TWAS
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Models
Genes
Traits
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Traits
:
Lung FEV1/FVC ratio
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chr1:180,672,792-181,235,009
Best TWAS P=3.85e-08 · Best GWAS P=3.51e-08 conditioned to 1
180.7M
180.8M
180.9M
181M
181.1M
181.2M
0
2
4
6
physical position
-log10 P
Conditional
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
3
The Cancer Genome Atlas
Thyroid Carcinoma
STX6
0.05
0.04
enet
3
0.04
9.8e-05
5.5
5.5
3.9e-08
1.00
0.00
0.99
TRUE
2
The Cancer Genome Atlas
Liver Hepatocellular Carcinoma
STX6
0.10
0.01
blup
87
0.01
1.1e-01
5.3
5.4
6.6e-08
0.78
0.01
0.82
FALSE
1
The Cancer Genome Atlas
Bladder Urothelial Carcinoma
STX6
0.06
0.03
enet
8
0.03
2.8e-03
5.3
5.3
1.3e-07
0.87
0.00
0.90
FALSE