Best TWAS P=1.22e-22 · Best GWAS P=1.17e-29 conditioned to 5.9e-18
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | RRP15 | 0.55 | 0.46 | enet | 22 | 0.52 | 9.0e-74 | -7.6 | -8.3 | 1.2e-16 | -0.40 | 1.00 | 0.00 | FALSE |
| 2 | GTEx | Adipose Subcutaneous | RRP15 | 0.24 | 0.14 | lasso | 2 | 0.12 | 3.2e-10 | -8.2 | -8.1 | 8.1e-16 | -0.41 | 1.00 | 0.00 | FALSE |
| 3 | GTEx | Adipose Visceral Omentum | RRP15 | 0.32 | 0.18 | lasso | 8 | 0.22 | 1.2e-11 | -7.8 | -6.7 | 2.1e-11 | -0.41 | 1.00 | 0.00 | FALSE |
| 4 | GTEx | Adrenal Gland | RRP15 | 0.41 | 0.16 | enet | 30 | 0.12 | 5.6e-05 | -8.2 | -7.2 | 7.9e-13 | -0.39 | 0.81 | 0.06 | FALSE |
| 5 | GTEx | Artery Aorta | RRP15 | 0.23 | 0.17 | lasso | 3 | 0.15 | 8.3e-09 | -8.2 | -8.2 | 2.0e-16 | -0.41 | 0.97 | 0.02 | FALSE |
| 6 | GTEx | Artery Tibial | RRP15 | 0.19 | 0.16 | lasso | 4 | 0.14 | 8.7e-11 | -7.6 | -7.7 | 1.1e-14 | -0.41 | 1.00 | 0.00 | FALSE |
| 7 | GTEx | Brain Nucleus accumbens basal ganglia | RRP15 | 0.34 | 0.25 | lasso | 4 | 0.22 | 1.9e-06 | -7.6 | -8.1 | 8.0e-16 | -0.39 | 0.44 | 0.10 | FALSE |
| 8 | GTEx | Cells Transformed fibroblasts | RRP15 | 0.38 | 0.28 | lasso | 6 | 0.28 | 1.9e-21 | -7.6 | -8.0 | 1.7e-15 | -0.41 | 1.00 | 0.00 | FALSE |
| 9 | GTEx | Esophagus Mucosa | RRP15 | 0.38 | 0.29 | lasso | 6 | 0.31 | 3.3e-21 | -8.2 | -8.4 | 4.5e-17 | -0.33 | 1.00 | 0.00 | FALSE |
| 10 | GTEx | Esophagus Muscularis | RRP15 | 0.22 | 0.23 | enet | 8 | 0.22 | 8.9e-14 | -7.6 | -6.7 | 2.0e-11 | -0.37 | 1.00 | 0.00 | FALSE |
| 11 | GTEx | Lung | RRP15 | 0.11 | 0.13 | enet | 21 | 0.13 | 2.6e-10 | -7.6 | -6.0 | 1.5e-09 | -0.36 | 1.00 | 0.00 | FALSE |
| 12 | GTEx | Muscle Skeletal | RRP15 | 0.17 | 0.15 | lasso | 2 | 0.14 | 3.9e-14 | -7.6 | -7.8 | 9.0e-15 | -0.40 | 1.00 | 0.00 | FALSE |
| 13 | GTEx | Pituitary | RRP15 | 0.38 | 0.23 | lasso | 3 | 0.23 | 1.9e-06 | -7.8 | -8.4 | 6.5e-17 | -0.42 | 0.31 | 0.14 | FALSE |
| 14 | GTEx | Skin Sun Exposed Lower leg | RRP15 | 0.17 | 0.13 | lasso | 6 | 0.12 | 4.5e-10 | -8.2 | -7.7 | 1.1e-14 | -0.35 | 1.00 | 0.00 | FALSE |
| 15 | GTEx | Testis | RRP15 | 0.70 | 0.65 | lasso | 4 | 0.64 | 6.6e-36 | -7.6 | -7.4 | 1.4e-13 | -0.35 | 1.00 | 0.00 | FALSE |
| 16 | GTEx | Thyroid | RRP15 | 0.28 | 0.16 | lasso | 7 | 0.17 | 9.8e-13 | -8.2 | -9.5 | 2.6e-21 | -0.38 | 1.00 | 0.00 | FALSE |
| 17 | METSIM | Adipose | RRP15 | 0.28 | 0.24 | bslmm | 489 | 0.23 | 1.7e-34 | -8.2 | -7.9 | 3.0e-15 | -0.40 | 1.00 | 0.00 | FALSE |
| 18 | The Cancer Genome Atlas | Breast Invasive Carcinoma | RRP15 | 0.11 | 0.11 | lasso | 5 | 0.10 | 2.5e-20 | -7.6 | -7.7 | 1.1e-14 | -0.41 | 1.00 | 0.00 | FALSE |
| 19 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | RRP15 | 0.13 | 0.13 | lasso | 1 | 0.10 | 1.4e-05 | -7.8 | -7.8 | 9.2e-15 | -0.42 | 0.75 | 0.03 | FALSE |
| 20 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | RRP15 | 0.07 | 0.07 | lasso | 2 | 0.06 | 2.0e-07 | -9.7 | -9.8 | 1.2e-22 | -0.34 | 0.98 | 0.01 | TRUE |
| 21 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | RRP15 | 0.14 | 0.04 | enet | 11 | 0.06 | 4.0e-04 | -7.6 | -5.2 | 2.6e-07 | -0.17 | 0.18 | 0.03 | FALSE |
| 22 | The Cancer Genome Atlas | Brain Lower Grade Glioma | RRP15 | 0.10 | 0.10 | lasso | 1 | 0.10 | 4.7e-11 | -7.6 | -7.6 | 3.2e-14 | -0.40 | 1.00 | 0.00 | FALSE |
| 23 | The Cancer Genome Atlas | Lung Adenocarcinoma | RRP15 | 0.09 | 0.09 | lasso | 3 | 0.09 | 3.2e-10 | -7.6 | -7.1 | 9.6e-13 | -0.36 | 1.00 | 0.00 | FALSE |
| 24 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | RRP15 | 0.10 | 0.09 | lasso | 3 | 0.08 | 9.8e-10 | -7.8 | -8.1 | 7.2e-16 | -0.43 | 1.00 | 0.00 | FALSE |
| 25 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | RRP15 | 0.15 | 0.12 | lasso | 2 | 0.12 | 1.9e-05 | -8.2 | -8.0 | 1.9e-15 | -0.41 | 0.17 | 0.13 | FALSE |
| 26 | The Cancer Genome Atlas | Prostate Adenocarcinoma | RRP15 | 0.29 | 0.29 | lasso | 2 | 0.29 | 2.7e-30 | -7.6 | -7.7 | 1.9e-14 | -0.41 | 1.00 | 0.00 | FALSE |
| 27 | The Cancer Genome Atlas | Stomach Adenocarcinoma | RRP15 | 0.11 | 0.09 | lasso | 3 | 0.07 | 8.2e-06 | -7.8 | -7.3 | 3.7e-13 | -0.41 | 0.83 | 0.02 | FALSE |
| 28 | The Cancer Genome Atlas | Thyroid Carcinoma | RRP15 | 0.22 | 0.25 | lasso | 3 | 0.24 | 1.7e-23 | -7.6 | -7.6 | 2.5e-14 | -0.41 | 1.00 | 0.00 | FALSE |
| 29 | The Cancer Genome Atlas | Uterine Corpus Endometrial Carcinoma | TGFB2 | 0.24 | 0.11 | enet | 10 | 0.14 | 1.4e-04 | 4.5 | -5.2 | 2.6e-07 | 0.03 | 0.21 | 0.04 | TRUE |