[Hub]/) : Traits : Lung FEV1/FVC ratio : ← →

chr17:45,337,417-49,307,326

Best TWAS P=6.19e-15 · Best GWAS P=2.85e-16 conditioned to 0.015

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
7	GTEx	Brain Cerebellar Hemisphere	SNX11	0.25	0.19	enet	38	0.22	2.0e-06	-3.2	7.8	6.2e-15	-0.05	0.16	0.31	TRUE
44	The Cancer Genome Atlas	Lung Adenocarcinoma	ZNF652	0.05	0.02	blup	55	0.02	2.5e-03	-7.3	7.7	1.6e-14	-0.40	0.21	0.34	TRUE
10	GTEx	Esophagus Mucosa	NFE2L1	0.07	0.02	lasso	4	0.01	8.6e-02	-6.4	-6.7	2.3e-11	-0.03	0.03	0.92	TRUE
16	GTEx	Skin Not Sun Exposed Suprapubic	HOXB-AS1	0.09	0.00	enet	34	0.00	3.4e-01	2.2	-6.3	2.2e-10	0.02	0.09	0.54	TRUE
34	The Cancer Genome Atlas	Colon Adenocarcinoma	PRR15L	0.14	0.05	lasso	4	0.10	2.0e-06	-6.6	6.1	8.6e-10	0.03	0.00	1.00	TRUE
52	The Cancer Genome Atlas	Thyroid Carcinoma	NFE2L1	0.04	0.05	lasso	3	0.04	1.9e-04	-6.3	-6.0	2.0e-09	-0.02	0.01	0.97	TRUE
1	CommonMind	Brain Pre-frontal Cortex	MYCBPAP	0.14	0.05	lasso	5	0.11	1.4e-13	2.8	-5.2	1.5e-07	0.03	0.02	0.82	TRUE
49	The Cancer Genome Atlas	Rectum Adenocarcinoma	HOXB2	0.15	0.04	blup	46	0.04	3.3e-02	2.3	-5.2	1.7e-07	0.04	0.02	0.48	TRUE
50	The Cancer Genome Atlas	Soft Tissue Sarcoma	CDK5RAP3	0.13	0.02	blup	61	0.04	1.2e-03	-6.3	-5.1	2.8e-07	-0.03	0.01	0.94	TRUE
22	GTEx	Whole Blood	HOXB3	0.15	0.00	lasso	8	0.00	1.2e-01	6.4	-7.0	1.8e-12	0.01	0.02	0.86	FALSE
29	YFS	Blood	HOXB2	0.60	0.64	enet	48	0.69	1.0e-320	5.6	-7.0	2.1e-12	0.03	0.75	0.25	FALSE
39	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	ZNF652	0.03	0.03	enet	5	0.03	2.6e-04	-6.8	6.9	5.3e-12	-0.37	0.37	0.12	FALSE
35	The Cancer Genome Atlas	Colon Adenocarcinoma	ZNF652	0.09	0.01	enet	12	0.05	5.5e-04	-8.0	6.8	1.2e-11	-0.53	0.01	0.80	FALSE
24	GTEx	Whole Blood	HOXB-AS1	0.14	0.05	enet	27	0.07	6.7e-07	6.6	-6.6	3.1e-11	0.04	0.02	0.98	FALSE
31	YFS	Blood	HOXB7	0.03	0.01	blup	408	0.01	5.1e-05	6.4	-6.6	3.8e-11	0.07	0.03	0.96	FALSE
32	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	HOXB2	0.03	0.02	enet	3	0.02	3.5e-03	6.4	-6.6	3.8e-11	0.01	0.02	0.71	FALSE
41	The Cancer Genome Atlas	Brain Lower Grade Glioma	ZNF652	0.06	0.03	lasso	4	0.02	1.6e-03	-6.9	6.6	5.4e-11	-0.45	0.40	0.15	FALSE
25	METSIM	Adipose	HOXB2	0.16	0.22	lasso	6	0.22	2.9e-32	6.2	-6.5	6.7e-11	0.02	0.04	0.96	FALSE
30	YFS	Blood	HOXB4	0.03	0.02	blup	396	0.01	7.3e-05	6.4	-6.4	1.5e-10	0.09	0.01	0.98	FALSE
23	GTEx	Whole Blood	HOXB2	0.30	0.16	lasso	8	0.16	3.0e-14	6.4	-6.3	2.2e-10	0.01	0.03	0.97	FALSE
38	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	GNGT2	0.09	0.07	blup	48	0.06	2.7e-07	-5.7	-6.3	3.9e-10	0.23	0.16	0.84	FALSE
8	GTEx	Colon Transverse	RP5-890E16.2	0.14	0.03	lasso	7	0.02	5.9e-02	-3.8	6.2	4.9e-10	-0.04	0.10	0.58	FALSE
12	GTEx	Muscle Skeletal	HOXB2	0.16	0.07	lasso	9	0.08	3.4e-08	4.9	-6.2	5.2e-10	0.04	0.26	0.74	FALSE
46	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	SNX11	0.06	0.06	lasso	3	0.05	2.8e-06	-6.4	6.2	5.9e-10	0.03	0.00	1.00	FALSE
2	GTEx	Adipose Subcutaneous	HOXB3	0.10	0.06	lasso	4	0.04	6.8e-04	6.2	-6.1	8.6e-10	0.02	0.12	0.76	FALSE
37	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	HOXB2	0.03	0.02	blup	47	0.03	5.1e-04	6.4	-6.1	8.8e-10	0.03	0.03	0.88	FALSE
21	GTEx	Vagina	HOXB2	0.16	0.03	lasso	10	0.09	5.3e-03	6.3	-6.1	1.2e-09	0.03	0.05	0.61	FALSE
6	GTEx	Artery Coronary	RP11-6N17.6	0.13	0.01	lasso	18	0.00	3.1e-01	-3.6	6.1	1.3e-09	-0.02	0.06	0.48	FALSE
47	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	GNGT2	0.15	0.05	enet	4	0.08	3.4e-04	-5.7	-6.0	1.5e-09	0.20	0.06	0.60	FALSE
15	GTEx	Skin Not Sun Exposed Suprapubic	HOXB2	0.13	0.08	enet	14	0.11	9.7e-07	6.2	-6.0	1.6e-09	0.02	0.13	0.86	FALSE
28	YFS	Blood	GNGT2	0.13	0.13	lasso	5	0.12	1.1e-38	-5.7	-6.0	1.6e-09	0.18	1.00	0.00	FALSE
27	NTR	Blood	HOXB2	0.03	0.02	lasso	4	0.02	1.2e-08	5.6	-6.0	2.5e-09	0.01	0.06	0.94	FALSE
11	GTEx	Lung	HOXB-AS1	0.07	0.04	lasso	6	0.05	1.6e-04	6.2	-5.9	3.1e-09	0.05	0.21	0.76	FALSE
40	The Cancer Genome Atlas	Brain Lower Grade Glioma	GNGT2	0.08	0.06	enet	7	0.08	3.9e-09	-5.7	-5.9	3.4e-09	0.26	0.72	0.27	FALSE
26	METSIM	Adipose	ZNF652	0.05	0.03	lasso	8	0.05	6.2e-08	3.4	5.9	3.9e-09	-0.28	0.98	0.02	FALSE
33	The Cancer Genome Atlas	Breast Invasive Carcinoma	GNGT2	0.04	0.04	lasso	4	0.03	1.3e-07	-5.7	-5.9	4.4e-09	0.18	0.75	0.24	FALSE
48	The Cancer Genome Atlas	Prostate Adenocarcinoma	GNGT2	0.04	0.04	lasso	3	0.03	2.8e-04	-5.7	-5.8	7.0e-09	0.18	0.21	0.25	FALSE
45	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	GNGT2	0.06	0.04	lasso	2	0.04	3.5e-05	-5.7	-5.7	1.0e-08	0.17	0.22	0.09	FALSE
14	GTEx	Nerve Tibial	RP5-890E16.2	0.16	0.09	lasso	7	0.08	3.2e-06	-3.3	5.7	1.1e-08	0.02	0.15	0.85	FALSE
51	The Cancer Genome Atlas	Thyroid Carcinoma	HOXB2	0.05	0.07	blup	47	0.07	2.0e-07	5.0	-5.6	1.9e-08	0.03	0.06	0.94	FALSE
42	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	GNGT2	0.16	0.07	lasso	5	0.07	4.8e-04	-5.7	-5.5	3.1e-08	0.13	0.03	0.05	FALSE
18	GTEx	Small Intestine Terminal Ileum	SNX11	0.29	0.13	lasso	18	0.22	1.2e-05	-3.6	5.5	3.5e-08	-0.06	0.38	0.15	FALSE
5	GTEx	Adipose Visceral Omentum	HOXB2	0.12	0.16	lasso	3	0.17	3.6e-09	5.5	-5.4	5.5e-08	0.04	0.33	0.66	FALSE
20	GTEx	Spleen	HOXB-AS1	0.27	0.21	enet	25	0.19	1.5e-05	5.0	-5.4	6.0e-08	0.05	0.20	0.69	FALSE
17	GTEx	Skin Sun Exposed Lower leg	RP11-6N17.6	0.07	0.02	enet	12	0.04	1.6e-04	-3.5	5.4	7.3e-08	0.01	0.04	0.88	FALSE
19	GTEx	Spleen	HOXB2	0.36	0.19	lasso	9	0.19	1.3e-05	6.2	-5.4	7.9e-08	0.03	0.07	0.83	FALSE
53	The Cancer Genome Atlas	Thyroid Carcinoma	PRR15L	0.06	0.02	blup	60	0.04	5.2e-05	-3.5	5.3	1.1e-07	0.01	0.10	0.30	FALSE
3	GTEx	Adipose Subcutaneous	HOXB2	0.17	0.18	lasso	9	0.16	5.7e-13	5.0	-5.3	1.2e-07	0.04	0.89	0.11	FALSE
43	The Cancer Genome Atlas	Lung Adenocarcinoma	HOXB2	0.04	0.02	lasso	4	0.02	4.4e-03	5.0	-5.3	1.5e-07	0.03	0.08	0.70	FALSE
13	GTEx	Nerve Tibial	HOXB2	0.09	0.08	lasso	7	0.09	8.9e-07	6.2	-5.2	1.7e-07	0.04	0.14	0.84	FALSE
9	GTEx	Esophagus Gastroesophageal Junction	HOXB2	0.14	0.19	lasso	3	0.17	1.2e-06	5.3	-5.2	2.1e-07	0.04	0.41	0.42	FALSE
36	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	GNGT2	0.07	0.05	lasso	3	0.05	3.3e-06	-5.7	-5.2	2.4e-07	0.10	0.46	0.31	FALSE
4	GTEx	Adipose Subcutaneous	HOXB-AS1	0.14	0.08	lasso	7	0.08	7.9e-07	5.3	-5.1	2.8e-07	0.05	0.53	0.47	FALSE