[Hub]/) : Traits : Lung FEV1/FVC ratio : ← →

chr20:30,060,562-35,916,342

Best TWAS P=4.06e-17 · Best GWAS P=1.42e-14 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	MAP1LC3A	0.22	0.14	blup	309	0.19	3.9e-22	-5.54	7.0	2.0e-12	0.02	0.16	0.84	TRUE
2	GTEx	Adipose Subcutaneous	MAP1LC3A	0.17	0.18	enet	22	0.19	2.1e-15	7.00	6.7	1.8e-11	-0.01	0.07	0.93	FALSE
3	GTEx	Adipose Subcutaneous	TGIF2	0.06	0.02	enet	8	0.02	6.5e-03	5.43	5.4	5.6e-08	0.01	0.01	0.94	TRUE
4	GTEx	Adipose Subcutaneous	TSPY26P	0.08	0.01	lasso	4	0.03	1.7e-03	2.56	5.8	5.6e-09	-0.61	0.08	0.73	FALSE
5	GTEx	Adipose Visceral Omentum	MAP1LC3A	0.17	0.11	enet	62	0.10	4.7e-06	7.22	5.6	2.2e-08	-0.02	0.05	0.95	TRUE
6	GTEx	Artery Aorta	KIF3B	0.15	0.00	enet	33	0.00	2.9e-01	1.07	-5.3	1.1e-07	0.51	0.02	0.57	FALSE
7	GTEx	Artery Aorta	MAP1LC3A	0.19	0.22	enet	36	0.23	4.3e-13	7.06	7.7	1.3e-14	0.01	0.05	0.95	FALSE
8	GTEx	Artery Aorta	TSPY26P	0.13	0.00	lasso	7	0.00	5.7e-01	-6.77	8.0	1.8e-15	-0.60	0.04	0.39	FALSE
9	GTEx	Artery Coronary	MAP1LC3A	0.26	0.21	lasso	7	0.24	8.3e-09	-7.28	7.5	7.4e-14	-0.03	0.04	0.95	FALSE
10	GTEx	Artery Tibial	MAP1LC3A	0.13	0.15	enet	23	0.21	2.2e-16	6.91	7.0	2.0e-12	0.01	0.06	0.94	FALSE
11	GTEx	Artery Tibial	PIGU	0.05	0.05	lasso	3	0.04	2.2e-04	-5.54	5.9	2.9e-09	0.00	0.19	0.76	FALSE
12	GTEx	Brain Cerebellar Hemisphere	MAP1LC3A	0.28	0.22	lasso	13	0.29	4.0e-08	-7.23	6.7	2.8e-11	-0.01	0.05	0.95	FALSE
13	GTEx	Brain Cerebellar Hemisphere	ACSS2	0.22	0.17	enet	25	0.17	3.1e-05	-4.34	5.5	4.0e-08	0.05	0.52	0.27	TRUE
14	GTEx	Brain Cerebellum	MAP1LC3A	0.30	0.31	enet	29	0.39	1.1e-12	7.00	6.1	1.0e-09	0.01	0.06	0.94	FALSE
15	GTEx	Brain Cerebellum	TSPY26P	0.25	0.06	lasso	6	0.15	2.9e-05	-5.92	6.2	6.4e-10	-0.71	0.06	0.50	FALSE
16	GTEx	Brain Cerebellum	RP4-614O4.12	0.20	0.05	lasso	5	0.03	3.7e-02	6.16	-6.3	3.5e-10	0.01	0.01	0.96	FALSE
17	GTEx	Brain Cortex	GSS	0.14	0.02	lasso	3	0.00	3.7e-01	-5.54	5.4	7.1e-08	-0.01	0.06	0.57	FALSE
18	GTEx	Brain Cortex	MAP1LC3A	0.39	0.26	enet	16	0.33	6.6e-10	-7.23	6.7	2.4e-11	0.00	0.05	0.95	FALSE
19	GTEx	Brain Frontal Cortex BA9	MAP1LC3A	0.18	0.17	lasso	4	0.16	5.3e-05	-5.05	5.2	2.1e-07	0.02	0.29	0.46	FALSE
20	GTEx	Breast Mammary Tissue	ITCH	0.09	0.04	enet	28	0.09	2.5e-05	6.90	-6.6	4.8e-11	-0.01	0.07	0.92	FALSE
21	GTEx	Breast Mammary Tissue	MAP1LC3A	0.16	0.15	enet	19	0.14	1.8e-07	-7.26	7.1	1.3e-12	-0.02	0.04	0.96	TRUE
22	GTEx	Breast Mammary Tissue (Male)	MAP1LC3A	0.13	0.05	enet	12	0.00	3.4e-01	-5.69	6.2	4.4e-10	0.01	0.05	0.35	FALSE
23	GTEx	Breast Mammary Tissue (Female)	ITCH	0.09	0.02	enet	16	0.06	8.2e-03	-4.43	-7.2	7.6e-13	-0.01	0.09	0.59	TRUE
24	GTEx	Breast Mammary Tissue (Female)	MAP1LC3A	0.12	0.05	lasso	10	0.05	1.0e-02	7.00	6.7	2.7e-11	-0.02	0.06	0.86	FALSE
25	GTEx	Breast Mammary Tissue (Female)	RP5-1085F17.3	0.01	-0.01	enet	20	0.00	3.1e-01	0.71	6.2	4.2e-10	-0.12	0.04	0.05	FALSE
26	GTEx	Cells Transformed fibroblasts	MAP1LC3A	0.07	0.07	enet	19	0.06	3.4e-05	7.04	6.9	4.7e-12	-0.02	0.06	0.94	FALSE
27	GTEx	Cells Transformed fibroblasts	TSPY26P	0.07	0.05	lasso	5	0.03	1.2e-03	-7.69	7.7	1.5e-14	-0.98	0.01	0.96	FALSE
28	GTEx	Colon Sigmoid	MAP1LC3A	0.10	0.04	enet	19	0.10	3.1e-04	7.22	6.7	1.9e-11	0.01	0.06	0.91	TRUE
29	GTEx	Colon Sigmoid	PIGU	0.13	0.09	enet	10	0.12	6.9e-05	-4.32	5.3	1.4e-07	0.03	0.38	0.28	FALSE
30	GTEx	Colon Transverse	MAP1LC3A	0.15	0.14	lasso	3	0.09	3.2e-05	7.06	7.5	7.1e-14	-0.02	0.05	0.94	FALSE
31	GTEx	Esophagus Gastroesophageal Junction	MAP1LC3A	0.14	0.09	enet	9	0.07	1.4e-03	-7.28	7.8	8.0e-15	-0.03	0.05	0.92	TRUE
32	GTEx	Esophagus Mucosa	TSPY26P	0.13	0.00	enet	8	0.02	1.3e-02	-3.73	7.7	1.5e-14	-0.57	0.05	0.27	TRUE
33	GTEx	Esophagus Muscularis	ITCH	0.07	0.02	lasso	3	0.01	6.3e-02	4.71	-6.3	2.4e-10	0.01	0.06	0.86	FALSE
34	GTEx	Esophagus Muscularis	MAP1LC3A	0.18	0.19	enet	28	0.23	2.3e-14	7.06	7.2	8.3e-13	0.00	0.06	0.94	FALSE
35	GTEx	Heart Atrial Appendage	MAP1LC3A	0.12	0.09	enet	16	0.16	1.4e-07	4.73	6.2	4.4e-10	0.01	0.12	0.88	TRUE
36	GTEx	Heart Left Ventricle	MAP1LC3A	0.12	0.11	lasso	14	0.13	1.8e-07	-4.87	6.3	3.7e-10	0.02	0.19	0.81	FALSE
37	GTEx	Lung	MAP1LC3A	0.08	0.09	lasso	2	0.09	1.6e-07	7.00	7.0	2.6e-12	-0.03	0.07	0.93	FALSE
38	GTEx	Muscle Skeletal	GSS	0.04	0.05	enet	11	0.03	2.7e-04	-5.70	5.6	2.4e-08	0.06	0.82	0.08	FALSE
39	GTEx	Muscle Skeletal	MAP1LC3A	0.03	0.03	lasso	3	0.03	7.1e-04	6.90	6.8	9.4e-12	0.00	0.06	0.92	FALSE
40	GTEx	Muscle Skeletal	GGT7	0.07	0.02	enet	26	0.03	7.2e-04	3.86	5.5	4.0e-08	0.04	0.48	0.48	FALSE
41	GTEx	Muscle Skeletal	ACSS2	0.04	0.04	enet	12	0.04	3.1e-05	3.25	5.3	1.2e-07	0.01	0.25	0.70	FALSE
42	GTEx	Nerve Tibial	MAP1LC3A	0.19	0.24	enet	18	0.22	1.0e-15	-7.30	7.2	6.1e-13	-0.03	0.03	0.97	FALSE
43	GTEx	Nerve Tibial	RP5-1085F17.3	0.12	0.02	enet	16	0.08	4.2e-06	2.70	5.4	7.1e-08	-0.18	0.37	0.02	FALSE
44	GTEx	Ovary	MAP1LC3A	0.10	0.03	lasso	5	0.08	6.3e-03	6.43	6.1	8.7e-10	-0.01	0.08	0.53	FALSE
45	GTEx	Ovary	RP4-614O4.12	0.23	0.13	lasso	3	0.19	2.3e-05	-4.34	-5.2	2.4e-07	-0.01	0.14	0.13	FALSE
46	GTEx	Pancreas	MAP1LC3A	0.06	0.09	lasso	4	0.08	3.0e-04	7.24	7.0	2.2e-12	-0.03	0.05	0.92	FALSE
47	GTEx	Pituitary	MAP1LC3A	0.26	0.29	enet	19	0.29	5.9e-08	7.09	7.3	3.4e-13	-0.03	0.04	0.96	FALSE
48	GTEx	Prostate	MAP1LC3A	0.33	0.26	lasso	8	0.31	1.6e-08	7.06	7.0	2.5e-12	0.00	0.06	0.93	FALSE
49	GTEx	Skin Not Sun Exposed Suprapubic	RP5-1085F17.3	0.29	0.16	lasso	4	0.17	2.0e-09	5.24	5.7	1.5e-08	-0.06	0.96	0.00	TRUE
50	GTEx	Skin Sun Exposed Lower leg	ITCH	0.04	0.04	enet	11	0.04	6.3e-04	-7.26	-7.4	1.0e-13	0.02	0.04	0.95	FALSE
51	GTEx	Skin Sun Exposed Lower leg	UQCC1	0.19	0.13	enet	16	0.10	8.1e-09	3.84	-5.2	2.4e-07	0.00	0.93	0.04	FALSE
52	GTEx	Skin Sun Exposed Lower leg	MAP1LC3A	0.03	0.04	lasso	3	0.04	4.7e-04	-5.69	5.9	4.1e-09	0.02	0.14	0.74	FALSE
53	GTEx	Skin Sun Exposed Lower leg	RP5-1085F17.3	0.20	0.16	lasso	1	0.15	1.3e-12	5.24	5.2	1.6e-07	-0.05	1.00	0.00	FALSE
54	GTEx	Spleen	MAP1LC3A	0.28	0.05	enet	14	0.13	3.4e-04	6.43	6.1	1.1e-09	0.01	0.06	0.65	FALSE
55	GTEx	Stomach	MAP1LC3A	0.10	0.04	enet	10	0.05	1.3e-03	-7.30	7.5	6.5e-14	-0.03	0.05	0.86	FALSE
56	GTEx	Testis	MAP1LC3A	0.42	0.38	enet	33	0.40	3.0e-19	7.23	7.7	1.2e-14	-0.03	0.05	0.95	FALSE
57	GTEx	Testis	PIGU	0.38	0.48	lasso	6	0.47	1.9e-23	-5.54	5.8	6.1e-09	0.02	1.00	0.00	FALSE
58	GTEx	Thyroid	MAP1LC3A	0.17	0.27	enet	19	0.26	2.7e-20	7.04	7.0	2.5e-12	-0.02	0.13	0.87	FALSE
59	GTEx	Thyroid	C20orf112	0.05	0.00	lasso	5	0.00	1.4e-01	-7.66	7.1	8.8e-13	-0.89	0.03	0.79	TRUE
60	GTEx	Vagina	RSL24D1P6	0.44	-0.01	lasso	13	0.00	2.5e-01	-6.94	8.4	4.1e-17	-0.70	0.03	0.58	TRUE
61	GTEx	Whole Blood	MAP1LC3A	0.05	0.03	enet	15	0.00	1.8e-01	6.91	7.3	3.3e-13	-0.03	0.07	0.87	FALSE
62	METSIM	Adipose	EIF6	0.07	0.02	bslmm	343	0.04	2.7e-07	3.76	6.4	2.1e-10	0.04	0.80	0.16	TRUE
63	METSIM	Adipose	MAP1LC3A	0.05	0.06	blup	309	0.06	7.2e-09	7.27	7.5	5.0e-14	-0.04	0.04	0.96	TRUE
64	METSIM	Adipose	MAPRE1	0.03	0.02	lasso	5	0.02	1.6e-03	5.24	-5.3	1.3e-07	0.05	0.72	0.01	FALSE
65	METSIM	Adipose	PROCR	0.04	0.00	bslmm	351	0.01	2.4e-02	3.67	-5.3	1.4e-07	-0.05	0.07	0.74	TRUE
66	ROSMAP	Brain Pre-frontal Cortex	MAP1LC3A	0.33	0.51	lasso	7	0.56	1.4e-87	-5.54	6.5	9.0e-11	-0.01	1.00	0.00	FALSE
67	ROSMAP	Brain Pre-frontal Cortex	RALY	0.09	0.16	lasso	7	0.15	2.7e-18	-5.87	-6.6	5.8e-11	0.00	1.00	0.00	TRUE
68	ROSMAP	Brain Pre-frontal Cortex	BAK1P1	0.30	0.20	lasso	6	0.22	5.7e-28	-5.95	5.5	3.2e-08	0.04	1.00	0.00	FALSE
69	ROSMAP	Brain Pre-frontal Cortex	C20orf203	0.35	0.25	enet	14	0.27	1.8e-34	-5.86	-6.5	7.6e-11	0.00	1.00	0.00	TRUE
70	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	C20orf24	0.06	0.01	blup	20	0.02	1.2e-02	-5.51	5.2	2.1e-07	0.06	0.00	0.87	TRUE
71	The Cancer Genome Atlas	Breast Invasive Carcinoma	C20orf203	0.02	0.01	enet	4	0.02	1.6e-04	-5.86	-5.7	9.9e-09	-0.01	0.18	0.07	FALSE
72	The Cancer Genome Atlas	Glioblastoma Multiforme	UQCC	0.15	0.02	blup	67	0.04	2.0e-02	4.72	-5.6	2.3e-08	0.02	0.01	0.41	FALSE
73	The Cancer Genome Atlas	Brain Lower Grade Glioma	C20orf203	0.06	0.06	blup	48	0.05	1.6e-06	4.13	-6.4	1.3e-10	0.05	0.86	0.04	FALSE
74	The Cancer Genome Atlas	Brain Lower Grade Glioma	MAP1LC3A	0.02	0.03	lasso	3	0.02	8.3e-04	-7.29	7.3	3.0e-13	-0.04	0.01	0.98	FALSE
75	The Cancer Genome Atlas	Prostate Adenocarcinoma	C20orf203	0.04	0.03	blup	48	0.02	3.7e-03	-5.74	-5.3	1.0e-07	0.01	0.03	0.23	FALSE
76	The Cancer Genome Atlas	Stomach Adenocarcinoma	GDF5	0.09	0.04	enet	13	0.05	2.4e-04	4.47	5.2	2.1e-07	-0.05	0.05	0.63	FALSE
77	The Cancer Genome Atlas	Testicular Germ Cell Tumors	PIGU	0.10	0.10	lasso	2	0.10	2.8e-04	-4.88	5.1	2.8e-07	0.03	0.18	0.33	FALSE
78	The Cancer Genome Atlas	Thyroid Carcinoma	ITCH	0.04	0.06	blup	64	0.06	8.4e-07	-7.23	7.0	3.2e-12	-0.03	0.03	0.96	FALSE