[Hub]/) : Traits : Lung FEV1/FVC ratio : ← →

chr12:123,387,922-125,118,479

Best TWAS P=2.55e-10 · Best GWAS P=7.33e-10 conditioned to 0.273

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
6	GTEx	Adipose Subcutaneous	TCTN2	0.30	0.27	enet	37	0.37	2.3e-31	5.2	6.3	2.5e-10	0.90	0.16	0.84	TRUE
31	GTEx	Esophagus Mucosa	TCTN2	0.16	0.04	enet	28	0.11	1.0e-07	-3.2	6.2	4.4e-10	0.67	0.29	0.70	FALSE
28	GTEx	Colon Transverse	ATP6V0A2	0.17	0.08	enet	22	0.17	1.4e-08	5.4	6.2	4.9e-10	0.89	0.04	0.96	FALSE
49	GTEx	Stomach	TCTN2	0.22	0.18	lasso	11	0.20	1.2e-09	5.5	6.2	5.4e-10	0.91	0.04	0.96	FALSE
14	GTEx	Artery Coronary	TCTN2	0.38	0.27	lasso	9	0.40	9.8e-15	5.5	6.2	6.2e-10	0.75	0.16	0.84	FALSE
21	GTEx	Breast Mammary Tissue (Female)	DDX55	0.15	0.03	lasso	7	0.03	5.4e-02	4.9	-6.1	8.7e-10	-0.90	0.04	0.86	FALSE
16	GTEx	Breast Mammary Tissue	DDX55	0.21	0.08	lasso	5	0.12	9.5e-07	4.4	-6.1	9.0e-10	-0.73	0.14	0.86	FALSE
18	GTEx	Breast Mammary Tissue	ATP6V0A2	0.09	0.02	lasso	4	0.03	9.7e-03	5.2	6.1	9.9e-10	0.74	0.10	0.75	FALSE
1	CommonMind	Brain Pre-frontal Cortex	ATP6V0A2	0.08	0.11	lasso	5	0.11	1.4e-13	5.6	6.1	1.2e-09	0.97	0.04	0.96	FALSE
47	GTEx	Skin Sun Exposed Lower leg	TCTN2	0.24	0.16	lasso	11	0.22	2.1e-18	5.1	6.0	1.6e-09	0.81	0.17	0.83	FALSE
13	GTEx	Artery Coronary	DDX55	0.32	0.15	lasso	3	0.23	2.9e-08	6.2	-6.0	2.2e-09	-0.86	0.01	0.98	FALSE
62	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	ATP6V0A2	0.06	0.08	blup	53	0.08	1.4e-05	5.4	6.0	2.3e-09	0.97	0.02	0.98	FALSE
22	GTEx	Breast Mammary Tissue (Female)	TCTN2	0.32	0.10	enet	25	0.12	1.6e-04	-3.3	6.0	2.5e-09	0.64	0.15	0.69	FALSE
23	GTEx	Cells EBV-transformed lymphocytes	TCTN2	0.23	0.15	lasso	3	0.21	2.6e-07	5.5	5.9	3.0e-09	0.77	0.13	0.82	FALSE
27	GTEx	Colon Transverse	TCTN2	0.25	0.15	enet	14	0.23	3.1e-11	5.5	5.9	3.2e-09	0.74	0.12	0.88	FALSE
17	GTEx	Breast Mammary Tissue	TCTN2	0.28	0.20	lasso	12	0.23	4.0e-12	5.2	5.9	3.3e-09	0.83	0.20	0.80	FALSE
39	GTEx	Nerve Tibial	TCTN2	0.34	0.39	enet	29	0.43	1.1e-32	5.2	5.9	3.7e-09	0.89	0.38	0.61	FALSE
63	The Cancer Genome Atlas	Brain Lower Grade Glioma	ATP6V0A2	0.16	0.15	lasso	5	0.15	2.0e-16	5.6	5.9	3.7e-09	0.98	0.02	0.98	FALSE
52	GTEx	Thyroid	ATP6V0A2	0.07	0.02	enet	9	0.02	9.8e-03	5.7	5.9	3.9e-09	0.81	0.02	0.94	FALSE
7	GTEx	Adipose Subcutaneous	ATP6V0A2	0.08	0.08	lasso	7	0.07	4.3e-06	6.0	5.9	4.2e-09	0.98	0.01	0.99	FALSE
15	GTEx	Artery Tibial	TCTN2	0.32	0.34	enet	31	0.39	1.2e-32	5.2	5.8	5.7e-09	0.85	0.36	0.64	FALSE
41	GTEx	Ovary	TCTN2	0.37	0.22	lasso	17	0.22	3.1e-06	5.2	5.8	6.0e-09	0.90	0.08	0.91	FALSE
65	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	ATP6V0A2	0.03	0.01	blup	53	0.01	4.1e-02	5.6	5.8	6.6e-09	0.95	0.02	0.74	FALSE
67	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	ATP6V0A2	0.17	0.14	blup	53	0.28	4.7e-12	5.1	5.8	6.9e-09	0.90	0.06	0.94	FALSE
34	GTEx	Heart Atrial Appendage	TCTN2	0.32	0.21	enet	26	0.22	3.4e-10	5.1	5.8	7.0e-09	0.90	0.13	0.87	FALSE
56	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	ATP6V0A2	0.05	0.06	blup	53	0.06	1.4e-05	5.5	5.8	7.0e-09	0.87	0.07	0.90	FALSE
45	GTEx	Skin Not Sun Exposed Suprapubic	TCTN2	0.27	0.18	enet	32	0.22	2.3e-12	5.1	5.8	7.7e-09	0.77	0.24	0.76	FALSE
35	GTEx	Heart Left Ventricle	TCTN2	0.23	0.10	enet	20	0.12	8.1e-07	5.5	5.8	7.8e-09	0.79	0.03	0.97	FALSE
11	GTEx	Artery Aorta	TCTN2	0.35	0.27	lasso	7	0.34	2.8e-19	5.5	5.7	9.6e-09	0.78	0.14	0.86	FALSE
53	GTEx	Uterus	TCTN2	0.26	0.13	enet	15	0.11	3.2e-03	5.2	5.7	9.7e-09	0.88	0.05	0.71	FALSE
10	GTEx	Adrenal Gland	TCTN2	0.24	0.09	enet	11	0.23	1.0e-08	-3.3	5.7	1.0e-08	0.70	0.13	0.84	FALSE
71	The Cancer Genome Atlas	Soft Tissue Sarcoma	TCTN2	0.23	0.03	blup	56	0.09	5.3e-06	-3.3	5.7	1.1e-08	0.48	0.30	0.53	FALSE
19	GTEx	Breast Mammary Tissue (Male)	TCTN2	0.16	0.07	lasso	2	0.07	1.3e-02	5.8	5.7	1.2e-08	0.95	0.04	0.88	FALSE
55	METSIM	Adipose	TCTN2	0.22	0.11	blup	395	0.12	2.0e-17	5.5	5.7	1.4e-08	0.68	0.13	0.87	FALSE
69	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	DDX55	0.11	0.06	blup	46	0.09	2.6e-04	4.4	-5.7	1.4e-08	-0.53	0.02	0.68	FALSE
44	GTEx	Skin Not Sun Exposed Suprapubic	DDX55	0.25	0.09	lasso	10	0.18	5.2e-10	3.7	-5.6	1.7e-08	-0.81	0.06	0.94	FALSE
9	GTEx	Adipose Visceral Omentum	TCTN2	0.15	0.13	lasso	5	0.13	2.4e-07	5.1	5.6	1.9e-08	0.90	0.05	0.95	FALSE
61	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	ATP6V0A2	0.18	0.15	blup	53	0.17	4.0e-19	5.4	5.6	1.9e-08	0.94	0.02	0.98	FALSE
60	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	ATP6V0A2	0.06	0.04	enet	8	0.05	2.4e-06	6.0	5.6	2.1e-08	0.91	0.01	0.99	FALSE
32	GTEx	Esophagus Mucosa	ATP6V0A2	0.08	0.05	lasso	8	0.04	7.0e-04	5.4	5.6	2.2e-08	0.96	0.03	0.96	FALSE
74	The Cancer Genome Atlas	Thyroid Carcinoma	ATP6V0A2	0.16	0.21	lasso	4	0.20	1.2e-19	5.6	5.6	2.2e-08	0.99	0.03	0.97	FALSE
36	GTEx	Lung	TCTN2	0.25	0.25	lasso	11	0.24	2.1e-18	5.2	5.6	2.4e-08	0.84	0.41	0.59	FALSE
58	The Cancer Genome Atlas	Colon Adenocarcinoma	ATP6V0A2	0.16	0.12	blup	53	0.12	2.2e-07	5.6	5.5	2.8e-08	0.96	0.01	0.99	FALSE
12	GTEx	Artery Aorta	ATP6V0A2	0.11	0.12	lasso	11	0.09	2.0e-05	5.4	5.5	3.2e-08	0.95	0.04	0.96	FALSE
42	GTEx	Pancreas	DDX55	0.14	0.06	lasso	3	0.06	1.2e-03	4.4	-5.5	3.3e-08	-0.62	0.19	0.58	FALSE
46	GTEx	Skin Sun Exposed Lower leg	DDX55	0.13	0.05	enet	13	0.10	1.6e-08	4.4	-5.5	3.4e-08	-0.65	0.77	0.22	FALSE
8	GTEx	Adipose Visceral Omentum	DDX55	0.12	0.10	lasso	5	0.07	1.1e-04	5.1	-5.5	3.5e-08	-0.85	0.24	0.75	FALSE
73	The Cancer Genome Atlas	Testicular Germ Cell Tumors	TMED2	0.10	0.03	enet	14	0.06	3.1e-03	4.2	5.5	3.5e-08	0.67	0.00	0.26	FALSE
70	The Cancer Genome Atlas	Prostate Adenocarcinoma	ATP6V0A2	0.16	0.08	lasso	2	0.08	1.3e-08	5.6	5.5	3.7e-08	0.99	0.01	0.99	FALSE
64	The Cancer Genome Atlas	Lung Adenocarcinoma	ATP6V0A2	0.07	0.10	blup	53	0.10	2.2e-11	6.0	5.5	4.0e-08	0.95	0.01	0.99	FALSE
30	GTEx	Esophagus Mucosa	DDX55	0.09	0.07	lasso	5	0.07	1.2e-05	5.2	-5.5	4.6e-08	-0.88	0.09	0.90	FALSE
66	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	TCTN2	0.31	0.11	blup	56	0.12	1.4e-08	-3.2	5.5	4.7e-08	0.40	0.92	0.06	FALSE
38	GTEx	Muscle Skeletal	TCTN2	0.17	0.20	lasso	7	0.19	2.9e-18	5.2	5.4	5.4e-08	0.86	0.42	0.58	FALSE
48	GTEx	Stomach	DDX55	0.10	0.04	enet	9	0.04	5.6e-03	5.1	-5.4	5.6e-08	-0.78	0.19	0.37	FALSE
57	The Cancer Genome Atlas	Breast Invasive Carcinoma	ATP6V0A2	0.05	0.06	blup	53	0.07	1.6e-14	6.0	5.4	5.8e-08	0.95	0.01	0.99	FALSE
51	GTEx	Thyroid	TCTN2	0.39	0.25	enet	27	0.32	2.6e-25	5.2	5.4	5.9e-08	0.76	0.39	0.61	FALSE
68	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	ATP6V0A2	0.08	0.07	enet	5	0.08	3.7e-04	5.4	5.4	6.4e-08	0.96	0.04	0.88	FALSE
72	The Cancer Genome Atlas	Skin Cutaneous Melanoma	TCTN2	0.27	-0.01	blup	57	0.04	3.1e-02	-3.3	5.4	6.8e-08	0.70	0.03	0.40	FALSE
37	GTEx	Lung	ATP6V0A2	0.12	0.11	lasso	4	0.11	1.8e-08	4.5	5.4	7.8e-08	0.93	0.06	0.94	FALSE
54	GTEx	Whole Blood	ATP6V0A2	0.12	0.06	lasso	11	0.04	1.1e-04	5.2	5.4	7.8e-08	0.85	0.16	0.82	FALSE
40	GTEx	Nerve Tibial	ATP6V0A2	0.10	0.07	lasso	4	0.08	1.8e-06	5.7	5.3	9.3e-08	0.95	0.08	0.92	FALSE
3	CommonMind	Brain Pre-frontal Cortex	DNAH10	0.05	0.01	blup	488	0.01	1.0e-02	5.8	5.3	9.6e-08	0.61	0.03	0.91	FALSE
4	CommonMind	Brain Pre-frontal Cortex	TCTN2	0.28	0.19	lasso	7	0.24	4.5e-29	-3.3	5.3	1.3e-07	0.61	1.00	0.00	FALSE
50	GTEx	Testis	ATP6V0A2	0.32	0.27	lasso	16	0.30	8.4e-14	5.2	5.3	1.4e-07	0.92	0.18	0.82	FALSE
59	The Cancer Genome Atlas	Glioblastoma Multiforme	TCTN2	0.34	0.10	blup	54	0.16	1.3e-05	-3.2	5.3	1.4e-07	0.44	0.39	0.17	FALSE
20	GTEx	Breast Mammary Tissue (Male)	ATP6V0A2	0.18	0.01	lasso	2	-0.01	6.1e-01	5.2	5.2	1.5e-07	0.86	0.05	0.44	FALSE
26	GTEx	Colon Transverse	DDX55	0.16	0.14	lasso	3	0.14	3.5e-07	5.5	-5.2	1.5e-07	-0.88	0.11	0.89	FALSE
29	GTEx	Esophagus Gastroesophageal Junction	TCTN2	0.22	0.27	lasso	10	0.25	1.6e-09	5.2	5.2	2.0e-07	0.86	0.23	0.77	FALSE
33	GTEx	Esophagus Muscularis	DDX55	0.21	0.21	lasso	3	0.24	1.2e-14	4.2	-5.2	2.0e-07	-0.82	0.64	0.35	FALSE
43	GTEx	Prostate	TCTN2	0.34	0.12	lasso	7	0.19	1.5e-05	5.5	5.2	2.3e-07	0.66	0.06	0.49	FALSE
25	GTEx	Cells Transformed fibroblasts	ATP6V0A2	0.23	0.25	lasso	6	0.23	1.8e-17	5.8	5.2	2.4e-07	0.96	0.06	0.94	FALSE
2	CommonMind	Brain Pre-frontal Cortex	DDX55	0.33	0.23	enet	47	0.33	1.1e-40	5.5	-5.2	2.5e-07	-0.74	0.11	0.89	FALSE
24	GTEx	Cells Transformed fibroblasts	TCTN2	0.50	0.30	lasso	8	0.36	6.7e-28	-3.3	5.1	2.9e-07	0.49	1.00	0.00	FALSE
5	GTEx	Adipose Subcutaneous	DDX55	0.12	0.08	lasso	7	0.10	2.7e-08	4.9	-5.1	3.0e-07	-0.74	0.25	0.75	FALSE