Best TWAS P=2.63e-18 · Best GWAS P=2.42e-17 conditioned to 1.77e-06
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | PLEKHM1P | 0.24 | 0.26 | lasso | 6 | 0.27 | 8.0e-33 | -7.1 | 7.6 | 4.0e-14 | -0.89 | 0.06 | 0.94 | FALSE |
| 2 | GTEx | Artery Tibial | DDX5 | 0.12 | 0.13 | lasso | 2 | 0.12 | 1.5e-09 | 5.9 | -6.0 | 2.6e-09 | -0.10 | 1.00 | 0.00 | TRUE |
| 3 | GTEx | Cells Transformed fibroblasts | SMURF2 | 0.17 | 0.13 | enet | 8 | 0.13 | 3.7e-10 | -8.2 | -8.7 | 4.0e-18 | 0.77 | 0.01 | 0.99 | FALSE |
| 4 | GTEx | Pancreas | MILR1 | 0.18 | 0.01 | lasso | 7 | 0.03 | 1.3e-02 | -8.0 | -6.3 | 2.2e-10 | 0.59 | 0.02 | 0.76 | FALSE |
| 5 | GTEx | Skin Sun Exposed Lower leg | hsa-mir-6080 | 0.11 | 0.10 | lasso | 2 | 0.08 | 1.7e-07 | -8.0 | 8.2 | 3.1e-16 | -0.72 | 0.03 | 0.97 | FALSE |
| 6 | NTR | Blood | DDX5 | 0.10 | 0.04 | lasso | 3 | 0.04 | 5.2e-13 | 5.9 | -5.8 | 6.4e-09 | -0.12 | 1.00 | 0.00 | FALSE |
| 7 | YFS | Blood | DDX5 | 0.42 | 0.21 | bslmm | 215 | 0.21 | 7.7e-68 | 5.9 | -5.5 | 3.1e-08 | -0.15 | 1.00 | 0.00 | FALSE |
| 8 | The Cancer Genome Atlas | Breast Invasive Carcinoma | PLEKHM1P | 0.01 | 0.01 | enet | 7 | 0.01 | 1.9e-02 | -8.5 | 5.9 | 3.5e-09 | -0.79 | 0.00 | 0.94 | FALSE |
| 9 | The Cancer Genome Atlas | Glioblastoma Multiforme | PLEKHM1P | 0.08 | 0.04 | blup | 7 | 0.04 | 2.7e-02 | -7.2 | 7.4 | 1.2e-13 | -0.89 | 0.00 | 0.45 | FALSE |
| 10 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | PLEKHM1P | 0.08 | 0.03 | enet | 4 | 0.04 | 4.0e-05 | -7.1 | 5.2 | 1.5e-07 | -0.69 | 0.06 | 0.75 | FALSE |
| 11 | The Cancer Genome Atlas | Lung Adenocarcinoma | PLEKHM1P | 0.02 | 0.01 | blup | 7 | 0.02 | 4.7e-03 | -8.5 | 8.0 | 1.6e-15 | -0.92 | 0.00 | 0.76 | FALSE |
| 12 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | SMURF2 | 0.10 | 0.01 | blup | 14 | 0.05 | 5.5e-03 | -7.7 | -8.7 | 2.6e-18 | 0.52 | 0.00 | 0.77 | TRUE |
| 13 | The Cancer Genome Atlas | Prostate Adenocarcinoma | PLEKHM1P | 0.02 | 0.02 | blup | 7 | 0.02 | 6.7e-03 | -8.5 | 8.0 | 1.0e-15 | -0.95 | 0.00 | 0.87 | TRUE |
| 14 | The Cancer Genome Atlas | Thyroid Carcinoma | PLEKHM1P | 0.04 | 0.03 | blup | 7 | 0.05 | 1.2e-05 | -7.1 | 7.4 | 1.4e-13 | -0.90 | 0.01 | 0.99 | FALSE |