Best TWAS P=8.75e-10 · Best GWAS P=2.61e-08 conditioned to 0.293
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | STRA13 | 0.45 | 0.38 | lasso | 4 | 0.40 | 1.6e-51 | -5.2 | 5.3 | 9.0e-08 | -0.95 | 0.02 | 0.97 | FALSE |
2 | GTEx | Adipose Subcutaneous | STRA13 | 0.28 | 0.26 | lasso | 3 | 0.26 | 5.0e-21 | -5.2 | 5.2 | 2.0e-07 | -0.92 | 0.02 | 0.98 | FALSE |
3 | GTEx | Adipose Visceral Omentum | STRA13 | 0.18 | 0.15 | lasso | 4 | 0.14 | 8.0e-08 | -5.2 | -5.3 | 1.3e-07 | 0.91 | 0.02 | 0.98 | FALSE |
4 | GTEx | Artery Aorta | STRA13 | 0.20 | 0.14 | enet | 16 | 0.11 | 7.9e-07 | -5.2 | 6.1 | 8.7e-10 | -0.81 | 0.02 | 0.97 | TRUE |
5 | GTEx | Artery Tibial | STRA13 | 0.37 | 0.22 | enet | 14 | 0.22 | 1.6e-17 | -5.2 | 6.0 | 1.6e-09 | -0.89 | 0.02 | 0.98 | FALSE |
6 | GTEx | Cells Transformed fibroblasts | STRA13 | 0.19 | 0.23 | lasso | 1 | 0.22 | 4.9e-16 | -5.2 | 5.2 | 2.4e-07 | -0.92 | 0.02 | 0.98 | FALSE |
7 | GTEx | Colon Sigmoid | STRA13 | 0.36 | 0.26 | enet | 16 | 0.24 | 3.9e-09 | -5.2 | 5.2 | 2.5e-07 | -0.89 | 0.01 | 0.99 | FALSE |
8 | GTEx | Colon Transverse | STRA13 | 0.26 | 0.08 | enet | 18 | 0.05 | 1.6e-03 | -5.2 | 5.5 | 4.4e-08 | -0.74 | 0.02 | 0.96 | FALSE |
9 | GTEx | Esophagus Mucosa | STRA13 | 0.19 | 0.14 | lasso | 2 | 0.12 | 2.8e-08 | -5.2 | 5.5 | 3.8e-08 | -0.91 | 0.02 | 0.98 | FALSE |
10 | GTEx | Esophagus Muscularis | STRA13 | 0.40 | 0.33 | lasso | 2 | 0.32 | 4.2e-20 | -5.2 | 5.2 | 2.1e-07 | -0.92 | 0.02 | 0.98 | FALSE |
11 | GTEx | Heart Atrial Appendage | STRA13 | 0.25 | 0.15 | enet | 4 | 0.16 | 1.2e-07 | -5.0 | 5.3 | 1.2e-07 | -0.95 | 0.01 | 0.99 | FALSE |
12 | GTEx | Lung | STRA13 | 0.16 | 0.16 | lasso | 3 | 0.15 | 1.2e-11 | -5.2 | 5.3 | 9.0e-08 | -0.95 | 0.02 | 0.98 | FALSE |
13 | GTEx | Muscle Skeletal | STRA13 | 0.20 | 0.09 | lasso | 6 | 0.10 | 5.4e-10 | -5.2 | 5.5 | 2.9e-08 | -0.97 | 0.00 | 1.00 | FALSE |
14 | GTEx | Nerve Tibial | STRA13 | 0.18 | 0.17 | enet | 2 | 0.12 | 1.4e-08 | -5.2 | 5.2 | 2.4e-07 | -0.92 | 0.02 | 0.98 | FALSE |
15 | GTEx | Skin Not Sun Exposed Suprapubic | STRA13 | 0.23 | 0.18 | enet | 5 | 0.10 | 6.6e-06 | -5.2 | 5.7 | 1.1e-08 | -0.92 | 0.02 | 0.98 | FALSE |
16 | GTEx | Skin Sun Exposed Lower leg | STRA13 | 0.12 | 0.13 | lasso | 3 | 0.12 | 7.9e-10 | -5.2 | 5.1 | 2.8e-07 | -0.92 | 0.02 | 0.98 | FALSE |
17 | GTEx | Thyroid | STRA13 | 0.40 | 0.34 | lasso | 5 | 0.34 | 2.3e-26 | -5.2 | 5.1 | 3.0e-07 | -0.92 | 0.02 | 0.98 | FALSE |
18 | The Cancer Genome Atlas | Thyroid Carcinoma | STRA13 | 0.07 | 0.12 | lasso | 6 | 0.10 | 3.2e-10 | -5.6 | 5.3 | 1.4e-07 | -0.99 | 0.00 | 1.00 | FALSE |