[Hub]/) : Traits : Lung FEV1/FVC ratio : ← →

chr12:55,601,472-58,303,535

Best TWAS P=3e-30 · Best GWAS P=8.88e-30 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
4	GTEx	Artery Tibial	LRP1	0.15	0.12	lasso	2	0.10	3.9e-08	11.3	-11.4	3.0e-30	-1.00	0.00	1.00	TRUE
30	GTEx	Prostate	SUOX	0.22	0.04	enet	11	0.05	2.3e-02	-7.3	8.7	2.6e-18	0.00	0.04	0.72	TRUE
60	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	RPS26	0.30	0.20	lasso	4	0.24	3.9e-16	-7.8	-8.6	6.5e-18	0.00	0.05	0.95	FALSE
22	GTEx	Muscle Skeletal	RAB5B	0.29	0.32	lasso	4	0.33	1.3e-33	-8.4	8.6	8.2e-18	0.00	0.61	0.39	FALSE
24	GTEx	Muscle Skeletal	AC034102.1	0.28	0.31	lasso	4	0.31	2.3e-31	-8.3	8.6	8.3e-18	0.00	0.52	0.48	FALSE
57	The Cancer Genome Atlas	Lung Adenocarcinoma	RAB5B	0.03	0.02	enet	7	0.02	4.3e-03	-8.4	-8.4	3.8e-17	0.03	0.02	0.49	FALSE
66	The Cancer Genome Atlas	Skin Cutaneous Melanoma	RPS26	0.28	0.15	lasso	2	0.17	3.0e-05	-8.4	-8.3	1.2e-16	0.00	0.01	0.94	FALSE
59	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	RPS26	0.22	0.31	lasso	3	0.31	1.6e-35	-7.8	-8.3	1.4e-16	0.00	0.98	0.02	FALSE
46	The Cancer Genome Atlas	Breast Invasive Carcinoma	RPS26	0.30	0.44	enet	10	0.45	5.2e-104	-7.8	-8.3	1.5e-16	0.00	0.99	0.01	FALSE
48	The Cancer Genome Atlas	Colon Adenocarcinoma	RPS26	0.43	0.48	lasso	4	0.47	1.8e-30	-7.8	-8.2	3.2e-16	0.00	0.75	0.25	FALSE
58	The Cancer Genome Atlas	Lung Adenocarcinoma	RPS26	0.26	0.45	enet	9	0.47	3.6e-61	-7.8	-8.1	5.2e-16	0.00	1.00	0.00	FALSE
63	The Cancer Genome Atlas	Prostate Adenocarcinoma	RPS26	0.33	0.52	enet	9	0.54	5.6e-66	-7.8	-8.1	5.6e-16	0.00	0.99	0.01	FALSE
69	The Cancer Genome Atlas	Testicular Germ Cell Tumors	RPS26	0.46	0.64	lasso	4	0.65	8.5e-30	-7.8	-8.1	5.6e-16	0.00	0.44	0.56	FALSE
53	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	RPS26	0.27	0.38	enet	8	0.40	5.0e-24	-7.8	-8.1	5.9e-16	0.00	0.99	0.01	FALSE
13	GTEx	Breast Mammary Tissue (Female)	RPS26	0.20	0.11	lasso	3	0.10	6.6e-04	-7.3	-8.1	7.1e-16	-0.05	0.05	0.17	FALSE
47	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	RPS26	0.23	0.40	lasso	2	0.39	1.5e-20	-7.8	-8.1	7.8e-16	0.00	0.25	0.75	FALSE
49	The Cancer Genome Atlas	Esophageal Carcinoma	RPS26	0.19	0.13	lasso	5	0.11	2.4e-04	-7.8	-8.1	8.5e-16	0.00	0.01	0.98	FALSE
12	GTEx	Breast Mammary Tissue	RPS26	0.29	0.05	enet	37	0.12	9.4e-07	-7.8	-8.0	1.2e-15	-0.06	0.70	0.28	FALSE
7	GTEx	Artery Tibial	RPS26	0.07	0.02	enet	5	0.01	3.5e-02	-7.8	-7.9	2.1e-15	0.00	0.06	0.78	FALSE
65	The Cancer Genome Atlas	Soft Tissue Sarcoma	RPS26	0.23	0.31	lasso	3	0.30	2.4e-18	-7.8	-7.9	2.6e-15	0.00	0.64	0.36	FALSE
55	The Cancer Genome Atlas	Brain Lower Grade Glioma	RPS26	0.31	0.53	enet	8	0.55	1.7e-74	-7.8	-7.9	3.2e-15	0.00	1.00	0.00	FALSE
50	The Cancer Genome Atlas	Glioblastoma Multiforme	RPS26	0.41	0.38	enet	9	0.39	7.9e-13	-7.5	-7.8	4.7e-15	0.00	0.40	0.60	FALSE
68	The Cancer Genome Atlas	Stomach Adenocarcinoma	RPS26	0.19	0.32	lasso	5	0.34	2.0e-25	-7.5	-7.8	4.9e-15	0.00	1.00	0.00	FALSE
20	GTEx	Heart Atrial Appendage	SUOX	0.09	0.10	enet	8	0.09	1.1e-04	-7.8	7.8	5.0e-15	0.01	0.09	0.76	FALSE
1	CommonMind	Brain Pre-frontal Cortex	RPS26	0.48	0.62	lasso	5	0.63	5.9e-99	-7.8	-7.8	6.0e-15	0.00	1.00	0.00	FALSE
51	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	RPS26	0.17	0.29	lasso	4	0.29	6.2e-33	-7.5	-7.8	6.7e-15	0.00	1.00	0.00	FALSE
72	The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	RPS26	0.17	0.19	lasso	4	0.18	1.3e-05	-7.8	-7.8	8.1e-15	0.00	0.02	0.97	FALSE
64	The Cancer Genome Atlas	Rectum Adenocarcinoma	RPS26	0.24	0.18	lasso	2	0.20	1.9e-05	-7.8	-7.7	1.0e-14	0.00	0.05	0.57	FALSE
56	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	RPS26	0.18	0.31	lasso	2	0.29	3.9e-14	-7.8	-7.7	1.1e-14	0.00	0.97	0.03	FALSE
17	GTEx	Esophagus Gastroesophageal Junction	SUOX	0.20	0.16	lasso	5	0.19	2.7e-07	-7.3	7.7	1.2e-14	0.00	0.12	0.87	FALSE
41	METSIM	Adipose	RPS26	0.30	0.40	lasso	5	0.41	7.2e-66	-7.5	-7.7	1.2e-14	0.00	1.00	0.00	FALSE
61	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	RPS26	0.36	0.44	lasso	7	0.42	2.4e-19	-7.5	-7.7	1.8e-14	0.00	0.99	0.01	FALSE
40	METSIM	Adipose	IKZF4	0.04	0.04	enet	3	0.04	1.0e-06	-7.6	-7.6	2.2e-14	0.00	0.98	0.02	FALSE
36	GTEx	Testis	SUOX	0.27	0.18	lasso	14	0.18	1.4e-08	-7.3	7.6	2.3e-14	0.01	0.09	0.91	FALSE
45	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	RPS26	0.14	0.22	lasso	2	0.23	4.8e-19	-7.5	-7.6	2.7e-14	0.00	0.94	0.06	FALSE
62	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	RPS26	0.47	0.43	lasso	2	0.44	3.2e-19	-7.3	-7.6	2.7e-14	0.00	0.98	0.02	FALSE
32	GTEx	Skin Sun Exposed Lower leg	SUOX	0.23	0.30	lasso	3	0.29	1.9e-24	-7.3	7.6	4.0e-14	0.02	1.00	0.00	FALSE
44	YFS	Blood	SUOX	0.11	0.09	bslmm	269	0.09	3.4e-27	-7.3	7.5	7.7e-14	0.05	1.00	0.00	FALSE
38	GTEx	Whole Blood	SUOX	0.07	0.01	enet	20	0.02	1.1e-02	-7.8	7.5	9.0e-14	-0.02	0.01	0.97	FALSE
70	The Cancer Genome Atlas	Thyroid Carcinoma	RPS26	0.33	0.51	enet	19	0.50	7.3e-56	-7.8	-7.4	1.5e-13	0.00	0.99	0.01	FALSE
35	GTEx	Stomach	RPS26	0.16	0.08	enet	5	0.05	1.8e-03	-7.3	-7.4	1.6e-13	0.00	0.13	0.32	FALSE
37	GTEx	Thyroid	SUOX	0.37	0.40	lasso	7	0.38	5.4e-31	-7.3	7.3	2.0e-13	0.03	1.00	0.00	FALSE
39	GTEx	Whole Blood	RPS26	0.05	0.05	lasso	1	0.05	3.4e-05	-7.3	-7.3	2.0e-13	-0.01	0.05	0.92	FALSE
31	GTEx	Skin Not Sun Exposed Suprapubic	SUOX	0.10	0.14	lasso	2	0.12	2.5e-07	-7.3	7.3	2.1e-13	0.02	0.26	0.71	FALSE
15	GTEx	Colon Sigmoid	SUOX	0.23	0.18	lasso	4	0.15	7.9e-06	-7.3	7.3	2.3e-13	0.01	0.12	0.86	FALSE
26	GTEx	Nerve Tibial	RPS26	0.12	0.09	enet	7	0.11	3.0e-08	-8.4	-7.3	3.8e-13	0.00	0.76	0.23	FALSE
2	CommonMind	Brain Pre-frontal Cortex	STAT6	0.11	0.08	lasso	3	0.11	9.1e-14	5.3	7.2	4.7e-13	0.52	0.98	0.02	FALSE
71	The Cancer Genome Atlas	Thyroid Carcinoma	STAT6	0.04	0.01	blup	47	0.01	2.3e-02	9.1	7.2	4.8e-13	0.79	0.02	0.73	FALSE
9	GTEx	Brain Cortex	SUOX	0.16	0.11	lasso	4	0.10	1.1e-03	-7.3	7.2	5.2e-13	0.02	0.04	0.61	FALSE
19	GTEx	Esophagus Muscularis	SUOX	0.24	0.19	enet	16	0.15	2.3e-09	-7.3	7.2	5.4e-13	0.02	0.99	0.01	FALSE
34	GTEx	Stomach	SUOX	0.15	0.17	enet	8	0.09	6.7e-05	-7.3	7.2	5.7e-13	0.01	0.79	0.12	FALSE
3	GTEx	Artery Aorta	SUOX	0.36	0.30	lasso	7	0.35	3.8e-20	-7.3	7.1	1.7e-12	0.00	0.99	0.01	FALSE
54	The Cancer Genome Atlas	Brain Lower Grade Glioma	ERBB3	0.07	0.02	blup	29	0.05	2.1e-06	-9.1	-7.0	2.5e-12	0.02	0.00	1.00	FALSE
52	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	RPS26	0.50	0.45	enet	13	0.52	1.4e-67	-7.5	-6.9	5.8e-12	-0.01	1.00	0.00	FALSE
14	GTEx	Cells Transformed fibroblasts	RPS26	0.11	0.08	enet	15	0.09	3.4e-07	-7.5	-6.6	3.4e-11	-0.01	0.58	0.41	FALSE
23	GTEx	Muscle Skeletal	SUOX	0.11	0.04	lasso	7	0.04	4.4e-05	-7.3	6.6	5.1e-11	0.02	0.34	0.56	FALSE
33	GTEx	Spleen	SUOX	0.34	0.31	enet	15	0.28	5.4e-08	-7.3	6.5	9.0e-11	0.07	0.29	0.48	FALSE
8	GTEx	Brain Cerebellum	SUOX	0.24	0.20	lasso	6	0.20	1.2e-06	-7.3	6.5	9.6e-11	0.02	0.37	0.37	FALSE
6	GTEx	Artery Tibial	STAT6	0.08	0.03	enet	4	0.02	1.3e-02	8.4	6.3	2.1e-10	0.61	0.23	0.24	FALSE
18	GTEx	Esophagus Gastroesophageal Junction	WIBG	0.16	0.02	lasso	5	0.04	1.9e-02	1.4	6.2	4.5e-10	0.02	0.01	0.72	FALSE
27	GTEx	Ovary	SUOX	0.23	0.14	enet	12	0.21	8.4e-06	-7.3	6.2	4.5e-10	0.02	0.11	0.29	FALSE
42	METSIM	Adipose	STAT6	0.08	0.02	blup	343	0.03	5.0e-06	8.4	-6.2	5.1e-10	-0.53	0.42	0.55	FALSE
43	METSIM	Adipose	SUOX	0.04	0.01	blup	288	0.02	1.1e-03	-7.6	6.2	5.2e-10	-0.01	0.55	0.23	FALSE
5	GTEx	Artery Tibial	SUOX	0.18	0.14	enet	23	0.18	2.1e-14	-7.3	6.2	6.4e-10	0.00	0.77	0.23	FALSE
25	GTEx	Nerve Tibial	SUOX	0.34	0.30	enet	22	0.35	8.5e-26	-7.3	6.0	1.9e-09	0.01	1.00	0.00	FALSE
10	GTEx	Brain Nucleus accumbens basal ganglia	SUOX	0.18	0.08	lasso	4	0.10	1.1e-03	-7.3	6.0	2.6e-09	0.02	0.07	0.41	FALSE
21	GTEx	Lung	SUOX	0.34	0.23	enet	38	0.26	4.6e-20	-7.3	5.9	3.1e-09	0.01	1.00	0.00	FALSE
28	GTEx	Ovary	RPS26	0.50	0.24	enet	25	0.22	5.0e-06	-7.6	-5.8	4.8e-09	0.00	0.37	0.52	FALSE
67	The Cancer Genome Atlas	Stomach Adenocarcinoma	ERBB3	0.13	0.01	enet	12	0.03	1.9e-03	-7.5	5.7	1.4e-08	-0.02	0.01	0.27	FALSE
11	GTEx	Brain Putamen basal ganglia	RP11-977G19.11	0.30	0.15	enet	33	0.20	1.5e-05	-8.0	5.5	3.9e-08	0.01	0.37	0.04	FALSE
29	GTEx	Pancreas	SUOX	0.30	0.20	enet	23	0.30	3.5e-13	-7.3	5.5	4.0e-08	0.01	0.96	0.02	FALSE
16	GTEx	Colon Transverse	SUOX	0.24	0.22	enet	24	0.25	3.8e-12	-7.3	5.4	7.7e-08	0.05	0.89	0.10	FALSE