TWAS
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Traits
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Lung FEV1/FVC ratio
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chr20:24,532,613-26,307,797
Best TWAS P=6.22e-09 · Best GWAS P=9.4e-09 conditioned to 0.173
24.6M
24.8M
25M
25.2M
25.4M
25.6M
25.8M
26M
26.2M
26.4M
0
2
4
6
8
physical position
-log10 P
Conditional
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
2
GTEx
Brain Cerebellum
CTD-2514C3.1
0.21
0.05
lasso
5
0.15
3.5e-05
-5.7
5.8
6.2e-09
-0.87
0.01
0.94
TRUE
4
GTEx
Esophagus Mucosa
PYGB
0.12
0.01
enet
19
0.02
9.7e-03
-5.0
-5.5
4.2e-08
0.54
0.02
0.87
FALSE
5
GTEx
Esophagus Muscularis
PYGB
0.22
0.19
enet
13
0.21
1.1e-12
-5.1
-5.5
4.9e-08
0.54
0.02
0.98
FALSE
3
GTEx
Breast Mammary Tissue (Female)
VN1R108P
0.15
0.11
lasso
6
0.09
1.5e-03
-5.3
-5.3
1.3e-07
0.62
0.02
0.86
FALSE
1
GTEx
Artery Tibial
PYGB
0.13
0.01
enet
21
0.08
4.2e-07
-5.1
-5.2
2.3e-07
0.57
0.03
0.90
FALSE