TWAS hub - VN1R108P

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Breast Mammary Tissue	0.1050	0.0520	0.00057	0.034	NA	0.048	NA	0.038	0.00720	NA	0.0017	NA	0.0047
2	GTEx	Breast Mammary Tissue (Male)	0.0217	0.0490	0.34000	-0.005	NA	0.023	NA	0.021	0.44000	NA	0.0980	NA	0.1100
3	GTEx	Breast Mammary Tissue (Female)	0.1502	0.0832	0.00330	0.106	NA	0.058	NA	0.086	0.00046	NA	0.0084	NA	0.0015
4	GTEx	Thyroid	0.0460	0.0280	0.00180	0.013	NA	0.010	NA	0.017	0.03000	NA	0.0550	NA	0.0180
5	ROSMAP	Brain Pre-frontal Cortex	0.0499	0.0288	0.00540	0.009	0.018	0.005	0.018	0.010	0.02400	0.0021	0.0760	0.0021	0.0140

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	3	4	5
Forced expiratory volume in 1-second (FEV1), predicted percentage	6.8	14.3	35.1	-4.0	-4.3	-5.9	-1.4
Loneliness, isolation	5.2	7.2	9.9	3.0	3.1	2.9	2.9
Smoking Status	4.7	11.3	17.5	3.8	4.0	4.2	2.8
Blood Red Count	4.1	39.2	60.8	-7.3	-7.7	-4.7	-7.8
Forced expiratory volume in 1-second (FEV1), Best measure	4.0	12.7	28.3	-4.0	-4.0	-5.3	-1.8
Respiratory disease	3.9	8.7	13.1	3.6	3.5	3.2	2.8
Lung FVC	3.8	19.2	41.5	-5.1	-5.0	-6.4	-1.8
Forced expiratory volume in 1-second (FEV1)	3.8	12.7	26.2	-4.2	-4.1	-5.1	-1.5
Medication: Ventolin 100micrograms inhaler	3.6	4.7	7.5	2.6	2.7	2.6	1.5
Lung FEV1/FVC ratio	3.5	17.6	27.8	-5.0	-5.3	-4.3	-4.0
Asthma (self-reported)	3.5	7.0	10.6	3.1	3.3	3.1	2.2
Wheeze or whistling in the chest in last year	3.2	5.7	11.8	2.4	2.6	3.4	2.0
Chronic bronchitis/emphysema (father)	3.0	3.6	7.2	2.7	2.4	2.2	-0.4
Number of live births	3.0	4.2	9.0	2.4	2.4	3.0	0.7
Diabetes (father)	2.9	3.5	6.7	-2.1	-2.3	-2.6	-1.2
Asthma	2.9	5.6	8.7	2.7	2.9	2.9	1.9
Number of full sisters	2.9	3.6	5.9	2.2	2.4	1.8	2.0
Unable to work because of sickness or disability	2.8	3.6	5.5	-1.9	-2.0	-2.2	-2.3
Pack years adult smoking proportion	2.7	4.1	9.0	2.4	2.4	3.0	0.2
Diverticular disease/diverticulitis (self-reported)	2.7	3.2	5.3	2.3	2.0	2.0	1.7
Mouth/teeth dental problems	2.7	4.1	8.6	-2.0	-2.1	-1.8	-2.9
Mouth/teeth dental problems: Bleeding gums	2.5	3.2	5.0	2.1	2.0	1.6	2.2
Forced vital capacity (FVC), Best measure	2.4	8.6	19.9	-3.2	-3.2	-4.5	-1.6
Emphysema/chronic bronchitis	2.4	2.7	5.1	2.2	2.2	1.8	0.5
Peak expiratory flow (PEF)	2.3	5.4	9.9	-2.9	-3.0	-3.1	-0.1
Guilty feelings	2.3	3.5	7.0	2.6	2.2	1.5	1.8
Other serious medical condition/disability diagnosed by doctor	2.2	2.9	5.3	-1.8	-2.3	-2.2	-1.2
Qualifications: O levels/GCSEs or equivalent	2.2	3.5	6.6	-2.6	-2.1	-2.3	-1.3
Medication: Paracetamol	2.2	3.7	6.3	-2.3	-2.2	-2.5	-1.5
Body fat percentage	2.2	8.8	31.2	2.5	2.5	5.6	-0.3
Average weekly champagne plus white wine intake	2.2	3.0	4.8	-1.7	-2.0	-1.7	-2.2
Trunk fat percentage	2.1	8.4	30.5	2.4	2.3	5.5	-0.6
Exposure to tobacco smoke at home	2.1	2.3	4.4	1.8	1.8	2.1	0.9
Leg fat percentage (right)	2.1	7.5	27.6	2.1	2.3	5.2	0.5
Age at first live birth	2.1	3.7	7.6	-1.8	-2.4	-2.8	-1.2
Mood swings	2.1	3.8	8.8	3.0	2.2	2.2	0.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.1	2.5	7.6	-1.3	-1.6	-2.8	-0.8
Pack years of smoking	2.1	3.1	8.1	1.8	2.0	2.8	-0.2
Systolic Blood Pressure	2.0	9.8	15.9	-4.0	-3.7	-3.5	-2.7
Past tobacco smoking	2.0	3.6	6.0	-1.9	-2.3	-1.8	-2.4
Forced vital capacity (FVC)	2.0	7.8	18.4	-3.2	-3.0	-4.3	-0.9
Worry too long after embarrassment	2.0	3.3	5.7	2.4	2.0	1.1	2.4
Chest pain or discomfort	2.0	2.9	5.4	2.3	2.2	2.1	0.1
Miserableness	2.0	3.4	5.8	2.4	2.0	2.0	1.8
Leg fat percentage (left)	2.0	7.2	25.3	2.2	2.4	5.0	0.6
Depressed Affect (Nagel 2018)	1.9	3.9	6.6	2.5	2.4	2.6	1.2
Medication: Lansoprazole	1.9	2.2	4.6	1.7	1.8	0.6	2.1
Age at First Birth	1.8	2.6	7.4	-1.4	-1.1	-2.7	1.5
Alcohol intake versus 10 years previously	1.8	2.7	7.1	-1.3	-1.7	-1.4	-2.7
Medication: Blood pressure	1.8	3.2	7.0	-2.6	-2.0	-2.0	-0.9
Frequency of unenthusiasm / disinterest in last 2 weeks	1.6	2.2	4.5	2.1	1.6	1.7	0.9
Trunk fat mass	1.6	6.8	26.9	1.8	1.8	5.2	-0.7
Mouth/teeth dental problems: Dentures	1.6	2.8	5.7	2.2	1.8	2.4	0.2
Comparative body size at age 10	1.6	4.5	10.0	1.8	2.7	3.2	1.6
Heart attack/myocardial infarction (self-reported)	1.6	2.0	5.0	-2.2	-1.7	-0.9	-1.2
Systolic blood pressure, automated reading	1.5	4.5	11.1	-2.2	-2.4	-0.9	-3.3
Diabetes (mother)	1.5	1.9	5.2	-2.3	-1.6	-1.1	-0.6
Had menopause	1.5	1.8	7.9	-0.7	-0.9	0.2	-2.8
Heart attack	1.5	1.9	4.3	-2.1	-1.7	-0.7	-1.3
Arm fat percentage (right)	1.5	6.1	22.0	2.1	1.9	4.7	0.1
Noisy workplace	1.5	1.9	2.9	-1.5	-1.6	-1.7	-1.3
Whole body fat mass	1.5	6.4	25.4	1.8	1.8	5.0	-0.5
Supplements: Calcium	1.5	1.7	3.9	-1.0	-1.6	-0.9	-2.0
Neuroticism score	1.4	3.0	6.8	2.6	1.9	1.4	1.6
Mouth/teeth dental problems: Loose teeth	1.4	1.6	5.4	0.2	1.2	1.2	2.3
Leg fat mass (right)	1.4	5.4	21.8	1.5	1.7	4.7	-0.2
Pulse rate, automated reading	1.4	4.5	13.2	-1.8	-2.2	-1.0	-3.6
Smoking status: Previous	1.4	2.0	4.9	1.1	1.7	1.1	2.2
Smoking status: Current	1.4	2.2	4.9	2.0	1.5	2.2	-0.1
Medication: Paracetamol	1.4	2.1	3.1	-1.4	-1.6	-1.8	-1.7
HDL Cholesterol	1.3	2.2	4.8	2.2	1.8	0.6	1.6
Neuroticism	1.3	3.2	5.6	2.4	2.0	2.1	1.5
Depression (self-reported)	1.3	1.6	3.6	1.9	1.6	0.9	0.9
Had major operations	1.3	1.5	2.8	-1.7	-1.4	-1.6	-0.0
Arm fat percentage (left)	1.3	5.1	20.0	1.8	1.6	4.5	-0.3
Leg fat mass (left)	1.3	5.0	20.3	1.5	1.6	4.5	-0.1
Prostate Cancer	1.2	1.6	5.7	-0.2	0.7	-1.4	2.4
Ever used hormone-replacement therapy (HRT)	1.2	1.5	4.5	1.3	1.1	2.1	-0.6
Stomach or abdominal pain in last month	1.2	1.4	4.1	-2.0	-1.3	-1.1	-0.5
Medication for cholesterol, blood pressure or diabetes	1.2	2.0	4.8	2.2	1.5	1.6	0.5
Chronic bronchitis/emphysema (mother)	1.2	1.4	3.6	1.1	1.3	1.9	0.7
Fasting Glucose	1.1	1.3	2.7	-1.2	-1.5	-1.6	0.2
LDL Cholesterol	1.1	1.7	6.8	1.1	0.8	2.6	-0.3
Blood White Count	1.1	7.8	13.7	3.6	3.1	3.7	1.7
Current tobacco smoking	1.1	1.9	4.8	1.7	1.2	2.2	-0.3
Waist circumference	1.1	3.9	15.3	1.4	1.2	3.9	-0.8
Frequency of tenseness / restlessness in last 2 weeks	1.1	1.7	3.9	2.0	1.5	1.5	0.4
Hearing difficulty/problems with background noise	1.1	1.7	6.2	1.1	1.1	-0.4	2.5
Ever unenthusiastic/disinterested for a whole week	1.1	1.3	2.3	1.5	1.3	0.5	1.5
Medication: Ramipril	1.1	1.4	2.7	-1.3	-1.3	-0.9	-1.6
Arm fat mass (right)	1.1	4.7	19.5	1.4	1.4	4.4	-0.2
Pulse wave reflection index	1.1	1.3	5.7	0.4	0.8	0.1	2.4
Eye problems/disorders: None of the above	1.1	1.2	3.6	-1.9	-1.2	-1.0	0.4
Commuting to job workplace: Car/motor vehicle	1.1	1.2	2.2	-1.5	-1.4	-0.6	-1.2
Forced expiratory volume in 1-second (FEV1), predicted	1.1	2.3	3.6	1.8	1.9	1.3	1.6
Ever had stillbirth, spontaneous miscarriage or termination	1.1	1.2	2.0	-1.4	-1.4	-1.2	-0.7
Arm fat mass (left)	1.1	4.5	18.7	1.3	1.3	4.3	-0.5
Reaction Time	1.0	1.8	3.8	1.8	1.4	1.9	0.1
Mean Putamen Volume	1.0	1.1	2.5	-0.6	-1.2	-1.6	-1.0
Tanning	1.0	11.8	23.9	4.0	3.7	2.5	4.9
High blood pressure (mother)	1.0	1.4	3.1	-0.5	-1.5	-1.1	-1.8
Qualifications: nursing, teaching	1.0	1.5	3.2	1.8	1.7	1.1	0.4
Ever smoked	1.0	1.7	2.8	1.5	1.7	1.3	1.4
Alcohol usually taken with meals	0.9	1.5	2.5	-1.2	-1.3	-1.6	-1.2
Length of working week for main job	0.9	1.0	2.2	1.1	1.1	1.5	0.4
Loud music exposure frequency	0.9	1.0	1.4	-1.0	-1.0	-1.2	-1.2
Osteoporosis (self-reported)	0.9	1.1	4.4	-0.2	-0.9	0.3	-2.1
Medication: Lisinopril	0.9	1.1	3.3	-1.8	-1.0	-0.7	1.0
Age started oral contraceptive pill	0.9	1.1	3.1	-0.4	-0.9	-1.3	-1.8
Heart disease (siblings)	0.9	1.1	3.0	-1.0	-1.2	-0.1	-1.7
Breast Cancer	0.8	1.9	5.0	1.6	1.3	2.2	0.3
Vitamin and mineral supplements	0.8	1.1	2.8	1.1	1.0	1.7	0.6
Qualifications: CSEs or equivalent	0.8	1.0	2.7	-0.7	-1.3	-0.5	-1.6
Sitting height	0.8	5.9	17.2	2.4	2.2	4.2	-1.3
Weight	0.8	3.8	16.5	1.1	1.1	4.1	-0.7
Falls in the last year	0.8	1.0	3.5	-0.1	0.2	-1.9	1.3
Happiness	0.8	0.9	1.5	-1.2	-1.2	-1.2	-0.6
Angina (self-reported)	0.8	1.1	1.9	1.3	1.3	1.4	0.3
Qualifications: NVQ or HND or HNC or equivalent	0.8	0.9	2.3	1.5	1.0	1.1	-0.0
Osteoarthritis (self-reported)	0.8	1.0	2.2	-0.4	-1.3	-1.5	-1.0
Illnesses of father: High blood pressure	0.8	1.0	1.8	-0.9	-1.3	-1.1	-1.0
Myopia	0.8	1.1	2.2	-1.3	-1.5	-1.3	-0.0
Neuroticism (Nagel 2018)	0.7	1.7	4.0	2.0	1.5	1.5	0.5
Schizophrenia (2018)	0.7	1.4	2.7	-1.4	-1.7	-0.5	-1.4
Schizophrenia vs Biploar Disorder	0.7	0.9	2.2	-0.8	-1.2	-0.6	-1.5
Alzheimer’s Disease (in father)	0.7	0.8	1.8	-0.9	-1.0	-1.3	-0.4
Ulcerative Colitis (UC)	0.7	1.2	2.9	-1.1	-1.3	-1.7	-0.5
Lupus	0.7	1.1	2.6	-1.6	-1.4	-0.7	-0.7
Type 2 Diabetes (T2D) (2012)	0.7	0.8	1.8	-0.8	-1.3	-1.2	-0.3
BMI	0.7	4.0	16.9	1.0	1.4	4.1	0.2
Number of treatments/medications taken	0.7	1.2	1.8	-1.3	-1.2	-1.3	-1.0
High blood pressure	0.7	2.0	3.6	-1.9	-1.6	-1.4	-1.4
Hayfever, allergic rhinitis or eczema	0.7	1.5	4.8	-0.6	-0.8	-2.2	1.2
Illnesses of mother	0.7	0.8	2.8	0.6	1.0	0.2	1.7
Headache pain in last month	0.7	1.2	2.8	-1.2	-1.2	-1.7	0.3
Glaucoma (self-reported)	0.7	0.8	1.7	-0.8	-0.5	-1.3	1.1
Mean time to correctly identify matches	0.7	1.4	3.0	1.5	1.1	1.7	-0.4
Family relationship satisfaction	0.7	0.8	1.4	1.1	1.2	0.6	1.1
Illnesses of siblings: Diabetes	0.7	0.9	1.9	-1.0	-1.4	-0.9	-0.8
Commuting to job workplace: Walk	0.7	0.8	2.8	-0.5	-0.9	-1.7	0.2
Breast cancer (self-reported)	0.7	0.8	2.5	-0.7	-0.9	-1.6	-0.7
Tinnitus: Yes, now most or all of the time	0.7	0.8	1.9	-0.4	-0.8	-1.4	-1.1
Medication: Atorvastatin	0.7	0.9	3.2	-0.7	-0.9	-0.3	-1.8
Ever depressed for a whole week	0.7	0.9	1.6	1.0	1.3	0.3	1.3
Schizophrenia (2014)	0.6	1.4	3.3	-1.4	-1.8	-0.5	-1.1
Hand grip strength (left)	0.6	1.6	4.2	-2.0	-1.3	-1.2	0.7
Hearing difficulty/problems: Yes	0.6	0.9	2.3	1.1	1.0	-0.0	1.5
Eye problems/disorders: Diabetes related eye disease	0.6	0.7	1.3	1.0	0.3	1.1	-1.0
Angina	0.6	0.8	1.4	1.1	1.1	1.2	0.2
Maternal smoking around birth	0.6	0.9	3.6	0.6	0.8	1.9	-0.2
Medication: Levothyroxine sodium	0.6	1.0	1.9	-1.2	-1.1	-1.4	0.7
Body mass index (BMI)	0.6	2.6	12.0	0.6	0.8	3.5	-0.3
Nervous feelings	0.6	1.2	2.3	-0.7	-1.5	-1.4	-1.1
Financial difficulties in last 2 years	0.6	0.8	3.1	0.7	0.6	0.5	1.8
Allergy	0.6	1.3	4.2	-1.1	-1.1	-0.1	-2.0
Illnesses of siblings	0.6	0.9	1.5	1.2	1.2	0.5	1.1
Father’s age at death	0.6	0.8	1.7	-0.3	-0.9	-1.3	-1.2
Prospective memory result	0.6	0.7	1.5	-1.2	-1.1	-0.9	0.0
Ever highly irritable/argumentative for 2 days	0.6	0.7	1.4	1.0	1.1	1.2	0.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.6	0.7	1.6	-0.5	-1.0	-0.8	-1.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.6	0.7	1.2	-1.1	-1.0	-0.8	-0.8
Wears glasses or contact lenses	0.6	0.7	1.9	-0.5	-0.9	-1.4	-0.6
Commuting to job workplace: Public transport	0.6	0.7	1.5	-1.0	-1.2	-1.0	-0.2
Ever had prostate specific antigen (PSA) test	0.6	0.7	1.4	-1.2	-1.0	-0.9	0.5
Bipolar Disorder or Schizophrenia	0.5	1.2	3.0	-1.1	-1.3	0.1	-1.7
Alzheimer’s Disease (in mother)	0.5	0.6	1.7	0.3	0.9	0.3	1.3
Triglycerides	0.5	0.9	1.9	-1.1	-1.4	-1.0	-0.7
Allergy or Eczema	0.5	1.2	5.3	-0.2	-0.7	-2.3	0.4
Supplements: Zinc	0.5	0.6	1.8	-1.4	-0.7	-0.5	0.4
Townsend deprivation index at recruitment	0.5	0.7	1.5	1.2	0.6	1.2	0.4
Tinnitus: Yes, but not now, but have in the past	0.5	0.6	1.6	1.3	0.7	0.9	0.1
Supplements: Glucosamine	0.5	0.6	1.6	-0.9	-0.8	-0.3	-1.3
Hayfever/allergic rhinitis (self-reported)	0.5	0.7	1.4	-0.9	-1.1	-1.2	-0.3
Hip circumference	0.5	2.1	9.0	0.9	1.0	3.0	0.0
Pulse rate	0.5	0.9	2.0	-1.4	-1.2	-0.7	-0.7
Tense / ‘highly strung’	0.5	0.8	1.6	1.3	1.0	0.4	1.0
Birth weight of first child	0.5	0.9	2.0	1.1	1.1	1.4	-0.1
Number of full brothers	0.5	0.6	1.2	1.0	0.8	1.1	-0.3
Shortness of breath walking on level ground	0.5	0.6	1.2	1.1	0.9	0.8	-0.7
Qualifications: College or University degree	0.5	1.5	4.1	-1.3	-1.3	-2.0	0.2
Medication for pain relief, constipation, heartburn	0.5	0.8	1.5	1.2	0.8	1.2	0.5
Age at last live birth	0.5	0.7	1.8	-0.7	-1.0	-1.3	-0.4
Long-standing illness, disability or infirmity	0.5	0.8	1.7	-1.0	-1.1	-1.3	0.2
Eye problems/disorders: Cataract	0.5	0.5	2.0	1.4	0.6	0.6	0.1
Mineral and other dietary supplements	0.5	0.7	1.3	-1.1	-1.1	-0.1	-0.9
Illnesses of father: None of the above (group 1)	0.5	0.6	2.3	0.6	0.6	0.4	1.5
Alcohol drinker status: Never	0.5	0.6	1.9	1.4	0.3	0.3	-0.9
Average weekly beer plus cider intake	0.5	0.7	1.2	0.7	1.0	1.1	0.8
Vascular/heart problems diagnosed by doctor	0.5	1.4	2.9	1.7	1.3	0.9	1.3
Ovarian Cancer	0.4	0.5	1.2	0.9	0.4	1.1	-0.7
Coronary Artery Disease (CAD)	0.4	0.5	1.1	1.0	1.1	0.6	0.4
Neuroticism (2016)	0.4	0.5	1.5	0.8	0.2	-0.7	1.2
Rheumatoid Arthritis	0.4	0.5	1.3	1.1	0.7	0.9	-0.2
Ulcerative Colitis	0.4	0.6	2.2	-0.5	-0.6	-1.5	0.1
Blood Platelet Count	0.4	4.1	16.7	0.3	1.7	4.1	-0.8
Waist Hip Ratio (WHR)	0.4	1.6	3.7	1.4	0.8	1.9	-1.3
Average weekly fortified wine intake	0.4	0.5	1.5	1.2	0.9	0.3	0.0
Multivitamins +/- minerals	0.4	0.5	1.7	-0.5	-0.3	-1.3	0.4
Impedance of arm (right)	0.4	1.9	5.2	2.3	1.6	1.2	0.6
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.7	1.6	-0.6	-1.3	-0.7	-1.0
Breastfed as a baby	0.4	0.5	1.6	-0.5	-0.2	-1.3	0.7
Birth weight	0.4	0.9	1.7	-1.2	-1.3	0.1	-1.2
Neck or shoulder pain in last month	0.4	0.6	1.6	-1.0	-0.8	-1.3	0.1
Migraine (self-reported)	0.4	0.5	1.6	-0.6	-0.8	-1.3	-0.3
Heart disease (mother)	0.4	0.4	1.8	0.1	-0.2	0.6	-1.3
Alcohol intake frequency.	0.4	0.9	3.2	-0.1	-0.7	-1.0	-1.8
Supplements: Vitamin C	0.4	0.4	1.9	-0.1	-0.3	0.4	-1.4
Hypertension (Self-reported)	0.4	1.2	2.2	-1.5	-1.2	-1.1	-1.3
Handedness (chirality/laterality): Left-handed	0.4	0.5	1.8	-0.0	-0.5	-0.8	-1.3
Mouth/teeth dental problems: Mouth ulcers	0.4	0.7	2.9	-0.0	0.3	-0.7	1.7
Medication: Aspirin	0.4	0.5	1.8	0.5	0.7	1.3	-0.3
Number of operations (self-reported)	0.4	0.6	1.6	-0.4	-0.8	-0.7	-1.2
Diastolic blood pressure, automated reading	0.4	1.2	2.4	-1.3	-1.3	-0.7	-1.5
Deep venous thrombosis (DVT) (self-reported)	0.4	0.5	1.3	-1.1	-1.0	-0.0	-0.6
Depression (Nagel 2018)	0.3	0.4	1.0	1.0	0.5	0.8	-0.6
Alzheimer’s Disease (including proxy)	0.3	0.5	2.0	-0.0	0.6	-0.1	1.4
Bipolar Disorder (2011)	0.3	0.3	0.5	-0.7	-0.1	0.6	0.7
Body Mass Index (BMI) (2010)	0.3	0.4	1.4	0.5	0.3	1.2	-0.6
Chronotype (morning person)	0.3	0.6	1.0	-1.0	-0.9	-1.0	-0.6
Medication for hormone replacement therapy	0.3	0.4	1.3	-0.3	-0.1	-0.6	1.2
Medication: Co-codamol	0.3	0.3	0.6	0.8	0.7	-0.5	0.3
Hand grip strength (right)	0.3	0.9	2.1	-1.5	-1.2	-0.9	-0.1
Age when periods started (menarche)	0.3	0.8	3.7	-0.4	-0.2	-0.3	-1.9
Leg predicted mass (left)	0.3	1.4	6.1	0.3	0.4	2.5	-0.7
Had other major operations	0.3	0.3	1.1	-0.2	-0.5	-0.5	-1.1
Medication: Simvastatin	0.3	0.4	0.8	0.6	0.8	0.9	0.5
Hair/balding pattern: Pattern 3	0.3	0.4	2.0	-0.0	-0.2	-0.1	-1.4
Qualifications: A levels/AS levels or equivalent	0.3	0.6	1.8	-1.3	-0.9	-0.6	-0.1
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.3	0.9	-0.8	0.1	-0.4	0.9
Pulse wave Arterial Stiffness index	0.3	0.4	1.1	0.5	0.6	0.5	1.0
Blood clot in the leg (DVT)	0.3	0.4	1.0	-1.0	-0.9	-0.2	-0.6
Gout (self-reported)	0.3	0.4	1.0	-0.7	0.0	0.7	1.0
Exposure to tobacco smoke outside home	0.3	0.4	1.1	0.3	1.0	1.0	0.2
Pulse wave peak to peak time	0.3	0.4	1.4	-0.3	-0.6	-0.3	-1.2
Health satisfaction	0.3	0.4	1.9	-0.0	0.1	-0.4	1.4
Medication: Seretide 50 evohaler	0.3	0.3	0.9	1.0	0.6	0.4	-0.5
Overall health rating	0.3	0.6	1.7	-1.3	-1.0	-0.4	0.3
Medication: Aspirin	0.3	0.5	1.7	0.2	0.7	1.3	-0.3
Knee pain experienced in last month	0.3	0.5	1.2	0.6	1.0	1.1	0.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.3	1.1	-0.3	0.2	-0.7	1.1
Ever had bowel cancer screening	0.3	0.4	0.9	-0.6	-0.6	-0.9	0.6
Medication: Gliclazide	0.3	0.3	0.8	-0.5	-0.5	-0.9	0.4
Ever taken oral contraceptive pill	0.3	0.3	0.6	0.1	0.6	0.7	0.8
Mother’s age at death	0.3	0.4	0.9	-0.5	-0.8	0.0	-0.9
Eye problems/disorders: Glaucoma	0.3	0.4	1.1	-0.7	-0.1	-0.6	1.0
Medication: Blood pressure	0.3	0.6	1.3	-0.8	-0.8	-1.1	-0.6
Supplements: Fish oil (including cod liver oil)	0.3	0.4	0.8	0.4	0.4	-0.9	0.8
Fractured/broken bones in last 5 years	0.3	0.4	1.1	-0.2	-0.1	-1.1	0.9
Cholesterol lowering medication	0.3	0.4	0.6	0.7	0.8	0.8	-0.6
Impedance of whole body	0.3	1.7	3.8	2.0	1.6	1.3	0.5
Bipolar Disorder (2018)	0.2	0.3	1.0	0.0	0.0	0.8	-1.0
Crohns Disease (2017)	0.2	0.5	1.4	0.9	0.6	1.2	-0.1
Verbal and Numeric Reasoning (VNR)	0.2	0.4	1.7	-0.1	0.5	1.3	-0.2
Crohns Disease (2012)	0.2	0.3	0.9	0.5	0.4	0.9	0.3
Primary Biliary Cirrhosis	0.2	0.3	1.4	-0.4	-0.1	0.1	1.2
Heel T-Score	0.2	1.9	3.5	1.8	1.7	-0.2	1.9
Cardiovascular Disease	0.2	0.8	2.0	-1.4	-0.8	-0.7	-0.9
Hair Pigment	0.2	4.3	15.8	-1.8	-1.5	-0.7	-4.0
Average weekly spirits intake	0.2	0.2	0.6	0.4	0.5	0.8	-0.1
Sensitivity / hurt feelings	0.2	0.4	1.5	1.2	0.4	0.4	0.0
Severe depression (siblings)	0.2	0.3	1.1	0.1	0.4	1.0	0.3
Leg fat-free mass (left)	0.2	1.3	6.0	0.3	0.3	2.4	-0.7
Bilateral oophorectomy (both ovaries removed)	0.2	0.2	0.7	0.5	0.3	0.3	-0.8
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.4	0.8	0.9	0.8	-0.4	0.7
Medication: Atenolol	0.2	0.3	0.6	-0.4	-0.3	-0.6	0.8
Impedance of leg (left)	0.2	0.9	1.8	1.1	1.4	0.5	1.1
Number of incorrect matches in round	0.2	0.4	1.5	0.4	-0.1	0.6	-1.2
Qualifications: None of the above	0.2	0.5	0.9	0.8	0.9	1.0	-0.2
Diabetes (self-reported)	0.2	0.3	0.6	0.1	-0.7	-0.8	-0.5
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.3	0.9	-0.4	-0.2	-0.4	-0.9
Medication: Cholesterol lowering	0.2	0.3	0.9	-0.9	-0.5	-0.1	-0.4
Impedance of arm (left)	0.2	0.8	2.4	1.6	1.0	0.6	0.0
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.3	1.0	0.4	0.3	-0.1	1.0
High blood pressure (siblings)	0.2	0.2	0.7	-0.8	-0.4	-0.5	-0.5
Arm fat-free mass (right)	0.2	1.1	2.0	-1.2	-0.8	1.2	-1.4
Arm predicted mass (right)	0.2	0.8	2.3	-0.8	-0.3	1.5	-1.0
Leg pain on walking	0.2	0.2	0.5	0.5	0.5	0.7	0.2
Illness, injury, bereavement, stress in last 2 years	0.2	0.2	0.5	-0.4	-0.3	-0.7	0.5
Illnesses of father: Heart disease	0.2	0.3	0.9	-0.6	-0.2	-0.9	-0.6
Leg fat-free mass (right)	0.2	0.9	3.8	0.3	0.3	1.9	-0.7
Average weekly red wine intake	0.2	0.3	1.3	-0.5	-0.0	0.3	1.1
Back pain experienced in last month	0.2	0.3	1.1	0.3	-0.2	0.3	-1.0
Leg predicted mass (right)	0.2	0.8	3.5	0.3	0.3	1.9	-0.6
Hearing aid user	0.2	0.2	0.6	0.1	-0.4	-0.8	-0.5
High cholesterol (Self-reported)	0.2	0.4	1.1	-0.8	-0.5	-0.0	-1.0
Basal metabolic rate	0.2	1.0	4.8	-0.1	0.1	2.2	-0.6
Arm fat-free mass (left)	0.2	0.9	3.8	-0.5	0.0	1.9	-0.8
Commuting to job workplace: Cycle	0.2	0.2	0.9	-0.1	-0.1	-0.9	-0.5
Arm predicted mass (left)	0.2	1.0	4.0	-0.5	0.0	2.0	-0.8
Intelligence (Savage-Jansen 2018)	0.1	0.3	0.7	-0.6	-0.2	-0.9	0.4
Major Depression (MDD)	0.1	0.1	0.2	-0.1	0.2	0.5	0.2
HbA1C	0.1	0.1	0.3	0.3	0.2	0.2	0.6
Blood Eosinophil Count	0.1	0.6	1.8	0.3	-0.3	1.3	-0.9
Height	0.1	2.7	9.2	1.4	1.1	3.0	-1.1
Hypothyroidism (self reported)	0.1	0.1	0.6	-0.0	-0.8	-0.2	0.1
Type 2 Diabetes (T2D) (2018)	0.1	0.2	0.9	-0.0	-0.3	-0.9	0.1
Relative age of first facial hair	0.1	0.2	0.6	-0.1	0.1	0.6	-0.8
Medication: Metformin	0.1	0.1	0.2	0.0	-0.4	-0.2	-0.5
Impedance of leg (right)	0.1	0.6	1.2	0.7	1.0	0.5	1.1
Relative age voice broke	0.1	0.1	0.6	0.1	0.7	0.4	0.1
Taking other prescription medications	0.1	0.2	0.4	-0.2	-0.5	-0.4	0.6
Serious illness, injury or assault to yourself	0.1	0.1	0.3	0.6	0.1	0.4	-0.5
Hair/balding pattern: Pattern 2	0.1	0.1	0.2	0.4	0.2	0.5	0.4
Pain all over the body in last month	0.1	0.1	0.4	0.4	0.6	0.3	0.2
Fluid intelligence score	0.1	0.2	0.7	-0.4	0.0	0.8	0.2
Trunk fat-free mass	0.1	0.5	1.2	-1.1	-0.6	0.8	-0.6
Time employed in main current job	0.1	0.1	0.2	-0.5	-0.3	0.3	-0.2
Lung cancer (father)	0.1	0.1	0.3	0.5	0.1	-0.3	0.5
Trunk predicted mass	0.1	0.5	1.1	-1.1	-0.6	0.9	-0.6
Standing height	0.1	0.8	2.4	0.6	0.4	1.5	-1.2
Hypothyroidism/myxoedema (self-reported)	0.1	0.2	0.9	0.2	-0.3	-0.3	1.0
Medication: Amlodipine	0.1	0.1	0.2	0.4	0.4	0.1	-0.2
Number of children fathered	0.1	0.1	0.4	0.2	0.4	0.6	-0.3
Reason for reducing amount of alcohol drunk: Health precaution	0.1	0.1	0.6	-0.1	-0.3	-0.0	-0.8
Medication: Ibuprofen	0.1	0.1	0.3	-0.4	0.4	-0.2	0.5
Medication: Allopurinol	0.1	0.2	0.4	-0.6	-0.2	0.4	0.6
Whole body fat-free mass	0.1	0.6	1.9	-0.6	-0.3	1.4	-0.7
Diabetes diagnosed by doctor	0.1	0.2	0.5	0.2	-0.3	-0.7	-0.5
Friendships satisfaction	0.1	0.2	0.5	0.1	0.2	0.7	0.6
Medication for cholesterol	0.1	0.2	0.6	0.5	0.4	0.8	0.3
Whole body water mass	0.1	0.6	1.8	-0.7	-0.4	1.3	-0.8
Number of self-reported non-cancer illnesses	0.1	0.1	0.3	-0.6	-0.5	0.1	0.3
Financial situation satisfaction	0.1	0.1	0.3	0.2	0.5	0.1	-0.1
Risk taking	0.1	0.1	0.3	-0.4	-0.3	0.0	-0.6
Medication: Omeprazole (e.g. Zanprol)	0.1	0.1	0.4	0.1	0.3	0.0	0.6
Pain experienced in last month	0.1	0.1	0.3	0.5	0.6	0.2	0.3
Basal cell carcinoma (self-reported)	0.1	0.2	0.7	-0.8	-0.3	-0.1	-0.3
Alcohol drinker status: Previous	0.1	0.1	0.3	0.1	0.1	-0.2	0.6
Worry (Nagel 2018)	0.0	0.0	0.1	0.2	-0.1	-0.1	-0.4
Irritable Bowel Disease (IBD)	0.0	0.1	0.3	-0.1	-0.3	-0.6	-0.4
Frequency of depressed mood in last 2 weeks	0.0	0.1	0.1	0.4	0.1	0.1	0.3
Ever had hysterectomy (womb removed)	0.0	0.1	0.2	-0.4	-0.2	0.1	-0.2
Fed-up feelings	0.0	0.1	0.2	0.5	0.1	0.3	0.3
Heel bone mineral density (BMD) T-score, automated (right)	0.0	0.1	0.5	0.1	0.0	-0.7	0.1
Worrier / anxious feelings	0.0	0.0	0.0	0.1	-0.1	-0.2	0.1
Hair/balding pattern: Pattern 4	0.0	0.1	0.2	0.4	0.4	0.1	-0.1
Medication: Omeprazole	0.0	0.0	0.1	0.2	0.1	0.3	0.1
Comparative height size at age 10	0.0	0.2	0.5	0.0	-0.4	0.6	-0.7
Suffer from ‘nerves’	0.0	0.0	0.1	0.3	-0.1	0.3	0.0
Pain type(s) experienced in last month: Hip pain	0.0	0.0	0.1	0.3	0.1	-0.1	0.1
Medication: Bendroflumethiazide	0.0	0.1	0.1	-0.3	0.3	0.1	0.3
Irritability	0.0	0.1	0.1	0.4	-0.0	0.3	-0.1

Hub : Genes

VN1R108P

Models

Trait associations