TWAS hub - STX6

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1040	0.0280	2.3e-07	0.114	0.080	0.108	0.106	0.107	1.0e-13	5.1e-10	4.9e-13	7.1e-13	5.8e-13
2	GTEx	Spleen	0.3320	0.1120	2.3e-03	-0.012	NA	0.043	NA	0.010	9.9e-01	NA	3.0e-02	NA	1.8e-01
3	YFS	Blood	0.1028	0.0248	1.7e-10	0.038	0.047	0.059	0.056	0.053	1.2e-12	3.8e-15	1.2e-18	7.5e-18	5.6e-17
4	TCGA	Bladder Urothelial Carcinoma	0.0570	0.0280	4.7e-03	0.025	0.023	0.026	NA	0.006	3.1e-03	4.7e-03	2.8e-03	NA	9.8e-02
5	TCGA	Brain Lower Grade Glioma	0.0361	0.0175	3.8e-03	-0.002	0.009	0.000	NA	-0.002	9.4e-01	2.7e-02	3.1e-01	NA	7.4e-01
6	TCGA	Liver Hepatocellular Carcinoma	0.0950	0.0430	3.6e-03	0.007	0.009	-0.002	NA	-0.005	1.4e-01	1.1e-01	4.3e-01	NA	6.8e-01
7	TCGA	Thyroid Carcinoma	0.0530	0.0280	1.0e-02	0.043	0.026	0.039	NA	0.039	5.1e-05	1.3e-03	9.8e-05	NA	1.1e-04

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Ever used hormone-replacement therapy (HRT)	14.2	18.0	31.5	5.6	-0.4	-1.0	5.6	4.6	4.7	4.4
Had menopause	7.6	9.5	14.7	3.8	-1.4	-0.3	3.8	3.4	3.4	3.5
Other serious medical condition/disability diagnosed by doctor	6.0	7.8	16.2	3.3	-0.9	0.7	2.2	4.0	3.1	3.4
Osteoarthritis (self-reported)	4.7	6.1	11.9	3.5	0.3	-0.2	2.3	2.9	3.0	2.9
Medication for hormone replacement therapy	4.5	5.0	9.2	2.6	-1.5	-1.8	3.0	2.5	2.0	2.0
Alzheimer’s Disease (including proxy)	4.4	6.4	14.0	3.7	-0.3	-1.3	2.9	3.0	2.7	2.2
Lupus	3.7	5.6	10.2	-3.2	2.7	2.0	-1.2	-3.2	-1.5	-2.0
Lung FEV1/FVC ratio	3.5	18.0	30.2	4.7	0.4	1.4	5.3	3.8	5.4	5.5
Number of live births	3.5	5.0	10.2	2.9	-0.9	1.6	2.2	2.0	1.9	3.2
Medication for cholesterol	3.3	5.0	7.5	-2.7	2.3	2.1	-2.0	-2.7	-1.9	-1.8
Ever had hysterectomy (womb removed)	2.7	3.0	6.1	2.0	-0.4	0.9	1.1	2.5	1.7	2.5
Number of full sisters	2.7	3.2	6.5	1.2	-0.1	2.2	2.4	-0.6	2.0	2.6
Illnesses of mother	2.5	3.0	10.2	-2.1	-0.3	2.0	-1.2	-3.2	-0.7	-0.7
Friendships satisfaction	2.5	3.1	9.5	0.8	-1.5	-3.1	-2.0	0.6	-1.1	-1.8
Pain type(s) experienced in last month: Hip pain	2.5	3.1	7.0	2.6	0.3	-0.1	2.0	2.0	1.7	1.9
Alzheimer’s Disease (in mother)	2.4	2.8	4.8	2.0	-0.5	-0.6	2.1	2.2	1.9	1.4
Frequency of tiredness / lethargy in last 2 weeks	2.4	3.8	7.8	2.6	-0.3	-0.3	1.6	2.8	2.4	1.9
Frequency of unenthusiasm / disinterest in last 2 weeks	2.3	3.1	6.7	2.1	-2.4	-1.0	1.0	2.6	0.8	1.3
Ulcerative Colitis	2.2	3.2	6.5	0.7	1.6	2.5	1.3	2.3	1.4	1.9
Medication: Allopurinol	2.1	2.9	12.2	1.9	-3.5	-1.6	0.4	1.2	0.3	-0.0
High cholesterol (Self-reported)	2.1	3.7	6.6	2.5	-0.8	-0.4	1.9	2.4	1.8	2.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	2.0	2.4	4.4	1.6	0.2	0.8	2.1	1.8	1.7	1.8
Mouth/teeth dental problems	1.9	3.0	5.3	-2.3	1.7	0.1	-1.6	-1.6	-1.9	-2.0
Commuting to job workplace: Cycle	1.9	2.2	5.9	-1.4	2.4	-1.3	-0.8	-1.6	-0.5	-1.6
Happiness	1.8	2.2	7.0	1.6	-0.7	-2.1	0.8	2.6	0.4	-0.0
Medication: Lansoprazole	1.8	2.1	4.6	1.9	1.0	-0.9	1.1	1.6	2.1	1.0
Financial situation satisfaction	1.8	2.3	6.5	1.7	-0.5	-0.4	1.2	2.5	1.7	1.4
Qualifications: CSEs or equivalent	1.7	2.2	6.4	-0.6	1.6	2.3	-0.7	-2.5	-0.4	-0.3
Diverticular disease/diverticulitis (self-reported)	1.7	2.0	4.3	1.1	-0.2	0.7	2.1	0.7	1.9	1.9
Long-standing illness, disability or infirmity	1.7	2.7	5.8	2.2	-0.2	-0.1	0.9	2.1	2.4	1.6
Alzheimer’s Disease (in father)	1.6	1.7	3.6	1.9	1.1	-0.5	0.9	1.7	1.7	0.7
Migraine (self-reported)	1.6	1.9	8.4	0.1	-1.0	-2.9	-1.3	0.1	-0.7	-1.3
Mean time to correctly identify matches	1.6	3.1	7.1	2.3	-1.2	0.4	1.5	2.7	1.3	2.0
Overall health rating	1.6	3.4	8.6	2.5	0.0	-0.9	1.5	2.9	1.7	1.7
Mean Putamen Volume	1.5	1.7	5.0	-1.5	1.8	0.3	0.0	-2.2	-0.8	-1.0
Forced vital capacity (FVC), Best measure	1.5	5.6	9.9	-3.0	3.1	-0.4	-2.1	-2.9	0.0	-2.7
Medication: Ibuprofen	1.5	1.8	4.4	-1.5	0.7	-0.5	-1.7	-1.1	-0.8	-2.1
Commuting to job workplace: Walk	1.5	1.6	3.1	-1.4	0.2	-0.2	-1.8	-0.8	-1.7	-1.5
HbA1C	1.4	1.6	4.7	1.6	1.4	0.3	0.8	0.5	2.2	0.8
Father’s age at death	1.4	1.8	4.2	1.9	-0.7	-0.9	1.2	2.0	0.8	1.2
Exposure to tobacco smoke at home	1.4	1.5	2.8	-1.7	1.6	1.6	-0.9	-1.2	0.3	-0.5
Seen a psychiatrist for nerves, anxiety, tension or depression	1.4	1.8	3.3	-1.7	1.1	0.2	-1.8	-1.1	-0.8	-1.8
Medication: Seretide 50 evohaler	1.4	1.6	4.3	0.2	1.4	-2.1	-1.1	-1.1	-0.3	-1.6
Forced expiratory volume in 1-second (FEV1), predicted	1.4	3.0	7.5	-2.7	1.5	1.5	-0.7	-2.0	-1.1	-1.8
Breast cancer (self-reported)	1.4	1.7	3.9	-0.7	1.4	-0.1	-1.9	-0.8	-1.2	-2.0
Bipolar Disorder (2011)	1.3	1.2	5.3	0.8	-0.7	-1.2	0.0	2.3	0.0	0.9
Rheumatoid Arthritis	1.3	1.8	6.9	-1.3	1.8	2.6	-0.2	-0.7	-0.5	-0.3
Supplements: Zinc	1.3	1.4	3.4	1.2	0.7	-0.0	1.8	1.8	0.8	0.9
Breastfed as a baby	1.3	1.6	3.4	-1.8	0.4	1.0	-1.5	-1.1	-1.1	-1.5
Age at first live birth	1.3	2.3	6.6	-1.2	0.1	-0.9	-2.6	-0.2	-1.9	-2.0
Number of self-reported non-cancer illnesses	1.3	2.3	4.5	2.1	0.8	-0.7	1.1	1.8	2.1	1.4
Unable to work because of sickness or disability	1.3	1.7	4.2	1.0	0.1	0.6	1.3	1.3	1.7	2.0
Frequency of tenseness / restlessness in last 2 weeks	1.2	1.8	5.6	1.1	-1.1	-2.4	-0.9	1.8	-0.2	-0.8
Time employed in main current job	1.2	1.4	2.8	1.4	-1.6	-1.7	-1.0	1.1	0.2	-0.5
Pulse wave reflection index	1.2	1.5	4.9	-1.9	-0.4	0.3	0.0	-2.2	-0.8	-0.9
Qualifications: O levels/GCSEs or equivalent	1.2	2.0	8.4	-0.9	2.9	-1.2	-1.0	0.2	-0.4	-1.4
Blood clot in the leg (DVT)	1.2	1.6	3.0	-1.7	0.8	1.7	-0.4	-1.6	-1.0	-1.0
Leg pain on walking	1.2	1.5	3.6	1.4	0.3	0.2	1.4	1.9	1.2	1.1
Average weekly red wine intake	1.2	1.8	2.4	1.5	-1.4	-1.5	1.5	1.3	0.9	1.3
Cholesterol lowering medication	1.2	1.8	3.3	1.8	-0.4	-0.6	1.4	1.6	1.5	1.4
Pain experienced in last month	1.2	2.0	4.6	-2.1	-0.6	-0.5	-1.1	-1.7	-2.1	-0.8
Age at First Birth	1.1	1.6	3.2	-1.6	0.3	0.1	-1.7	-1.8	-1.0	-1.3
Relative age of first facial hair	1.1	2.3	7.8	0.8	-0.7	-2.8	-1.8	1.4	-0.6	-1.2
Eye problems/disorders: Diabetes related eye disease	1.1	1.2	6.0	-0.2	2.4	1.2	0.5	0.0	-0.5	0.6
Worrier / anxious feelings	1.1	2.1	4.3	1.3	1.8	0.1	1.3	2.1	1.7	0.6
Number of children fathered	1.1	1.3	3.2	1.6	-0.2	0.1	1.2	1.8	0.8	1.2
Qualifications: College or University degree	1.1	3.5	9.7	-3.1	-0.1	0.3	-1.7	-1.2	-2.2	-2.3
Age at last live birth	1.1	1.6	4.6	-0.7	-0.0	-0.1	-2.1	0.1	-2.1	-1.4
Wears glasses or contact lenses	1.1	1.2	3.3	1.1	1.4	-1.3	-0.1	1.8	0.6	-0.5
Irritability	1.1	1.8	6.7	0.8	-2.2	-2.6	-0.2	0.4	-0.2	-0.3
Depression (Nagel 2018)	1.0	1.5	3.9	0.7	-2.0	-1.5	0.3	1.8	-0.3	-0.2
Serious illness, injury or assault to yourself	1.0	1.2	7.2	0.9	0.1	0.1	-0.7	2.7	-0.1	0.3
Alcohol usually taken with meals	1.0	1.7	5.2	1.5	-0.8	-0.6	1.1	2.3	1.1	0.9
Forced vital capacity (FVC)	1.0	3.7	6.4	-2.0	1.9	-0.8	-2.4	-2.3	0.5	-2.5
Qualifications: None of the above	1.0	2.2	4.3	1.9	-2.1	-0.1	1.3	0.9	0.9	1.9
Wheeze or whistling in the chest in last year	1.0	1.7	2.9	-1.4	1.1	0.6	-1.7	-1.7	-1.0	-1.3
Loneliness, isolation	1.0	1.4	4.8	-2.2	0.3	1.4	-0.5	-0.6	-1.1	-1.1
Alcohol drinker status: Previous	1.0	1.2	3.4	-0.9	1.9	1.7	0.9	-0.5	-0.1	0.5
Reaction Time	0.9	1.6	6.6	1.2	-1.3	0.6	0.5	2.6	0.2	1.0
Prostate Cancer	0.9	1.3	5.2	-0.9	0.9	2.3	0.5	-0.9	0.6	0.7
Chronotype (morning person)	0.9	2.1	6.4	-0.7	2.5	1.1	-1.1	-2.0	0.7	-1.0
Average weekly spirits intake	0.9	1.1	4.4	-1.2	-0.0	2.1	-0.6	-0.9	-0.8	0.5
Severe depression (siblings)	0.9	1.0	3.5	0.9	-1.2	-1.9	0.1	0.9	0.5	0.0
Pain all over the body in last month	0.9	0.9	2.4	0.9	0.0	-0.4	1.2	1.6	1.2	0.1
Gout (self-reported)	0.9	1.3	7.2	0.7	-2.7	-1.0	0.4	-0.2	-0.1	-0.5
Chest pain or discomfort	0.9	1.3	4.3	0.5	0.3	1.5	0.2	2.1	1.1	0.9
Family relationship satisfaction	0.9	1.0	4.2	1.0	-0.8	-2.1	0.5	0.7	0.9	-0.3
Medication: Aspirin	0.9	1.2	4.3	1.3	0.2	0.3	0.8	2.1	-0.2	1.3
Ever had stillbirth, spontaneous miscarriage or termination	0.9	1.0	2.2	1.2	-1.2	-1.5	0.6	0.8	0.7	0.2
Mouth/teeth dental problems: Mouth ulcers	0.9	1.4	2.8	1.4	-1.3	-0.7	0.6	1.4	1.7	0.5
Mineral and other dietary supplements	0.9	1.2	4.8	-0.5	-2.2	1.1	0.1	-0.2	-0.8	1.0
Medication: Aspirin	0.9	1.2	4.0	1.3	0.4	0.3	0.8	2.0	-0.1	1.3
Myopia	0.9	1.3	4.0	-2.0	-1.6	0.2	0.0	-0.3	-1.4	-0.9
Basal cell carcinoma (self-reported)	0.9	1.1	2.5	1.4	-1.6	-0.7	1.1	0.6	0.0	0.9
Hand grip strength (left)	0.8	2.1	5.9	-0.5	0.3	-1.4	-2.0	-2.4	0.0	-1.6
Taking other prescription medications	0.8	1.2	3.2	1.3	0.1	-1.6	-0.4	1.8	0.7	-0.6
Bilateral oophorectomy (both ovaries removed)	0.8	0.9	1.9	1.4	-0.7	-1.0	0.0	-0.4	1.3	1.0
Nervous feelings	0.8	1.6	6.2	-1.6	2.5	0.9	-0.7	0.1	-0.2	-1.0
Lung cancer (father)	0.8	0.9	1.7	1.1	-1.0	0.5	0.9	0.0	1.0	1.3
Forced expiratory volume in 1-second (FEV1), Best measure	0.8	2.5	7.6	-1.5	2.7	-0.3	-1.1	-1.5	1.1	-1.6
Loud music exposure frequency	0.8	0.9	2.0	1.0	-1.4	-0.9	1.1	0.4	0.3	1.0
Comparative body size at age 10	0.8	2.1	7.2	-1.5	-0.4	0.9	-0.3	-2.7	-1.9	-1.0
Miserableness	0.8	1.4	4.9	-1.1	1.6	-0.7	-0.7	0.1	-0.7	-2.2
Mother’s age at death	0.8	1.0	2.4	-0.6	1.3	-0.0	-1.6	0.5	-1.1	-0.9
Eye problems/disorders: Glaucoma	0.8	1.0	1.7	-1.0	0.4	-0.6	-1.2	-1.0	-1.1	-1.3
Risk taking	0.8	1.2	2.3	-1.1	-0.9	-0.7	-1.5	-1.0	-0.9	-1.2
Deep venous thrombosis (DVT) (self-reported)	0.8	1.1	2.5	-1.3	1.0	1.6	-0.3	-1.1	-0.6	-0.9
Pack years of smoking	0.8	1.1	3.4	-1.8	0.3	1.6	0.4	-1.1	-0.7	-0.2
Allergy or Eczema	0.7	1.7	4.5	1.2	-1.9	-1.4	-0.2	2.1	-0.4	0.2
Systolic blood pressure, automated reading	0.7	2.1	5.2	-0.4	2.3	1.6	0.6	-1.5	1.3	1.4
Medication: Co-codamol	0.7	0.8	2.0	1.4	-0.4	-0.7	0.9	0.0	1.2	1.0
Supplements: Glucosamine	0.7	1.0	2.4	1.4	0.3	-1.2	0.6	0.4	1.6	0.5
Sitting height	0.7	5.0	14.1	-2.9	2.4	-0.7	-0.9	-3.8	0.1	-2.3
Fluid intelligence score	0.7	1.4	3.7	-0.6	-1.9	-1.2	-1.0	-0.7	-1.4	-0.7
Mouth/teeth dental problems: Bleeding gums	0.7	0.9	2.0	1.1	-0.9	0.5	0.3	1.4	0.3	1.4
Worry too long after embarrassment	0.7	1.2	4.4	0.1	-1.1	-1.5	-0.5	2.1	-0.3	-0.7
Emphysema/chronic bronchitis	0.7	0.7	2.6	0.2	0.9	1.6	0.0	0.0	0.7	1.2
Had major operations	0.7	0.8	1.7	0.5	1.2	-1.1	-0.9	0.6	0.2	-1.3
Average weekly champagne plus white wine intake	0.7	0.9	2.6	0.5	-1.5	-0.5	0.6	1.6	0.8	0.6
Medication: Blood pressure	0.7	1.3	5.3	0.4	-2.3	-1.6	-0.1	1.1	0.3	0.1
Supplements: Fish oil (including cod liver oil)	0.7	0.9	2.6	-0.3	1.6	-0.8	-0.7	-0.5	0.2	-1.6
Medication: Lisinopril	0.7	1.0	3.9	-0.5	-2.0	-0.7	-0.9	-0.5	-0.7	-0.7
Depressed Affect (Nagel 2018)	0.6	1.3	4.0	-0.6	0.1	-1.2	-0.9	0.8	-1.2	-2.0
Verbal and Numeric Reasoning (VNR)	0.6	1.3	2.8	-0.3	-1.5	-1.7	-1.3	-0.8	-0.9	-0.9
Ovarian Cancer	0.6	0.8	1.6	-0.7	0.5	-0.4	-1.3	0.5	-1.3	-1.0
Neuroticism (2016)	0.6	0.9	2.0	0.3	-0.6	-1.4	-1.1	1.2	-0.7	-0.9
Type 2 Diabetes (T2D) (2012)	0.6	0.7	2.7	0.9	0.1	-1.6	-0.6	0.8	-0.2	-0.1
Blood Eosinophil Count	0.6	4.8	12.3	2.8	-2.9	-2.1	0.4	3.5	0.2	0.8
Hearing difficulty/problems: Yes	0.6	1.0	2.6	1.0	1.6	0.4	0.6	0.4	0.9	1.3
Pack years adult smoking proportion	0.6	0.8	2.7	-1.6	-0.0	1.3	0.5	-0.9	-0.7	-0.2
Financial difficulties in last 2 years	0.6	0.8	2.2	1.3	0.4	-1.5	-0.6	1.1	0.5	-0.0
Heart attack	0.6	0.8	1.4	1.1	0.8	0.6	0.9	1.2	0.8	0.8
Alcohol intake versus 10 years previously	0.6	0.9	3.6	0.2	0.3	0.8	1.9	-0.7	0.3	1.2
Mouth/teeth dental problems: Dentures	0.6	1.0	2.3	1.0	0.2	0.6	1.5	-0.1	1.4	1.1
Medication: Ibuprofen (e.g. Nurofen)	0.6	0.8	2.2	-0.3	1.0	-0.9	-1.0	-0.6	0.0	-1.5
Medication: Paracetamol	0.6	1.1	2.9	0.8	-0.3	1.7	1.3	-0.6	0.3	1.3
Hypothyroidism/myxoedema (self-reported)	0.6	1.2	2.8	0.8	-0.2	0.5	1.1	1.4	1.7	1.4
Pulse rate, automated reading	0.6	2.0	4.2	1.0	1.9	2.1	0.7	0.9	1.6	1.2
Knee pain experienced in last month	0.6	1.0	2.4	1.0	1.2	-1.5	-0.6	0.6	0.3	-1.1
Illnesses of siblings: Diabetes	0.6	0.7	2.1	-0.2	-1.0	-0.2	0.2	-1.3	-1.4	-0.2
Ever had bowel cancer screening	0.6	0.7	2.9	0.5	-0.9	-0.8	0.1	1.7	0.4	-0.3
Back pain experienced in last month	0.6	0.9	3.2	1.0	-0.5	0.2	0.9	1.8	0.8	0.3
Illnesses of father: None of the above (group 1)	0.6	0.7	2.8	-0.0	-1.7	0.1	-0.9	-0.8	-0.8	-0.2
Commuting to job workplace: Public transport	0.6	0.7	2.0	-1.0	-0.7	0.8	1.4	-0.4	0.0	0.6
Medication: Bendroflumethiazide	0.6	0.9	2.4	-0.3	1.2	-0.7	-1.6	-1.2	-0.1	-0.7
Number of operations (self-reported)	0.6	0.9	3.0	1.7	0.1	-0.4	-0.2	1.1	1.2	0.4
Fractured/broken bones in last 5 years	0.6	0.7	1.8	0.3	1.3	0.7	1.3	0.2	0.6	0.7
Supplements: Calcium	0.6	0.6	2.4	0.4	0.6	0.7	0.7	1.6	0.7	0.5
Heart attack/myocardial infarction (self-reported)	0.6	0.7	1.6	1.1	0.6	0.5	0.8	1.2	0.7	0.7
Worry (Nagel 2018)	0.5	1.0	4.4	-0.4	1.1	0.2	0.4	2.1	0.8	-0.4
Ulcerative Colitis (UC)	0.5	1.0	3.6	-0.2	1.6	1.9	-0.1	0.8	0.1	0.4
Major Depression (MDD)	0.5	0.6	3.3	0.1	-1.8	-0.1	-0.4	0.4	-0.3	0.4
Coronary Artery Disease (CAD)	0.5	0.6	1.5	-1.0	-0.2	0.2	-1.2	0.1	-1.0	-0.8
Fasting Glucose	0.5	0.6	1.3	-0.1	-1.1	0.3	1.1	0.6	1.1	0.3
Schizophrenia (2014)	0.5	1.1	5.3	0.4	1.0	-0.8	0.1	2.3	-0.6	0.2
Respiratory disease	0.5	1.1	3.7	-0.6	0.1	-0.1	-1.9	-1.2	-1.1	-1.1
Number of treatments/medications taken	0.5	0.9	3.6	1.1	-0.1	-1.9	-0.7	0.9	0.3	-0.6
Sensitivity / hurt feelings	0.5	0.9	1.8	-1.0	0.9	1.4	-1.1	-0.6	-0.2	-1.0
Frequency of depressed mood in last 2 weeks	0.5	0.6	1.6	-0.5	-0.7	-1.0	-0.6	0.2	-0.9	-1.2
Medication: Metformin	0.5	0.7	2.6	-0.7	0.1	-0.6	-0.8	-0.5	-1.6	-0.8
Impedance of leg (right)	0.5	2.3	9.9	1.3	1.2	1.1	0.5	3.1	0.5	1.2
Leg fat-free mass (left)	0.5	2.5	11.6	-1.5	0.2	-0.8	-0.7	-3.4	0.4	-1.5
Fed-up feelings	0.5	0.9	1.9	0.2	0.1	-1.0	-0.9	1.2	-1.0	-1.4
Relative age voice broke	0.5	0.8	2.8	-0.1	-0.2	-1.7	-1.0	0.0	0.1	-1.3
Stomach or abdominal pain in last month	0.5	0.6	2.3	1.5	-0.1	0.5	-0.6	1.1	0.3	0.5
Leg predicted mass (left)	0.5	2.5	11.6	-1.4	0.2	-0.8	-0.8	-3.4	0.4	-1.5
Number of incorrect matches in round	0.5	0.8	3.8	0.1	2.0	-0.8	-0.5	-0.2	0.1	-0.7
Hearing difficulty/problems with background noise	0.5	0.8	1.5	0.9	1.0	0.6	1.1	0.4	0.9	1.2
Ever unenthusiastic/disinterested for a whole week	0.5	0.6	1.3	-1.1	-0.4	0.4	-1.1	-0.6	-0.8	-0.7
Falls in the last year	0.5	0.7	1.8	0.5	1.4	-0.3	0.8	0.7	1.2	0.4
Hair/balding pattern: Pattern 3	0.5	0.7	1.7	-1.3	-0.2	-0.3	-1.1	-0.4	-1.1	-0.9
Qualifications: A levels/AS levels or equivalent	0.5	1.0	3.7	-0.9	1.9	-0.3	-0.8	-0.8	-0.5	-1.0
Asthma	0.5	1.0	2.8	-1.1	0.2	0.6	-1.0	-1.7	-1.1	-0.5
Pulse wave Arterial Stiffness index	0.5	0.6	2.1	-0.2	-0.1	0.6	1.4	-0.5	0.5	0.9
Tense / ‘highly strung’	0.5	0.8	3.9	0.7	0.8	-0.4	-0.3	2.0	0.7	0.1
Glaucoma (self-reported)	0.5	0.5	1.3	0.1	-0.2	-1.1	-1.2	0.1	-0.6	-0.9
Birth weight	0.5	1.2	2.6	-1.3	1.6	0.6	0.2	-1.1	1.1	-1.0
Pulse wave peak to peak time	0.5	0.5	2.2	-0.0	0.2	-0.6	-1.5	0.3	-0.5	-1.0
Health satisfaction	0.5	0.6	1.9	0.9	0.6	-1.0	0.5	1.4	0.5	0.1
Suffer from ‘nerves’	0.5	0.9	2.2	-1.5	0.7	0.1	-1.1	-0.2	-0.7	-1.3
Leg fat-free mass (right)	0.5	2.7	11.8	-1.6	0.2	-1.0	-0.8	-3.4	0.3	-1.7
Handedness (chirality/laterality): Left-handed	0.5	0.5	1.2	0.2	-0.4	0.4	1.1	-0.9	1.0	0.7
Mood swings	0.5	0.9	2.5	-0.0	0.2	-1.3	-1.4	0.0	-0.7	-1.6
Qualifications: nursing, teaching	0.5	0.8	2.2	-1.5	0.8	1.3	-0.4	-0.1	-0.7	-0.3
Asthma (self-reported)	0.5	0.9	3.1	-0.9	0.5	0.6	-1.0	-1.8	-0.9	-0.5
Leg predicted mass (right)	0.5	2.8	12.0	-1.6	0.2	-1.0	-0.8	-3.5	0.3	-1.8
Hearing aid user	0.5	0.5	1.6	0.9	0.3	-1.3	-0.3	-0.9	0.6	-0.0
Medication: Paracetamol	0.5	0.8	3.3	0.2	-0.4	1.8	1.0	-0.5	-0.2	1.0
Ever depressed for a whole week	0.5	0.6	1.3	0.9	0.6	0.3	1.1	0.4	1.0	0.7
Heart disease (siblings)	0.5	0.6	1.8	1.3	-0.3	-0.6	0.3	1.2	0.7	0.2
Intelligence (Savage-Jansen 2018)	0.4	1.1	1.7	-1.3	-1.1	-0.8	-1.1	-1.2	-1.0	-0.9
Neuroticism (Nagel 2018)	0.4	0.9	3.3	-0.2	-0.2	-0.9	-0.3	1.8	-0.1	-1.3
Schizophrenia (2018)	0.4	0.9	4.8	0.5	0.2	-0.1	0.9	2.2	-0.0	0.6
Schizophrenia vs Biploar Disorder	0.4	0.5	2.6	0.8	0.4	0.3	0.1	1.6	-0.6	0.0
Crohns Disease (2017)	0.4	0.9	1.6	-0.4	-0.4	-1.1	-0.9	-1.1	-1.2	-1.3
Crohns Disease (2012)	0.4	0.7	3.0	0.0	0.6	-1.7	-0.6	-0.2	-0.3	-0.9
Hypothyroidism (self reported)	0.4	0.9	2.3	0.5	0.0	0.9	1.1	0.9	1.5	0.9
Neuroticism	0.4	0.9	2.1	-0.2	-0.6	-1.3	-0.4	1.4	0.0	-1.3
Tanning	0.4	5.1	8.1	-2.7	1.2	1.1	-2.9	-2.5	-2.5	-2.3
Vitamin and mineral supplements	0.4	0.5	2.0	0.0	-0.5	1.4	0.3	-0.4	-0.5	0.9
Diabetes (mother)	0.4	0.5	1.9	0.7	0.3	-0.8	0.7	1.4	0.2	0.5
Townsend deprivation index at recruitment	0.4	0.6	3.1	-0.7	0.4	1.8	0.2	-0.7	0.1	0.3
Multivitamins +/- minerals	0.4	0.5	2.1	-0.1	-0.0	-1.5	-0.2	0.4	0.8	-0.8
High blood pressure (mother)	0.4	0.5	1.7	0.3	1.0	-1.3	-0.2	0.1	-0.0	-0.8
Impedance of leg (left)	0.4	2.1	10.2	1.1	1.2	0.9	0.3	3.2	0.5	0.9
Hair/balding pattern: Pattern 2	0.4	0.5	2.7	0.3	-0.8	1.7	-0.1	-0.1	-0.0	0.6
Hayfever/allergic rhinitis (self-reported)	0.4	0.5	1.2	0.3	-0.0	0.2	0.8	1.1	0.9	0.8
Medication: Simvastatin	0.4	0.5	1.3	1.1	-0.4	-0.1	0.3	1.1	0.5	1.0
Neuroticism score	0.4	0.8	2.2	-0.9	1.1	-0.4	-0.9	0.6	-0.6	-1.5
Forced expiratory volume in 1-second (FEV1)	0.4	1.5	4.1	-0.8	2.0	-0.2	-0.9	-1.1	1.7	-1.0
Serious illness, injury or assault of a close relative in last 2 years	0.4	0.4	0.9	0.7	-0.5	0.9	0.5	0.4	0.4	0.8
Medication: Cholesterol lowering	0.4	0.6	1.5	0.3	-1.2	-0.7	-0.7	1.1	-0.4	-0.1
Depression (self-reported)	0.4	0.4	2.0	-0.2	-0.7	-1.4	-0.4	0.1	-0.2	-0.6
Prospective memory result	0.4	0.4	1.1	-0.3	0.8	-0.5	-0.5	-0.0	-0.8	-1.0
Length of working week for main job	0.4	0.4	1.4	0.0	0.5	-0.7	0.4	1.2	0.7	-0.2
Peak expiratory flow (PEF)	0.4	0.9	3.9	-0.0	1.1	1.0	-0.3	-0.1	2.0	0.1
Ever highly irritable/argumentative for 2 days	0.4	0.5	2.2	-0.5	-0.1	0.6	-0.1	-0.9	-1.5	-0.5
Medication: Amlodipine	0.4	0.6	2.0	-0.4	1.4	1.0	-0.6	-0.6	0.7	0.4
Medication: Ventolin 100micrograms inhaler	0.4	0.5	1.9	0.0	0.4	-0.9	-0.5	-1.4	-0.3	-0.6
High blood pressure (siblings)	0.4	0.6	2.0	0.9	-0.8	-1.4	0.4	0.4	0.3	0.3
Number of full brothers	0.4	0.5	2.2	-0.0	1.5	0.1	-0.1	0.2	1.1	0.4
Shortness of breath walking on level ground	0.4	0.4	1.3	-0.6	1.0	-0.2	-0.0	-1.2	0.0	-0.6
Medication: Omeprazole	0.4	0.5	1.0	0.5	0.3	-0.6	-1.0	0.9	-0.4	-0.8
Heart disease (mother)	0.4	0.5	2.7	0.3	-0.2	-0.8	0.6	1.6	-0.0	0.1
Illness, injury, bereavement, stress in last 2 years	0.4	0.4	1.1	-0.3	-0.8	-0.7	-0.6	-0.3	-1.0	-0.5
Supplements: Vitamin C	0.4	0.5	1.7	-0.1	0.5	0.6	1.3	0.1	0.7	0.9
Whole body fat-free mass	0.4	2.1	9.2	-1.5	1.0	-0.2	-0.2	-3.0	1.1	-1.1
Eye problems/disorders: Cataract	0.4	0.5	0.8	0.9	0.1	-0.7	0.6	0.8	0.8	0.7
Osteoporosis (self-reported)	0.4	0.5	1.2	0.8	-0.7	-1.1	-0.5	0.9	-0.5	-0.5
Whole body water mass	0.4	2.1	9.4	-1.5	1.0	-0.1	-0.2	-3.1	1.1	-1.0
Alcohol drinker status: Never	0.4	0.5	1.6	-0.8	-0.4	0.0	-0.5	-0.2	-1.2	-0.9
Basal metabolic rate	0.4	2.0	9.4	-1.4	0.6	-0.3	-0.3	-3.1	1.0	-1.1
Average weekly beer plus cider intake	0.4	0.6	2.7	-0.7	1.6	0.5	0.3	-0.8	0.2	0.1
Diastolic blood pressure, automated reading	0.4	1.2	3.1	0.9	0.6	0.8	1.2	0.1	1.5	1.8
Medication: Omeprazole (e.g. Zanprol)	0.4	0.5	1.4	0.8	-0.0	-0.9	-0.4	1.2	0.1	-0.5
Bipolar Disorder or Schizophrenia	0.3	0.8	2.8	0.7	0.3	-0.6	0.9	1.7	0.4	0.9
HDL Cholesterol	0.3	0.5	2.7	-0.0	1.6	0.7	-0.0	0.2	0.1	-0.2
LDL Cholesterol	0.3	0.4	0.8	-0.2	0.2	0.9	0.8	-0.1	0.7	0.9
Blood Platelet Count	0.3	3.2	13.2	-1.3	0.1	0.2	-2.3	0.2	-3.6	-1.4
Blood Red Count	0.3	2.9	9.5	2.5	-1.1	-3.1	-0.7	1.4	1.1	-0.1
Height	0.3	6.2	12.3	-3.5	3.4	1.0	-1.3	-3.2	1.0	-2.2
Waist Hip Ratio (WHR)	0.3	1.4	5.3	0.8	1.0	0.5	0.4	2.3	1.0	1.1
Cardiovascular Disease	0.3	0.9	3.8	0.3	-0.7	-2.0	-1.0	0.7	-0.2	-0.4
Type 2 Diabetes (T2D) (2018)	0.3	0.6	2.1	-0.7	1.4	0.7	-0.2	0.3	-0.9	-0.1
Lung FVC	0.3	1.7	2.2	-1.1	1.5	-1.2	-1.3	-1.2	1.2	-1.5
Angina	0.3	0.3	0.8	0.0	-0.1	0.8	0.6	0.6	-0.4	0.9
Diabetes (father)	0.3	0.4	0.8	0.9	-0.3	-0.2	0.9	0.7	-0.4	0.7
Hand grip strength (right)	0.3	0.9	4.8	-0.1	-0.4	-0.1	-0.5	-2.2	0.8	-0.2
Maternal smoking around birth	0.3	0.4	0.8	-0.2	0.3	0.7	0.9	-0.1	-0.9	0.8
Age when periods started (menarche)	0.3	0.7	3.7	-0.2	0.4	1.9	0.4	0.2	0.9	0.5
High blood pressure	0.3	0.7	3.0	-0.2	-0.8	-1.7	-1.0	0.5	-0.1	-0.5
Hayfever, allergic rhinitis or eczema	0.3	0.7	2.9	0.8	-0.4	-1.0	-0.6	1.7	-0.4	-0.2
Medication: Atenolol	0.3	0.3	1.2	-1.1	-0.3	-0.4	-0.2	0.2	-0.3	-0.9
Had other major operations	0.3	0.4	1.2	0.6	-0.3	0.7	0.0	-0.1	1.1	0.6
Diabetes (self-reported)	0.3	0.4	0.8	-0.8	0.9	0.6	0.6	0.4	-0.9	0.1
Medication: Ramipril	0.3	0.4	0.9	0.9	0.6	-1.0	-0.3	-0.0	0.6	-0.2
Illnesses of siblings	0.3	0.4	1.0	-0.7	0.6	1.0	-0.6	-0.4	-0.3	-0.6
Weight	0.3	1.4	7.2	-0.8	-0.1	-0.6	-0.3	-2.7	0.7	-0.8
Trunk fat-free mass	0.3	2.0	7.0	-1.4	1.4	0.3	0.2	-2.6	1.6	-0.6
Hip circumference	0.3	1.1	2.8	-0.6	-1.6	-0.8	-0.7	-1.7	-0.4	-0.8
Pulse rate	0.3	0.6	1.9	0.8	0.3	0.8	-0.1	1.4	0.1	0.9
Trunk predicted mass	0.3	1.9	6.6	-1.2	1.4	0.1	0.3	-2.6	1.7	-0.6
Standing height	0.3	3.3	8.9	-1.9	3.0	0.1	-0.5	-2.4	1.4	-1.7
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.4	1.4	-0.5	0.2	-0.6	-0.8	0.3	-0.2	-1.2
Hair/balding pattern: Pattern 4	0.3	0.7	3.3	-0.4	-1.0	-1.8	-0.4	-0.3	-0.5	-0.6
Arm fat-free mass (right)	0.3	1.5	7.1	-1.3	0.6	-0.1	-0.1	-2.7	0.8	-1.0
Exposure to tobacco smoke outside home	0.3	0.4	0.8	0.8	-0.1	0.9	-0.1	-0.4	0.7	0.7
Eye problems/disorders: None of the above	0.3	0.3	1.1	-0.6	-1.0	0.6	0.1	-0.5	-0.4	-0.3
Medication for pain relief, constipation, heartburn	0.3	0.5	1.7	-1.2	-1.3	-0.0	-0.1	-0.3	0.1	-0.3
Neck or shoulder pain in last month	0.3	0.4	1.1	0.5	-0.7	0.6	0.3	1.0	-0.0	0.7
Angina (self-reported)	0.3	0.4	1.9	-0.4	0.1	1.4	0.4	0.1	-0.6	0.7
Arm predicted mass (right)	0.3	1.7	7.3	-1.4	0.7	-0.3	-0.2	-2.7	0.7	-1.2
Alcohol intake frequency.	0.3	0.7	2.0	-0.6	1.4	1.3	0.3	-0.3	-0.8	0.1
Comparative height size at age 10	0.3	1.7	5.9	-1.2	2.4	0.2	0.7	-1.7	1.0	-0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.3	0.9	0.2	1.0	0.8	-0.2	0.4	-0.5	0.1
Illnesses of father: Heart disease	0.3	0.4	1.1	0.1	0.5	-1.1	-0.5	0.9	0.5	-0.6
Diabetes diagnosed by doctor	0.3	0.5	1.8	-0.4	1.3	0.3	0.5	0.9	-0.9	-0.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.3	1.1	0.9	-0.4	-1.1	-0.2	-0.0	0.3	-0.2
Ever taken oral contraceptive pill	0.3	0.4	0.7	0.1	-0.3	-0.8	-0.8	0.8	-0.3	-0.7
Illnesses of father: High blood pressure	0.3	0.4	0.6	-0.8	0.4	0.6	0.7	0.7	0.3	0.5
Arm fat-free mass (left)	0.3	1.6	6.7	-1.2	1.0	0.3	0.2	-2.6	1.2	-0.5
Age started oral contraceptive pill	0.3	0.3	0.7	-0.8	0.5	0.5	-0.7	0.5	-0.6	-0.4
Vascular/heart problems diagnosed by doctor	0.3	0.7	3.5	-0.4	0.7	1.9	0.5	-0.6	-0.3	0.1
Impedance of whole body	0.3	1.4	7.5	1.4	0.4	0.1	0.3	2.7	0.1	0.6
Arm predicted mass (left)	0.3	1.6	6.4	-1.1	1.3	0.1	0.1	-2.5	1.3	-0.7
Bipolar Disorder (2018)	0.2	0.3	0.6	0.5	0.2	-0.8	0.3	-0.0	0.7	0.7
Irritable Bowel Disease (IBD)	0.2	0.4	0.9	-0.5	0.8	0.4	-0.8	-0.1	-0.9	-0.7
Breast Cancer	0.2	0.6	2.0	1.1	-0.3	-1.4	0.5	0.6	0.4	0.2
Body Mass Index (BMI) (2010)	0.2	0.3	0.8	-0.1	-0.9	0.8	0.5	-0.5	-0.4	0.5
Triglycerides	0.2	0.3	1.0	-0.4	-0.7	1.0	-0.7	-0.3	-0.1	0.4
Heel T-Score	0.2	1.9	6.4	-1.5	-2.5	-1.2	-0.9	-0.8	-1.0	-0.7
BMI	0.2	1.4	3.6	-0.4	-1.4	-1.4	-0.5	-1.9	-0.9	-0.8
Systolic Blood Pressure	0.2	1.1	3.5	-0.0	0.7	1.9	-0.1	-0.5	0.4	1.8
Smoking Status	0.2	0.4	1.8	0.2	-1.3	-0.7	-0.1	-0.5	-0.5	-0.0
Trunk fat percentage	0.2	0.8	1.8	0.3	-1.3	-1.3	-0.6	-1.2	-0.5	-0.5
Average weekly fortified wine intake	0.2	0.2	0.5	-0.2	-0.4	0.4	-0.7	0.1	-0.2	0.6
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.4	1.9	0.1	-1.4	-0.0	0.3	-0.3	0.4	0.7
Body mass index (BMI)	0.2	0.9	3.1	0.0	-1.6	-0.8	-0.0	-1.8	0.1	-0.2
Trunk fat mass	0.2	0.9	3.7	-0.2	-0.8	-1.1	-0.5	-1.9	0.0	-0.7
Impedance of arm (right)	0.2	1.1	5.2	1.1	0.8	0.1	0.2	2.3	0.3	0.8
Arm fat percentage (right)	0.2	0.6	2.4	0.2	-1.1	-0.8	-0.2	-1.5	-0.0	-0.1
Noisy workplace	0.2	0.2	0.6	0.6	0.8	-0.4	0.3	-0.6	-0.2	0.2
Impedance of arm (left)	0.2	0.9	3.9	1.3	-0.6	-0.5	0.0	2.0	-0.4	0.5
Arm fat mass (right)	0.2	0.8	4.0	0.0	-0.9	-0.7	-0.0	-2.0	0.5	-0.1
Birth weight of first child	0.2	0.3	0.9	-1.0	0.8	0.5	-0.2	0.2	0.2	-0.2
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.2	0.7	-0.2	-0.3	-0.5	-0.3	-0.5	0.9	-0.3
Mouth/teeth dental problems: Loose teeth	0.2	0.3	0.7	-0.3	0.6	0.8	-0.5	0.4	-0.1	-0.5
Medication: Blood pressure	0.2	0.4	1.9	0.1	1.4	0.2	-0.9	-0.1	-0.1	0.2
Whole body fat mass	0.2	0.8	3.6	-0.1	-0.7	-1.0	-0.5	-1.9	0.2	-0.6
Leg fat mass (right)	0.2	0.6	2.7	-0.2	-0.3	-0.8	-0.7	-1.6	-0.0	-0.6
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.3	0.9	0.7	-1.0	-0.5	0.2	-0.3	-0.1	-0.0
Hypertension (Self-reported)	0.2	0.5	1.8	-0.1	-0.8	-1.4	-0.5	0.5	0.3	0.2
Arm fat percentage (left)	0.2	0.9	3.0	0.4	-1.7	-0.9	-0.1	-1.4	-0.1	-0.0
Medication: Gliclazide	0.2	0.2	0.5	-0.4	-0.4	0.6	0.7	0.4	-0.3	0.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.5	1.9	0.1	0.7	-1.4	-0.1	0.5	0.7	-0.6
Arm fat mass (left)	0.2	0.8	3.4	0.1	-1.2	-0.9	0.0	-1.8	0.4	-0.2
Guilty feelings	0.2	0.3	0.6	0.8	0.1	-0.7	-0.2	0.7	0.1	-0.5
Medication: Atorvastatin	0.2	0.2	0.4	0.4	0.5	-0.6	-0.1	0.5	0.6	0.0
Ever had prostate specific antigen (PSA) test	0.2	0.3	0.6	-0.4	0.6	-0.6	-0.3	-0.8	-0.0	-0.5
Primary Biliary Cirrhosis	0.1	0.1	0.7	0.1	-0.2	0.8	0.3	-0.1	-0.0	0.3
Blood White Count	0.1	1.0	5.0	0.1	-0.4	0.5	-1.1	0.6	-2.2	0.1
Hair Pigment	0.1	1.7	3.6	1.4	1.1	0.1	1.8	0.8	1.9	1.1
Current tobacco smoking	0.1	0.1	0.4	-0.2	-0.6	-0.1	-0.2	-0.1	-0.7	0.2
Tinnitus: Yes, but not now, but have in the past	0.1	0.1	0.4	-0.1	-0.4	0.5	0.1	-0.4	0.6	0.4
Medication: Levothyroxine sodium	0.1	0.2	1.0	-0.3	-1.0	0.6	-0.0	-0.1	0.4	0.2
Chronic bronchitis/emphysema (father)	0.1	0.2	0.3	-0.1	-0.3	0.6	0.4	-0.5	0.3	0.4
Waist circumference	0.1	0.3	0.9	0.3	-0.3	-0.1	0.4	-0.6	1.0	0.4
Past tobacco smoking	0.1	0.2	0.9	-0.9	0.5	0.2	-0.6	0.3	-0.3	-0.2
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.2	0.7	-0.5	-0.2	-0.3	-0.3	-0.8	0.1	-0.2
Allergy	0.1	0.2	0.6	0.1	-0.3	-0.3	0.8	-0.4	0.7	0.3
Headache pain in last month	0.1	0.3	0.6	0.5	0.5	-0.5	0.2	-0.5	0.8	-0.3
Medication for cholesterol, blood pressure or diabetes	0.1	0.2	0.4	-0.5	-0.5	0.5	0.6	-0.5	0.2	-0.2
Chronic bronchitis/emphysema (mother)	0.1	0.1	0.3	-0.5	0.4	0.1	0.5	-0.3	-0.1	0.1
Body fat percentage	0.1	0.6	1.6	0.4	-1.3	-0.9	-0.4	-1.0	-0.2	-0.2
Leg fat percentage (right)	0.1	0.2	0.6	0.7	-0.8	-0.5	-0.3	-0.2	0.1	0.2
Commuting to job workplace: Car/motor vehicle	0.1	0.1	0.3	0.2	0.5	0.0	-0.6	-0.2	-0.2	-0.4
Smoking status: Previous	0.1	0.2	0.5	0.7	-0.2	-0.5	0.4	-0.7	0.3	-0.2
Smoking status: Current	0.1	0.2	0.5	-0.3	-0.7	0.0	-0.3	-0.1	-0.7	0.2
Tinnitus: Yes, now most or all of the time	0.1	0.1	0.4	0.2	0.4	0.3	-0.7	0.2	-0.4	-0.3
Ever smoked	0.1	0.1	0.4	0.6	-0.6	-0.4	0.1	0.0	-0.2	-0.1
Leg fat percentage (left)	0.1	0.3	0.9	0.7	-1.0	-0.6	-0.3	0.0	0.1	0.2
Leg fat mass (left)	0.1	0.5	2.3	-0.1	-0.5	-0.8	-0.5	-1.5	0.3	-0.5

Hub : Genes

STX6

Models

Trait associations