[Hub]/) : Traits : Lung FEV1/FVC ratio :

chr2:35,883,253-37,472,804

Best TWAS P=9.13e-23 · Best GWAS P=5.63e-28 conditioned to 9.09e-07

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 GTEx Heart Left Ventricle CRIM1 0.20 0.11 lasso 6 0.15 3.1e-08 6.3 -6.1 1.2e-09 -0.38 0.82 0.07 FALSE
2 GTEx Heart Left Ventricle RP11-490M8.1 0.28 0.11 lasso 6 0.14 3.7e-08 6.3 -5.1 2.8e-07 -0.46 0.99 0.00 FALSE
3 GTEx Lung CRIM1 0.19 0.01 enet 38 0.05 1.8e-04 -1.3 -7.0 2.3e-12 -0.52 0.04 0.80 FALSE
4 The Cancer Genome Atlas Prostate Adenocarcinoma CRIM1 0.05 0.04 lasso 2 0.03 3.2e-04 9.7 9.8 9.1e-23 0.92 0.01 0.95 TRUE