[Hub]/) : Traits : Lung FEV1/FVC ratio : ← →

chr1:217,760,821-219,208,920

Best TWAS P=1.22e-22 · Best GWAS P=1.17e-29 conditioned to 5.9e-18

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
20	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	RRP15	0.07	0.07	lasso	2	0.06	2.0e-07	-9.7	-9.8	1.2e-22	-0.34	0.98	0.01	TRUE
29	The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	TGFB2	0.24	0.11	enet	10	0.14	1.4e-04	4.5	-5.2	2.6e-07	0.03	0.21	0.04	TRUE
16	GTEx	Thyroid	RRP15	0.28	0.16	lasso	7	0.17	9.8e-13	-8.2	-9.5	2.6e-21	-0.38	1.00	0.00	FALSE
9	GTEx	Esophagus Mucosa	RRP15	0.38	0.29	lasso	6	0.31	3.3e-21	-8.2	-8.4	4.5e-17	-0.33	1.00	0.00	FALSE
13	GTEx	Pituitary	RRP15	0.38	0.23	lasso	3	0.23	1.9e-06	-7.8	-8.4	6.5e-17	-0.42	0.31	0.14	FALSE
1	CommonMind	Brain Pre-frontal Cortex	RRP15	0.55	0.46	enet	22	0.52	9.0e-74	-7.6	-8.3	1.2e-16	-0.40	1.00	0.00	FALSE
5	GTEx	Artery Aorta	RRP15	0.23	0.17	lasso	3	0.15	8.3e-09	-8.2	-8.2	2.0e-16	-0.41	0.97	0.02	FALSE
24	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	RRP15	0.10	0.09	lasso	3	0.08	9.8e-10	-7.8	-8.1	7.2e-16	-0.43	1.00	0.00	FALSE
7	GTEx	Brain Nucleus accumbens basal ganglia	RRP15	0.34	0.25	lasso	4	0.22	1.9e-06	-7.6	-8.1	8.0e-16	-0.39	0.44	0.10	FALSE
2	GTEx	Adipose Subcutaneous	RRP15	0.24	0.14	lasso	2	0.12	3.2e-10	-8.2	-8.1	8.1e-16	-0.41	1.00	0.00	FALSE
8	GTEx	Cells Transformed fibroblasts	RRP15	0.38	0.28	lasso	6	0.28	1.9e-21	-7.6	-8.0	1.7e-15	-0.41	1.00	0.00	FALSE
25	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	RRP15	0.15	0.12	lasso	2	0.12	1.9e-05	-8.2	-8.0	1.9e-15	-0.41	0.17	0.13	FALSE
17	METSIM	Adipose	RRP15	0.28	0.24	bslmm	489	0.23	1.7e-34	-8.2	-7.9	3.0e-15	-0.40	1.00	0.00	FALSE
12	GTEx	Muscle Skeletal	RRP15	0.17	0.15	lasso	2	0.14	3.9e-14	-7.6	-7.8	9.0e-15	-0.40	1.00	0.00	FALSE
19	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	RRP15	0.13	0.13	lasso	1	0.10	1.4e-05	-7.8	-7.8	9.2e-15	-0.42	0.75	0.03	FALSE
6	GTEx	Artery Tibial	RRP15	0.19	0.16	lasso	4	0.14	8.7e-11	-7.6	-7.7	1.1e-14	-0.41	1.00	0.00	FALSE
14	GTEx	Skin Sun Exposed Lower leg	RRP15	0.17	0.13	lasso	6	0.12	4.5e-10	-8.2	-7.7	1.1e-14	-0.35	1.00	0.00	FALSE
18	The Cancer Genome Atlas	Breast Invasive Carcinoma	RRP15	0.11	0.11	lasso	5	0.10	2.5e-20	-7.6	-7.7	1.1e-14	-0.41	1.00	0.00	FALSE
26	The Cancer Genome Atlas	Prostate Adenocarcinoma	RRP15	0.29	0.29	lasso	2	0.29	2.7e-30	-7.6	-7.7	1.9e-14	-0.41	1.00	0.00	FALSE
28	The Cancer Genome Atlas	Thyroid Carcinoma	RRP15	0.22	0.25	lasso	3	0.24	1.7e-23	-7.6	-7.6	2.5e-14	-0.41	1.00	0.00	FALSE
22	The Cancer Genome Atlas	Brain Lower Grade Glioma	RRP15	0.10	0.10	lasso	1	0.10	4.7e-11	-7.6	-7.6	3.2e-14	-0.40	1.00	0.00	FALSE
15	GTEx	Testis	RRP15	0.70	0.65	lasso	4	0.64	6.6e-36	-7.6	-7.4	1.4e-13	-0.35	1.00	0.00	FALSE
27	The Cancer Genome Atlas	Stomach Adenocarcinoma	RRP15	0.11	0.09	lasso	3	0.07	8.2e-06	-7.8	-7.3	3.7e-13	-0.41	0.83	0.02	FALSE
4	GTEx	Adrenal Gland	RRP15	0.41	0.16	enet	30	0.12	5.6e-05	-8.2	-7.2	7.9e-13	-0.39	0.81	0.06	FALSE
23	The Cancer Genome Atlas	Lung Adenocarcinoma	RRP15	0.09	0.09	lasso	3	0.09	3.2e-10	-7.6	-7.1	9.6e-13	-0.36	1.00	0.00	FALSE
10	GTEx	Esophagus Muscularis	RRP15	0.22	0.23	enet	8	0.22	8.9e-14	-7.6	-6.7	2.0e-11	-0.37	1.00	0.00	FALSE
3	GTEx	Adipose Visceral Omentum	RRP15	0.32	0.18	lasso	8	0.22	1.2e-11	-7.8	-6.7	2.1e-11	-0.41	1.00	0.00	FALSE
11	GTEx	Lung	RRP15	0.11	0.13	enet	21	0.13	2.6e-10	-7.6	-6.0	1.5e-09	-0.36	1.00	0.00	FALSE
21	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	RRP15	0.14	0.04	enet	11	0.06	4.0e-04	-7.6	-5.2	2.6e-07	-0.17	0.18	0.03	FALSE