TWAS hub - TMED2

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Aorta	0.1070	0.0500	0.00260	0.038	NA	0.016	NA	0.039	3.6e-03	NA	4.1e-02	NA	3.4e-03
2	GTEx	Artery Tibial	0.0879	0.0345	0.00011	0.042	NA	0.065	NA	0.051	3.0e-04	NA	8.7e-06	NA	6.8e-05
3	GTEx	Cells Transformed fibroblasts	0.1080	0.0460	0.00054	0.036	NA	0.011	NA	0.029	1.0e-03	NA	4.5e-02	NA	2.7e-03
4	GTEx	Lung	0.0669	0.0280	0.00079	0.030	NA	0.024	NA	0.027	2.4e-03	NA	5.5e-03	NA	3.3e-03
5	GTEx	Skin Sun Exposed Lower leg	0.0850	0.0360	0.00014	0.004	NA	0.053	NA	0.022	1.5e-01	NA	3.1e-05	NA	6.0e-03
6	METSIM	Adipose	0.0422	0.0208	0.00032	0.038	0.017	0.016	0.02	0.034	2.0e-06	0.0012	1.7e-03	0.00044	6.7e-06
7	TCGA	Colon Adenocarcinoma	0.0700	0.0400	0.00078	0.082	0.031	0.071	NA	0.071	1.7e-05	0.0068	6.7e-05	NA	6.7e-05
8	TCGA	Pancreatic Adenocarcinoma	0.0690	0.0470	0.00730	0.008	0.062	0.037	NA	0.024	1.5e-01	0.0013	1.1e-02	NA	3.5e-02
9	TCGA	Testicular Germ Cell Tumors	0.0980	0.0570	0.00560	0.034	0.057	0.062	NA	0.050	2.3e-02	0.0044	3.1e-03	NA	7.5e-03
10	TCGA	Thyroid Carcinoma	0.0230	0.0150	0.00710	0.034	0.019	0.018	NA	0.025	3.0e-04	0.0057	6.2e-03	NA	1.6e-03

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10
Waist Hip Ratio (WHR)	8.5	38.2	118.8	5.7	7.0	0.3	10.9	3.7	3.9	6.4	6.4	6.5	5.4
Alcohol drinker status: Never	6.5	7.8	15.1	-2.8	-2.7	-3.9	-2.2	-2.9	-2.7	-2.6	-2.4	-2.5	-2.9
Deep venous thrombosis (DVT) (self-reported)	6.2	7.9	16.9	-2.9	-3.5	-4.1	-2.8	-2.2	-2.7	-2.7	-2.1	-1.7	-2.6
Maternal smoking around birth	5.6	8.0	13.7	3.7	2.7	1.1	3.4	1.5	2.4	3.5	2.8	2.9	3.2
Blood clot in the leg (DVT)	4.9	6.4	14.7	-2.6	-3.2	-3.8	-2.4	-2.1	-2.4	-2.4	-1.8	-1.4	-2.2
Peak expiratory flow (PEF)	4.5	10.4	14.0	3.7	3.4	3.6	3.7	2.9	2.8	3.6	2.9	2.4	3.0
Gout (self-reported)	4.4	6.0	11.6	2.7	3.4	2.4	2.6	1.8	2.2	3.0	2.2	1.8	2.2
Average weekly red wine intake	4.2	6.2	17.6	2.1	2.4	4.2	2.1	3.7	2.1	1.9	1.7	1.1	2.0
Pulse wave Arterial Stiffness index	3.9	4.5	9.3	2.2	1.7	2.0	3.0	1.8	2.2	1.6	1.9	1.2	2.8
Primary Biliary Cirrhosis	3.8	5.4	11.9	2.3	2.7	3.4	2.4	3.1	2.2	2.1	1.4	0.5	1.6
Chronic bronchitis/emphysema (mother)	3.8	4.4	8.1	-2.2	-1.5	-1.3	-2.9	-1.1	-1.3	-2.1	-2.5	-2.6	-2.5
Supplements: Vitamin C	3.7	4.3	7.8	-2.4	-1.7	-2.7	-2.3	-1.4	-2.8	-1.8	-1.6	-0.8	-2.4
Pulse wave reflection index	3.6	4.5	7.2	2.6	2.2	1.8	1.7	1.7	2.3	2.7	1.7	1.6	2.5
Medication: Allopurinol	3.6	4.8	8.8	2.5	3.0	2.3	2.3	1.6	2.5	2.3	1.6	1.2	2.1
Coronary Artery Disease (CAD)	3.3	4.0	6.7	1.9	2.1	1.7	2.6	2.2	2.0	2.1	1.7	1.5	2.0
Severe depression (siblings)	3.0	3.4	7.6	-1.6	-1.8	-0.3	-1.9	-1.0	-0.4	-2.4	-2.5	-2.8	-1.9
Pain all over the body in last month	3.0	3.2	5.9	-1.8	-2.1	-1.8	-1.1	-1.9	-0.9	-2.4	-1.8	-2.1	-1.5
Height	2.9	56.6	145.3	7.0	5.9	12.1	7.2	6.7	6.5	6.3	7.3	5.9	8.3
Loud music exposure frequency	2.9	3.2	4.9	-2.0	-1.8	-1.8	-2.0	-0.2	-2.2	-2.0	-1.7	-1.2	-2.1
Osteoporosis (self-reported)	2.9	3.6	4.6	-2.0	-2.1	-2.0	-2.0	-1.9	-2.1	-2.0	-1.5	-1.1	-2.1
Comparative height size at age 10	2.8	15.2	43.6	3.5	3.4	6.6	3.7	4.5	3.7	2.7	3.1	2.3	4.0
Sitting height	2.7	18.9	73.8	3.9	3.3	8.6	3.5	3.4	3.8	3.2	3.6	2.8	4.4
Alcohol intake frequency.	2.7	6.2	23.0	-2.3	-2.1	-4.8	-1.7	-2.4	-2.9	-2.2	-1.3	-1.0	-2.2
HDL Cholesterol	2.6	4.3	8.4	-1.8	-1.0	-1.4	-2.9	-0.8	-1.8	-2.4	-2.6	-2.7	-2.1
Lung FEV1/FVC ratio	2.6	13.2	30.4	3.7	2.9	0.6	4.2	1.8	0.8	4.5	4.9	5.5	3.7
Standing height	2.6	26.0	68.9	4.8	4.3	8.3	4.7	4.4	4.5	4.5	4.7	4.1	5.4
Headache pain in last month	2.6	4.4	9.3	-2.7	-1.7	-2.8	-1.7	-0.8	-3.0	-2.3	-1.5	-0.8	-2.3
Comparative body size at age 10	2.5	7.0	13.1	-2.5	-1.4	0.4	-3.2	-1.5	-1.5	-3.0	-3.6	-3.6	-3.4
Number of full sisters	2.5	3.0	9.4	-1.8	-2.1	-2.2	-1.8	-0.9	-3.1	-0.7	-0.4	0.6	-1.6
Arm fat percentage (left)	2.5	10.1	25.6	-2.6	-2.2	-1.8	-5.1	-1.7	-1.8	-3.2	-4.1	-4.1	-3.2
Eye problems/disorders: Glaucoma	2.5	2.9	6.4	1.7	1.5	1.1	1.4	0.8	0.6	2.5	2.2	2.5	1.6
Illnesses of father: High blood pressure	2.5	3.1	6.2	-1.7	-1.4	-1.2	-2.0	-1.0	-1.6	-1.5	-2.3	-1.9	-2.5
Serious illness, injury or assault to yourself	2.4	3.0	4.3	1.8	2.1	2.0	1.8	1.5	1.6	1.7	1.7	1.3	1.7
Chronic bronchitis/emphysema (father)	2.4	2.8	6.0	1.6	2.4	0.7	1.2	1.7	1.1	2.0	1.7	1.9	1.7
Past tobacco smoking	2.4	4.4	6.4	-1.9	-1.5	-2.5	-1.9	-1.6	-2.0	-2.4	-2.2	-2.0	-2.4
Qualifications: O levels/GCSEs or equivalent	2.4	3.8	10.3	1.5	0.7	3.2	2.1	0.7	1.5	1.6	2.4	2.1	2.3
Pulse wave peak to peak time	2.4	2.8	6.3	-1.8	-1.4	-1.2	-2.5	-1.4	-1.8	-1.3	-1.5	-1.0	-2.3
Hand grip strength (left)	2.3	6.1	11.8	3.0	2.4	3.2	2.3	0.4	3.4	2.6	1.6	1.3	2.8
Glaucoma (self-reported)	2.3	2.8	7.8	1.6	1.6	0.2	1.0	0.8	0.2	2.8	2.0	2.7	1.2
Smoking status: Previous	2.3	3.4	5.4	1.8	1.1	2.0	1.9	1.0	1.9	2.1	2.1	2.0	2.3
Osteoarthritis (self-reported)	2.3	3.0	9.9	-1.5	-1.6	-3.2	-0.9	-2.7	-1.9	-1.5	-0.6	-0.5	-0.9
BMI	2.2	12.6	27.2	-3.0	-2.4	-1.2	-4.6	-2.5	-1.5	-3.8	-4.7	-5.2	-3.9
Leg fat percentage (right)	2.2	8.1	16.5	-2.2	-1.7	-2.0	-4.0	-1.8	-1.5	-2.9	-3.7	-4.1	-3.0
Leg fat percentage (left)	2.2	7.9	16.6	-2.0	-1.5	-2.0	-4.1	-1.9	-1.3	-2.8	-3.8	-4.1	-2.9
Medication: Simvastatin	2.1	3.0	5.9	1.2	2.4	0.8	1.8	2.1	0.7	1.7	2.1	2.1	1.6
Medication: Aspirin	2.1	2.8	5.7	-2.2	-1.4	-1.7	-1.2	-2.4	-2.2	-1.5	-0.9	-0.7	-1.8
Blood White Count	2.0	14.5	41.3	3.7	6.4	4.0	4.1	4.2	4.8	2.4	1.9	0.1	2.8
Diabetes (self-reported)	2.0	3.1	6.3	1.8	2.5	0.9	2.1	1.7	1.6	1.8	1.5	1.6	1.6
Arm fat percentage (right)	2.0	7.9	20.9	-2.1	-1.9	-1.4	-4.6	-1.3	-1.6	-2.7	-3.7	-3.8	-2.9
Hip circumference	2.0	8.5	21.6	-1.9	-1.9	1.4	-4.7	-1.4	-0.4	-3.1	-4.0	-4.5	-2.6
Frequency of tiredness / lethargy in last 2 weeks	2.0	3.3	6.6	-2.0	-0.7	-2.5	-1.7	0.1	-1.3	-2.6	-2.4	-1.6	-1.7
Handedness (chirality/laterality): Left-handed	2.0	2.4	4.3	2.1	1.8	1.5	1.5	0.1	1.5	2.1	1.3	1.2	1.4
Fasting Glucose	1.9	2.3	9.4	1.4	1.6	1.3	1.6	3.1	1.9	0.2	0.3	-0.3	1.0
Vitamin and mineral supplements	1.9	2.6	5.6	1.8	1.2	2.3	1.8	0.7	2.4	1.3	1.2	0.2	1.9
Hand grip strength (right)	1.9	5.1	15.1	2.7	2.4	3.5	1.8	0.6	3.9	1.6	0.1	-0.6	1.9
Body mass index (BMI)	1.9	7.9	18.0	-2.2	-1.4	-1.0	-4.0	-1.9	-1.1	-3.0	-3.9	-4.2	-3.0
Financial difficulties in last 2 years	1.9	2.5	5.6	-1.1	-1.0	-0.8	-2.2	-0.7	-0.4	-1.6	-2.4	-2.2	-2.0
Length of working week for main job	1.9	2.1	3.9	-1.7	-1.7	-2.0	-1.0	-0.8	-1.7	-1.4	-0.9	-1.2	-1.5
High blood pressure (siblings)	1.9	2.8	4.4	-1.8	-1.2	-1.2	-2.0	-1.9	-1.6	-1.6	-1.7	-1.2	-2.1
Ever depressed for a whole week	1.9	2.4	3.4	1.6	1.4	0.9	1.8	1.8	0.7	1.7	1.7	1.7	1.5
Pain experienced in last month	1.9	3.1	10.2	1.7	1.6	3.2	1.0	1.7	1.3	2.3	1.4	1.4	0.9
Diverticular disease/diverticulitis (self-reported)	1.8	2.1	4.2	-1.6	-1.4	-2.1	-1.6	-0.1	-1.9	-1.2	-0.9	-0.8	-1.6
Hayfever/allergic rhinitis (self-reported)	1.8	2.4	4.3	1.6	2.1	0.7	1.5	1.7	1.9	1.5	1.6	0.6	1.6
Body fat percentage	1.8	7.0	19.9	-1.9	-1.6	-1.2	-4.5	-1.4	-1.3	-2.5	-3.5	-3.7	-2.7
Myopia	1.8	2.6	3.8	1.6	1.4	1.8	1.9	1.7	0.9	1.7	1.6	1.4	1.8
Falls in the last year	1.7	2.3	4.9	-1.7	-0.9	-0.2	-2.2	-0.2	-0.6	-1.9	-1.9	-1.9	-1.7
Commuting to job workplace: Walk	1.7	1.8	6.0	-1.2	-1.4	-0.7	-2.5	-0.7	-1.2	-1.0	-1.5	-0.9	-1.6
Miserableness	1.7	2.9	5.8	-2.1	-1.4	-2.4	-1.2	-0.9	-1.9	-2.1	-1.1	-1.6	-1.7
Fractured/broken bones in last 5 years	1.7	2.2	6.1	1.5	1.9	2.5	1.3	1.2	2.0	1.2	0.7	0.1	1.1
Age when periods started (menarche)	1.6	3.8	8.7	1.9	1.5	0.2	1.8	1.5	0.5	2.6	2.5	2.9	2.2
Ever smoked	1.6	2.8	8.4	1.4	0.9	2.9	1.4	1.0	1.8	1.9	1.6	1.2	1.8
Pack years adult smoking proportion	1.5	2.2	4.1	-1.2	-1.2	-1.2	-1.5	-2.0	-0.8	-1.4	-2.0	-1.6	-1.6
Alcohol usually taken with meals	1.5	2.4	7.4	1.4	1.3	2.7	1.7	1.3	2.4	0.7	0.7	-0.1	1.4
Number of children fathered	1.5	1.7	3.5	1.3	1.3	1.9	1.6	1.0	1.7	0.9	0.9	0.2	1.4
Leg pain on walking	1.5	1.9	4.1	-1.5	-1.4	-2.0	-1.2	-1.5	-0.9	-1.5	-1.0	-1.3	-1.0
Mouth/teeth dental problems: Mouth ulcers	1.5	2.3	5.3	0.9	0.8	-1.3	1.8	1.9	0.1	1.1	2.1	2.3	1.7
Medication: Aspirin	1.5	1.9	5.2	-1.8	-1.2	-1.1	-0.8	-2.3	-2.0	-1.1	-0.5	-0.3	-1.4
Heel T-Score	1.4	11.5	55.1	-2.5	-3.0	-7.4	-3.6	-2.6	-4.4	-1.1	-0.6	0.4	-1.8
Illnesses of siblings	1.4	1.9	3.5	1.4	0.7	1.1	1.5	1.7	0.7	1.3	1.9	1.3	1.7
Leg fat mass (right)	1.4	5.4	13.8	-1.6	-1.2	-0.5	-3.4	-1.3	-0.7	-2.5	-3.2	-3.7	-2.3
Ever had stillbirth, spontaneous miscarriage or termination	1.4	1.5	2.9	1.6	0.9	1.7	0.9	1.2	1.6	1.3	0.3	0.7	1.1
Financial situation satisfaction	1.4	1.8	4.6	1.3	1.1	-0.2	0.8	1.0	-0.3	2.0	1.8	2.1	1.0
Leg fat mass (left)	1.4	5.5	13.8	-1.6	-1.1	-0.5	-3.5	-1.4	-0.7	-2.4	-3.3	-3.7	-2.3
Crohns Disease (2012)	1.3	2.1	6.1	1.8	1.1	1.7	2.0	0.8	2.5	0.5	0.3	-0.1	1.6
Trunk fat percentage	1.3	5.3	19.1	-1.6	-1.6	-0.8	-4.4	-1.1	-1.4	-2.0	-2.8	-2.9	-2.2
Exposure to tobacco smoke at home	1.3	1.5	3.5	1.2	1.1	0.6	0.9	0.3	0.6	1.4	1.9	1.8	1.4
Ever had bowel cancer screening	1.3	1.5	2.4	1.0	1.0	1.1	1.1	1.1	0.7	1.3	1.5	1.5	1.5
Depressed Affect (Nagel 2018)	1.2	2.4	6.3	-1.6	-1.2	-2.5	-0.6	0.6	-1.3	-2.3	-1.2	-1.8	-1.3
Triglycerides	1.2	1.9	3.6	1.0	1.2	0.3	1.9	1.4	1.1	1.3	1.6	1.5	1.6
Average weekly fortified wine intake	1.2	1.3	4.8	-0.9	-1.2	-0.2	-0.3	-0.9	-0.3	-1.3	-1.4	-2.2	-1.3
Time employed in main current job	1.2	1.3	5.4	1.0	1.5	0.5	1.5	2.3	1.1	0.7	0.4	-0.1	0.7
Noisy workplace	1.2	1.5	4.1	0.4	0.7	-1.7	0.9	0.9	-0.9	1.3	1.6	2.0	0.7
Mouth/teeth dental problems: Bleeding gums	1.2	1.6	5.2	1.3	1.4	2.3	0.8	1.4	1.8	0.8	0.0	-0.4	0.9
Cholesterol lowering medication	1.2	1.7	6.4	0.9	2.5	0.4	1.9	1.8	0.5	1.1	1.0	0.8	0.6
Bipolar Disorder (2011)	1.1	1.1	3.8	-0.6	0.1	0.5	-1.1	-0.7	0.5	-0.8	-1.6	-1.9	-1.0
Ever used hormone-replacement therapy (HRT)	1.1	1.4	2.7	1.5	0.9	1.7	1.1	0.0	1.6	1.0	0.7	1.0	1.4
Hair/balding pattern: Pattern 3	1.1	1.6	3.5	-1.3	-0.9	-1.1	-1.3	-1.2	-0.4	-1.9	-1.3	-1.6	-1.0
Diabetes diagnosed by doctor	1.1	1.8	4.2	1.4	2.1	0.4	1.7	1.7	1.1	1.2	1.0	1.2	1.1
Medication: Gliclazide	1.1	1.3	2.1	1.1	1.4	0.1	1.1	0.3	1.0	1.4	1.2	1.2	1.3
Supplements: Fish oil (including cod liver oil)	1.1	1.4	3.8	-0.8	-0.9	-1.8	-1.0	-1.0	-2.0	0.3	0.5	1.7	-0.5
Basal cell carcinoma (self-reported)	1.1	1.3	3.4	1.3	0.6	1.8	1.1	1.2	1.2	1.6	0.4	0.4	0.6
HbA1C	1.0	1.1	2.7	-0.2	-0.9	0.6	0.3	-1.6	-0.5	-1.6	-1.1	-1.3	-1.1
Medication for hormone replacement therapy	1.0	1.1	2.5	1.2	1.0	1.3	0.9	1.3	1.6	0.7	0.2	0.1	1.0
Townsend deprivation index at recruitment	1.0	1.4	3.2	-1.2	-1.4	-1.8	-1.5	-1.1	-1.3	-0.9	-0.5	0.2	-0.9
Trunk fat-free mass	1.0	5.7	26.3	1.9	2.4	5.1	2.2	1.7	2.8	0.9	1.0	0.2	1.9
Lung cancer (father)	1.0	1.2	3.5	-0.8	-0.3	-1.3	0.4	0.2	-1.9	-0.4	1.5	1.7	0.1
Arm fat mass (right)	1.0	4.0	11.1	-1.2	-0.7	0.4	-3.2	-0.8	-0.3	-2.0	-2.9	-3.3	-1.9
Trunk predicted mass	1.0	5.8	26.7	1.9	2.4	5.2	2.3	1.7	2.9	0.9	1.0	0.1	1.9
Arm fat mass (left)	1.0	4.2	11.8	-1.2	-0.8	0.4	-3.4	-0.9	-0.3	-2.0	-3.0	-3.3	-1.9
Diastolic blood pressure, automated reading	1.0	3.2	13.5	-1.2	-0.2	-3.7	-1.9	-1.5	-1.7	-0.8	-1.6	-0.9	-1.9
Lung FVC	0.9	4.5	10.1	-1.1	-3.2	-3.1	-1.6	-2.6	-2.1	-0.7	-1.7	-1.2	-2.2
Average weekly spirits intake	0.9	1.1	1.7	-1.3	-0.8	-1.2	-1.3	-1.1	-0.5	-1.1	-1.0	-1.1	-0.9
Medication: Co-codamol	0.9	1.1	1.8	-1.1	-0.4	-1.0	-1.0	-0.3	-0.8	-1.2	-1.3	-1.3	-1.4
Qualifications: CSEs or equivalent	0.9	1.1	1.9	1.0	0.9	-0.2	0.8	1.2	0.8	1.3	1.3	1.4	1.3
High blood pressure	0.9	2.4	4.0	-1.8	-0.8	-2.0	-1.3	-0.9	-1.6	-1.5	-1.6	-1.4	-1.9
Prospective memory result	0.9	1.2	3.3	-0.8	-1.1	-0.5	-0.6	-0.3	-0.3	-1.3	-1.5	-1.8	-1.3
Number of full brothers	0.9	1.1	3.0	0.8	0.1	-0.3	1.3	0.3	0.3	0.9	1.6	1.7	1.6
Qualifications: College or University degree	0.9	2.8	17.1	1.1	1.6	4.1	0.7	1.8	1.5	0.9	0.5	-0.2	0.7
Average weekly champagne plus white wine intake	0.9	1.3	3.4	1.5	0.6	1.8	1.0	0.2	1.5	1.1	0.7	0.5	1.3
High cholesterol (Self-reported)	0.9	1.6	4.1	0.6	1.7	-0.2	2.0	1.9	0.5	0.6	1.3	1.2	1.2
Arm fat-free mass (left)	0.9	4.3	21.9	1.8	2.4	4.7	1.4	0.9	2.6	0.8	0.5	-0.3	1.5
Pack years of smoking	0.9	1.3	3.1	-0.9	-0.9	-0.9	-1.0	-1.8	-0.6	-1.1	-1.6	-1.2	-1.1
Bipolar Disorder or Schizophrenia	0.8	1.9	4.0	-1.1	-0.2	2.0	-1.6	-0.2	-0.7	-0.8	-2.0	-1.6	-1.9
Neuroticism (Nagel 2018)	0.8	1.9	4.4	-1.3	-0.7	-1.8	-0.7	0.9	-0.8	-2.1	-1.6	-1.8	-1.4
Schizophrenia (2018)	0.8	1.8	3.9	-1.3	-0.6	1.1	-2.0	-1.1	-1.2	-0.8	-1.7	-1.0	-1.8
Schizophrenia vs Biploar Disorder	0.8	1.0	6.3	0.2	0.3	0.8	0.2	-2.5	-0.5	1.0	0.8	1.2	0.1
Major Depression (MDD)	0.8	1.0	3.8	-0.1	-0.2	-1.9	0.5	-0.3	-1.0	0.5	1.3	1.6	0.3
Ovarian Cancer	0.8	1.0	5.0	-0.7	-0.0	-2.2	-0.1	-1.8	-1.0	0.1	0.3	0.7	-0.1
Type 2 Diabetes (T2D) (2012)	0.8	0.9	3.4	-0.3	-0.4	-1.8	-0.2	-0.6	-1.4	0.4	-0.6	0.4	-1.5
Hypothyroidism (self reported)	0.8	1.8	3.7	-1.7	-0.7	-0.3	-1.6	-0.6	-1.9	-1.5	-1.4	-1.0	-1.8
Trunk fat mass	0.8	3.4	12.1	-1.1	-0.8	0.5	-3.5	-0.6	-0.5	-1.7	-2.4	-2.7	-1.6
Had menopause	0.8	1.0	6.7	0.7	0.4	2.6	0.3	0.6	1.1	0.1	-0.4	-0.5	0.2
Had other major operations	0.8	1.0	3.0	0.7	1.4	1.2	1.0	1.1	1.7	0.3	0.2	-0.4	0.9
Father’s age at death	0.8	1.0	3.2	-1.0	-1.8	0.3	-1.1	-1.0	-1.2	-1.0	-0.6	-0.4	-0.8
Serious illness, injury or assault of a close relative in last 2 years	0.8	0.9	3.3	0.4	0.7	0.3	-0.1	1.8	0.3	0.7	1.1	1.5	1.2
Asthma	0.8	1.6	4.3	1.6	1.8	0.6	1.4	0.8	2.1	1.1	0.3	0.1	1.2
Medication: Lansoprazole	0.8	0.9	2.6	0.4	0.7	-0.9	0.9	0.8	-0.1	0.8	1.3	1.6	0.8
Ever highly irritable/argumentative for 2 days	0.8	1.0	3.4	0.7	0.3	-1.8	0.4	1.0	-0.8	0.8	0.9	1.5	0.5
Medication: Seretide 50 evohaler	0.8	1.0	3.2	0.4	1.0	1.0	0.1	0.3	1.6	-0.2	-1.1	-1.8	-0.4
Illnesses of father: Heart disease	0.8	1.1	3.2	0.9	1.2	1.1	1.8	0.3	1.0	0.6	1.1	0.8	1.2
Qualifications: nursing, teaching	0.8	1.2	5.3	0.4	0.5	2.3	0.8	1.9	0.8	0.4	0.5	0.4	0.8
Age started oral contraceptive pill	0.8	1.1	3.6	-0.1	-0.2	-0.1	0.8	-0.8	-0.6	0.2	1.9	1.9	1.3
Commuting to job workplace: Cycle	0.8	1.0	2.9	0.9	0.0	1.2	1.7	0.3	0.8	0.8	1.2	0.7	1.0
Arm predicted mass (left)	0.8	4.2	21.5	1.7	2.3	4.6	1.3	0.8	2.7	0.7	0.3	-0.4	1.4
Reaction Time	0.7	1.2	5.7	-0.9	-0.9	-2.4	-0.7	-0.1	-1.7	-0.5	0.5	1.0	-0.1
Verbal and Numeric Reasoning (VNR)	0.7	1.6	3.6	-1.4	-1.9	-0.1	-0.8	-0.5	-1.2	-1.8	-1.5	-1.3	-1.2
Other serious medical condition/disability diagnosed by doctor	0.7	0.9	1.6	-1.2	-0.1	-0.2	-0.8	0.9	-1.2	-1.1	-1.1	-1.0	-1.3
Supplements: Zinc	0.7	0.8	3.8	-0.3	0.3	-0.6	-0.0	0.2	-0.8	0.8	1.3	1.9	0.5
Medication: Metformin	0.7	0.9	3.0	0.8	1.7	-0.1	0.7	1.0	-0.1	1.3	0.8	1.3	0.3
Diabetes (father)	0.7	0.8	4.9	0.8	0.3	0.3	0.6	-0.8	2.2	-0.1	-0.4	-0.7	0.9
Bilateral oophorectomy (both ovaries removed)	0.7	0.8	3.0	1.1	1.3	0.5	0.7	0.4	1.7	0.9	-0.4	-0.8	0.0
Heel bone mineral density (BMD) T-score, automated (left)	0.7	1.6	4.2	0.8	1.1	-1.6	0.0	0.8	-0.5	1.8	1.4	2.1	1.1
Stomach or abdominal pain in last month	0.7	0.9	2.2	-0.9	-0.5	-0.7	-1.2	-0.5	-0.2	-1.0	-1.5	-1.3	-1.0
Hair/balding pattern: Pattern 2	0.7	0.9	2.3	1.2	0.9	0.3	1.5	0.6	0.9	1.1	0.7	0.6	0.8
Illnesses of mother	0.7	0.9	1.9	0.6	0.0	-0.3	1.2	1.0	0.4	0.7	1.4	1.4	1.3
Mouth/teeth dental problems: Loose teeth	0.7	0.8	1.6	1.3	0.8	0.6	0.6	0.5	0.9	1.1	0.9	1.1	1.1
Whole body fat mass	0.7	3.1	9.7	-0.8	-0.5	0.6	-3.1	-0.6	-0.1	-1.6	-2.5	-2.9	-1.5
Loneliness, isolation	0.7	1.0	2.4	-0.7	-0.2	-1.0	-0.5	1.1	-0.0	-1.2	-1.4	-1.6	-0.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.7	0.9	2.5	0.3	1.1	0.3	-0.6	1.0	0.6	0.1	-1.4	-1.6	-0.9
Asthma (self-reported)	0.7	1.5	4.6	1.5	1.9	0.6	1.2	0.9	2.1	0.9	0.1	-0.3	1.0
Number of self-reported non-cancer illnesses	0.7	1.3	2.6	-1.2	0.2	-1.4	-0.6	-0.4	-1.0	-1.1	-1.4	-1.5	-1.6
Guilty feelings	0.7	1.0	4.0	0.8	1.4	-0.2	1.2	2.0	0.9	0.2	0.3	0.6	0.9
Medication: Omeprazole (e.g. Zanprol)	0.7	0.8	3.9	-0.6	-0.3	-2.0	0.1	1.1	-1.2	-0.4	-0.3	-0.1	-0.9
Body Mass Index (BMI) (2010)	0.6	0.9	2.6	0.1	0.5	1.6	-0.6	0.7	1.2	-0.6	-1.0	-1.4	-0.0
Neuroticism	0.6	1.5	4.1	-0.7	0.0	-0.9	-0.4	1.4	0.5	-1.8	-1.7	-2.0	-0.9
Chronotype (morning person)	0.6	1.3	3.5	-1.5	-0.4	0.1	-1.9	-0.5	-1.1	-1.3	-1.2	-1.0	-1.5
Ever had hysterectomy (womb removed)	0.6	0.7	1.8	-0.2	-0.2	-1.1	0.2	-0.9	0.1	-0.5	-1.3	-1.4	-1.0
Hayfever, allergic rhinitis or eczema	0.6	1.2	3.5	1.5	1.7	0.5	0.1	1.1	1.9	1.2	-0.5	-0.8	0.1
Heel bone mineral density (BMD) T-score, automated (right)	0.6	1.4	3.3	0.7	0.9	-1.6	-0.4	1.6	-0.7	1.6	1.0	1.8	0.7
Qualifications: None of the above	0.6	1.4	10.2	-0.6	-0.2	-3.2	-0.5	-0.8	-0.7	-0.6	-0.6	-0.5	-0.8
Mouth/teeth dental problems	0.6	1.0	2.2	-0.9	-0.8	-0.1	-1.1	-0.8	-0.6	-0.6	-1.4	-1.3	-1.5
Medication: Cholesterol lowering	0.6	1.0	2.8	0.4	1.5	0.4	1.0	1.7	0.3	0.6	1.0	1.2	0.8
Hypothyroidism/myxoedema (self-reported)	0.6	1.1	2.6	-1.2	0.1	0.1	-1.0	0.3	-1.6	-1.2	-1.3	-0.8	-1.6
Medication: Ventolin 100micrograms inhaler	0.6	0.8	2.4	1.1	0.4	-0.2	1.6	-0.2	0.7	1.1	0.6	0.9	0.8
Arm fat-free mass (right)	0.6	3.0	16.7	1.2	1.9	4.1	1.1	0.5	2.3	0.1	0.1	-0.7	1.1
Worry too long after embarrassment	0.6	0.9	3.5	-0.9	-0.7	-0.7	-0.2	0.2	0.1	-1.9	-1.4	-1.3	-0.4
Medication for pain relief, constipation, heartburn	0.6	1.0	4.2	0.8	0.0	2.0	0.4	0.1	1.6	0.2	0.5	0.2	1.4
Medication: Omeprazole	0.6	0.8	2.9	-0.5	0.4	-1.7	0.1	1.7	-1.1	-0.2	0.1	0.2	-0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.6	0.7	2.0	0.9	0.8	1.2	0.7	-0.8	1.4	0.6	-0.3	-0.8	0.3
Arm predicted mass (right)	0.6	3.2	16.6	1.4	2.2	4.1	1.2	0.5	2.2	0.6	0.5	-0.1	1.3
Illness, injury, bereavement, stress in last 2 years	0.6	0.7	2.6	0.4	0.4	0.1	1.6	-0.2	0.0	0.7	1.4	1.0	1.0
Hypertension (Self-reported)	0.6	1.7	3.1	-1.5	-0.3	-1.6	-1.1	-0.1	-1.3	-1.2	-1.7	-1.3	-1.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.6	0.7	1.8	0.4	-0.0	-1.1	0.8	0.4	-0.6	0.7	1.2	1.4	0.4
Illnesses of siblings: Diabetes	0.6	0.7	1.7	0.6	0.4	-0.4	1.3	-0.3	0.3	1.2	0.9	1.3	0.5
Whole body fat-free mass	0.6	3.3	20.2	1.2	1.8	4.5	0.9	1.1	2.1	0.3	0.3	-0.4	1.2
Mood swings	0.6	1.1	4.2	-1.2	-0.8	-2.1	-0.3	0.3	-0.8	-1.8	-0.5	-0.8	-0.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.6	1.3	5.1	-0.2	-2.1	-0.7	-0.2	-2.2	-0.3	-0.7	-0.8	-1.2	-0.8
Whole body water mass	0.6	3.4	20.7	1.2	1.8	4.5	0.9	1.0	2.2	0.3	0.3	-0.4	1.2
Average weekly beer plus cider intake	0.6	0.9	2.1	-0.8	-1.3	-1.2	-0.9	-1.5	-1.3	-0.5	-0.2	0.2	-0.5
Vascular/heart problems diagnosed by doctor	0.6	1.8	3.5	1.6	0.5	1.9	1.0	0.9	1.4	1.2	1.4	1.2	1.7
Bipolar Disorder (2018)	0.5	0.8	3.1	-0.0	0.5	1.8	-0.1	1.2	0.3	-0.2	-1.1	-1.2	-0.8
Irritable Bowel Disease (IBD)	0.5	1.2	3.7	1.0	0.8	1.9	0.3	0.6	1.9	0.2	-0.6	-1.3	0.3
Cardiovascular Disease	0.5	1.5	3.5	-1.4	0.1	-1.1	-0.9	0.0	-1.1	-1.1	-1.9	-1.5	-1.9
Frequency of tenseness / restlessness in last 2 weeks	0.5	0.8	3.3	-0.9	0.3	-1.8	-0.2	0.6	-1.3	-0.5	-0.5	-0.1	-0.9
Neuroticism score	0.5	1.1	2.5	-0.8	0.2	-1.3	-0.4	1.2	0.1	-1.6	-1.3	-1.5	-0.6
Qualifications: A levels/AS levels or equivalent	0.5	1.2	7.1	-0.6	-0.5	2.7	-0.4	1.4	0.0	-0.6	-0.7	-0.8	-0.4
Depression (self-reported)	0.5	0.7	2.3	-0.7	0.0	-1.5	-0.3	1.1	-1.1	0.1	0.5	0.8	-0.5
Shortness of breath walking on level ground	0.5	0.6	2.0	0.7	0.9	0.1	0.1	1.4	0.1	0.7	0.6	0.9	0.9
Emphysema/chronic bronchitis	0.5	0.6	1.4	-0.2	-1.2	-0.7	-0.3	-1.2	0.3	-0.6	-1.1	-0.9	-0.4
Neck or shoulder pain in last month	0.5	0.7	3.7	0.3	1.0	-0.2	0.3	1.9	-0.0	0.5	0.6	0.7	0.6
Mean time to correctly identify matches	0.5	1.0	4.2	-0.7	-0.7	-2.0	-0.3	0.6	-1.6	-0.4	0.7	1.2	0.1
Knee pain experienced in last month	0.5	0.8	2.8	-0.0	0.2	-1.0	-0.7	0.5	0.7	-0.8	-1.3	-1.7	-0.3
Mineral and other dietary supplements	0.5	0.7	1.6	0.6	0.2	1.3	0.5	1.2	1.2	-0.3	-0.5	-1.2	0.3
Basal metabolic rate	0.5	2.7	17.6	1.0	1.5	4.2	0.3	0.9	1.9	0.0	-0.2	-0.8	0.8
Ever had prostate specific antigen (PSA) test	0.5	0.6	2.3	0.3	0.5	1.1	0.9	1.5	0.1	0.5	0.7	0.5	0.4
Depression (Nagel 2018)	0.4	0.5	3.6	-0.3	0.3	-0.8	-0.3	1.9	-0.8	0.0	0.2	0.3	-0.3
Intelligence (Savage-Jansen 2018)	0.4	1.4	3.1	-1.1	-0.9	1.4	-1.0	0.7	-0.4	-1.4	-1.5	-1.8	-1.0
Ulcerative Colitis (UC)	0.4	0.8	2.0	0.5	0.9	1.4	-0.6	0.9	1.0	0.5	-0.8	-1.4	-0.4
Age at First Birth	0.4	0.6	3.3	0.6	0.5	1.8	0.0	-0.4	1.0	0.6	-0.2	-0.4	0.3
Mean Putamen Volume	0.4	0.5	1.2	0.9	0.4	1.0	0.3	1.1	0.5	1.0	0.3	0.6	0.4
Neuroticism (2016)	0.4	0.5	3.4	0.1	0.8	-0.0	0.8	1.8	0.2	-0.3	-0.5	-0.5	-0.1
Ulcerative Colitis	0.4	0.6	1.8	0.8	1.2	1.4	0.2	0.5	1.0	1.0	0.3	-0.3	0.3
Blood Platelet Count	0.4	4.5	36.1	-1.0	1.4	-6.0	-0.2	-1.1	-1.8	-0.1	0.2	0.2	-1.1
Allergy or Eczema	0.4	1.1	2.8	1.0	1.4	-0.2	-0.3	1.4	1.7	0.7	-0.8	-1.3	-0.1
Type 2 Diabetes (T2D) (2018)	0.4	0.8	2.4	0.5	1.6	-0.7	0.9	1.1	0.4	0.7	0.6	1.0	0.5
Eye problems/disorders: Diabetes related eye disease	0.4	0.4	1.6	-0.4	-0.1	-0.9	0.4	-1.3	-0.6	0.2	0.6	1.0	-0.0
Current tobacco smoking	0.4	0.6	1.8	-0.4	-0.2	-1.1	-0.6	0.0	-0.3	-0.6	-1.3	-1.1	-1.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.5	1.8	0.0	0.8	-1.3	0.1	1.3	-0.4	-0.2	0.4	0.8	0.2
Taking other prescription medications	0.4	0.6	2.7	-0.6	-0.0	-1.6	0.4	0.2	-1.3	-0.7	0.3	0.6	-0.6
Tinnitus: Yes, but not now, but have in the past	0.4	0.4	1.4	-0.9	-0.6	-0.6	-0.7	-0.2	-1.2	-0.5	0.0	0.3	-0.6
Medication: Levothyroxine sodium	0.4	0.7	1.8	-0.0	1.1	1.4	-0.1	0.4	0.2	-0.5	-1.2	-1.2	-0.7
Ever unenthusiastic/disinterested for a whole week	0.4	0.5	1.7	-0.3	-0.1	-1.0	0.5	0.9	-1.3	0.2	0.9	0.7	-0.1
Allergy	0.4	1.0	4.1	-1.1	-1.2	0.2	0.2	0.0	-2.0	-0.7	1.0	1.3	0.0
Weight	0.4	2.1	8.4	0.1	0.7	2.9	-1.7	0.3	1.1	-0.8	-1.6	-2.2	-0.4
Alcohol intake versus 10 years previously	0.4	0.6	1.6	0.6	1.0	-1.2	0.7	-0.6	-0.1	0.7	1.0	1.0	0.4
Forced expiratory volume in 1-second (FEV1)	0.4	1.3	3.4	1.8	0.5	1.5	1.1	0.2	1.0	1.7	0.7	0.8	0.8
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.2	3.4	1.8	0.6	1.6	1.0	-0.1	1.0	1.6	0.4	0.7	0.6
Hair/balding pattern: Pattern 4	0.4	0.9	2.2	0.8	0.6	1.1	0.4	-0.7	0.1	1.3	1.2	1.5	1.1
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.5	2.0	0.7	0.3	1.4	0.2	0.7	0.9	0.5	-0.2	-0.6	0.1
Health satisfaction	0.4	0.5	1.9	-0.4	-0.6	-1.4	0.5	0.3	-1.3	-0.4	0.3	0.6	0.3
Eye problems/disorders: None of the above	0.4	0.5	3.2	-0.0	-0.7	-0.3	0.0	-1.8	0.3	-0.7	0.0	-0.3	0.6
Heart disease (mother)	0.4	0.5	2.4	-0.2	0.6	0.3	-0.0	-1.5	0.4	-0.7	-1.0	-0.8	-0.3
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.4	1.1	0.6	0.7	-0.3	0.9	0.6	0.1	0.6	0.8	1.0	0.5
Smoking status: Current	0.4	0.7	1.5	-0.5	-0.3	-1.2	-0.9	0.1	-0.7	-0.4	-1.2	-0.8	-1.2
Ever taken oral contraceptive pill	0.4	0.4	1.0	0.8	-0.0	0.9	1.0	0.2	0.9	0.3	0.3	0.4	0.8
Hearing aid user	0.4	0.5	3.1	0.4	0.6	0.5	-0.1	1.8	0.5	0.5	0.3	0.2	0.4
Commuting to job workplace: Public transport	0.4	0.4	1.4	0.0	0.7	1.2	-0.3	0.8	0.4	-0.2	-0.6	-0.8	-0.3
Medication: Atorvastatin	0.4	0.5	1.3	0.3	1.2	1.0	0.8	1.0	0.6	0.6	0.2	0.2	0.4
Number of operations (self-reported)	0.4	0.6	1.5	0.5	1.2	-0.1	1.2	0.7	0.4	0.7	0.9	0.6	0.8
Risk taking	0.4	0.5	1.2	0.1	0.6	1.1	-1.1	-0.2	0.6	0.6	-0.9	-0.7	-0.8
Alcohol drinker status: Previous	0.4	0.5	1.0	0.9	0.6	0.4	0.6	0.7	0.8	0.5	0.8	0.5	1.0
Worry (Nagel 2018)	0.3	0.6	1.7	-0.3	0.0	-0.1	0.0	1.3	0.5	-0.9	-1.2	-1.3	-0.6
Crohns Disease (2017)	0.3	0.7	2.4	0.7	-0.1	1.2	0.7	-0.7	1.5	-0.5	-0.7	-1.0	0.5
Lupus	0.3	0.5	1.3	0.9	1.0	0.7	1.2	0.3	0.8	0.5	0.5	-0.1	0.5
Rheumatoid Arthritis	0.3	0.4	1.3	0.7	0.6	-0.3	0.6	1.1	0.2	0.8	0.4	0.5	0.4
Schizophrenia (2014)	0.3	0.6	4.2	-0.2	0.3	2.1	-0.7	-0.1	-0.5	0.3	-0.5	0.1	-0.7
Respiratory disease	0.3	0.8	2.6	0.7	0.8	-0.3	0.2	0.0	1.6	-0.2	-1.3	-1.5	-0.0
Sensitivity / hurt feelings	0.3	0.5	1.2	0.7	1.1	0.3	0.7	1.1	0.8	0.3	0.3	0.1	0.6
Frequency of depressed mood in last 2 weeks	0.3	0.5	2.7	-0.1	0.5	-0.8	-0.0	1.6	-0.8	0.2	0.4	0.6	-0.2
Diabetes (mother)	0.3	0.4	1.3	0.6	1.0	0.4	0.6	1.1	0.3	0.8	0.1	0.2	-0.3
Leg fat-free mass (left)	0.3	1.3	10.4	0.2	0.5	3.2	-0.8	0.3	0.8	-0.5	-0.5	-0.9	0.3
Fed-up feelings	0.3	0.6	2.6	-0.5	0.1	-1.6	-0.5	0.7	-0.3	-0.7	-0.6	-1.0	-0.5
Impedance of leg (left)	0.3	1.2	3.4	1.5	0.9	-0.7	1.2	0.7	0.7	1.8	1.0	1.1	0.8
Leg predicted mass (left)	0.3	1.4	10.8	0.3	0.7	3.3	-0.7	0.4	0.9	-0.4	-0.4	-0.8	0.3
Worrier / anxious feelings	0.3	0.5	1.6	-0.8	-0.8	-1.3	-0.1	-0.1	-0.3	-1.2	-0.5	-0.6	-0.3
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.3	1.3	-0.1	-0.5	-0.4	-0.4	-0.3	-0.3	-0.3	-0.9	-1.1	-0.7
Tense / ‘highly strung’	0.3	0.4	1.6	0.3	0.2	-0.9	0.8	1.3	0.4	-0.2	-0.6	-0.7	-0.1
Birth weight of first child	0.3	0.5	2.0	0.4	0.3	-0.0	1.4	0.7	0.2	0.1	0.9	0.9	0.7
Medication for cholesterol, blood pressure or diabetes	0.3	0.6	1.3	-0.2	-1.1	0.5	-0.9	-0.8	0.0	-0.5	-1.0	-1.1	-0.5
Medication: Amlodipine	0.3	0.4	1.5	0.2	0.3	0.1	0.4	0.9	0.1	0.3	0.9	1.2	0.9
Birth weight	0.3	0.6	2.3	0.4	-0.3	0.7	1.5	0.1	0.4	0.1	1.1	0.8	1.1
Wheeze or whistling in the chest in last year	0.3	0.5	1.7	0.1	0.6	-0.2	-0.3	0.5	1.0	-0.2	-1.3	-1.3	-0.3
Pulse rate, automated reading	0.3	1.0	3.7	-0.4	0.4	-0.2	0.2	-0.5	-0.1	-1.4	-1.5	-1.9	-1.2
Overall health rating	0.3	0.6	1.6	-0.7	0.2	-1.3	-0.5	-0.2	-0.0	-1.2	-0.9	-1.1	-0.2
Chest pain or discomfort	0.3	0.4	1.3	0.7	0.7	1.1	-0.0	0.5	1.1	0.5	-0.1	0.2	0.5
Family relationship satisfaction	0.3	0.4	0.9	-0.9	-0.8	-0.9	-0.2	-0.5	-0.9	-0.9	0.1	-0.2	-0.1
Leg fat-free mass (right)	0.3	1.8	13.2	0.5	0.9	3.6	-0.5	0.5	1.3	-0.2	-0.3	-0.7	0.6
Friendships satisfaction	0.3	0.4	1.2	-0.5	0.0	0.5	-0.0	0.7	0.2	-1.1	-0.6	-1.1	-0.4
Medication for cholesterol	0.3	0.4	1.9	-0.3	-1.4	-0.3	-0.9	-0.6	-0.4	0.0	0.3	0.6	0.2
Leg predicted mass (right)	0.3	1.7	12.6	0.4	0.9	3.6	-0.7	0.4	1.2	-0.3	-0.4	-0.7	0.5
Irritability	0.3	0.5	1.2	-0.8	0.4	-0.5	-1.1	-0.2	-0.2	-0.4	-0.9	-0.8	-0.7
Unable to work because of sickness or disability	0.3	0.4	1.5	-0.5	0.3	-0.7	-0.4	1.2	-1.0	0.1	-0.3	0.1	-0.7
Supplements: Calcium	0.3	0.4	1.4	-0.4	-0.2	-0.1	0.6	-0.3	-0.8	-0.0	0.9	1.2	0.3
Heart attack/myocardial infarction (self-reported)	0.3	0.3	1.6	0.2	0.3	-0.2	0.5	-1.2	-0.3	0.5	0.8	0.6	0.3
Heart disease (siblings)	0.3	0.4	1.0	-0.3	0.0	-0.7	-0.8	-0.8	-0.1	-0.0	-1.0	-0.3	-0.7
LDL Cholesterol	0.2	0.3	1.9	-0.2	1.4	0.3	-0.2	0.9	0.4	-0.1	0.4	-0.2	0.4
Blood Eosinophil Count	0.2	1.7	8.9	0.3	3.0	-2.2	-0.3	1.4	0.3	0.3	-0.4	-0.4	-0.6
Blood Red Count	0.2	1.7	7.6	-0.4	-0.3	-0.8	0.0	-2.8	1.3	-0.9	-1.4	-1.8	-0.8
Hair Pigment	0.2	5.0	16.4	-2.0	-1.6	-4.0	-1.9	-2.2	-1.3	-2.2	-1.9	-2.2	-1.7
Systolic blood pressure, automated reading	0.2	0.5	0.9	0.9	0.5	-0.3	0.9	-0.8	0.7	0.8	0.5	0.4	0.8
Impedance of leg (right)	0.2	1.1	2.9	1.3	0.6	-0.7	1.3	0.7	0.4	1.7	1.1	1.2	0.7
Relative age voice broke	0.2	0.3	0.9	-0.3	-0.7	-1.0	0.2	-0.8	-0.3	-0.3	-0.3	-0.5	-0.4
Supplements: Glucosamine	0.2	0.3	0.9	-0.3	0.1	-0.9	-0.7	-0.9	-0.2	-0.0	-0.4	0.0	-0.4
Medication: Atenolol	0.2	0.2	0.6	0.4	0.3	0.8	0.5	0.1	0.6	0.5	0.5	0.1	0.5
Waist circumference	0.2	0.8	2.4	0.4	1.4	0.6	0.4	0.3	1.1	-0.3	-1.1	-1.5	-0.2
Nervous feelings	0.2	0.3	2.4	0.3	0.5	0.3	0.2	1.6	0.1	-0.1	0.1	0.2	0.3
Hearing difficulty/problems with background noise	0.2	0.3	1.0	-0.1	-0.2	0.9	0.2	1.0	0.4	-0.6	-0.6	-0.6	-0.1
Forced vital capacity (FVC)	0.2	0.6	2.7	1.2	0.1	1.6	0.4	-0.3	1.0	0.9	-0.3	-0.3	0.2
Heart attack	0.2	0.3	2.0	0.1	0.3	-0.1	0.5	-1.4	-0.2	0.4	0.6	0.4	0.2
Medication: Ramipril	0.2	0.2	1.1	-0.3	-0.1	-0.5	0.2	-1.1	-0.6	-0.2	0.2	0.1	-0.2
Fluid intelligence score	0.2	0.3	2.6	0.1	-0.2	1.6	0.3	0.2	0.2	-0.1	0.2	0.2	0.5
Impedance of arm (right)	0.2	0.9	1.9	0.1	-1.0	-0.5	-1.4	1.3	-1.2	0.9	0.7	1.3	0.2
Number of live births	0.2	0.2	0.9	0.5	0.1	1.0	-0.5	0.6	0.0	0.7	-0.1	0.3	-0.0
Mouth/teeth dental problems: Dentures	0.2	0.3	0.8	-0.5	-0.3	-0.9	-0.3	-0.9	-0.5	-0.9	-0.2	-0.1	-0.2
Impedance of arm (left)	0.2	0.9	2.7	-0.1	-1.2	-0.7	-1.7	0.8	-1.3	0.7	0.4	1.1	-0.1
Breastfed as a baby	0.2	0.2	1.8	-0.0	-0.3	1.3	-0.0	0.2	0.3	-0.5	-0.2	-0.1	0.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.4	2.8	-0.3	-0.2	-1.7	-0.2	-0.2	-0.6	-0.1	-0.2	0.2	-0.4
Medication: Paracetamol	0.2	0.3	1.2	0.1	0.8	-0.7	0.1	1.1	-0.2	0.8	0.3	0.5	-0.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.3	1.2	-0.4	-0.0	-1.1	0.1	0.3	-0.7	-0.5	-0.5	-0.3	-0.5
Age at first live birth	0.2	0.3	1.3	-0.3	-0.7	1.1	-0.3	0.3	0.1	-0.5	-0.2	-0.8	-0.3
Medication: Blood pressure	0.2	0.3	1.1	0.2	0.6	-0.6	0.3	-0.1	-0.2	0.4	0.8	1.0	0.5
Angina (self-reported)	0.2	0.3	0.7	-0.2	0.8	0.6	-0.3	0.8	-0.4	0.6	0.0	0.1	-0.4
Migraine (self-reported)	0.2	0.3	0.9	-0.5	-0.0	-0.8	0.0	-1.0	-1.0	-0.0	0.1	0.3	-0.3
Suffer from ‘nerves’	0.2	0.3	0.8	-0.1	0.7	-0.5	0.6	0.9	0.3	-0.6	-0.2	-0.3	0.0
Age at last live birth	0.2	0.3	1.7	0.0	-0.5	1.3	-0.6	0.2	0.2	-0.1	-0.2	-0.4	-0.2
Commuting to job workplace: Car/motor vehicle	0.2	0.2	0.8	0.2	0.5	-0.9	0.3	-0.0	0.1	0.4	0.4	0.4	0.3
Long-standing illness, disability or infirmity	0.2	0.4	1.4	-0.4	0.5	-1.2	0.3	0.1	-0.1	-0.9	-0.4	-0.9	-0.4
Eye problems/disorders: Cataract	0.2	0.3	0.6	-0.7	0.1	-0.4	-0.6	0.6	-0.5	-0.4	-0.6	-0.3	-0.8
Back pain experienced in last month	0.2	0.3	0.8	0.5	0.6	-0.9	0.1	0.6	0.3	0.6	0.5	0.6	0.8
Breast cancer (self-reported)	0.2	0.2	1.2	0.2	-0.0	1.1	0.7	0.6	0.3	0.1	0.1	-0.4	0.1
Illnesses of father: None of the above (group 1)	0.2	0.3	0.9	-0.5	-0.4	-0.3	-0.3	0.9	-0.9	-0.2	0.4	0.5	-0.2
Wears glasses or contact lenses	0.2	0.2	1.0	-0.6	-0.7	0.5	0.0	-0.1	-0.3	-1.0	-0.1	-0.2	-0.2
Mother’s age at death	0.2	0.3	1.1	-0.7	-1.1	0.4	-0.6	0.1	-0.6	-0.7	0.1	0.0	-0.2
Medication: Blood pressure	0.2	0.3	0.7	-0.4	0.5	-0.7	0.2	-0.4	-0.3	-0.4	-0.8	-0.8	-0.8
Medication: Lisinopril	0.2	0.3	1.0	0.0	0.3	-1.0	0.5	1.0	0.3	-0.2	-0.2	-0.2	0.3
Impedance of whole body	0.2	0.8	2.3	0.8	-0.1	-0.8	-0.3	0.8	-0.3	1.5	1.0	1.5	0.6
Alzheimer’s Disease (in father)	0.1	0.1	0.4	0.3	-0.6	0.6	-0.2	-0.1	0.1	0.5	0.2	0.2	0.3
Alzheimer’s Disease (including proxy)	0.1	0.1	0.3	0.3	-0.6	0.1	-0.2	-0.3	-0.2	0.6	0.3	0.4	0.4
Systolic Blood Pressure	0.1	0.5	2.0	0.4	-0.0	-0.6	1.1	-1.4	0.2	0.7	0.4	0.7	0.6
Tanning	0.1	1.1	3.8	-0.1	-0.6	1.6	-0.6	0.1	0.7	-0.7	-1.6	-1.9	-0.9
Number of treatments/medications taken	0.1	0.2	0.6	-0.1	0.8	-0.6	0.4	0.7	-0.6	0.0	0.0	0.2	-0.4
Hearing difficulty/problems: Yes	0.1	0.2	0.6	0.5	-0.2	-0.2	0.3	0.4	0.0	0.5	0.4	0.8	0.6
Relative age of first facial hair	0.1	0.2	0.4	0.7	0.5	-0.1	0.3	0.6	0.3	0.6	-0.5	-0.6	-0.3
Angina	0.1	0.2	0.4	-0.3	0.6	0.5	-0.4	0.5	-0.5	0.4	-0.2	-0.0	-0.6
Multivitamins +/- minerals	0.1	0.2	0.7	-0.3	-0.4	-0.8	-0.5	0.2	-0.5	-0.1	-0.4	0.0	-0.4
High blood pressure (mother)	0.1	0.2	0.4	0.0	0.6	0.1	-0.4	0.4	-0.6	0.3	0.3	0.6	-0.1
Number of incorrect matches in round	0.1	0.2	0.5	-0.1	-0.7	-0.7	0.2	-0.4	-0.2	-0.4	0.2	-0.1	0.1
Pulse rate	0.1	0.2	0.6	-0.0	-0.1	-0.1	0.8	-0.7	0.2	-0.7	-0.3	-0.7	-0.1
Happiness	0.1	0.2	1.0	-0.2	0.2	0.4	0.3	1.0	-0.1	-0.3	0.0	-0.5	-0.0
Forced vital capacity (FVC), Best measure	0.1	0.5	2.2	0.9	-0.3	1.5	0.2	-0.3	0.8	0.5	-0.8	-0.6	-0.2
Exposure to tobacco smoke outside home	0.1	0.2	0.5	-0.5	-0.2	-0.6	-0.7	-0.4	-0.6	-0.0	-0.1	0.3	-0.4
Medication: Ibuprofen	0.1	0.1	0.3	0.1	-0.1	0.4	-0.3	0.2	-0.3	0.1	-0.3	-0.6	-0.4
Had major operations	0.1	0.1	0.9	-0.0	0.4	0.1	0.2	-1.0	0.1	-0.0	0.0	-0.1	-0.1
Forced expiratory volume in 1-second (FEV1), predicted	0.1	0.3	1.5	0.2	-0.3	1.2	0.1	-0.9	0.3	0.0	0.0	0.1	0.2
Tinnitus: Yes, now most or all of the time	0.1	0.1	0.3	0.2	-0.0	-0.5	0.1	-0.3	0.1	-0.1	-0.4	-0.4	-0.2
Pain type(s) experienced in last month: Hip pain	0.1	0.1	0.4	0.2	0.6	0.6	-0.4	0.2	0.5	-0.1	-0.3	-0.3	0.2
Medication: Bendroflumethiazide	0.1	0.2	0.4	-0.5	0.6	-0.5	-0.3	0.2	-0.0	-0.4	-0.6	-0.5	-0.5
Medication: Paracetamol	0.1	0.2	0.5	-0.1	0.3	-0.3	-0.5	0.7	-0.4	0.7	-0.1	0.2	-0.6
Alzheimer’s Disease (in mother)	0.0	0.0	0.1	0.1	-0.3	0.3	-0.1	0.3	-0.2	0.1	-0.1	-0.1	-0.1
Breast Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Smoking Status	0.0	0.1	0.3	-0.1	-0.1	-0.5	-0.1	0.5	-0.1	0.1	-0.4	-0.0	-0.3

Hub : Genes

TMED2

Models

Trait associations