Best TWAS P=2.84e-19 · Best GWAS P=2.92e-18 conditioned to 0.000231
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Cells Transformed fibroblasts | MRC2 | 0.10 | 0.02 | enet | 17 | 0.02 | 1.5e-02 | 6.6 | -9.0 | 2.8e-19 | 0.66 | 0.01 | 0.94 | TRUE |
| 2 | GTEx | Lung | MRC2 | 0.13 | 0.01 | enet | 12 | 0.06 | 1.6e-05 | 7.7 | -7.9 | 3.7e-15 | 0.28 | 0.23 | 0.21 | FALSE |
| 3 | The Cancer Genome Atlas | Esophageal Carcinoma | METTL2A | 0.14 | 0.03 | blup | 16 | 0.04 | 2.4e-02 | -3.1 | -6.2 | 4.7e-10 | 0.06 | 0.00 | 0.40 | FALSE |