[Hub]/) : Traits : Lung FEV1/FVC ratio : ← →

chr20:43,293,270-44,801,026

Best TWAS P=7.17e-16 · Best GWAS P=3.13e-11 conditioned to 0.118

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex WFDC2 0.08 0.00 bslmm 497 0.02 1.9e-03 4.0 -6.0 1.8e-09 0.09 0.09 0.03 FALSE
2 GTEx Artery Tibial DBNDD2 0.19 0.16 lasso 3 0.14 2.8e-11 -6.4 -6.4 1.5e-10 0.99 0.01 0.99 FALSE
3 GTEx Colon Transverse DBNDD2 0.29 0.20 lasso 3 0.20 9.8e-10 -6.4 -7.0 2.8e-12 0.97 0.00 1.00 FALSE
4 GTEx Esophagus Mucosa DBNDD2 0.41 0.37 lasso 7 0.36 1.6e-25 -6.4 -6.5 9.3e-11 1.00 0.00 1.00 FALSE
5 GTEx Esophagus Muscularis DBNDD2 0.17 0.14 lasso 4 0.11 2.3e-07 -6.1 -6.2 6.7e-10 0.94 0.01 0.99 FALSE
6 GTEx Skin Not Sun Exposed Suprapubic DBNDD2 0.22 0.17 enet 25 0.17 1.4e-09 -6.4 -6.2 5.5e-10 0.86 0.01 0.99 FALSE
7 GTEx Skin Sun Exposed Lower leg DBNDD2 0.38 0.26 enet 9 0.26 3.5e-21 -6.6 -6.7 2.1e-11 0.99 0.00 1.00 FALSE
8 NTR Blood SYS1 0.06 0.03 bslmm 488 0.03 6.5e-11 -6.4 -6.3 2.2e-10 0.97 0.01 0.99 FALSE
9 The Cancer Genome Atlas Breast Invasive Carcinoma SYS1-DBNDD2 0.02 0.00 blup 81 0.01 4.8e-04 -6.0 -8.1 7.2e-16 0.68 0.02 0.79 TRUE
10 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma SYS1-DBNDD2 0.06 0.02 blup 81 0.03 9.2e-05 4.6 -6.0 2.4e-09 0.34 0.69 0.04 FALSE
11 The Cancer Genome Atlas Lung Squamous Cell Carcinoma SYS1-DBNDD2 0.03 0.02 enet 6 0.02 2.4e-03 4.6 -6.0 1.8e-09 0.58 0.15 0.48 FALSE
12 The Cancer Genome Atlas Thyroid Carcinoma SYS1-DBNDD2 0.06 0.04 blup 81 0.03 1.4e-03 -6.1 -6.9 6.6e-12 0.84 0.01 0.93 FALSE