TWAS hub - CRIM1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Tibial	0.0963	0.0386	0.00340	0.045	NA	0.040	NA	0.047	1.9e-04	NA	4.4e-04	NA	1.4e-04
2	GTEx	Brain Cerebellar Hemisphere	0.3610	0.1020	0.00092	0.211	NA	0.133	NA	0.164	3.9e-06	NA	2.8e-04	NA	5.4e-05
3	GTEx	Heart Left Ventricle	0.2034	0.0626	0.00073	0.107	NA	0.120	NA	0.147	2.6e-06	NA	6.4e-07	NA	3.1e-08
4	GTEx	Lung	0.1914	0.0510	0.00022	0.012	NA	0.046	NA	0.024	3.7e-02	NA	1.8e-04	NA	5.7e-03
5	NTR	Blood	0.0888	0.0163	0.00000	0.099	0.097	0.103	0.104	0.106	3.3e-30	1.7e-29	1.8e-31	1.2e-31	3.1e-32
6	TCGA	Prostate Adenocarcinoma	0.0524	0.0254	0.00510	0.043	0.028	0.029	NA	0.031	2.5e-05	6.0e-04	5.0e-04	NA	3.2e-04

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Trunk fat mass	6.4	27.6	55.5	-7.5	7.0	-0.4	0.4	-7.0	-3.5
Lung FEV1/FVC ratio	6.3	32.0	96.4	3.0	-0.1	-6.1	-7.0	0.6	9.8
Forced vital capacity (FVC), Best measure	6.3	23.2	46.6	-6.8	5.4	1.4	0.7	-5.9	-5.2
Whole body fat mass	5.9	24.5	49.7	-7.0	6.6	-0.6	0.2	-6.7	-3.0
Weight	5.7	27.8	57.9	-7.6	7.0	-0.0	-0.1	-6.6	-3.9
Trunk fat percentage	5.6	22.3	45.3	-6.7	6.2	-0.5	0.3	-6.5	-2.8
Forced vital capacity (FVC)	5.6	21.5	45.8	-6.8	5.0	0.7	1.1	-5.7	-4.9
Comparative height size at age 10	4.9	27.1	56.6	-7.5	5.7	-0.2	2.6	-6.1	-5.4
Arm fat mass (right)	4.8	19.9	43.3	-6.6	5.8	-0.8	-0.5	-5.8	-2.7
Height	4.7	91.2	179.6	-13.4	10.6	5.3	1.7	-11.6	-9.5
Hip circumference	4.7	20.4	43.3	-6.6	5.8	0.7	0.0	-5.4	-4.1
Leg fat-free mass (left)	4.6	24.5	50.0	-7.1	6.5	0.4	-0.6	-6.1	-4.1
Leg predicted mass (left)	4.6	24.5	50.4	-7.1	6.5	0.3	-0.6	-6.1	-4.1
Body fat percentage	4.6	18.0	37.3	-6.1	5.6	-0.5	0.3	-5.8	-2.2
Leg fat mass (right)	4.6	17.8	36.7	-6.1	5.8	-0.7	0.3	-5.5	-2.2
Arm fat mass (left)	4.6	18.8	39.2	-6.3	5.8	-0.8	-0.6	-5.7	-2.5
Waist circumference	4.5	16.5	34.5	-5.9	5.7	-0.8	-0.7	-5.3	-1.7
Birth weight of first child	4.5	8.2	21.6	-3.7	2.4	1.1	0.3	-2.6	-4.7
Leg fat mass (left)	4.4	17.0	35.6	-6.0	5.7	-1.0	-0.1	-5.4	-2.0
Standing height	4.3	42.5	74.8	-8.7	7.1	2.2	2.9	-7.4	-7.9
Leg predicted mass (right)	4.3	22.8	47.1	-6.9	6.2	0.1	-0.9	-5.7	-4.2
Leg fat-free mass (right)	4.2	22.2	46.4	-6.8	6.1	0.2	-1.0	-5.6	-4.1
Number of self-reported non-cancer illnesses	4.2	7.3	16.8	-4.1	4.0	0.4	-1.2	-3.0	-1.0
Forced expiratory volume in 1-second (FEV1), Best measure	4.1	13.0	25.6	-5.1	4.7	0.0	-1.3	-4.9	-2.0
Arm fat percentage (left)	4.0	16.1	32.7	-5.7	5.4	-0.7	-0.2	-5.5	-2.1
Basal metabolic rate	4.0	22.0	46.1	-6.8	6.1	0.2	-0.5	-5.8	-3.9
Arm fat percentage (right)	3.9	15.4	33.3	-5.8	5.1	-1.0	-0.0	-5.3	-2.2
Medication: Omeprazole (e.g. Zanprol)	3.4	4.2	8.9	-3.0	2.4	-1.0	-0.9	-2.7	-1.1
Bilateral oophorectomy (both ovaries removed)	3.3	3.8	7.8	-2.1	2.8	-0.8	-1.4	-2.6	-0.9
Sitting height	3.3	23.4	45.6	-6.8	5.3	2.1	0.7	-5.5	-5.6
Whole body fat-free mass	3.3	18.9	39.6	-6.3	5.6	0.1	-0.5	-5.3	-3.8
Allergy	3.2	7.3	15.0	3.4	-3.7	1.7	1.0	3.9	0.5
Forced expiratory volume in 1-second (FEV1)	3.2	10.7	21.9	-4.7	4.3	-0.6	-0.9	-4.5	-1.6
Whole body water mass	3.1	17.7	38.1	-6.2	5.3	-0.0	-0.7	-5.1	-3.6
Prostate Cancer	3.0	4.2	9.0	-3.0	2.0	0.3	-0.6	-1.6	-3.0
Forced expiratory volume in 1-second (FEV1), predicted	3.0	6.2	10.4	-3.2	2.6	1.2	0.8	-2.8	-3.2
Irritability	3.0	5.0	9.5	-3.1	2.6	0.9	0.2	-2.2	-2.9
Financial difficulties in last 2 years	2.9	3.9	7.4	-2.7	2.5	-0.7	-1.9	-2.4	0.0
Fractured/broken bones in last 5 years	2.9	3.8	12.4	1.0	-1.4	-1.7	3.5	1.9	-0.8
High blood pressure (mother)	2.7	3.8	8.3	-2.4	2.4	0.2	-1.3	-2.9	-1.1
Arm fat-free mass (right)	2.7	13.6	29.2	-5.4	4.9	-0.3	-1.4	-4.5	-2.5
BMI	2.6	14.8	32.8	-5.2	5.7	-0.8	-1.4	-5.0	-1.1
Illnesses of father: Heart disease	2.6	3.7	12.3	1.0	-1.1	-3.5	-1.4	0.2	2.3
LDL Cholesterol	2.5	3.9	7.1	-2.7	2.5	0.6	1.3	-2.6	-1.1
Arm predicted mass (right)	2.5	12.7	26.9	-5.2	4.7	-0.3	-1.6	-4.5	-2.2
Guilty feelings	2.5	3.8	9.1	2.2	-1.6	-3.0	-0.6	2.1	1.4
Bipolar Disorder (2011)	2.4	2.3	5.3	2.0	-0.9	-1.4	-0.6	1.1	2.3
Body Mass Index (BMI) (2010)	2.4	3.3	5.4	-2.0	2.3	-2.1	-1.0	-2.3	-0.2
Trunk fat-free mass	2.4	13.8	29.1	-5.4	4.7	0.2	-0.4	-4.5	-3.4
Trunk predicted mass	2.4	13.7	28.5	-5.3	4.7	0.1	-0.4	-4.5	-3.4
Leg fat percentage (right)	2.4	8.7	17.5	-4.0	4.2	-0.5	0.8	-4.1	-0.8
Arm fat-free mass (left)	2.4	12.1	28.1	-5.3	4.3	-0.1	-1.5	-4.3	-2.3
Illnesses of mother	2.3	2.8	6.4	2.1	-2.2	-0.2	0.9	2.5	0.9
Medication for pain relief, constipation, heartburn	2.3	3.9	9.1	3.0	-2.7	1.0	-0.2	2.4	0.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	2.3	2.7	7.0	-0.1	-0.6	-1.1	2.6	1.0	-2.6
Ever had prostate specific antigen (PSA) test	2.3	2.7	4.4	-2.1	1.9	1.7	-1.1	-1.8	-0.9
Lung FVC	2.2	11.2	25.7	-5.1	3.9	-0.3	-1.8	-4.6	-1.3
Time employed in main current job	2.2	2.5	7.1	2.3	-0.9	-0.3	-0.9	0.8	2.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.2	2.5	5.4	-1.5	1.1	-0.6	-2.3	-1.1	2.2
Illnesses of father: None of the above (group 1)	2.2	2.7	7.5	-0.6	0.3	2.7	1.9	0.3	-2.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	2.2	4.6	8.8	-2.8	2.4	-0.2	-2.2	-3.0	0.4
Commuting to job workplace: Cycle	2.2	2.6	5.2	2.0	-2.3	-1.2	-0.3	2.0	1.1
Arm predicted mass (left)	2.2	11.4	26.1	-5.1	4.2	-0.4	-1.4	-4.1	-2.2
Leg fat percentage (left)	2.1	7.6	15.0	-3.8	3.9	-1.0	0.3	-3.9	-0.7
Lung cancer (father)	2.0	2.3	4.2	-1.5	1.7	2.0	-0.2	-1.6	-1.3
Average weekly beer plus cider intake	2.0	2.9	8.2	0.3	-1.4	2.9	1.2	1.1	-2.1
Body mass index (BMI)	1.9	8.2	16.9	-4.0	4.1	-1.1	-1.5	-3.6	-0.3
Peak expiratory flow (PEF)	1.9	4.5	9.0	-2.7	2.4	1.5	-0.9	-3.0	-1.4
Qualifications: nursing, teaching	1.9	2.9	6.0	-2.0	1.3	0.1	1.5	-1.9	-2.5
Wears glasses or contact lenses	1.9	2.2	5.6	1.8	-1.3	-0.1	2.4	1.6	-0.2
Medication for hormone replacement therapy	1.8	2.0	5.4	-1.1	1.4	2.3	-1.0	-1.4	-0.6
Diabetes (father)	1.8	2.2	5.1	1.4	-1.2	0.2	-2.2	0.9	1.9
Impedance of arm (left)	1.8	8.1	13.2	-2.8	2.3	1.6	3.4	-2.9	-3.6
Medication: Omeprazole	1.8	2.2	4.5	-2.1	1.8	-1.1	-0.7	-1.9	-0.3
Medication: Seretide 50 evohaler	1.8	2.1	4.0	-2.0	1.9	1.4	-0.4	-1.6	-0.3
Eye problems/disorders: Glaucoma	1.8	2.1	4.6	1.8	-2.0	-0.3	0.6	2.1	0.6
Medication: Atorvastatin	1.8	2.2	4.4	-2.0	2.0	-0.4	-0.4	-2.1	-0.5
Schizophrenia (2014)	1.7	3.7	5.6	2.4	-2.1	-1.2	-1.8	2.0	1.8
Relative age voice broke	1.7	2.6	7.3	1.9	-2.7	0.3	0.1	2.0	0.7
Taking other prescription medications	1.7	2.6	5.6	-2.2	2.4	-1.4	0.6	-1.6	-0.5
Hypertension (Self-reported)	1.7	4.8	11.1	-2.8	3.3	-0.9	-0.8	-2.6	-1.2
Handedness (chirality/laterality): Left-handed	1.7	2.1	11.1	-0.6	0.4	-0.7	-3.3	-0.6	0.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.7	2.0	5.8	-2.4	1.8	0.2	-0.3	-1.7	-0.6
Mean Putamen Volume	1.6	1.8	4.7	-1.3	2.2	0.3	0.2	-2.1	-0.4
Cardiovascular Disease	1.6	5.2	12.7	-2.5	3.6	0.5	0.2	-2.4	-2.5
Respiratory disease	1.6	3.6	8.1	-2.9	2.4	-0.8	0.7	-2.5	-0.8
Chronotype (morning person)	1.6	3.8	8.6	2.2	-1.9	-0.4	-1.6	1.7	2.9
Hayfever, allergic rhinitis or eczema	1.6	3.5	8.0	-1.9	2.6	-1.5	-0.8	-2.8	0.3
Hearing difficulty/problems with background noise	1.6	2.6	6.1	1.6	-2.3	-0.1	0.4	2.5	-1.2
Impedance of arm (right)	1.6	7.4	13.0	-2.8	1.8	1.1	3.5	-2.6	-3.6
Headache pain in last month	1.6	2.8	4.9	-2.1	1.4	-1.8	1.1	-1.0	-2.2
Birth weight	1.6	3.5	6.7	-2.5	2.2	0.3	0.6	-1.6	-2.6
Number of full brothers	1.6	2.0	4.7	1.5	-1.5	1.0	0.9	2.2	1.0
Ever had stillbirth, spontaneous miscarriage or termination	1.6	1.7	2.8	-1.1	1.4	1.1	0.9	-1.4	-1.7
Age at First Birth	1.5	2.2	4.0	-1.3	1.0	1.5	1.7	-1.2	-2.0
Number of treatments/medications taken	1.5	2.7	5.8	-2.4	2.3	-1.3	-0.3	-1.8	0.1
Angina	1.5	2.0	6.8	0.4	-0.4	-0.7	-2.1	0.3	2.6
Tinnitus: Yes, but not now, but have in the past	1.5	1.6	3.6	0.9	-0.4	-1.2	-1.8	0.4	1.9
High blood pressure	1.5	4.2	10.0	-2.6	3.2	-0.2	-1.2	-2.5	-0.9
Loud music exposure frequency	1.5	1.6	2.9	1.7	-1.6	-0.4	-0.8	1.6	1.0
Mouth/teeth dental problems: Loose teeth	1.5	1.8	3.6	1.1	-1.6	-1.0	-0.9	1.1	1.9
Average weekly red wine intake	1.5	2.2	8.3	0.3	0.9	-1.1	2.9	-0.2	-1.7
Medication: Gliclazide	1.5	1.7	4.1	-1.3	1.7	-1.1	0.5	-2.0	0.5
Ever had bowel cancer screening	1.4	1.6	3.6	0.4	-0.9	-1.9	-1.5	0.2	1.6
Hearing aid user	1.4	1.5	3.2	-1.5	1.4	-0.2	0.6	-1.8	-1.2
Number of operations (self-reported)	1.4	2.1	5.8	-2.4	1.5	-1.1	0.2	-1.7	-0.7
Deep venous thrombosis (DVT) (self-reported)	1.4	1.8	4.0	-1.7	2.0	-0.4	-0.7	-1.6	-0.8
Chronic bronchitis/emphysema (father)	1.3	1.6	3.7	-0.9	1.5	1.9	0.1	-0.8	-1.4
Medication: Allopurinol	1.3	1.8	3.0	-1.7	0.8	-0.9	-1.7	-1.2	1.3
Average weekly champagne plus white wine intake	1.3	1.8	4.5	1.3	-0.2	-2.1	-0.8	0.5	2.0
Medication: Paracetamol	1.3	2.0	5.8	-2.4	1.5	-0.1	0.8	-1.3	-1.2
Ever depressed for a whole week	1.3	1.6	4.8	0.8	-0.2	-2.2	-1.7	0.6	1.0
Pack years of smoking	1.3	1.9	3.9	-2.0	1.7	-1.3	-0.6	-1.5	-0.4
Schizophrenia vs Biploar Disorder	1.2	1.6	4.6	0.5	-2.1	-0.1	-1.7	1.0	1.0
Sensitivity / hurt feelings	1.2	2.0	7.6	-0.7	0.6	-0.9	-2.8	-0.5	1.6
Medication: Metformin	1.2	1.7	3.4	-1.6	1.2	1.8	-0.4	-1.3	-0.9
Pack years adult smoking proportion	1.2	1.8	3.6	-1.9	1.9	-1.1	-0.6	-1.5	-0.2
Pulse wave reflection index	1.2	1.5	2.8	1.2	-1.7	-1.0	1.5	1.2	-0.4
Blood clot in the leg (DVT)	1.2	1.5	3.7	-1.5	1.9	-0.1	-0.7	-1.4	-0.9
Medication: Paracetamol	1.2	1.9	4.3	-2.1	1.7	-0.5	1.1	-1.7	-0.5
Medication for cholesterol, blood pressure or diabetes	1.2	2.0	3.5	1.6	-1.6	0.3	1.9	1.8	-0.6
Glaucoma (self-reported)	1.2	1.4	2.8	1.0	-1.7	-1.3	-0.2	1.6	0.4
Supplements: Vitamin C	1.2	1.4	3.3	1.6	-0.9	-1.1	-0.1	0.9	1.8
Loneliness, isolation	1.2	1.7	4.3	1.1	-1.3	1.1	-1.2	2.1	-0.4
Mouth/teeth dental problems: Mouth ulcers	1.2	1.9	3.3	1.8	-1.1	-1.7	-0.5	1.6	1.1
Financial situation satisfaction	1.2	1.5	4.5	1.0	-0.2	-1.3	-1.2	-0.1	2.1
Supplements: Fish oil (including cod liver oil)	1.2	1.6	3.9	-2.0	1.1	0.2	1.0	-1.5	-1.1
Risk taking	1.2	1.7	3.2	1.5	-1.3	-0.9	-0.3	1.5	1.8
Vascular/heart problems diagnosed by doctor	1.2	3.2	7.8	2.1	-2.8	0.8	1.3	2.1	0.5
Pain experienced in last month	1.2	2.1	6.0	1.8	-0.2	1.6	-0.7	0.3	2.5
Allergy or Eczema	1.1	3.0	6.8	-2.0	2.3	-1.3	-0.1	-2.6	-0.4
Townsend deprivation index at recruitment	1.1	1.6	3.9	1.3	-1.3	-0.1	-0.3	1.4	2.0
Hair/balding pattern: Pattern 3	1.1	1.7	7.1	-1.5	-0.2	-2.7	0.6	-0.3	-0.4
Length of working week for main job	1.1	1.3	3.1	-0.1	1.2	-1.8	1.3	-1.0	0.5
Medication: Amlodipine	1.1	1.5	3.8	-0.0	0.4	-1.3	-1.9	-0.0	1.8
Qualifications: College or University degree	1.1	3.4	5.6	-1.8	2.1	-1.7	1.4	-2.4	-1.4
Angina (self-reported)	1.1	1.4	4.3	0.2	-0.2	-0.5	-2.0	0.3	2.1
Migraine (self-reported)	1.1	1.4	2.6	-1.5	1.6	0.8	-0.3	-1.6	-0.4
Miserableness	1.1	1.8	5.2	-0.3	-0.7	1.1	1.7	1.1	-2.3
Ever had hysterectomy (womb removed)	1.0	1.2	4.0	0.4	0.2	-0.5	-2.0	-0.3	1.6
Medication: Simvastatin	1.0	1.5	2.7	-0.9	1.6	-0.6	-1.5	-1.5	0.5
Exposure to tobacco smoke at home	1.0	1.1	3.5	0.1	0.6	-1.2	-1.1	-0.3	1.9
Eye problems/disorders: None of the above	1.0	1.1	2.4	-1.6	1.0	0.5	0.3	-1.4	-1.0
Heart disease (mother)	1.0	1.2	4.1	0.0	0.4	-0.9	-2.0	-0.1	1.4
Had major operations	1.0	1.1	3.2	-0.6	1.3	-1.8	-0.1	-1.2	0.0
Osteoporosis (self-reported)	1.0	1.2	3.7	1.9	-0.8	-0.5	0.6	1.1	1.1
Pain type(s) experienced in last month: Hip pain	1.0	1.2	3.2	-1.6	1.8	0.9	0.1	-0.8	-0.1
High cholesterol (Self-reported)	1.0	1.7	3.4	-1.4	1.2	-0.2	-1.8	-1.5	1.0
Average weekly spirits intake	0.9	1.1	2.3	-0.9	0.9	-1.5	-0.4	-0.8	1.4
Hearing difficulty/problems: Yes	0.9	1.4	5.9	-0.1	-0.7	0.8	0.7	1.1	-2.4
Other serious medical condition/disability diagnosed by doctor	0.9	1.2	3.8	-2.0	0.2	0.9	-1.2	-0.2	-1.0
Medication: Ramipril	0.9	1.2	3.8	-0.4	0.3	-1.2	-1.9	-0.3	1.2
Medication: Cholesterol lowering	0.9	1.3	3.6	-0.9	0.9	0.3	-1.9	-1.3	1.0
Medication: Blood pressure	0.9	1.7	2.5	-1.5	1.6	-0.7	-1.1	-1.6	1.1
Overall health rating	0.9	2.0	3.6	-1.9	1.7	-0.3	-1.9	-1.1	0.6
Medication: Aspirin	0.9	1.2	1.9	-1.1	0.8	-1.4	-0.5	-1.2	1.2
Friendships satisfaction	0.9	1.1	4.6	0.7	-0.5	-0.3	-2.1	0.7	0.9
Commuting to job workplace: Walk	0.9	1.0	1.6	1.3	-1.0	-1.1	-0.3	0.8	1.2
Osteoarthritis (self-reported)	0.9	1.2	3.4	-1.3	0.9	0.9	0.2	-0.6	-1.8
Crohns Disease (2012)	0.8	1.2	2.4	1.0	-0.6	-1.6	-0.6	1.3	1.2
Rheumatoid Arthritis	0.8	1.1	2.2	-1.0	1.5	0.9	0.1	-1.4	0.7
Frequency of depressed mood in last 2 weeks	0.8	1.2	2.2	1.0	-1.1	1.1	-1.2	1.5	-0.4
Age when periods started (menarche)	0.8	1.9	5.0	-1.3	1.1	0.6	1.2	-1.2	-2.2
Alcohol intake versus 10 years previously	0.8	1.2	3.8	-1.9	1.2	-0.4	-0.3	-1.3	-0.4
Falls in the last year	0.8	1.1	2.2	-0.6	-0.8	-1.5	-1.2	1.2	0.7
Qualifications: O levels/GCSEs or equivalent	0.8	1.4	3.9	0.2	-1.3	1.3	-0.2	0.9	-2.0
Medication: Ventolin 100micrograms inhaler	0.8	1.1	3.2	-1.3	1.8	0.1	0.6	-1.1	0.0
Comparative body size at age 10	0.8	2.3	3.5	1.8	-1.4	-0.8	-1.2	1.9	1.7
Suffer from ‘nerves’	0.8	1.3	2.1	-1.3	1.5	1.0	-0.9	-0.8	-1.2
Family relationship satisfaction	0.8	0.9	1.5	1.1	-0.8	0.3	-1.2	1.2	0.8
Medication: Aspirin	0.8	1.0	2.4	-1.0	0.5	-1.2	-0.8	-0.8	1.5
Ever taken oral contraceptive pill	0.8	0.9	2.1	1.2	-0.9	-0.3	1.0	1.4	0.2
Commuting to job workplace: Public transport	0.8	0.9	2.0	-1.1	0.9	1.4	0.0	-0.7	-1.1
Alcohol drinker status: Never	0.8	0.9	2.0	1.4	-0.7	0.2	-0.4	1.3	1.1
Diastolic blood pressure, automated reading	0.8	2.5	7.2	-1.7	2.7	0.6	0.7	-1.6	-1.3
Depressed Affect (Nagel 2018)	0.7	1.4	6.6	-1.1	0.2	0.7	0.3	0.2	-2.6
Schizophrenia (2018)	0.7	1.4	4.3	1.0	-0.9	-0.7	-2.1	0.6	1.2
Alzheimer’s Disease (in father)	0.7	0.7	2.4	1.5	-0.7	-1.1	-0.2	0.6	0.1
Fasting Glucose	0.7	0.9	3.1	-0.4	0.6	-0.9	-0.2	-0.8	-1.8
Type 2 Diabetes (T2D) (2012)	0.7	0.8	3.1	0.1	-0.3	0.0	-1.3	0.1	1.7
Diabetes (mother)	0.7	0.9	3.1	-0.7	0.8	0.8	-0.0	-0.6	-1.7
Maternal smoking around birth	0.7	1.0	2.7	0.9	0.0	1.7	-0.2	1.4	-0.8
Qualifications: CSEs or equivalent	0.7	0.9	2.0	-0.5	1.3	-0.9	1.4	-0.8	-0.4
Worrier / anxious feelings	0.7	1.3	5.2	-0.8	-1.0	-0.1	0.4	0.8	-2.3
Medication: Ibuprofen (e.g. Nurofen)	0.7	0.9	3.5	-0.3	0.7	1.9	0.1	-0.1	-1.2
Medication: Lansoprazole	0.7	0.7	1.8	-1.3	0.3	-0.7	-1.3	-0.3	-0.6
Wheeze or whistling in the chest in last year	0.7	1.2	2.7	-1.6	1.4	-0.2	0.1	-1.1	-1.0
Reason for reducing amount of alcohol drunk: Health precaution	0.7	0.9	1.8	0.7	-1.1	-0.7	-0.7	0.8	1.4
Smoking status: Previous	0.7	1.0	1.6	0.8	-1.2	-1.2	-0.3	1.0	1.3
Supplements: Calcium	0.7	0.7	2.2	0.7	0.3	-1.5	0.3	0.5	1.2
Depression (Nagel 2018)	0.6	0.9	2.0	0.8	-0.3	0.5	-1.4	1.3	-0.9
Alzheimer’s Disease (in mother)	0.6	0.7	3.1	0.2	0.2	-1.7	-0.5	-0.6	0.8
Major Depression (MDD)	0.6	0.7	2.5	1.2	0.2	-1.6	0.4	-0.1	0.3
Reaction Time	0.6	1.1	3.1	0.9	0.1	-0.4	-1.7	0.7	1.5
Waist Hip Ratio (WHR)	0.6	2.6	6.2	-0.0	1.2	-2.4	-0.9	-1.2	2.5
Neuroticism	0.6	1.4	5.5	-0.5	0.8	0.1	1.3	-0.2	-2.4
Impedance of leg (right)	0.6	2.8	11.8	1.0	-1.1	1.5	3.4	0.3	-0.2
Fed-up feelings	0.6	1.0	3.8	-1.2	0.4	-0.3	0.8	-0.3	-1.9
Hair/balding pattern: Pattern 2	0.6	0.8	2.0	1.4	-0.7	1.0	-0.7	0.8	-0.1
Pain all over the body in last month	0.6	0.6	1.6	-0.9	1.0	0.2	-0.5	-1.3	-0.2
Fluid intelligence score	0.6	1.2	5.0	-0.4	-0.3	1.3	-2.2	-0.5	-0.5
Depression (self-reported)	0.6	0.7	3.1	0.4	-0.0	0.6	1.8	0.8	-0.4
Prospective memory result	0.6	0.7	2.7	-0.1	0.8	1.7	-0.6	-0.5	-0.3
Breastfed as a baby	0.6	0.7	2.0	1.4	-0.3	-1.2	0.4	0.5	0.2
High blood pressure (siblings)	0.6	0.8	2.8	-0.7	0.0	-1.1	-1.7	-0.1	0.6
Health satisfaction	0.6	0.7	2.9	-0.4	1.0	0.4	-1.7	-0.4	0.3
Medication: Ibuprofen	0.6	0.7	2.2	-0.5	0.8	1.5	-0.2	-0.1	-1.2
Mean time to correctly identify matches	0.6	1.2	3.2	0.3	-0.2	-1.0	-1.8	0.4	1.6
Commuting to job workplace: Car/motor vehicle	0.6	0.7	2.2	-0.0	0.4	0.3	-1.1	-0.7	1.5
Eye problems/disorders: Cataract	0.6	0.7	1.4	1.2	-0.8	-0.0	1.2	1.0	0.1
Medication for cholesterol	0.6	1.0	2.0	1.1	-1.4	-0.8	0.2	1.4	0.3
Back pain experienced in last month	0.6	0.8	2.3	-1.5	0.3	-0.2	0.0	-0.3	-1.5
Mineral and other dietary supplements	0.6	0.8	2.1	1.1	-0.3	0.0	-1.5	0.2	1.2
Medication: Bendroflumethiazide	0.6	0.9	2.0	-0.8	1.1	-1.3	-0.3	-1.4	-0.2
Age started oral contraceptive pill	0.6	0.7	1.8	0.5	-0.3	-0.7	-1.4	0.2	1.3
Basal cell carcinoma (self-reported)	0.6	0.7	3.0	-0.5	-0.2	0.8	-0.4	0.2	-1.7
Intelligence (Savage-Jansen 2018)	0.5	1.6	5.3	-1.1	0.4	2.3	-1.1	-0.9	-0.9
Neuroticism (2016)	0.5	0.8	3.2	0.7	-0.2	-1.8	0.2	0.8	-0.1
Ulcerative Colitis	0.5	0.7	1.9	1.4	0.6	0.2	0.5	0.3	1.1
Blood Eosinophil Count	0.5	3.5	8.6	-1.4	1.4	-2.9	-1.9	-1.5	1.6
Systolic blood pressure, automated reading	0.5	1.5	3.0	0.5	1.7	-1.5	-0.2	-0.7	1.7
Severe depression (siblings)	0.5	0.5	1.2	0.6	-0.7	-0.5	1.1	0.7	-0.6
Serious illness, injury or assault to yourself	0.5	0.6	1.8	-0.6	0.7	-0.8	-0.6	-0.0	-1.3
Stomach or abdominal pain in last month	0.5	0.6	2.2	-0.1	-0.7	-1.5	-0.5	0.9	0.1
Supplements: Glucosamine	0.5	0.6	1.4	0.2	-0.6	-0.8	1.2	0.3	-0.9
Diverticular disease/diverticulitis (self-reported)	0.5	0.6	1.3	-0.5	1.1	0.9	-0.1	-0.6	-1.0
Medication: Atenolol	0.5	0.6	1.4	-0.8	1.2	-0.3	-0.6	-0.8	-0.7
Impedance of leg (left)	0.5	2.2	7.3	1.3	-1.7	0.8	2.7	0.9	-0.1
Nervous feelings	0.5	0.9	1.9	1.0	-0.6	0.6	-1.4	1.1	0.7
Ever unenthusiastic/disinterested for a whole week	0.5	0.7	1.5	-1.0	1.2	-0.6	-0.2	-1.0	-0.2
Hayfever/allergic rhinitis (self-reported)	0.5	0.6	1.4	-0.7	1.2	0.5	-0.2	-1.2	0.1
Father’s age at death	0.5	0.7	2.2	0.9	-0.1	0.7	0.3	0.5	-1.5
Serious illness, injury or assault of a close relative in last 2 years	0.5	0.6	1.9	0.9	-0.1	-1.4	0.7	0.4	-0.1
Mouth/teeth dental problems: Dentures	0.5	0.9	2.0	-0.6	1.2	-1.4	1.2	-0.4	-0.6
Ever highly irritable/argumentative for 2 days	0.5	0.6	1.8	-0.2	1.3	-0.1	0.4	-0.4	-1.3
Mouth/teeth dental problems: Bleeding gums	0.5	0.7	2.2	-0.1	-1.5	-0.1	-1.2	0.8	0.1
Gout (self-reported)	0.5	0.6	1.3	-0.5	0.8	-0.7	-0.8	-0.6	1.1
Chronic bronchitis/emphysema (mother)	0.5	0.6	3.2	0.4	-0.1	1.8	-0.2	0.5	-0.2
Exposure to tobacco smoke outside home	0.5	0.7	2.4	0.1	-0.6	-1.1	0.2	0.6	1.6
Neck or shoulder pain in last month	0.5	0.7	1.9	0.5	-0.8	-1.1	0.3	1.4	-0.4
Age at last live birth	0.5	0.7	2.2	1.5	-0.7	0.6	-0.7	0.9	-0.0
Breast cancer (self-reported)	0.5	0.6	1.2	-0.3	0.4	1.1	-0.8	-0.4	-1.1
Medication: Blood pressure	0.5	1.0	2.2	-1.0	1.5	-1.2	-0.4	-1.1	-0.2
Heart attack/myocardial infarction (self-reported)	0.5	0.7	1.3	-1.2	0.9	-0.7	-0.3	-1.1	0.1
Impedance of whole body	0.5	2.6	8.6	-0.6	0.2	1.5	2.9	-0.8	-1.9
Bipolar Disorder (2018)	0.4	0.7	1.8	1.1	-0.1	-1.0	1.3	0.3	0.1
Bipolar Disorder or Schizophrenia	0.4	1.0	2.3	1.5	-0.7	-1.1	-0.8	0.7	1.0
Neuroticism (Nagel 2018)	0.4	1.0	4.7	-1.1	0.3	-0.1	-0.2	-0.0	-2.2
Worry (Nagel 2018)	0.4	0.8	4.3	-0.2	-0.3	0.4	-0.1	0.7	-2.1
Ulcerative Colitis (UC)	0.4	0.7	2.8	0.6	1.0	1.7	-0.3	-0.2	0.3
Verbal and Numeric Reasoning (VNR)	0.4	0.9	3.2	0.1	-0.3	1.8	-0.6	0.1	-1.4
Ovarian Cancer	0.4	0.5	1.6	0.2	-1.3	-0.4	-0.1	0.6	0.8
Systolic Blood Pressure	0.4	1.8	7.1	-0.4	2.7	-1.1	0.4	-1.4	0.6
Hypothyroidism (self reported)	0.4	0.8	2.7	0.4	-0.5	-1.6	0.6	0.6	1.2
Ever used hormone-replacement therapy (HRT)	0.4	0.5	1.2	-0.6	1.1	-0.4	-0.7	-0.5	0.8
Medication: Co-codamol	0.4	0.5	1.7	0.2	0.1	0.3	0.9	0.4	-1.3
Average weekly fortified wine intake	0.4	0.5	2.7	0.2	-0.2	-0.4	1.6	0.0	0.2
Medication: Levothyroxine sodium	0.4	0.7	1.9	0.3	-1.4	-0.9	0.5	0.7	0.7
Past tobacco smoking	0.4	0.8	1.3	-0.8	1.1	0.7	0.1	-1.1	-1.0
Heart attack	0.4	0.5	0.9	-1.0	0.7	-0.7	-0.1	-0.9	0.3
Diabetes (self-reported)	0.4	0.6	1.4	-1.0	1.2	0.6	0.1	-1.0	-0.5
Neuroticism score	0.4	0.8	3.2	-1.0	0.6	0.5	0.1	-0.0	-1.8
Number of live births	0.4	0.5	1.0	0.1	0.9	0.7	-0.8	-0.6	1.0
Hair/balding pattern: Pattern 4	0.4	0.9	3.4	0.8	-0.0	-0.2	-0.8	0.8	1.8
Number of children fathered	0.4	0.5	1.1	0.3	-0.6	0.7	-1.0	0.9	-0.1
Age at first live birth	0.4	0.7	2.2	1.0	-0.2	-0.3	0.9	0.5	-1.5
Pulse wave peak to peak time	0.4	0.5	0.9	-1.0	0.1	0.9	-0.8	-0.1	-0.5
Pulse rate, automated reading	0.4	1.2	5.5	-0.6	-0.1	2.3	-0.8	0.2	-0.8
Chest pain or discomfort	0.4	0.6	1.9	-0.2	-0.5	-0.8	-1.4	0.4	1.0
Ever smoked	0.4	0.8	1.4	0.7	-1.1	-0.6	0.9	1.2	0.4
Unable to work because of sickness or disability	0.4	0.5	1.1	0.0	-0.5	-1.0	-0.2	0.7	-0.9
Myopia	0.4	0.5	1.2	-0.6	1.1	1.0	0.5	-0.6	0.1
Cholesterol lowering medication	0.4	0.6	1.1	-1.0	0.9	-0.0	-0.0	-1.1	-0.7
Alzheimer’s Disease (including proxy)	0.3	0.4	1.3	0.8	-0.2	-1.2	-0.4	-0.2	0.1
Primary Biliary Cirrhosis	0.3	0.4	0.8	-0.4	0.8	-0.9	0.0	-0.5	0.8
Blood Platelet Count	0.3	3.4	8.8	2.6	-1.1	-0.8	-1.3	3.0	1.0
Heel T-Score	0.3	2.6	7.6	1.6	-0.1	-2.1	0.9	-0.1	2.8
Relative age of first facial hair	0.3	0.6	2.0	-0.3	0.4	0.1	1.4	-0.5	-1.0
Eye problems/disorders: Diabetes related eye disease	0.3	0.4	0.8	0.8	-0.9	0.3	-0.3	0.7	0.3
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.4	1.4	-0.1	-0.0	0.8	0.1	0.7	-1.2
Multivitamins +/- minerals	0.3	0.4	1.2	-0.2	0.7	-0.6	1.1	-0.3	-0.4
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.5	1.8	0.4	-0.8	0.2	0.1	1.3	-0.8
Had menopause	0.3	0.4	1.0	-1.0	0.5	0.1	-1.0	-0.6	-0.1
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.7	1.5	0.8	-0.8	-0.7	-0.5	0.6	1.2
Pulse rate	0.3	0.5	2.5	-0.1	0.0	1.6	0.2	-0.2	-0.7
Happiness	0.3	0.3	1.1	0.5	0.1	0.4	-0.3	0.5	-1.1
Noisy workplace	0.3	0.4	1.3	-0.6	1.1	-0.6	-0.4	-0.5	0.0
Asthma	0.3	0.6	1.5	-1.2	0.9	-0.8	-0.0	-0.8	0.0
Pulse wave Arterial Stiffness index	0.3	0.4	1.5	0.5	0.3	-0.6	1.2	-0.3	-0.2
Tense / ‘highly strung’	0.3	0.5	2.6	-0.5	0.2	-0.1	0.3	0.3	-1.6
Hypothyroidism/myxoedema (self-reported)	0.3	0.6	1.8	0.3	-0.5	-1.4	0.2	0.3	1.0
Leg pain on walking	0.3	0.4	1.5	0.6	-0.0	-0.5	-0.0	0.4	1.2
Long-standing illness, disability or infirmity	0.3	0.5	1.3	-0.8	0.3	1.0	-1.1	0.2	0.2
Diabetes diagnosed by doctor	0.3	0.5	1.3	-0.9	1.1	0.3	-0.1	-0.9	-0.4
Asthma (self-reported)	0.3	0.7	1.4	-1.2	1.0	-1.1	-0.0	-0.7	0.2
Tinnitus: Yes, now most or all of the time	0.3	0.3	1.1	-0.3	0.3	1.0	-0.1	0.2	-0.9
Alcohol drinker status: Previous	0.3	0.4	0.7	0.0	-0.8	0.0	0.8	0.5	-0.8
Crohns Disease (2017)	0.2	0.5	1.1	0.2	0.7	-1.0	-1.0	-0.1	0.6
Irritable Bowel Disease (IBD)	0.2	0.5	0.9	0.9	0.6	0.3	-0.9	0.2	0.9
Coronary Artery Disease (CAD)	0.2	0.3	1.2	-0.1	0.3	-0.4	-0.4	-0.5	1.1
HbA1C	0.2	0.2	0.5	0.6	-0.2	-0.4	0.5	0.3	0.7
HDL Cholesterol	0.2	0.3	1.0	0.1	0.1	0.6	0.7	0.4	-1.0
Lupus	0.2	0.3	0.6	-0.6	0.7	-0.4	0.3	-0.7	0.2
Triglycerides	0.2	0.4	1.0	-0.4	0.5	-0.6	-0.5	-0.8	1.0
Type 2 Diabetes (T2D) (2018)	0.2	0.3	1.0	-0.2	1.0	0.7	0.3	-0.4	0.1
Supplements: Zinc	0.2	0.2	0.5	0.7	0.5	-0.1	0.5	0.0	0.4
Hand grip strength (right)	0.2	0.5	1.5	0.1	1.1	0.7	0.2	-0.1	-1.2
Current tobacco smoking	0.2	0.3	1.5	0.1	-0.2	1.2	-0.4	0.2	0.6
Number of incorrect matches in round	0.2	0.4	0.9	0.3	-1.0	-0.6	-0.8	0.3	0.4
Alcohol usually taken with meals	0.2	0.3	0.9	0.4	-0.9	-0.8	0.0	0.1	-0.0
Had other major operations	0.2	0.2	0.5	-0.7	0.6	-0.1	0.3	-0.6	0.2
Qualifications: None of the above	0.2	0.4	1.8	-0.2	-0.3	-0.2	-0.2	0.8	1.4
Mouth/teeth dental problems	0.2	0.3	1.0	0.1	0.3	1.0	0.2	-0.6	0.2
Illnesses of siblings	0.2	0.3	0.9	0.9	0.0	0.7	0.1	0.5	-0.0
Worry too long after embarrassment	0.2	0.4	0.9	-0.9	0.2	-0.5	0.5	-0.4	-0.9
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.3	0.8	-0.7	-0.4	0.5	0.1	0.4	-0.9
Shortness of breath walking on level ground	0.2	0.2	0.6	0.6	0.8	-0.6	0.2	0.1	-0.3
Emphysema/chronic bronchitis	0.2	0.3	0.5	0.2	-0.7	-0.7	-0.6	0.5	0.0
Number of full sisters	0.2	0.2	0.6	-0.1	-0.2	0.4	-0.8	-0.0	0.6
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.2	0.7	0.2	0.5	0.1	-0.9	-0.3	0.4
Illness, injury, bereavement, stress in last 2 years	0.2	0.3	0.8	-0.4	0.1	0.9	-0.1	-0.7	0.4
Knee pain experienced in last month	0.2	0.3	0.7	-0.3	0.8	0.7	-0.2	0.1	-0.5
Illnesses of siblings: Diabetes	0.2	0.2	0.6	-0.2	0.1	0.8	-0.8	-0.1	-0.2
Mood swings	0.2	0.4	1.0	-1.0	0.1	-0.5	0.4	-0.3	-1.0
Smoking status: Current	0.2	0.3	1.3	0.5	-0.2	1.1	-0.2	0.3	0.5
Medication: Lisinopril	0.2	0.3	0.6	-0.4	0.4	-0.6	0.2	-0.6	-0.7
Illnesses of father: High blood pressure	0.2	0.3	0.7	-0.3	-0.3	-0.8	-0.7	-0.0	0.5
Heart disease (siblings)	0.2	0.3	0.9	-0.3	-0.5	-0.9	0.3	0.2	0.6
Breast Cancer	0.1	0.2	0.4	-0.6	-0.0	0.4	-0.6	-0.4	0.1
Blood Red Count	0.1	0.6	2.8	-0.3	0.4	1.7	-0.7	-0.2	0.1
Smoking Status	0.1	0.2	0.8	0.4	-0.5	0.9	-0.1	0.3	0.4
Hand grip strength (left)	0.1	0.3	1.0	0.1	0.3	-0.0	0.8	0.2	-1.0
Vitamin and mineral supplements	0.1	0.1	0.2	-0.0	-0.4	0.4	-0.4	-0.0	-0.0
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.3	0.9	-0.4	0.0	-1.0	-0.0	-0.4	0.8
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.2	0.5	-0.1	0.1	-0.4	0.2	0.7	-0.5
Qualifications: A levels/AS levels or equivalent	0.1	0.2	0.7	0.1	-0.3	-0.4	0.5	-0.1	-0.8
Seen doctor (GP) for nerves, anxiety, tension or depression	0.1	0.2	0.5	-0.7	-0.6	-0.1	0.2	0.2	-0.4
Alcohol intake frequency.	0.1	0.2	0.8	0.2	-0.0	-0.6	-0.1	0.2	0.9
Mother’s age at death	0.1	0.2	0.4	-0.3	0.6	0.4	-0.4	-0.4	-0.4
Blood White Count	0.0	0.2	0.7	-0.4	-0.1	0.2	-0.3	0.5	0.8
Hair Pigment	0.0	1.3	4.4	0.5	-0.8	1.1	-2.1	1.1	0.2
Tanning	0.0	0.2	0.5	0.5	0.1	-0.7	0.2	0.4	-0.3

Hub : Genes

CRIM1

Models

Trait associations