Best TWAS P=1.49e-10 · Best GWAS P=1.47e-13 conditioned to 1.26e-07
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | SHISA4 | 0.09 | 0.04 | lasso | 3 | 0.03 | 1.5e-03 | 5.2 | 6.0 | 1.6e-09 | 0.00 | 0.27 | 0.09 | FALSE |
| 2 | GTEx | Adipose Subcutaneous | RP11-134G8.8 | 0.20 | 0.09 | enet | 15 | 0.12 | 2.9e-10 | 4.4 | 5.2 | 2.0e-07 | 0.41 | 1.00 | 0.00 | FALSE |
| 3 | GTEx | Artery Aorta | RP11-134G8.8 | 0.19 | 0.15 | enet | 8 | 0.22 | 1.6e-12 | 4.4 | 5.5 | 4.2e-08 | 0.57 | 0.99 | 0.01 | FALSE |
| 4 | GTEx | Cells Transformed fibroblasts | SHISA4 | 0.19 | 0.05 | enet | 23 | 0.11 | 2.5e-08 | -1.2 | 5.7 | 1.6e-08 | -0.02 | 0.78 | 0.10 | FALSE |
| 5 | GTEx | Colon Sigmoid | RP11-134G8.8 | 0.41 | 0.32 | lasso | 4 | 0.30 | 2.3e-11 | 4.4 | 5.5 | 3.3e-08 | 0.56 | 0.77 | 0.22 | FALSE |
| 6 | GTEx | Esophagus Mucosa | RP11-134G8.8 | 0.43 | 0.32 | lasso | 8 | 0.34 | 3.2e-23 | 4.4 | 5.5 | 4.0e-08 | 0.51 | 1.00 | 0.00 | FALSE |
| 7 | GTEx | Esophagus Muscularis | RP11-134G8.8 | 0.39 | 0.29 | lasso | 3 | 0.32 | 2.6e-20 | 4.4 | 5.4 | 5.3e-08 | 0.53 | 1.00 | 0.00 | FALSE |
| 8 | GTEx | Lung | RP11-134G8.8 | 0.23 | 0.17 | lasso | 3 | 0.22 | 5.0e-17 | 4.4 | 5.3 | 9.6e-08 | 0.53 | 1.00 | 0.00 | FALSE |
| 9 | GTEx | Muscle Skeletal | RP11-134G8.8 | 0.19 | 0.11 | lasso | 4 | 0.13 | 5.1e-13 | 4.4 | 5.5 | 3.3e-08 | 0.55 | 0.98 | 0.02 | FALSE |
| 10 | GTEx | Nerve Tibial | RP11-134G8.8 | 0.40 | 0.33 | enet | 10 | 0.31 | 1.5e-22 | 4.4 | 5.3 | 1.3e-07 | 0.51 | 1.00 | 0.00 | FALSE |
| 11 | GTEx | Skin Not Sun Exposed Suprapubic | RP11-134G8.8 | 0.43 | 0.18 | lasso | 4 | 0.24 | 2.9e-13 | 4.4 | 5.6 | 1.8e-08 | 0.54 | 0.98 | 0.02 | TRUE |
| 12 | GTEx | Skin Sun Exposed Lower leg | RP11-134G8.8 | 0.35 | 0.23 | lasso | 6 | 0.31 | 8.2e-26 | 4.4 | 5.6 | 1.8e-08 | 0.52 | 1.00 | 0.00 | FALSE |
| 13 | METSIM | Adipose | LMOD1 | 0.09 | 0.07 | bslmm | 496 | 0.07 | 4.8e-10 | -4.8 | 5.3 | 1.3e-07 | 0.07 | 1.00 | 0.00 | FALSE |
| 14 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | SHISA4 | 0.03 | 0.01 | enet | 5 | 0.00 | 2.5e-01 | 6.4 | 5.7 | 9.7e-09 | -0.03 | 0.00 | 0.93 | FALSE |
| 15 | The Cancer Genome Atlas | Brain Lower Grade Glioma | LMOD1 | 0.04 | 0.07 | enet | 6 | 0.05 | 9.4e-07 | 6.4 | 6.4 | 1.5e-10 | -0.02 | 0.00 | 1.00 | TRUE |