TWAS hub - SYS1-DBNDD2

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	TCGA	Breast Invasive Carcinoma	0.0198	0.0095	0.00130	0.002	0.014	0.014	NA	0.005	1.0e-01	4.8e-04	0.00067	NA	0.02500
2	TCGA	Colon Adenocarcinoma	0.0830	0.0410	0.00097	0.071	0.036	0.046	NA	0.049	6.1e-05	3.7e-03	0.00110	NA	0.00085
3	TCGA	Head and Neck Squamous Cell Carcinoma	0.0624	0.0301	0.00015	0.022	0.034	0.020	NA	0.025	1.3e-03	9.2e-05	0.00200	NA	0.00079
4	TCGA	Lung Squamous Cell Carcinoma	0.0298	0.0145	0.00140	0.017	0.014	0.019	NA	0.013	4.5e-03	9.1e-03	0.00240	NA	0.00990
5	TCGA	Thyroid Carcinoma	0.0630	0.0310	0.00170	0.038	0.026	0.015	NA	0.014	1.2e-04	1.4e-03	0.01200	NA	0.01300

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Lung FEV1/FVC ratio	8.0	40.8	65.1	-8.1	-4.5	-6.0	-6.0	-6.9
Pulse rate, automated reading	4.9	15.8	21.2	-4.6	-3.3	-3.9	-3.8	-4.1
Average weekly spirits intake	3.6	4.5	6.2	-1.7	-2.4	-2.2	-2.5	-1.8
Mouth/teeth dental problems: Bleeding gums	3.6	4.6	8.0	-2.4	-2.5	-2.8	-1.7	-0.4
Had major operations	3.6	4.2	6.5	2.4	2.2	2.5	1.9	0.6
Loud music exposure frequency	3.5	3.8	6.3	1.6	1.9	2.0	2.5	1.7
Glaucoma (self-reported)	3.5	4.1	5.5	2.4	1.9	1.5	1.8	2.3
Commuting to job workplace: Cycle	3.5	4.2	5.6	2.4	1.3	2.1	1.9	2.4
Medication: Allopurinol	3.3	4.3	5.4	-2.3	-1.7	-2.3	-2.0	-2.0
Current tobacco smoking	3.0	4.9	6.5	-2.1	-2.2	-2.4	-2.6	-1.7
Leg pain on walking	2.9	3.6	6.5	-1.9	-1.6	-2.5	-2.1	-0.7
Coronary Artery Disease (CAD)	2.8	3.4	5.0	2.2	1.8	1.3	2.1	1.6
Migraine (self-reported)	2.8	3.5	5.4	2.1	1.6	1.1	2.3	2.0
Smoking status: Current	2.8	4.4	6.5	-2.0	-2.1	-2.0	-2.5	-1.8
Reaction Time	2.6	4.9	6.5	2.3	2.3	2.5	2.3	1.5
Pulse rate	2.5	4.2	6.9	-2.6	-1.5	-1.7	-1.9	-2.3
Pulse wave reflection index	2.5	3.1	4.6	2.1	1.3	1.6	1.7	2.0
Commuting to job workplace: Walk	2.5	2.7	4.1	2.0	1.3	1.8	1.5	1.6
Medication: Lisinopril	2.5	3.2	7.2	-1.4	-2.7	-2.0	-1.7	-0.1
Verbal and Numeric Reasoning (VNR)	2.3	5.5	8.2	-2.8	-1.9	-2.0	-2.9	-1.9
Chronic bronchitis/emphysema (father)	2.2	2.6	3.6	1.9	1.2	1.9	1.7	1.2
Shortness of breath walking on level ground	2.2	2.6	6.5	-0.8	-2.3	-2.5	-1.0	0.1
Mean time to correctly identify matches	2.2	4.2	6.6	2.1	2.2	2.6	1.8	1.3
Hayfever/allergic rhinitis (self-reported)	2.1	2.8	3.7	-1.8	-1.9	-1.7	-1.8	-0.9
Depression (Nagel 2018)	2.0	3.0	4.0	1.8	1.6	1.1	2.0	2.0
Crohns Disease (2012)	2.0	3.1	4.3	2.1	1.7	1.7	1.9	1.4
Triglycerides	2.0	3.3	4.3	-2.1	-1.8	-2.1	-1.6	-1.5
Number of full brothers	2.0	2.5	3.3	1.4	1.7	1.8	1.7	1.3
Alcohol intake frequency.	1.9	4.4	6.1	2.1	1.2	2.1	2.5	2.3
Supplements: Fish oil (including cod liver oil)	1.9	2.5	5.8	1.3	2.4	1.9	1.0	-0.2
Knee pain experienced in last month	1.8	2.8	3.8	1.6	1.9	1.1	2.0	1.7
Alzheimer’s Disease (including proxy)	1.6	2.3	4.3	-1.1	-2.1	-1.8	-1.6	-0.5
Hair/balding pattern: Pattern 2	1.6	2.1	4.1	2.0	0.5	1.3	0.7	2.0
Length of working week for main job	1.6	1.7	2.8	-1.5	-1.6	-1.7	-0.9	-0.6
Health satisfaction	1.6	2.1	3.1	-1.7	-1.1	-1.8	-1.2	-1.3
Chest pain or discomfort	1.6	2.2	4.5	-1.5	-1.6	-2.1	-1.4	-0.0
Supplements: Calcium	1.6	1.8	2.6	1.6	1.1	1.5	1.2	1.1
Gout (self-reported)	1.5	2.1	4.3	-1.7	-0.8	-2.1	-0.9	-1.4
Financial situation satisfaction	1.5	1.9	3.5	-1.0	-1.8	-1.9	-1.3	-0.5
Body Mass Index (BMI) (2010)	1.4	1.9	3.3	1.6	1.0	0.4	1.5	1.8
HDL Cholesterol	1.4	2.3	4.0	1.6	1.2	2.0	1.1	1.5
Pack years adult smoking proportion	1.4	2.2	3.9	-2.0	-1.3	-1.0	-1.6	-1.4
Forced vital capacity (FVC)	1.4	5.2	7.2	2.7	1.7	2.4	2.4	2.1
Medication: Ramipril	1.4	1.8	4.0	-1.0	-1.5	-2.0	-1.2	-0.5
Smoking status: Previous	1.4	2.1	3.5	1.3	0.9	1.1	1.9	1.9
Medication: Atorvastatin	1.4	1.7	3.5	-1.9	-0.4	-0.7	-1.3	-1.7
Basal cell carcinoma (self-reported)	1.4	1.6	4.5	1.2	0.3	0.8	1.1	2.1
Heart disease (siblings)	1.4	1.7	2.7	1.4	1.0	0.5	1.6	1.6
Stomach or abdominal pain in last month	1.3	1.6	2.9	-1.2	-1.7	-1.7	-0.9	-0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.3	2.8	4.4	-1.2	-1.8	-1.4	-1.7	-2.1
Pain type(s) experienced in last month: Hip pain	1.3	1.7	2.6	-1.6	-1.5	-1.3	-1.1	-0.6
Alzheimer’s Disease (in father)	1.2	1.4	2.9	-0.7	-1.5	-0.8	-1.7	-0.5
Chronic bronchitis/emphysema (mother)	1.2	1.4	2.6	1.6	1.4	1.0	0.9	0.7
Commuting to job workplace: Car/motor vehicle	1.2	1.4	3.1	-1.6	-0.2	-0.6	-1.0	-1.8
Ovarian Cancer	1.1	1.4	2.8	0.4	1.7	1.7	1.2	-0.2
Type 2 Diabetes (T2D) (2012)	1.1	1.3	1.9	1.4	0.8	1.3	1.2	0.8
Blood Eosinophil Count	1.1	8.5	13.2	-3.1	-2.0	-1.6	-3.6	-3.6
Smoking Status	1.1	2.7	4.0	-2.0	-1.4	-1.5	-1.6	-1.6
Lung FVC	1.1	5.5	8.0	2.8	2.2	2.3	2.7	1.5
Supplements: Zinc	1.1	1.2	2.8	1.7	1.0	1.0	0.7	0.9
Illnesses of siblings	1.1	1.5	2.6	-0.9	-1.6	-1.3	-1.2	-1.1
Noisy workplace	1.1	1.3	2.2	1.2	0.8	0.9	1.5	1.3
Qualifications: O levels/GCSEs or equivalent	1.1	1.8	2.7	-1.6	-0.8	-0.9	-1.5	-1.6
Ever taken oral contraceptive pill	1.1	1.2	2.0	-1.2	-1.4	-1.1	-1.3	-0.3
Tinnitus: Yes, now most or all of the time	1.1	1.2	2.4	1.5	0.9	0.8	1.3	0.7
Irritability	1.1	1.9	2.9	-1.7	-0.7	-1.2	-1.7	-1.5
Age started oral contraceptive pill	1.1	1.3	4.2	-1.2	-0.1	-0.7	-0.7	-2.1
Pack years of smoking	1.1	1.6	2.7	-1.7	-1.2	-0.6	-1.3	-1.2
Age at First Birth	1.0	1.4	2.1	1.5	1.3	1.2	1.1	0.7
Eye problems/disorders: Diabetes related eye disease	1.0	1.1	2.1	-1.5	-0.6	-0.6	-1.1	-1.1
Diabetes (father)	1.0	1.3	1.8	-1.2	-1.3	-1.0	-1.3	-0.7
Severe depression (siblings)	1.0	1.2	2.6	-0.8	-1.6	-0.8	-1.4	-0.0
Multivitamins +/- minerals	1.0	1.3	3.2	-0.5	-0.1	-1.1	-1.4	-1.8
Hair/balding pattern: Pattern 3	1.0	1.5	3.0	-1.7	-0.7	-1.5	-0.5	-1.3
Long-standing illness, disability or infirmity	1.0	1.5	2.4	1.3	1.5	0.9	1.5	0.8
High cholesterol (Self-reported)	1.0	1.7	3.7	-1.8	-0.4	-1.9	-0.4	-1.2
Neuroticism (Nagel 2018)	0.9	2.0	3.5	1.5	0.7	1.1	1.6	1.9
Crohns Disease (2017)	0.9	2.0	3.6	1.3	1.5	1.9	1.3	0.8
Blood White Count	0.9	6.9	10.3	-2.9	-2.4	-2.0	-3.2	-2.5
Systolic Blood Pressure	0.9	4.7	8.6	-1.9	-2.9	-2.6	-1.9	-1.2
Vitamin and mineral supplements	0.9	1.2	3.2	0.4	-0.0	1.0	1.2	1.8
Supplements: Glucosamine	0.9	1.1	2.4	-0.3	1.5	0.8	-0.5	-1.5
Falls in the last year	0.9	1.3	2.7	-1.1	-0.2	-0.9	-1.3	-1.6
Hair/balding pattern: Pattern 4	0.9	2.1	3.4	-1.3	-1.0	-1.2	-1.7	-1.8
Worry too long after embarrassment	0.9	1.6	4.1	1.4	0.0	0.3	1.3	2.0
Comparative height size at age 10	0.9	5.0	6.1	2.2	2.4	2.2	2.5	1.9
Mineral and other dietary supplements	0.9	1.1	3.0	-0.5	-1.7	-1.3	-0.6	0.6
Commuting to job workplace: Public transport	0.9	1.1	1.9	1.4	0.5	1.4	1.0	0.7
Alcohol drinker status: Never	0.9	1.1	2.1	0.3	1.0	1.4	1.2	0.9
Risk taking	0.9	1.3	2.2	1.4	0.7	0.5	1.3	1.5
Irritable Bowel Disease (IBD)	0.8	1.9	3.9	1.2	1.6	2.0	1.3	0.3
Ulcerative Colitis (UC)	0.8	1.5	3.1	1.0	1.5	1.8	1.1	0.3
Bipolar Disorder (2011)	0.8	0.8	2.9	-0.5	-0.8	-0.2	-1.7	-0.4
LDL Cholesterol	0.8	1.3	2.1	-1.5	-0.5	-1.1	-1.1	-1.3
Bilateral oophorectomy (both ovaries removed)	0.8	0.9	1.8	-1.0	-1.4	-1.0	-0.8	0.1
Diverticular disease/diverticulitis (self-reported)	0.8	0.9	1.4	-0.7	-1.2	-1.2	-0.6	0.9
Fluid intelligence score	0.8	1.6	2.2	-1.2	-1.1	-1.2	-1.5	-1.1
Number of live births	0.8	1.1	2.3	1.0	0.0	0.9	1.1	1.5
Pulse wave Arterial Stiffness index	0.8	0.9	2.7	1.0	-0.1	0.4	0.7	1.7
High blood pressure (siblings)	0.8	1.2	3.2	0.6	1.8	1.3	0.8	0.4
Seen a psychiatrist for nerves, anxiety, tension or depression	0.8	1.0	3.0	-0.3	-1.7	-1.1	-0.8	0.2
Eye problems/disorders: None of the above	0.8	0.9	2.4	-0.3	-1.5	-1.2	-0.8	0.3
Family relationship satisfaction	0.8	0.9	2.9	-0.4	1.7	0.7	0.5	-1.0
Diastolic blood pressure, automated reading	0.8	2.3	3.6	-1.8	-1.0	-1.2	-1.5	-1.9
Cholesterol lowering medication	0.8	1.2	3.8	-1.0	-0.4	-1.9	-0.5	-1.0
Depressed Affect (Nagel 2018)	0.7	1.5	2.2	1.5	0.7	1.2	1.4	1.3
Mean Putamen Volume	0.7	0.8	1.8	1.3	0.5	1.2	0.8	0.3
Frequency of depressed mood in last 2 weeks	0.7	1.0	1.8	1.1	0.5	-0.2	1.3	1.2
Medication for hormone replacement therapy	0.7	0.8	1.9	-1.1	-0.0	-0.5	-0.9	-1.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.7	1.0	2.8	0.6	0.4	-0.3	1.2	1.7
Tinnitus: Yes, but not now, but have in the past	0.7	0.7	1.6	1.1	-0.1	0.6	0.8	1.3
Had menopause	0.7	0.8	3.1	-0.4	0.2	-0.1	-0.9	-1.8
Medication: Ibuprofen (e.g. Nurofen)	0.7	0.9	1.3	1.0	0.8	1.1	0.5	1.2
Headache pain in last month	0.7	1.1	1.8	0.7	1.4	1.2	1.3	0.4
Number of full sisters	0.7	0.9	2.1	-0.7	-1.5	-1.1	-0.8	0.1
Age at last live birth	0.7	1.0	1.7	-1.3	-1.2	-1.1	-0.9	0.1
Ever had stillbirth, spontaneous miscarriage or termination	0.7	0.8	1.8	0.2	-1.3	-0.6	0.3	1.2
Illnesses of father: None of the above (group 1)	0.7	0.9	1.2	-1.1	-1.0	-1.1	-1.0	-0.3
Eye problems/disorders: Glaucoma	0.7	0.8	1.2	1.1	1.0	0.9	0.5	0.9
Bipolar Disorder (2018)	0.6	0.9	3.0	-0.8	-0.5	-0.5	-1.7	-0.6
Ulcerative Colitis	0.6	0.8	1.6	1.1	0.9	1.3	0.6	0.2
Allergy or Eczema	0.6	1.7	3.7	-1.9	-1.0	-0.9	-1.2	-1.2
Type 2 Diabetes (T2D) (2018)	0.6	1.1	2.1	1.0	1.4	0.9	1.3	0.1
Townsend deprivation index at recruitment	0.6	0.8	1.3	1.1	0.7	-0.1	0.9	1.2
Relative age voice broke	0.6	0.9	1.7	-0.7	-1.1	-1.3	-1.1	0.1
Medication: Levothyroxine sodium	0.6	1.1	2.9	0.2	1.7	0.8	1.3	0.1
Impedance of leg (left)	0.6	2.8	5.0	-1.8	-1.6	-1.1	-2.2	-1.4
Number of incorrect matches in round	0.6	0.9	3.1	0.1	0.5	0.9	-0.7	-1.7
Past tobacco smoking	0.6	1.1	1.6	-0.9	-1.0	-0.9	-1.3	-1.3
Ever unenthusiastic/disinterested for a whole week	0.6	0.7	1.7	0.4	1.3	0.7	1.0	0.2
Financial difficulties in last 2 years	0.6	0.8	2.4	0.9	-0.5	-0.2	0.7	1.6
Pulse wave peak to peak time	0.6	0.7	2.3	-0.9	0.3	-0.1	-0.5	-1.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.6	0.7	1.5	0.2	1.2	0.9	1.0	-0.3
Qualifications: NVQ or HND or HNC or equivalent	0.6	0.7	1.1	0.4	1.1	0.8	1.0	0.6
Intelligence (Savage-Jansen 2018)	0.5	1.5	3.2	-1.4	-0.5	-0.6	-1.4	-1.8
Alzheimer’s Disease (in mother)	0.5	0.5	1.3	-0.9	-0.6	-1.1	-0.4	-0.3
Lupus	0.5	0.8	1.7	0.6	1.1	0.7	1.3	0.4
Neuroticism (2016)	0.5	0.8	1.9	0.5	0.6	0.6	1.4	1.1
Chronotype (morning person)	0.5	1.2	3.1	1.1	0.2	0.5	1.3	1.7
Impedance of leg (right)	0.5	2.3	3.8	-1.7	-1.5	-0.9	-2.0	-1.1
Frequency of tenseness / restlessness in last 2 weeks	0.5	0.7	1.3	-0.1	-1.1	-1.1	0.4	1.1
Mouth/teeth dental problems	0.5	0.7	1.6	0.7	0.8	1.3	0.2	-0.9
Worrier / anxious feelings	0.5	0.9	2.4	0.9	-0.9	-0.2	0.5	1.6
Forced vital capacity (FVC), Best measure	0.5	1.9	3.2	1.8	0.6	1.3	1.4	1.6
Medication for pain relief, constipation, heartburn	0.5	0.8	1.2	-0.9	-0.8	-1.1	-0.7	-0.8
Angina (self-reported)	0.5	0.6	2.3	0.7	0.2	0.1	0.6	1.5
Medication: Ibuprofen	0.5	0.6	1.1	1.0	0.8	1.1	0.1	0.6
Average weekly champagne plus white wine intake	0.5	0.6	2.3	0.4	1.5	0.6	0.5	-0.2
Hearing aid user	0.5	0.6	1.3	0.2	1.0	0.7	1.2	-0.3
Average weekly beer plus cider intake	0.5	0.7	1.4	-1.2	-0.4	-0.5	-1.1	-0.7
Ever had prostate specific antigen (PSA) test	0.5	0.6	1.4	0.6	0.3	1.2	0.9	0.7
Ever depressed for a whole week	0.5	0.7	1.2	0.6	1.1	0.7	1.1	0.0
Alcohol drinker status: Previous	0.5	0.6	1.4	0.8	0.0	0.1	1.2	0.9
Worry (Nagel 2018)	0.4	0.9	2.7	1.1	-0.2	0.3	0.8	1.6
Rheumatoid Arthritis	0.4	0.6	1.1	-1.0	-0.7	-0.8	0.7	0.5
Hearing difficulty/problems: Yes	0.4	0.6	1.3	1.1	0.5	0.5	0.6	1.1
Systolic blood pressure, automated reading	0.4	1.2	2.3	-0.5	-1.2	-1.5	-0.8	-1.0
Angina	0.4	0.5	2.0	0.6	0.1	-0.1	0.4	1.4
Diabetes (mother)	0.4	0.4	1.4	-0.1	-0.4	-0.2	-0.8	-1.2
Leg fat-free mass (left)	0.4	1.9	3.2	1.1	1.5	1.1	1.8	1.4
Leg predicted mass (left)	0.4	2.1	3.5	1.1	1.6	1.1	1.9	1.4
Nervous feelings	0.4	0.8	2.2	1.1	0.3	0.6	0.6	1.5
Heart attack	0.4	0.6	1.3	-0.7	-0.2	-0.1	-1.0	-1.1
Mouth/teeth dental problems: Dentures	0.4	0.7	1.2	0.5	1.0	0.4	1.1	1.0
Medication: Lansoprazole	0.4	0.4	0.6	0.8	0.7	0.8	0.6	0.4
Prospective memory result	0.4	0.5	1.0	1.0	0.1	0.7	0.6	0.8
Standing height	0.4	3.8	5.7	1.7	1.8	1.8	2.0	2.4
Tense / ‘highly strung’	0.4	0.7	1.7	0.5	-0.8	-0.8	0.1	1.3
Birth weight of first child	0.4	0.8	1.5	-1.0	-0.7	-1.2	-0.6	-0.9
Ever highly irritable/argumentative for 2 days	0.4	0.5	1.2	-0.3	-0.2	-0.5	-1.0	-1.1
Blood clot in the leg (DVT)	0.4	0.6	1.3	0.1	0.9	1.1	0.8	0.3
Hypothyroidism/myxoedema (self-reported)	0.4	0.8	2.1	0.2	1.5	0.6	1.2	-0.2
Mouth/teeth dental problems: Loose teeth	0.4	0.5	1.2	-0.3	-0.8	-1.1	-0.6	0.3
Overall health rating	0.4	0.9	1.8	-1.1	-0.7	-1.3	-0.7	-0.6
Illnesses of siblings: Diabetes	0.4	0.5	1.4	0.4	1.1	1.2	0.3	-0.2
Handedness (chirality/laterality): Left-handed	0.4	0.5	1.1	1.0	0.4	0.8	0.8	0.2
Friendships satisfaction	0.4	0.5	1.3	-0.8	0.4	-0.7	-0.4	-1.2
Eye problems/disorders: Cataract	0.4	0.5	0.9	-0.7	-0.4	-1.0	-0.6	-0.8
Breast cancer (self-reported)	0.4	0.5	1.3	0.1	-0.7	-0.5	0.5	1.2
Leg predicted mass (right)	0.4	2.2	3.3	1.3	1.6	1.0	1.8	1.6
Heart attack/myocardial infarction (self-reported)	0.4	0.5	1.2	-0.6	-0.3	-0.2	-1.0	-1.1
Primary Biliary Cirrhosis	0.3	0.5	0.9	-0.8	-0.4	-0.6	-0.6	-0.9
Schizophrenia (2014)	0.3	0.8	2.0	0.8	1.4	0.7	0.7	0.5
Other serious medical condition/disability diagnosed by doctor	0.3	0.4	1.3	-0.6	-0.4	-1.1	-0.1	-0.1
Medication: Co-codamol	0.3	0.3	0.6	0.5	0.0	0.8	0.4	0.8
Maternal smoking around birth	0.3	0.4	1.1	-0.1	-0.6	-1.0	-0.4	-0.7
Had other major operations	0.3	0.4	1.3	0.3	1.1	0.0	0.6	0.1
Time employed in main current job	0.3	0.4	0.6	-0.0	0.8	0.8	0.2	-0.7
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.3	0.6	-0.8	-0.3	-0.4	-0.4	-0.7
Depression (self-reported)	0.3	0.3	0.8	0.6	0.9	0.3	0.2	-0.6
Medication: Paracetamol	0.3	0.5	0.9	0.6	0.4	0.3	1.0	0.9
Medication: Amlodipine	0.3	0.4	1.0	0.2	-1.0	-0.8	0.0	0.6
Comparative body size at age 10	0.3	0.8	1.9	1.0	1.4	0.3	0.8	0.5
Wheeze or whistling in the chest in last year	0.3	0.6	2.2	0.4	-0.3	0.4	-0.5	1.5
Number of children fathered	0.3	0.4	0.8	-0.6	-0.5	-0.6	-0.4	-0.9
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.3	1.0	0.1	1.0	0.8	0.3	0.1
Medication: Seretide 50 evohaler	0.3	0.3	0.8	-0.4	-0.7	-0.1	-0.9	-0.1
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.7	0.8	-0.9	-0.9	-0.9	-0.7	0.7
Leg fat-free mass (right)	0.3	1.9	2.9	1.1	1.5	1.0	1.7	1.4
Ever had bowel cancer screening	0.3	0.3	0.5	0.6	0.7	0.4	0.4	-0.7
Mouth/teeth dental problems: Mouth ulcers	0.3	0.4	0.9	-0.3	-1.0	-0.7	-0.8	0.1
Wears glasses or contact lenses	0.3	0.3	1.1	0.0	-0.2	0.0	-0.7	-1.0
Mother’s age at death	0.3	0.3	0.7	-0.2	0.4	0.8	-0.4	-0.8
Fractured/broken bones in last 5 years	0.3	0.3	0.8	0.9	0.5	0.7	0.3	0.2
Unable to work because of sickness or disability	0.3	0.4	0.7	0.4	0.6	0.8	0.8	-0.0
Myopia	0.3	0.4	1.1	0.4	0.7	1.1	0.6	0.1
Pain experienced in last month	0.3	0.6	1.5	-0.8	-0.5	-0.6	-1.2	-0.4
Schizophrenia (2018)	0.2	0.4	1.0	0.4	1.0	0.6	0.7	0.4
Schizophrenia vs Biploar Disorder	0.2	0.3	0.7	0.0	0.8	0.1	0.8	-0.2
Fasting Glucose	0.2	0.3	0.8	0.5	-0.2	0.5	0.1	0.9
Blood Red Count	0.2	1.8	2.8	1.5	1.1	1.7	1.1	1.2
BMI	0.2	0.9	1.5	0.9	1.2	1.0	1.0	0.4
Height	0.2	4.6	6.0	1.6	2.1	2.3	2.2	2.4
Hypothyroidism (self reported)	0.2	0.4	1.1	0.2	1.0	0.5	0.7	-0.5
Neuroticism	0.2	0.5	1.2	0.8	0.0	0.2	0.7	1.1
Sensitivity / hurt feelings	0.2	0.3	0.5	0.5	0.2	-0.5	0.7	0.6
Relative age of first facial hair	0.2	0.3	0.7	0.3	-0.7	-0.8	-0.4	0.5
Ever used hormone-replacement therapy (HRT)	0.2	0.3	0.5	0.3	0.3	0.7	-0.3	-0.7
Taking other prescription medications	0.2	0.4	1.2	0.5	1.1	0.5	0.3	-0.3
Qualifications: CSEs or equivalent	0.2	0.2	0.8	-0.9	0.2	0.2	-0.1	-0.6
High blood pressure	0.2	0.5	0.9	1.0	0.5	0.2	0.9	0.6
Hayfever, allergic rhinitis or eczema	0.2	0.5	1.4	-1.2	-0.5	-0.4	-0.7	-0.6
Medication: Atenolol	0.2	0.2	0.6	-0.0	-0.2	-0.8	-0.1	-0.6
Sitting height	0.2	1.3	3.1	1.0	0.6	0.7	1.1	1.8
High blood pressure (mother)	0.2	0.2	0.6	-0.6	-0.8	-0.3	-0.2	0.2
Hearing difficulty/problems with background noise	0.2	0.3	0.7	0.4	0.4	0.4	0.6	0.8
Medication: Simvastatin	0.2	0.3	1.2	-0.5	0.3	-1.1	0.3	-0.2
Neuroticism score	0.2	0.4	0.9	0.2	-0.9	-0.8	0.2	0.6
Impedance of arm (right)	0.2	0.9	1.8	1.1	0.9	1.3	0.6	0.7
Trunk fat-free mass	0.2	1.0	2.0	0.8	1.0	0.5	1.4	1.1
Hip circumference	0.2	0.7	0.8	0.8	0.9	0.8	0.9	0.7
Alcohol intake versus 10 years previously	0.2	0.2	0.4	-0.4	-0.7	0.1	-0.5	-0.5
Forced expiratory volume in 1-second (FEV1)	0.2	0.7	1.1	0.7	0.5	1.1	0.9	0.8
Medication: Cholesterol lowering	0.2	0.4	1.0	-1.0	0.4	-0.4	0.2	-0.7
Lung cancer (father)	0.2	0.2	0.9	0.5	-0.1	0.1	-0.2	0.9
Exposure to tobacco smoke at home	0.2	0.3	0.8	-0.9	-0.6	-0.5	-0.0	-0.1
Breastfed as a baby	0.2	0.3	0.9	0.4	0.4	0.0	0.9	0.4
Exposure to tobacco smoke outside home	0.2	0.3	1.0	0.2	0.6	1.0	0.1	-0.5
Qualifications: College or University degree	0.2	0.8	1.7	-0.3	-1.3	-0.3	-1.3	0.5
Neck or shoulder pain in last month	0.2	0.3	1.0	0.4	-0.2	0.2	0.4	1.0
Medication: Blood pressure	0.2	0.3	1.0	-0.6	-0.2	-0.4	-0.4	-1.0
Medication: Omeprazole	0.2	0.2	0.3	-0.5	-0.5	-0.6	-0.3	0.3
Heart disease (mother)	0.2	0.2	0.5	0.1	-0.7	-0.5	-0.6	0.0
Illness, injury, bereavement, stress in last 2 years	0.2	0.2	0.6	-0.0	-0.1	0.2	-0.8	-0.7
Hypertension (Self-reported)	0.2	0.5	0.9	0.9	0.5	0.2	1.0	0.4
Whole body fat-free mass	0.2	0.9	1.8	0.7	1.0	0.4	1.4	1.1
Mood swings	0.2	0.3	1.1	0.4	-0.6	0.2	0.2	1.0
Medication for cholesterol	0.2	0.3	1.1	-0.0	0.3	1.0	0.3	0.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.3	0.9	-0.1	0.9	0.1	-0.2	-0.6
Back pain experienced in last month	0.2	0.3	0.7	0.7	0.6	0.1	0.8	0.3
Miserableness	0.2	0.3	0.7	0.8	0.2	0.6	0.4	0.3
Medication: Paracetamol	0.2	0.3	0.8	0.4	0.3	0.1	0.9	0.8
Basal metabolic rate	0.2	1.0	1.8	0.7	1.1	0.6	1.4	1.0
Medication: Omeprazole (e.g. Zanprol)	0.2	0.3	0.8	-0.1	-0.6	-0.9	-0.0	0.5
Deep venous thrombosis (DVT) (self-reported)	0.2	0.2	0.5	-0.1	0.5	0.7	0.6	0.4
Major Depression (MDD)	0.1	0.2	0.3	0.5	0.4	0.4	0.5	-0.2
HbA1C	0.1	0.2	0.6	-0.3	-0.0	-0.2	0.0	0.8
Waist Hip Ratio (WHR)	0.1	0.4	1.1	-0.3	-0.6	-1.0	0.3	0.5
Respiratory disease	0.1	0.2	0.6	-0.1	0.2	-0.1	-0.8	-0.5
Hair Pigment	0.1	3.5	7.2	-1.6	-2.7	-2.2	-1.6	-0.8
Hand grip strength (left)	0.1	0.1	0.3	-0.6	-0.4	-0.3	-0.3	0.1
Number of treatments/medications taken	0.1	0.1	0.4	0.5	0.6	-0.1	0.2	-0.1
Ever had hysterectomy (womb removed)	0.1	0.1	0.3	-0.0	0.6	0.2	0.0	0.3
Medication: Metformin	0.1	0.2	0.4	0.3	0.7	0.1	0.5	-0.2
Fed-up feelings	0.1	0.1	0.2	0.1	0.3	0.5	0.3	-0.2
Age when periods started (menarche)	0.1	0.2	0.6	-0.2	-0.1	0.3	-0.4	-0.7
Serious illness, injury or assault to yourself	0.1	0.1	0.4	-0.2	-0.3	-0.7	-0.0	-0.0
Waist circumference	0.1	0.3	0.7	0.3	0.7	0.2	0.8	0.5
Alcohol usually taken with meals	0.1	0.1	0.3	-0.1	-0.5	0.0	-0.2	0.4
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.2	0.5	-0.3	-0.0	-0.7	0.4	-0.5
Allergy	0.1	0.2	0.4	0.7	0.3	0.3	0.6	0.4
Pain all over the body in last month	0.1	0.1	0.5	-0.4	0.2	-0.1	0.1	-0.7
Weight	0.1	0.6	1.1	0.4	1.1	0.7	1.0	0.5
Arm fat percentage (right)	0.1	0.2	0.7	-0.0	0.8	0.4	0.4	-0.1
Father’s age at death	0.1	0.1	0.3	-0.6	-0.4	-0.4	-0.3	0.1
Happiness	0.1	0.1	0.3	-0.4	0.5	0.1	-0.1	-0.6
Qualifications: A levels/AS levels or equivalent	0.1	0.3	0.9	0.6	0.2	0.9	0.2	0.4
Asthma	0.1	0.2	0.3	0.6	0.4	0.4	0.0	0.3
Illnesses of mother	0.1	0.1	0.3	-0.5	-0.2	-0.4	-0.2	-0.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.2	0.3	-0.6	-0.6	-0.3	-0.4	-0.3
Arm fat mass (right)	0.1	0.3	0.9	0.0	1.0	0.5	0.6	-0.1
Trunk predicted mass	0.1	0.8	1.8	0.6	1.0	0.4	1.4	0.9
Seen doctor (GP) for nerves, anxiety, tension or depression	0.1	0.2	0.5	0.5	0.3	0.3	0.3	0.7
Medication for cholesterol, blood pressure or diabetes	0.1	0.2	0.4	0.6	-0.2	0.4	0.3	0.6
Medication: Ventolin 100micrograms inhaler	0.1	0.1	0.4	-0.1	-0.4	0.3	-0.6	-0.1
Birth weight	0.1	0.3	1.1	0.4	0.1	-0.2	0.3	1.0
Leg fat percentage (right)	0.1	0.4	1.1	-0.9	0.1	-0.0	-0.4	-1.1
Age at first live birth	0.1	0.2	0.2	-0.3	-0.4	-0.4	-0.4	0.5
Emphysema/chronic bronchitis	0.1	0.1	0.2	0.5	-0.2	-0.2	-0.4	-0.1
Suffer from ‘nerves’	0.1	0.1	0.6	-0.0	-0.2	-0.8	-0.1	-0.0
Medication: Aspirin	0.1	0.1	0.3	-0.2	0.5	0.1	0.1	0.1
Supplements: Vitamin C	0.1	0.2	0.5	0.3	-0.3	-0.7	-0.1	0.3
Average weekly red wine intake	0.1	0.2	0.5	0.2	-0.7	0.1	-0.3	0.6
Loneliness, isolation	0.1	0.1	0.5	-0.2	-0.2	-0.7	0.3	-0.2
Diabetes diagnosed by doctor	0.1	0.1	0.3	-0.3	-0.1	-0.5	-0.1	-0.6
Qualifications: nursing, teaching	0.1	0.2	0.4	-0.6	0.3	0.3	-0.4	-0.6
Asthma (self-reported)	0.1	0.2	0.4	0.6	0.6	0.5	0.1	0.2
Osteoporosis (self-reported)	0.1	0.1	0.2	0.3	-0.4	-0.5	-0.0	0.5
Osteoarthritis (self-reported)	0.1	0.1	0.2	-0.1	-0.0	0.4	-0.2	0.5
Medication: Aspirin	0.1	0.1	0.2	-0.2	0.3	0.0	0.2	0.5
Whole body water mass	0.1	0.8	1.6	0.6	0.9	0.4	1.3	1.0
Number of self-reported non-cancer illnesses	0.1	0.3	0.9	0.1	0.9	-0.1	0.6	0.2
Guilty feelings	0.1	0.1	0.3	-0.1	-0.5	-0.3	0.5	0.2
Medication: Blood pressure	0.1	0.3	0.6	0.6	-0.3	-0.3	0.5	0.8
Medication: Bendroflumethiazide	0.1	0.2	0.8	0.9	-0.0	0.1	0.3	0.4
Illnesses of father: High blood pressure	0.1	0.2	0.3	-0.3	-0.6	-0.0	-0.5	-0.5
Ever smoked	0.1	0.2	0.3	0.2	0.6	0.2	0.6	0.5
Leg fat percentage (left)	0.1	0.4	1.3	-0.8	0.1	-0.1	-0.5	-1.1
Number of operations (self-reported)	0.1	0.1	0.2	0.4	0.5	0.1	0.4	-0.0
Vascular/heart problems diagnosed by doctor	0.1	0.3	0.4	-0.6	-0.3	0.2	-0.7	-0.6
Impedance of whole body	0.1	0.4	1.1	-0.6	-0.6	0.0	-1.0	-0.1
Bipolar Disorder or Schizophrenia	0.0	0.1	0.3	-0.2	0.5	0.1	-0.5	-0.1
Breast Cancer	0.0	0.1	0.5	0.1	0.2	0.7	-0.2	0.0
Prostate Cancer	0.0	0.1	0.1	0.2	0.1	-0.4	-0.2	-0.2
Blood Platelet Count	0.0	0.6	1.3	0.7	-0.2	-0.5	1.1	0.9
Heel T-Score	0.0	0.3	0.6	0.7	0.1	0.2	0.8	0.7
Cardiovascular Disease	0.0	0.1	0.2	-0.1	0.2	0.0	0.3	-0.5
Tanning	0.0	0.4	0.9	0.4	0.6	0.7	0.9	0.2
Trunk fat percentage	0.0	0.2	0.3	-0.6	0.6	0.2	-0.1	-0.3
Hand grip strength (right)	0.0	0.1	0.2	-0.5	-0.1	-0.2	-0.4	0.0
Average weekly fortified wine intake	0.0	0.0	0.1	-0.0	0.1	-0.2	0.1	0.4
Heel bone mineral density (BMD) T-score, automated (left)	0.0	0.1	0.2	-0.2	0.1	-0.5	0.4	-0.3
Body mass index (BMI)	0.0	0.1	0.3	-0.4	0.3	-0.2	0.0	-0.6
Trunk fat mass	0.0	0.2	0.6	-0.3	0.8	0.4	0.3	0.1
Qualifications: None of the above	0.0	0.1	0.2	0.4	-0.3	-0.2	0.3	-0.0
Diabetes (self-reported)	0.0	0.1	0.2	0.1	0.3	-0.0	0.5	-0.1
Frequency of tiredness / lethargy in last 2 weeks	0.0	0.0	0.1	-0.2	0.0	-0.4	0.1	-0.2
Impedance of arm (left)	0.0	0.2	0.5	0.3	0.3	0.7	-0.0	0.7
Peak expiratory flow (PEF)	0.0	0.0	0.0	-0.0	-0.1	0.1	-0.1	-0.0
Body fat percentage	0.0	0.2	0.4	-0.6	0.5	0.2	-0.1	-0.4
Arm fat-free mass (right)	0.0	0.1	0.3	-0.5	0.1	-0.5	0.3	0.1
Whole body fat mass	0.0	0.2	0.5	-0.4	0.7	0.3	0.2	-0.1
Leg fat mass (right)	0.0	0.1	0.3	-0.4	0.5	0.2	0.1	-0.4
Arm predicted mass (right)	0.0	0.2	0.4	-0.6	0.1	-0.6	0.3	0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.0	0.1	0.1	-0.2	0.2	0.2	0.4	0.1
Illnesses of father: Heart disease	0.0	0.1	0.2	0.1	0.2	-0.4	-0.1	-0.3
Arm fat percentage (left)	0.0	0.1	0.4	-0.3	0.6	0.2	0.2	-0.1
Medication: Gliclazide	0.0	0.1	0.1	0.0	-0.2	0.3	-0.3	-0.3
Arm fat mass (left)	0.0	0.1	0.5	-0.1	0.7	0.2	0.4	0.1
Arm fat-free mass (left)	0.0	0.1	0.3	-0.1	0.4	-0.3	0.6	0.1
Leg fat mass (left)	0.0	0.1	0.4	-0.3	0.6	0.2	0.2	-0.4
Arm predicted mass (left)	0.0	0.2	0.5	0.1	0.6	0.1	0.7	0.3

Hub : Genes

SYS1-DBNDD2

Models

Trait associations