[Hub]/) : Traits : Lung FEV1/FVC ratio :

chr12:123,387,922-125,118,479

Best TWAS P=2.55e-10 · Best GWAS P=7.33e-10 conditioned to 0.273

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex ATP6V0A2 0.08 0.11 lasso 5 0.11 1.4e-13 5.6 6.1 1.2e-09 0.97 0.04 0.96 FALSE
2 CommonMind Brain Pre-frontal Cortex DDX55 0.33 0.23 enet 47 0.33 1.1e-40 5.5 -5.2 2.5e-07 -0.74 0.11 0.89 FALSE
3 CommonMind Brain Pre-frontal Cortex DNAH10 0.05 0.01 blup 488 0.01 1.0e-02 5.8 5.3 9.6e-08 0.61 0.03 0.91 FALSE
4 CommonMind Brain Pre-frontal Cortex TCTN2 0.28 0.19 lasso 7 0.24 4.5e-29 -3.3 5.3 1.3e-07 0.61 1.00 0.00 FALSE
5 GTEx Adipose Subcutaneous DDX55 0.12 0.08 lasso 7 0.10 2.7e-08 4.9 -5.1 3.0e-07 -0.74 0.25 0.75 FALSE
6 GTEx Adipose Subcutaneous TCTN2 0.30 0.27 enet 37 0.37 2.3e-31 5.2 6.3 2.5e-10 0.90 0.16 0.84 TRUE
7 GTEx Adipose Subcutaneous ATP6V0A2 0.08 0.08 lasso 7 0.07 4.3e-06 6.0 5.9 4.2e-09 0.98 0.01 0.99 FALSE
8 GTEx Adipose Visceral Omentum DDX55 0.12 0.10 lasso 5 0.07 1.1e-04 5.1 -5.5 3.5e-08 -0.85 0.24 0.75 FALSE
9 GTEx Adipose Visceral Omentum TCTN2 0.15 0.13 lasso 5 0.13 2.4e-07 5.1 5.6 1.9e-08 0.90 0.05 0.95 FALSE
10 GTEx Adrenal Gland TCTN2 0.24 0.09 enet 11 0.23 1.0e-08 -3.3 5.7 1.0e-08 0.70 0.13 0.84 FALSE
11 GTEx Artery Aorta TCTN2 0.35 0.27 lasso 7 0.34 2.8e-19 5.5 5.7 9.6e-09 0.78 0.14 0.86 FALSE
12 GTEx Artery Aorta ATP6V0A2 0.11 0.12 lasso 11 0.09 2.0e-05 5.4 5.5 3.2e-08 0.95 0.04 0.96 FALSE
13 GTEx Artery Coronary DDX55 0.32 0.15 lasso 3 0.23 2.9e-08 6.2 -6.0 2.2e-09 -0.86 0.01 0.98 FALSE
14 GTEx Artery Coronary TCTN2 0.38 0.27 lasso 9 0.40 9.8e-15 5.5 6.2 6.2e-10 0.75 0.16 0.84 FALSE
15 GTEx Artery Tibial TCTN2 0.32 0.34 enet 31 0.39 1.2e-32 5.2 5.8 5.7e-09 0.85 0.36 0.64 FALSE
16 GTEx Breast Mammary Tissue DDX55 0.21 0.08 lasso 5 0.12 9.5e-07 4.4 -6.1 9.0e-10 -0.73 0.14 0.86 FALSE
17 GTEx Breast Mammary Tissue TCTN2 0.28 0.20 lasso 12 0.23 4.0e-12 5.2 5.9 3.3e-09 0.83 0.20 0.80 FALSE
18 GTEx Breast Mammary Tissue ATP6V0A2 0.09 0.02 lasso 4 0.03 9.7e-03 5.2 6.1 9.9e-10 0.74 0.10 0.75 FALSE
19 GTEx Breast Mammary Tissue (Male) TCTN2 0.16 0.07 lasso 2 0.07 1.3e-02 5.8 5.7 1.2e-08 0.95 0.04 0.88 FALSE
20 GTEx Breast Mammary Tissue (Male) ATP6V0A2 0.18 0.01 lasso 2 -0.01 6.1e-01 5.2 5.2 1.5e-07 0.86 0.05 0.44 FALSE
21 GTEx Breast Mammary Tissue (Female) DDX55 0.15 0.03 lasso 7 0.03 5.4e-02 4.9 -6.1 8.7e-10 -0.90 0.04 0.86 FALSE
22 GTEx Breast Mammary Tissue (Female) TCTN2 0.32 0.10 enet 25 0.12 1.6e-04 -3.3 6.0 2.5e-09 0.64 0.15 0.69 FALSE
23 GTEx Cells EBV-transformed lymphocytes TCTN2 0.23 0.15 lasso 3 0.21 2.6e-07 5.5 5.9 3.0e-09 0.77 0.13 0.82 FALSE
24 GTEx Cells Transformed fibroblasts TCTN2 0.50 0.30 lasso 8 0.36 6.7e-28 -3.3 5.1 2.9e-07 0.49 1.00 0.00 FALSE
25 GTEx Cells Transformed fibroblasts ATP6V0A2 0.23 0.25 lasso 6 0.23 1.8e-17 5.8 5.2 2.4e-07 0.96 0.06 0.94 FALSE
26 GTEx Colon Transverse DDX55 0.16 0.14 lasso 3 0.14 3.5e-07 5.5 -5.2 1.5e-07 -0.88 0.11 0.89 FALSE
27 GTEx Colon Transverse TCTN2 0.25 0.15 enet 14 0.23 3.1e-11 5.5 5.9 3.2e-09 0.74 0.12 0.88 FALSE
28 GTEx Colon Transverse ATP6V0A2 0.17 0.08 enet 22 0.17 1.4e-08 5.4 6.2 4.9e-10 0.89 0.04 0.96 FALSE
29 GTEx Esophagus Gastroesophageal Junction TCTN2 0.22 0.27 lasso 10 0.25 1.6e-09 5.2 5.2 2.0e-07 0.86 0.23 0.77 FALSE
30 GTEx Esophagus Mucosa DDX55 0.09 0.07 lasso 5 0.07 1.2e-05 5.2 -5.5 4.6e-08 -0.88 0.09 0.90 FALSE
31 GTEx Esophagus Mucosa TCTN2 0.16 0.04 enet 28 0.11 1.0e-07 -3.2 6.2 4.4e-10 0.67 0.29 0.70 FALSE
32 GTEx Esophagus Mucosa ATP6V0A2 0.08 0.05 lasso 8 0.04 7.0e-04 5.4 5.6 2.2e-08 0.96 0.03 0.96 FALSE
33 GTEx Esophagus Muscularis DDX55 0.21 0.21 lasso 3 0.24 1.2e-14 4.2 -5.2 2.0e-07 -0.82 0.64 0.35 FALSE
34 GTEx Heart Atrial Appendage TCTN2 0.32 0.21 enet 26 0.22 3.4e-10 5.1 5.8 7.0e-09 0.90 0.13 0.87 FALSE
35 GTEx Heart Left Ventricle TCTN2 0.23 0.10 enet 20 0.12 8.1e-07 5.5 5.8 7.8e-09 0.79 0.03 0.97 FALSE
36 GTEx Lung TCTN2 0.25 0.25 lasso 11 0.24 2.1e-18 5.2 5.6 2.4e-08 0.84 0.41 0.59 FALSE
37 GTEx Lung ATP6V0A2 0.12 0.11 lasso 4 0.11 1.8e-08 4.5 5.4 7.8e-08 0.93 0.06 0.94 FALSE
38 GTEx Muscle Skeletal TCTN2 0.17 0.20 lasso 7 0.19 2.9e-18 5.2 5.4 5.4e-08 0.86 0.42 0.58 FALSE
39 GTEx Nerve Tibial TCTN2 0.34 0.39 enet 29 0.43 1.1e-32 5.2 5.9 3.7e-09 0.89 0.38 0.61 FALSE
40 GTEx Nerve Tibial ATP6V0A2 0.10 0.07 lasso 4 0.08 1.8e-06 5.7 5.3 9.3e-08 0.95 0.08 0.92 FALSE
41 GTEx Ovary TCTN2 0.37 0.22 lasso 17 0.22 3.1e-06 5.2 5.8 6.0e-09 0.90 0.08 0.91 FALSE
42 GTEx Pancreas DDX55 0.14 0.06 lasso 3 0.06 1.2e-03 4.4 -5.5 3.3e-08 -0.62 0.19 0.58 FALSE
43 GTEx Prostate TCTN2 0.34 0.12 lasso 7 0.19 1.5e-05 5.5 5.2 2.3e-07 0.66 0.06 0.49 FALSE
44 GTEx Skin Not Sun Exposed Suprapubic DDX55 0.25 0.09 lasso 10 0.18 5.2e-10 3.7 -5.6 1.7e-08 -0.81 0.06 0.94 FALSE
45 GTEx Skin Not Sun Exposed Suprapubic TCTN2 0.27 0.18 enet 32 0.22 2.3e-12 5.1 5.8 7.7e-09 0.77 0.24 0.76 FALSE
46 GTEx Skin Sun Exposed Lower leg DDX55 0.13 0.05 enet 13 0.10 1.6e-08 4.4 -5.5 3.4e-08 -0.65 0.77 0.22 FALSE
47 GTEx Skin Sun Exposed Lower leg TCTN2 0.24 0.16 lasso 11 0.22 2.1e-18 5.1 6.0 1.6e-09 0.81 0.17 0.83 FALSE
48 GTEx Stomach DDX55 0.10 0.04 enet 9 0.04 5.6e-03 5.1 -5.4 5.6e-08 -0.78 0.19 0.37 FALSE
49 GTEx Stomach TCTN2 0.22 0.18 lasso 11 0.20 1.2e-09 5.5 6.2 5.4e-10 0.91 0.04 0.96 FALSE
50 GTEx Testis ATP6V0A2 0.32 0.27 lasso 16 0.30 8.4e-14 5.2 5.3 1.4e-07 0.92 0.18 0.82 FALSE
51 GTEx Thyroid TCTN2 0.39 0.25 enet 27 0.32 2.6e-25 5.2 5.4 5.9e-08 0.76 0.39 0.61 FALSE
52 GTEx Thyroid ATP6V0A2 0.07 0.02 enet 9 0.02 9.8e-03 5.7 5.9 3.9e-09 0.81 0.02 0.94 FALSE
53 GTEx Uterus TCTN2 0.26 0.13 enet 15 0.11 3.2e-03 5.2 5.7 9.7e-09 0.88 0.05 0.71 FALSE
54 GTEx Whole Blood ATP6V0A2 0.12 0.06 lasso 11 0.04 1.1e-04 5.2 5.4 7.8e-08 0.85 0.16 0.82 FALSE
55 METSIM Adipose TCTN2 0.22 0.11 blup 395 0.12 2.0e-17 5.5 5.7 1.4e-08 0.68 0.13 0.87 FALSE
56 The Cancer Genome Atlas Bladder Urothelial Carcinoma ATP6V0A2 0.05 0.06 blup 53 0.06 1.4e-05 5.5 5.8 7.0e-09 0.87 0.07 0.90 FALSE
57 The Cancer Genome Atlas Breast Invasive Carcinoma ATP6V0A2 0.05 0.06 blup 53 0.07 1.6e-14 6.0 5.4 5.8e-08 0.95 0.01 0.99 FALSE
58 The Cancer Genome Atlas Colon Adenocarcinoma ATP6V0A2 0.16 0.12 blup 53 0.12 2.2e-07 5.6 5.5 2.8e-08 0.96 0.01 0.99 FALSE
59 The Cancer Genome Atlas Glioblastoma Multiforme TCTN2 0.34 0.10 blup 54 0.16 1.3e-05 -3.2 5.3 1.4e-07 0.44 0.39 0.17 FALSE
60 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma ATP6V0A2 0.06 0.04 enet 8 0.05 2.4e-06 6.0 5.6 2.1e-08 0.91 0.01 0.99 FALSE
61 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma ATP6V0A2 0.18 0.15 blup 53 0.17 4.0e-19 5.4 5.6 1.9e-08 0.94 0.02 0.98 FALSE
62 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma ATP6V0A2 0.06 0.08 blup 53 0.08 1.4e-05 5.4 6.0 2.3e-09 0.97 0.02 0.98 FALSE
63 The Cancer Genome Atlas Brain Lower Grade Glioma ATP6V0A2 0.16 0.15 lasso 5 0.15 2.0e-16 5.6 5.9 3.7e-09 0.98 0.02 0.98 FALSE
64 The Cancer Genome Atlas Lung Adenocarcinoma ATP6V0A2 0.07 0.10 blup 53 0.10 2.2e-11 6.0 5.5 4.0e-08 0.95 0.01 0.99 FALSE
65 The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma ATP6V0A2 0.03 0.01 blup 53 0.01 4.1e-02 5.6 5.8 6.6e-09 0.95 0.02 0.74 FALSE
66 The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma TCTN2 0.31 0.11 blup 56 0.12 1.4e-08 -3.2 5.5 4.7e-08 0.40 0.92 0.06 FALSE
67 The Cancer Genome Atlas Pancreatic Adenocarcinoma ATP6V0A2 0.17 0.14 blup 53 0.28 4.7e-12 5.1 5.8 6.9e-09 0.90 0.06 0.94 FALSE
68 The Cancer Genome Atlas Pheochromocytoma and Paraganglioma ATP6V0A2 0.08 0.07 enet 5 0.08 3.7e-04 5.4 5.4 6.4e-08 0.96 0.04 0.88 FALSE
69 The Cancer Genome Atlas Pheochromocytoma and Paraganglioma DDX55 0.11 0.06 blup 46 0.09 2.6e-04 4.4 -5.7 1.4e-08 -0.53 0.02 0.68 FALSE
70 The Cancer Genome Atlas Prostate Adenocarcinoma ATP6V0A2 0.16 0.08 lasso 2 0.08 1.3e-08 5.6 5.5 3.7e-08 0.99 0.01 0.99 FALSE
71 The Cancer Genome Atlas Soft Tissue Sarcoma TCTN2 0.23 0.03 blup 56 0.09 5.3e-06 -3.3 5.7 1.1e-08 0.48 0.30 0.53 FALSE
72 The Cancer Genome Atlas Skin Cutaneous Melanoma TCTN2 0.27 -0.01 blup 57 0.04 3.1e-02 -3.3 5.4 6.8e-08 0.70 0.03 0.40 FALSE
73 The Cancer Genome Atlas Testicular Germ Cell Tumors TMED2 0.10 0.03 enet 14 0.06 3.1e-03 4.2 5.5 3.5e-08 0.67 0.00 0.26 FALSE
74 The Cancer Genome Atlas Thyroid Carcinoma ATP6V0A2 0.16 0.21 lasso 4 0.20 1.2e-19 5.6 5.6 2.2e-08 0.99 0.03 0.97 FALSE