TWAS
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Traits
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Traits
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Lung FEV1/FVC ratio
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chr12:101,441,467-103,101,412
Best TWAS P=1.23e-08 · Best GWAS P=5.32e-06 conditioned to 0.664
101.4M
101.6M
101.8M
102M
102.2M
102.4M
102.6M
102.8M
103M
0
1
2
3
4
5
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
3
GTEx
Prostate
DRAM1
0.57
0.08
lasso
20
0.00
2.7e-01
0.9
-5.7
1.2e-08
0.19
0.01
0.04
TRUE
4
The Cancer Genome Atlas
Prostate Adenocarcinoma
GNPTAB
0.04
0.03
blup
62
0.04
9.7e-05
-4.5
5.3
9.6e-08
-0.91
0.01
0.81
TRUE
1
GTEx
Adipose Subcutaneous
GNPTAB
0.08
0.02
enet
13
0.03
8.2e-04
-4.0
5.4
6.6e-08
-0.70
0.02
0.52
FALSE
2
GTEx
Artery Tibial
GNPTAB
0.25
0.15
lasso
5
0.21
4.1e-16
-4.3
5.3
1.2e-07
-0.83
0.01
0.94
FALSE