Best TWAS P=5.02e-09 · Best GWAS P=8.02e-08 conditioned to 4.27e-05
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Tibial | RP11-378J18.8 | 0.06 | 0.03 | enet | 14 | 0.04 | 4.1e-04 | -4.9 | -5.8 | 5.4e-09 | -0.34 | 0.04 | 0.86 | FALSE |
| 2 | GTEx | Brain Hypothalamus | RP11-378J18.8 | 0.28 | 0.17 | lasso | 6 | 0.07 | 8.9e-03 | -5.2 | -5.5 | 3.4e-08 | -0.25 | 0.03 | 0.69 | FALSE |
| 3 | GTEx | Colon Sigmoid | RP11-378J18.8 | 0.29 | 0.09 | lasso | 5 | 0.10 | 2.7e-04 | -5.1 | -5.1 | 2.7e-07 | -0.26 | 0.04 | 0.88 | FALSE |
| 4 | GTEx | Esophagus Gastroesophageal Junction | RP11-378J18.8 | 0.19 | 0.05 | lasso | 9 | 0.05 | 6.4e-03 | -5.1 | -5.5 | 3.3e-08 | -0.27 | 0.03 | 0.93 | FALSE |
| 5 | GTEx | Nerve Tibial | MIA3 | 0.08 | 0.00 | lasso | 4 | 0.01 | 6.6e-02 | -4.9 | -5.2 | 1.6e-07 | -0.28 | 0.04 | 0.85 | FALSE |
| 6 | GTEx | Nerve Tibial | RP11-378J18.8 | 0.13 | 0.13 | lasso | 7 | 0.11 | 3.0e-08 | -4.9 | -5.4 | 7.8e-08 | -0.30 | 0.05 | 0.94 | FALSE |
| 7 | GTEx | Pancreas | RP11-378J18.8 | 0.26 | 0.07 | enet | 20 | 0.13 | 5.2e-06 | -5.1 | -5.8 | 5.0e-09 | -0.24 | 0.03 | 0.92 | TRUE |
| 8 | GTEx | Skin Sun Exposed Lower leg | RP11-378J18.8 | 0.10 | 0.08 | lasso | 4 | 0.07 | 8.8e-07 | -4.9 | -5.5 | 4.2e-08 | -0.25 | 0.05 | 0.94 | FALSE |
| 9 | GTEx | Thyroid | RP11-378J18.8 | 0.08 | 0.01 | enet | 22 | 0.03 | 3.1e-03 | -5.1 | -5.5 | 4.9e-08 | -0.47 | 0.03 | 0.90 | FALSE |