[Hub]/) : Traits : Lung FEV1/FVC ratio : ← →

chr1:203,890,813-207,334,619

Best TWAS P=2.72e-17 · Best GWAS P=7.29e-18 conditioned to 2.39e-07

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
31	GTEx	Pancreas	NUCKS1	0.16	0.00	lasso	4	0.00	4.5e-01	7.3	8.5	2.7e-17	-0.63	0.08	0.37	TRUE
84	The Cancer Genome Atlas	Prostate Adenocarcinoma	CNTN2	0.09	0.04	enet	16	0.07	3.8e-08	-8.5	-8.3	7.1e-17	-0.07	0.01	0.99	TRUE
45	GTEx	Thyroid	LRRN2	0.10	0.06	lasso	6	0.06	4.8e-05	-4.3	-5.8	6.1e-09	-0.02	0.96	0.01	TRUE
33	GTEx	Pancreas	SRGAP2	0.17	0.06	lasso	7	0.06	1.2e-03	-5.3	-5.4	5.7e-08	-0.09	0.00	0.98	TRUE
6	GTEx	Adipose Subcutaneous	NUCKS1	0.11	0.10	lasso	3	0.08	9.4e-07	-5.2	5.2	1.5e-07	-0.46	0.98	0.01	TRUE
56	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	CNTN2	0.04	0.02	enet	8	0.02	1.3e-02	-8.2	-8.1	4.9e-16	-0.07	0.01	0.88	FALSE
95	The Cancer Genome Atlas	Thyroid Carcinoma	RBBP5	0.09	0.04	blup	80	0.05	4.8e-06	-8.5	-7.5	6.0e-14	-0.07	0.03	0.96	FALSE
3	CommonMind	Brain Pre-frontal Cortex	RBBP5	0.15	0.07	bslmm	617	0.10	2.3e-12	-8.5	-7.5	6.3e-14	-0.07	0.01	0.99	FALSE
18	GTEx	Cells Transformed fibroblasts	RAB7L1	0.30	0.23	enet	19	0.36	8.6e-28	5.2	-7.3	3.1e-13	0.43	1.00	0.00	FALSE
20	GTEx	Esophagus Mucosa	NUCKS1	0.12	0.11	enet	6	0.06	7.2e-05	6.9	7.3	3.1e-13	-0.41	0.73	0.24	FALSE
59	The Cancer Genome Atlas	Breast Invasive Carcinoma	RAB7L1	0.02	0.02	enet	5	0.02	3.1e-04	6.4	-7.2	4.2e-13	0.35	0.01	0.98	FALSE
12	GTEx	Brain Caudate basal ganglia	NUCKS1	0.25	0.24	lasso	3	0.25	8.1e-08	6.8	-7.2	4.5e-13	0.35	0.42	0.05	FALSE
77	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	RAB7L1	0.06	0.05	enet	6	0.06	2.6e-07	6.4	-7.1	1.3e-12	0.47	0.04	0.96	FALSE
87	The Cancer Genome Atlas	Prostate Adenocarcinoma	RAB7L1	0.12	0.12	lasso	2	0.12	3.8e-12	6.9	-7.0	2.1e-12	0.36	0.00	1.00	FALSE
53	YFS	Blood	RAB7L1	0.06	0.07	lasso	6	0.06	1.1e-19	6.8	-7.0	2.5e-12	0.40	1.00	0.00	FALSE
68	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	RAB7L1	0.09	0.08	enet	11	0.08	1.7e-09	6.8	-7.0	2.5e-12	0.41	0.00	1.00	FALSE
23	GTEx	Heart Atrial Appendage	NUCKS1	0.12	0.14	enet	4	0.08	1.7e-04	6.9	7.0	2.9e-12	-0.39	0.44	0.06	FALSE
35	GTEx	Prostate	NUCKS1	0.38	0.23	lasso	8	0.32	7.5e-09	5.7	-6.9	4.6e-12	0.48	0.33	0.16	FALSE
40	GTEx	Stomach	NUCKS1	0.21	0.11	lasso	8	0.15	1.1e-07	-5.2	6.9	5.6e-12	-0.48	0.94	0.02	FALSE
71	The Cancer Genome Atlas	Brain Lower Grade Glioma	RAB7L1	0.09	0.08	lasso	2	0.07	1.1e-08	6.8	-6.8	8.0e-12	0.35	0.00	1.00	FALSE
83	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	RAB7L1	0.17	0.13	lasso	2	0.11	4.4e-05	6.9	-6.8	8.3e-12	0.35	0.00	0.99	FALSE
94	The Cancer Genome Atlas	Thyroid Carcinoma	RAB7L1	0.13	0.17	enet	15	0.21	3.6e-20	6.9	-6.8	8.5e-12	0.45	0.00	1.00	FALSE
81	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	RAB7L1	0.09	0.04	blup	46	0.04	1.2e-02	6.8	-6.8	9.0e-12	0.42	0.00	0.97	FALSE
75	The Cancer Genome Atlas	Lung Adenocarcinoma	RBBP5	0.03	0.01	blup	79	0.02	1.2e-03	3.1	-6.8	9.5e-12	-0.08	0.02	0.83	FALSE
60	The Cancer Genome Atlas	Colon Adenocarcinoma	PM20D1	0.26	0.13	enet	14	0.16	9.7e-10	5.7	6.8	1.2e-11	-0.49	0.00	1.00	FALSE
64	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	RAB7L1	0.09	0.13	lasso	6	0.13	3.6e-14	6.1	-6.8	1.3e-11	0.41	0.10	0.90	FALSE
24	GTEx	Heart Atrial Appendage	RAB7L1	0.20	0.17	enet	12	0.14	4.9e-07	6.9	-6.7	1.9e-11	0.42	0.97	0.02	FALSE
44	GTEx	Thyroid	NUCKS1	0.26	0.16	lasso	6	0.19	1.8e-14	-5.4	6.7	2.1e-11	-0.46	1.00	0.00	FALSE
72	The Cancer Genome Atlas	Brain Lower Grade Glioma	TMEM81	0.10	0.05	lasso	3	0.06	6.0e-07	4.0	-6.7	2.3e-11	-0.07	0.26	0.74	FALSE
38	GTEx	Skin Sun Exposed Lower leg	SLC45A3	0.08	0.00	lasso	5	0.00	3.6e-01	6.9	6.7	2.4e-11	-0.36	0.13	0.05	FALSE
79	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	RAB7L1	0.06	0.06	blup	46	0.06	5.2e-05	-6.0	-6.7	2.5e-11	0.48	0.11	0.85	FALSE
48	METSIM	Adipose	NUCKS1	0.05	0.02	lasso	6	0.01	4.3e-03	-5.4	6.6	3.1e-11	-0.46	0.62	0.04	FALSE
92	The Cancer Genome Atlas	Thyroid Carcinoma	CNTN2	0.14	0.03	blup	98	0.11	1.0e-10	-4.3	-6.6	4.0e-11	0.00	0.03	0.97	FALSE
74	The Cancer Genome Atlas	Lung Adenocarcinoma	RAB7L1	0.02	0.02	enet	5	0.03	4.6e-04	6.1	-6.6	4.4e-11	0.42	0.01	0.73	FALSE
91	The Cancer Genome Atlas	Stomach Adenocarcinoma	RAB7L1	0.07	0.04	blup	46	0.07	1.2e-05	-5.5	-6.5	1.0e-10	0.43	0.00	0.99	FALSE
85	The Cancer Genome Atlas	Prostate Adenocarcinoma	NUCKS1	0.04	0.05	lasso	2	0.03	1.5e-04	-6.0	6.5	1.1e-10	-0.49	0.24	0.58	FALSE
66	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	CNTN2	0.03	0.01	blup	98	0.01	8.7e-03	-3.9	-6.4	1.2e-10	-0.07	0.02	0.59	FALSE
2	CommonMind	Brain Pre-frontal Cortex	RAB7L1	0.07	0.03	enet	16	0.05	4.1e-07	6.1	-6.4	1.4e-10	0.38	0.97	0.00	FALSE
8	GTEx	Artery Aorta	NUCKS1	0.14	0.11	lasso	3	0.08	3.7e-05	-6.0	6.4	1.5e-10	-0.44	0.76	0.13	FALSE
11	GTEx	Artery Tibial	RAB7L1	0.29	0.27	lasso	9	0.31	9.7e-25	6.9	-6.3	2.2e-10	0.36	1.00	0.00	FALSE
96	The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	NUCKS1	0.11	0.02	blup	58	0.09	1.9e-03	6.4	6.3	2.2e-10	-0.42	0.02	0.69	FALSE
42	GTEx	Testis	NUCKS1	0.16	0.16	enet	15	0.16	1.3e-07	-5.4	6.3	2.4e-10	-0.47	0.95	0.01	FALSE
21	GTEx	Esophagus Muscularis	NUCKS1	0.21	0.22	lasso	5	0.20	3.6e-12	-5.2	6.2	4.9e-10	-0.46	1.00	0.00	FALSE
52	YFS	Blood	NUCKS1	0.15	0.24	lasso	4	0.25	1.4e-80	-5.2	6.2	5.7e-10	-0.45	1.00	0.00	FALSE
30	GTEx	Nerve Tibial	SLC41A1	0.12	0.02	lasso	4	0.05	2.5e-04	-5.2	-6.2	6.2e-10	0.42	0.75	0.01	FALSE
55	YFS	Blood	TMCC2	0.03	0.02	blup	582	0.02	2.5e-06	3.5	-6.2	6.2e-10	-0.09	0.99	0.00	FALSE
9	GTEx	Artery Aorta	RAB7L1	0.43	0.20	lasso	8	0.29	1.9e-16	6.9	-6.2	7.6e-10	0.36	1.00	0.00	FALSE
19	GTEx	Colon Transverse	RAB7L1	0.14	0.05	lasso	5	0.04	7.7e-03	6.4	-6.1	9.7e-10	0.32	0.18	0.04	FALSE
29	GTEx	Nerve Tibial	NUCKS1	0.25	0.21	enet	16	0.22	7.3e-16	-5.3	6.0	1.4e-09	-0.47	1.00	0.00	FALSE
41	GTEx	Stomach	RAB7L1	0.22	0.11	lasso	5	0.12	2.7e-06	6.4	-6.1	1.4e-09	0.33	0.76	0.01	FALSE
51	NTR	Blood	RAB7L1	0.03	0.01	bslmm	385	0.02	1.9e-07	5.3	-6.1	1.4e-09	0.24	0.98	0.00	FALSE
15	GTEx	Brain Nucleus accumbens basal ganglia	RBBP5	0.25	0.00	enet	16	0.04	3.5e-02	2.0	-5.9	3.1e-09	-0.04	0.08	0.44	FALSE
54	YFS	Blood	SLC41A1	0.06	0.05	enet	15	0.05	2.6e-17	-5.5	-5.9	4.0e-09	0.45	1.00	0.00	FALSE
14	GTEx	Brain Cerebellum	TMEM81	0.25	0.02	enet	21	0.11	3.0e-04	-7.6	-5.8	5.0e-09	-0.10	0.06	0.78	FALSE
61	The Cancer Genome Atlas	Esophageal Carcinoma	RAB7L1	0.14	0.03	blup	46	0.07	2.5e-03	4.3	-5.8	5.0e-09	0.25	0.02	0.54	FALSE
25	GTEx	Heart Left Ventricle	NUCKS1	0.10	0.04	lasso	3	0.05	1.4e-03	-6.0	5.8	6.4e-09	-0.45	0.19	0.30	FALSE
57	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	PM20D1	0.22	0.26	lasso	5	0.26	1.7e-22	-5.5	5.8	6.6e-09	-0.51	0.01	0.99	FALSE
26	GTEx	Heart Left Ventricle	RAB7L1	0.33	0.09	lasso	10	0.22	4.8e-12	3.5	-5.8	7.7e-09	0.33	1.00	0.00	FALSE
7	GTEx	Adipose Subcutaneous	RAB7L1	0.20	0.09	lasso	4	0.18	7.6e-15	3.3	-5.8	8.4e-09	0.34	1.00	0.00	FALSE
82	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	SLC26A9	0.15	0.06	lasso	3	0.05	5.2e-03	5.6	5.8	8.6e-09	-0.57	0.10	0.34	FALSE
39	GTEx	Spleen	RAB7L1	0.31	0.00	lasso	7	0.00	2.8e-01	3.7	-5.8	8.7e-09	0.26	0.08	0.19	FALSE
63	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	PM20D1	0.19	0.25	lasso	5	0.25	3.0e-28	-5.2	5.7	1.1e-08	-0.50	0.02	0.98	FALSE
73	The Cancer Genome Atlas	Lung Adenocarcinoma	PM20D1	0.31	0.39	enet	16	0.41	5.1e-52	-5.2	5.7	1.2e-08	-0.49	0.02	0.98	FALSE
86	The Cancer Genome Atlas	Prostate Adenocarcinoma	PM20D1	0.16	0.14	enet	15	0.16	5.6e-16	-5.2	5.7	1.2e-08	-0.54	0.00	1.00	FALSE
34	GTEx	Pituitary	NUCKS1	0.26	0.19	lasso	2	0.20	7.6e-06	-5.2	5.7	1.6e-08	-0.44	0.11	0.67	FALSE
47	GTEx	Whole Blood	RAB7L1	0.14	0.11	lasso	5	0.10	3.1e-09	3.7	-5.6	2.0e-08	0.33	1.00	0.00	FALSE
27	GTEx	Lung	NUCKS1	0.09	0.07	lasso	3	0.04	2.6e-04	-5.2	5.6	2.2e-08	-0.46	0.72	0.23	FALSE
69	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	PM20D1	0.19	0.19	enet	4	0.19	4.5e-11	-5.2	5.6	2.3e-08	-0.49	0.02	0.98	FALSE
22	GTEx	Esophagus Muscularis	RAB7L1	0.27	0.30	lasso	4	0.33	9.4e-21	3.3	-5.6	2.4e-08	0.32	1.00	0.00	FALSE
67	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	PM20D1	0.29	0.35	enet	18	0.35	5.1e-41	-5.2	5.5	2.9e-08	-0.47	0.03	0.96	FALSE
28	GTEx	Muscle Skeletal	TMCC2	0.04	0.04	lasso	1	0.03	4.4e-04	-5.5	5.5	3.0e-08	0.05	0.59	0.11	FALSE
37	GTEx	Skin Sun Exposed Lower leg	NUCKS1	0.20	0.26	lasso	5	0.26	1.5e-21	-5.2	5.5	3.7e-08	-0.47	1.00	0.00	FALSE
46	GTEx	Uterus	RBBP5	0.46	-0.01	lasso	12	0.01	2.0e-01	3.4	-5.5	4.3e-08	-0.01	0.09	0.10	FALSE
97	The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	PM20D1	0.19	0.09	lasso	4	0.12	4.2e-04	-5.5	5.5	4.5e-08	-0.50	0.01	0.84	FALSE
36	GTEx	Skin Not Sun Exposed Suprapubic	NUCKS1	0.20	0.14	lasso	4	0.13	2.0e-07	-5.2	5.5	4.8e-08	-0.46	0.99	0.00	FALSE
70	The Cancer Genome Atlas	Brain Lower Grade Glioma	PM20D1	0.41	0.43	enet	20	0.44	9.2e-55	-5.2	5.5	4.9e-08	-0.49	0.03	0.96	FALSE
76	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	PM20D1	0.26	0.34	lasso	3	0.34	1.9e-40	-5.2	5.5	4.9e-08	-0.49	0.03	0.96	FALSE
80	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	PM20D1	0.32	0.34	lasso	2	0.34	9.7e-15	-5.5	5.4	5.4e-08	-0.49	0.01	0.99	FALSE
13	GTEx	Brain Cerebellum	NUCKS1	0.22	0.13	lasso	3	0.08	2.0e-03	-5.5	5.4	6.1e-08	-0.49	0.26	0.16	FALSE
4	CommonMind	Brain Pre-frontal Cortex	SLC26A9	0.13	0.16	lasso	3	0.16	3.1e-19	-5.2	-5.4	6.3e-08	0.49	1.00	0.00	FALSE
78	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	PM20D1	0.12	0.13	blup	47	0.12	9.1e-09	-5.2	5.4	6.5e-08	-0.49	0.01	0.99	FALSE
49	METSIM	Adipose	PM20D1	0.25	0.30	bslmm	377	0.31	8.4e-47	-5.2	5.4	6.6e-08	-0.48	1.00	0.00	FALSE
43	GTEx	Testis	RAB7L1	0.41	0.21	lasso	13	0.26	9.2e-12	3.2	-5.4	6.8e-08	0.31	1.00	0.00	FALSE
5	CommonMind	Brain Pre-frontal Cortex	TMEM81	0.07	0.04	lasso	5	0.03	6.4e-05	-5.2	-5.4	7.2e-08	-0.07	0.82	0.09	FALSE
32	GTEx	Pancreas	SLC41A1	0.24	0.21	lasso	5	0.19	1.4e-08	-5.2	-5.4	8.0e-08	0.48	0.92	0.03	FALSE
93	The Cancer Genome Atlas	Thyroid Carcinoma	PM20D1	0.26	0.40	lasso	4	0.41	2.0e-42	-5.2	5.4	8.1e-08	-0.48	0.03	0.97	FALSE
17	GTEx	Breast Mammary Tissue	NUCKS1	0.15	0.05	lasso	4	0.09	2.5e-05	-5.2	5.3	1.2e-07	-0.44	0.82	0.02	FALSE
65	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	SLC45A3	0.08	0.00	blup	80	0.03	5.5e-04	2.2	-5.3	1.2e-07	0.25	0.01	0.84	FALSE
90	The Cancer Genome Atlas	Stomach Adenocarcinoma	PM20D1	0.09	0.11	enet	6	0.10	1.3e-07	5.8	5.3	1.2e-07	-0.46	0.00	1.00	FALSE
89	The Cancer Genome Atlas	Skin Cutaneous Melanoma	PM20D1	0.17	0.11	lasso	3	0.07	5.0e-03	-5.2	5.3	1.3e-07	-0.49	0.01	0.75	FALSE
88	The Cancer Genome Atlas	Soft Tissue Sarcoma	PM20D1	0.23	0.24	lasso	4	0.24	1.2e-14	-5.2	5.2	1.5e-07	-0.47	0.02	0.98	FALSE
58	The Cancer Genome Atlas	Breast Invasive Carcinoma	PM20D1	0.24	0.37	lasso	5	0.39	4.9e-85	-5.2	5.2	1.7e-07	-0.49	0.04	0.96	FALSE
50	METSIM	Adipose	RAB7L1	0.08	0.04	bslmm	401	0.05	8.6e-08	6.8	-5.2	1.8e-07	0.25	0.99	0.00	FALSE
1	CommonMind	Brain Pre-frontal Cortex	PM20D1	0.27	0.41	enet	15	0.41	7.8e-54	-5.2	-5.2	2.3e-07	0.47	1.00	0.00	FALSE
10	GTEx	Artery Tibial	NUCKS1	0.13	0.03	lasso	2	0.01	4.0e-02	-5.5	5.2	2.4e-07	-0.48	0.20	0.45	FALSE
62	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	DSTYK	0.02	0.01	enet	6	0.01	1.3e-02	-5.5	5.2	2.7e-07	0.05	0.18	0.11	FALSE
16	GTEx	Brain Putamen basal ganglia	NUCKS1	0.40	0.26	lasso	4	0.27	3.2e-07	-5.2	5.1	3.0e-07	-0.46	0.34	0.08	FALSE