
| 22 | GTEx | Muscle Skeletal | RAB5B | 0.29 | 0.32 | lasso | 4 | 0.33 | 1.3e-33 | -8.4 | 8.6 | 8.2e-18 | 0.00 | 0.61 | 0.39 | FALSE |
| 23 | GTEx | Muscle Skeletal | SUOX | 0.11 | 0.04 | lasso | 7 | 0.04 | 4.4e-05 | -7.3 | 6.6 | 5.1e-11 | 0.02 | 0.34 | 0.56 | FALSE |
| 24 | GTEx | Muscle Skeletal | AC034102.1 | 0.28 | 0.31 | lasso | 4 | 0.31 | 2.3e-31 | -8.3 | 8.6 | 8.3e-18 | 0.00 | 0.52 | 0.48 | FALSE |
| 25 | GTEx | Nerve Tibial | SUOX | 0.34 | 0.30 | enet | 22 | 0.35 | 8.5e-26 | -7.3 | 6.0 | 1.9e-09 | 0.01 | 1.00 | 0.00 | FALSE |
| 26 | GTEx | Nerve Tibial | RPS26 | 0.12 | 0.09 | enet | 7 | 0.11 | 3.0e-08 | -8.4 | -7.3 | 3.8e-13 | 0.00 | 0.76 | 0.23 | FALSE |
| 27 | GTEx | Ovary | SUOX | 0.23 | 0.14 | enet | 12 | 0.21 | 8.4e-06 | -7.3 | 6.2 | 4.5e-10 | 0.02 | 0.11 | 0.29 | FALSE |
| 28 | GTEx | Ovary | RPS26 | 0.50 | 0.24 | enet | 25 | 0.22 | 5.0e-06 | -7.6 | -5.8 | 4.8e-09 | 0.00 | 0.37 | 0.52 | FALSE |
| 29 | GTEx | Pancreas | SUOX | 0.30 | 0.20 | enet | 23 | 0.30 | 3.5e-13 | -7.3 | 5.5 | 4.0e-08 | 0.01 | 0.96 | 0.02 | FALSE |
| 30 | GTEx | Prostate | SUOX | 0.22 | 0.04 | enet | 11 | 0.05 | 2.3e-02 | -7.3 | 8.7 | 2.6e-18 | 0.00 | 0.04 | 0.72 | TRUE |
| 31 | GTEx | Skin Not Sun Exposed Suprapubic | SUOX | 0.10 | 0.14 | lasso | 2 | 0.12 | 2.5e-07 | -7.3 | 7.3 | 2.1e-13 | 0.02 | 0.26 | 0.71 | FALSE |
| 32 | GTEx | Skin Sun Exposed Lower leg | SUOX | 0.23 | 0.30 | lasso | 3 | 0.29 | 1.9e-24 | -7.3 | 7.6 | 4.0e-14 | 0.02 | 1.00 | 0.00 | FALSE |
| 33 | GTEx | Spleen | SUOX | 0.34 | 0.31 | enet | 15 | 0.28 | 5.4e-08 | -7.3 | 6.5 | 9.0e-11 | 0.07 | 0.29 | 0.48 | FALSE |
| 34 | GTEx | Stomach | SUOX | 0.15 | 0.17 | enet | 8 | 0.09 | 6.7e-05 | -7.3 | 7.2 | 5.7e-13 | 0.01 | 0.79 | 0.12 | FALSE |
| 35 | GTEx | Stomach | RPS26 | 0.16 | 0.08 | enet | 5 | 0.05 | 1.8e-03 | -7.3 | -7.4 | 1.6e-13 | 0.00 | 0.13 | 0.32 | FALSE |
| 36 | GTEx | Testis | SUOX | 0.27 | 0.18 | lasso | 14 | 0.18 | 1.4e-08 | -7.3 | 7.6 | 2.3e-14 | 0.01 | 0.09 | 0.91 | FALSE |
| 37 | GTEx | Thyroid | SUOX | 0.37 | 0.40 | lasso | 7 | 0.38 | 5.4e-31 | -7.3 | 7.3 | 2.0e-13 | 0.03 | 1.00 | 0.00 | FALSE |
| 38 | GTEx | Whole Blood | SUOX | 0.07 | 0.01 | enet | 20 | 0.02 | 1.1e-02 | -7.8 | 7.5 | 9.0e-14 | -0.02 | 0.01 | 0.97 | FALSE |
| 39 | GTEx | Whole Blood | RPS26 | 0.05 | 0.05 | lasso | 1 | 0.05 | 3.4e-05 | -7.3 | -7.3 | 2.0e-13 | -0.01 | 0.05 | 0.92 | FALSE |
| 40 | METSIM | Adipose | IKZF4 | 0.04 | 0.04 | enet | 3 | 0.04 | 1.0e-06 | -7.6 | -7.6 | 2.2e-14 | 0.00 | 0.98 | 0.02 | FALSE |
| 41 | METSIM | Adipose | RPS26 | 0.30 | 0.40 | lasso | 5 | 0.41 | 7.2e-66 | -7.5 | -7.7 | 1.2e-14 | 0.00 | 1.00 | 0.00 | FALSE |
| 42 | METSIM | Adipose | STAT6 | 0.08 | 0.02 | blup | 343 | 0.03 | 5.0e-06 | 8.4 | -6.2 | 5.1e-10 | -0.53 | 0.42 | 0.55 | FALSE |
| 43 | METSIM | Adipose | SUOX | 0.04 | 0.01 | blup | 288 | 0.02 | 1.1e-03 | -7.6 | 6.2 | 5.2e-10 | -0.01 | 0.55 | 0.23 | FALSE |
| 44 | YFS | Blood | SUOX | 0.11 | 0.09 | bslmm | 269 | 0.09 | 3.4e-27 | -7.3 | 7.5 | 7.7e-14 | 0.05 | 1.00 | 0.00 | FALSE |
| 45 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | RPS26 | 0.14 | 0.22 | lasso | 2 | 0.23 | 4.8e-19 | -7.5 | -7.6 | 2.7e-14 | 0.00 | 0.94 | 0.06 | FALSE |
| 46 | The Cancer Genome Atlas | Breast Invasive Carcinoma | RPS26 | 0.30 | 0.44 | enet | 10 | 0.45 | 5.2e-104 | -7.8 | -8.3 | 1.5e-16 | 0.00 | 0.99 | 0.01 | FALSE |
| 47 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | RPS26 | 0.23 | 0.40 | lasso | 2 | 0.39 | 1.5e-20 | -7.8 | -8.1 | 7.8e-16 | 0.00 | 0.25 | 0.75 | FALSE |
| 48 | The Cancer Genome Atlas | Colon Adenocarcinoma | RPS26 | 0.43 | 0.48 | lasso | 4 | 0.47 | 1.8e-30 | -7.8 | -8.2 | 3.2e-16 | 0.00 | 0.75 | 0.25 | FALSE |
| 49 | The Cancer Genome Atlas | Esophageal Carcinoma | RPS26 | 0.19 | 0.13 | lasso | 5 | 0.11 | 2.4e-04 | -7.8 | -8.1 | 8.5e-16 | 0.00 | 0.01 | 0.98 | FALSE |
| 50 | The Cancer Genome Atlas | Glioblastoma Multiforme | RPS26 | 0.41 | 0.38 | enet | 9 | 0.39 | 7.9e-13 | -7.5 | -7.8 | 4.7e-15 | 0.00 | 0.40 | 0.60 | FALSE |
| 51 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | RPS26 | 0.17 | 0.29 | lasso | 4 | 0.29 | 6.2e-33 | -7.5 | -7.8 | 6.7e-15 | 0.00 | 1.00 | 0.00 | FALSE |
| 52 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | RPS26 | 0.50 | 0.45 | enet | 13 | 0.52 | 1.4e-67 | -7.5 | -6.9 | 5.8e-12 | -0.01 | 1.00 | 0.00 | FALSE |
| 53 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | RPS26 | 0.27 | 0.38 | enet | 8 | 0.40 | 5.0e-24 | -7.8 | -8.1 | 5.9e-16 | 0.00 | 0.99 | 0.01 | FALSE |
| 54 | The Cancer Genome Atlas | Brain Lower Grade Glioma | ERBB3 | 0.07 | 0.02 | blup | 29 | 0.05 | 2.1e-06 | -9.1 | -7.0 | 2.5e-12 | 0.02 | 0.00 | 1.00 | FALSE |
| 55 | The Cancer Genome Atlas | Brain Lower Grade Glioma | RPS26 | 0.31 | 0.53 | enet | 8 | 0.55 | 1.7e-74 | -7.8 | -7.9 | 3.2e-15 | 0.00 | 1.00 | 0.00 | FALSE |
| 56 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | RPS26 | 0.18 | 0.31 | lasso | 2 | 0.29 | 3.9e-14 | -7.8 | -7.7 | 1.1e-14 | 0.00 | 0.97 | 0.03 | FALSE |
| 57 | The Cancer Genome Atlas | Lung Adenocarcinoma | RAB5B | 0.03 | 0.02 | enet | 7 | 0.02 | 4.3e-03 | -8.4 | -8.4 | 3.8e-17 | 0.03 | 0.02 | 0.49 | FALSE |
| 58 | The Cancer Genome Atlas | Lung Adenocarcinoma | RPS26 | 0.26 | 0.45 | enet | 9 | 0.47 | 3.6e-61 | -7.8 | -8.1 | 5.2e-16 | 0.00 | 1.00 | 0.00 | FALSE |
| 59 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | RPS26 | 0.22 | 0.31 | lasso | 3 | 0.31 | 1.6e-35 | -7.8 | -8.3 | 1.4e-16 | 0.00 | 0.98 | 0.02 | FALSE |
| 60 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | RPS26 | 0.30 | 0.20 | lasso | 4 | 0.24 | 3.9e-16 | -7.8 | -8.6 | 6.5e-18 | 0.00 | 0.05 | 0.95 | FALSE |
| 61 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | RPS26 | 0.36 | 0.44 | lasso | 7 | 0.42 | 2.4e-19 | -7.5 | -7.7 | 1.8e-14 | 0.00 | 0.99 | 0.01 | FALSE |
| 62 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | RPS26 | 0.47 | 0.43 | lasso | 2 | 0.44 | 3.2e-19 | -7.3 | -7.6 | 2.7e-14 | 0.00 | 0.98 | 0.02 | FALSE |
| 63 | The Cancer Genome Atlas | Prostate Adenocarcinoma | RPS26 | 0.33 | 0.52 | enet | 9 | 0.54 | 5.6e-66 | -7.8 | -8.1 | 5.6e-16 | 0.00 | 0.99 | 0.01 | FALSE |
| 64 | The Cancer Genome Atlas | Rectum Adenocarcinoma | RPS26 | 0.24 | 0.18 | lasso | 2 | 0.20 | 1.9e-05 | -7.8 | -7.7 | 1.0e-14 | 0.00 | 0.05 | 0.57 | FALSE |
| 65 | The Cancer Genome Atlas | Soft Tissue Sarcoma | RPS26 | 0.23 | 0.31 | lasso | 3 | 0.30 | 2.4e-18 | -7.8 | -7.9 | 2.6e-15 | 0.00 | 0.64 | 0.36 | FALSE |
| 66 | The Cancer Genome Atlas | Skin Cutaneous Melanoma | RPS26 | 0.28 | 0.15 | lasso | 2 | 0.17 | 3.0e-05 | -8.4 | -8.3 | 1.2e-16 | 0.00 | 0.01 | 0.94 | FALSE |
| 67 | The Cancer Genome Atlas | Stomach Adenocarcinoma | ERBB3 | 0.13 | 0.01 | enet | 12 | 0.03 | 1.9e-03 | -7.5 | 5.7 | 1.4e-08 | -0.02 | 0.01 | 0.27 | FALSE |
| 68 | The Cancer Genome Atlas | Stomach Adenocarcinoma | RPS26 | 0.19 | 0.32 | lasso | 5 | 0.34 | 2.0e-25 | -7.5 | -7.8 | 4.9e-15 | 0.00 | 1.00 | 0.00 | FALSE |
| 69 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | RPS26 | 0.46 | 0.64 | lasso | 4 | 0.65 | 8.5e-30 | -7.8 | -8.1 | 5.6e-16 | 0.00 | 0.44 | 0.56 | FALSE |
| 70 | The Cancer Genome Atlas | Thyroid Carcinoma | RPS26 | 0.33 | 0.51 | enet | 19 | 0.50 | 7.3e-56 | -7.8 | -7.4 | 1.5e-13 | 0.00 | 0.99 | 0.01 | FALSE |
| 71 | The Cancer Genome Atlas | Thyroid Carcinoma | STAT6 | 0.04 | 0.01 | blup | 47 | 0.01 | 2.3e-02 | 9.1 | 7.2 | 4.8e-13 | 0.79 | 0.02 | 0.73 | FALSE |
| 72 | The Cancer Genome Atlas | Uterine Corpus Endometrial Carcinoma | RPS26 | 0.17 | 0.19 | lasso | 4 | 0.18 | 1.3e-05 | -7.8 | -7.8 | 8.1e-15 | 0.00 | 0.02 | 0.97 | FALSE |