Best TWAS P=9.13e-23 · Best GWAS P=5.63e-28 conditioned to 9.09e-07
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Heart Left Ventricle | CRIM1 | 0.20 | 0.11 | lasso | 6 | 0.15 | 3.1e-08 | 6.3 | -6.1 | 1.2e-09 | -0.38 | 0.82 | 0.07 | FALSE |
| 2 | GTEx | Heart Left Ventricle | RP11-490M8.1 | 0.28 | 0.11 | lasso | 6 | 0.14 | 3.7e-08 | 6.3 | -5.1 | 2.8e-07 | -0.46 | 0.99 | 0.00 | FALSE |
| 3 | GTEx | Lung | CRIM1 | 0.19 | 0.01 | enet | 38 | 0.05 | 1.8e-04 | -1.3 | -7.0 | 2.3e-12 | -0.52 | 0.04 | 0.80 | FALSE |
| 4 | The Cancer Genome Atlas | Prostate Adenocarcinoma | CRIM1 | 0.05 | 0.04 | lasso | 2 | 0.03 | 3.2e-04 | 9.7 | 9.8 | 9.1e-23 | 0.92 | 0.01 | 0.95 | TRUE |