[Hub]/) : Traits : Lung FEV1/FVC ratio : ← →

chr2:41,701,800-44,521,246

Best TWAS P=1.37e-23 · Best GWAS P=3.08e-28 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
27	GTEx	Nerve Tibial	EML4	0.24	0.09	enet	15	0.13	9.7e-10	8.95	-10.0	1.4e-23	-0.84	0.03	0.97	TRUE
1	GTEx	Adipose Subcutaneous	EML4	0.17	0.14	lasso	2	0.14	6.9e-12	9.00	-9.1	7.0e-20	-0.63	1.00	0.00	TRUE
44	GTEx	Thyroid	EML4	0.13	0.09	enet	13	0.11	5.4e-09	8.95	-8.8	1.3e-18	-0.80	0.52	0.48	TRUE
26	GTEx	Muscle Skeletal	EML4	0.13	0.03	lasso	5	0.04	1.1e-04	9.00	-8.6	6.3e-18	-0.58	0.55	0.19	TRUE
52	ROSMAP	Brain Pre-frontal Cortex	FTOP1	0.03	0.02	lasso	3	0.01	4.3e-03	7.45	7.2	8.9e-13	0.48	0.56	0.33	TRUE
17	GTEx	Cells Transformed fibroblasts	MTA3	0.09	0.00	enet	16	0.00	1.8e-01	-1.57	6.7	3.0e-11	0.47	0.06	0.44	TRUE
46	GTEx	Thyroid	AC010883.5	0.11	0.09	lasso	2	0.08	1.5e-06	6.32	6.4	1.5e-10	-0.03	0.91	0.07	TRUE
62	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	OXER1	0.03	0.02	blup	52	0.02	1.7e-03	6.21	-6.0	2.1e-09	-0.34	0.07	0.33	TRUE
57	The Cancer Genome Atlas	Breast Invasive Carcinoma	KCNG3	0.03	0.02	lasso	2	0.02	4.8e-05	4.71	-5.8	7.1e-09	-0.37	0.09	0.14	TRUE
9	GTEx	Brain Frontal Cortex BA9	COX7A2L	0.41	0.34	enet	10	0.32	2.4e-09	-4.61	-5.4	5.3e-08	-0.56	0.90	0.07	TRUE
63	The Cancer Genome Atlas	Brain Lower Grade Glioma	HAAO	0.09	0.11	lasso	5	0.11	4.7e-12	5.34	-5.4	6.3e-08	-0.26	0.99	0.01	TRUE
22	GTEx	Esophagus Muscularis	EML4	0.10	0.08	lasso	3	0.06	2.4e-04	10.01	-9.7	3.2e-22	-0.84	0.25	0.54	FALSE
48	METSIM	Adipose	EML4	0.11	0.08	blup	604	0.09	9.6e-13	8.94	-9.4	4.0e-21	-0.78	0.39	0.61	FALSE
25	GTEx	Muscle Skeletal	COX7A2L	0.06	0.05	lasso	3	0.06	4.0e-06	9.79	9.4	6.2e-21	0.77	0.10	0.89	FALSE
23	GTEx	Esophagus Muscularis	HAAO	0.18	0.03	lasso	5	0.07	6.0e-05	5.34	-7.8	9.1e-15	-0.54	0.62	0.03	FALSE
8	GTEx	Brain Cerebellar Hemisphere	FTOP1	0.36	0.41	lasso	5	0.40	1.8e-11	7.45	7.5	6.1e-14	0.46	0.94	0.03	FALSE
68	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	OXER1	0.05	0.04	lasso	2	0.03	8.9e-05	6.21	-7.4	1.8e-13	-0.39	0.03	0.94	FALSE
71	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	COX7A2L	0.17	0.13	enet	8	0.18	4.2e-08	-5.02	-7.3	3.3e-13	-0.72	0.07	0.93	FALSE
67	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	HAAO	0.04	0.05	lasso	4	0.05	2.7e-06	5.92	-7.2	4.2e-13	-0.39	0.06	0.94	FALSE
10	GTEx	Brain Hypothalamus	OXER1	0.19	0.02	lasso	13	0.09	4.4e-03	5.80	-7.2	5.9e-13	-0.51	0.24	0.20	FALSE
59	The Cancer Genome Atlas	Esophageal Carcinoma	COX7A2L	0.16	0.09	blup	40	0.09	7.6e-04	-4.43	-7.2	8.9e-13	-0.67	0.18	0.63	FALSE
11	GTEx	Brain Hypothalamus	HAAO	0.34	0.30	lasso	11	0.26	7.2e-07	6.00	-7.1	9.2e-13	-0.44	0.65	0.06	FALSE
36	GTEx	Skin Not Sun Exposed Suprapubic	COX7A2L	0.39	0.38	lasso	6	0.41	8.3e-24	-4.61	-7.1	1.6e-12	-0.69	1.00	0.00	FALSE
31	GTEx	Pancreas	OXER1	0.38	0.19	lasso	6	0.30	6.1e-13	5.34	7.0	3.1e-12	0.37	1.00	0.00	FALSE
19	GTEx	Colon Transverse	OXER1	0.15	0.19	enet	29	0.21	1.8e-10	-3.77	7.0	3.3e-12	0.42	0.96	0.01	FALSE
4	GTEx	Artery Aorta	OXER1	0.20	0.20	lasso	8	0.24	9.8e-14	7.45	6.8	7.3e-12	0.44	1.00	0.00	FALSE
39	GTEx	Spleen	MTA3	0.40	-0.01	lasso	6	0.02	9.2e-02	7.77	6.8	7.8e-12	0.54	0.10	0.18	FALSE
6	GTEx	Artery Tibial	FTOP1	0.08	0.07	enet	14	0.07	3.3e-06	6.16	6.8	1.0e-11	0.39	0.91	0.02	FALSE
15	GTEx	Cells EBV-transformed lymphocytes	MTA3	0.35	0.00	enet	22	0.04	2.4e-02	-4.35	6.8	1.4e-11	0.38	0.14	0.11	FALSE
54	YFS	Blood	MTA3	0.02	0.00	blup	598	0.01	1.2e-03	-5.27	-6.7	2.9e-11	-0.54	0.33	0.11	FALSE
35	GTEx	Prostate	COX7A2L	0.33	0.20	lasso	6	0.28	1.0e-07	-5.02	-6.6	4.4e-11	-0.68	0.56	0.38	FALSE
24	GTEx	Lung	HAAO	0.09	0.00	lasso	2	0.01	4.7e-02	5.34	-6.5	5.7e-11	-0.36	0.32	0.10	FALSE
34	GTEx	Pituitary	HAAO	0.38	0.07	lasso	13	0.15	1.2e-04	6.16	-6.5	6.7e-11	-0.33	0.28	0.04	FALSE
20	GTEx	Esophagus Mucosa	COX7A2L	0.30	0.36	enet	31	0.38	2.2e-26	-4.61	-6.4	1.8e-10	-0.56	1.00	0.00	FALSE
30	GTEx	Nerve Tibial	HAAO	0.41	0.22	lasso	11	0.30	1.3e-21	5.34	-6.3	2.4e-10	-0.32	1.00	0.00	FALSE
51	ROSMAP	Brain Pre-frontal Cortex	HAAO	0.06	0.03	blup	462	0.04	9.0e-06	6.00	-6.3	2.5e-10	-0.44	0.99	0.00	FALSE
47	GTEx	Whole Blood	OXER1	0.10	0.04	lasso	4	0.04	1.8e-04	7.06	-6.3	3.5e-10	-0.30	0.69	0.01	FALSE
61	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	HAAO	0.02	0.01	blup	59	0.02	6.9e-03	5.95	-6.2	5.0e-10	-0.33	0.11	0.26	FALSE
12	GTEx	Brain Nucleus accumbens basal ganglia	HAAO	0.33	0.29	lasso	12	0.26	1.6e-07	-5.62	-6.2	5.6e-10	-0.33	0.69	0.16	FALSE
50	ROSMAP	Brain Pre-frontal Cortex	OXER1	0.05	0.09	lasso	3	0.08	6.3e-10	6.09	-6.2	7.4e-10	-0.36	1.00	0.00	FALSE
14	GTEx	Breast Mammary Tissue (Male)	COX7A2L	0.26	0.30	lasso	2	0.26	1.2e-06	-4.99	-6.1	9.1e-10	-0.59	0.38	0.35	FALSE
49	ROSMAP	Brain Pre-frontal Cortex	EML4	0.05	0.04	lasso	3	0.04	1.4e-05	5.22	-6.1	1.1e-09	-0.74	0.20	0.79	FALSE
32	GTEx	Pancreas	HAAO	0.27	0.32	lasso	2	0.29	1.4e-12	6.09	6.1	1.3e-09	0.35	1.00	0.00	FALSE
7	GTEx	Brain Caudate basal ganglia	HAAO	0.33	0.18	enet	25	0.26	5.6e-08	6.16	-6.0	1.9e-09	-0.31	0.71	0.07	FALSE
45	GTEx	Thyroid	HAAO	0.21	0.15	enet	16	0.16	3.8e-12	5.34	-5.8	5.6e-09	-0.31	1.00	0.00	FALSE
21	GTEx	Esophagus Mucosa	HAAO	0.19	0.07	enet	26	0.09	7.0e-07	5.34	-5.8	8.5e-09	-0.41	0.96	0.00	FALSE
58	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	HAAO	0.08	0.04	blup	59	0.04	7.0e-03	3.77	-5.7	9.4e-09	-0.33	0.23	0.18	FALSE
18	GTEx	Colon Sigmoid	COX7A2L	0.19	0.17	lasso	3	0.12	7.0e-05	-5.24	-5.7	9.7e-09	-0.47	0.48	0.03	FALSE
66	The Cancer Genome Atlas	Lung Adenocarcinoma	ZFP36L2	0.03	0.01	blup	38	0.01	1.1e-02	2.43	-5.7	9.8e-09	0.02	0.02	0.55	FALSE
16	GTEx	Cells EBV-transformed lymphocytes	COX7A2L	0.33	0.25	lasso	9	0.28	8.7e-10	-4.61	-5.7	1.1e-08	-0.56	0.99	0.00	FALSE
2	GTEx	Adipose Subcutaneous	FTOP1	0.08	0.01	enet	17	0.03	3.6e-03	5.16	5.7	1.4e-08	0.28	0.46	0.02	FALSE
42	GTEx	Stomach	COX7A2L	0.43	0.39	lasso	8	0.37	1.5e-18	-4.61	-5.6	1.9e-08	-0.56	1.00	0.00	FALSE
69	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	HAAO	0.06	0.04	blup	59	0.04	1.8e-03	3.81	-5.6	2.2e-08	-0.33	0.37	0.33	FALSE
73	The Cancer Genome Atlas	Thyroid Carcinoma	HAAO	0.05	0.03	blup	59	0.02	8.7e-03	5.34	-5.6	2.3e-08	-0.34	0.09	0.21	FALSE
60	The Cancer Genome Atlas	Glioblastoma Multiforme	HAAO	0.18	0.09	blup	59	0.07	3.8e-03	6.00	-5.5	2.9e-08	-0.30	0.03	0.13	FALSE
3	GTEx	Artery Aorta	COX7A2L	0.13	0.12	lasso	7	0.10	2.4e-06	-4.61	-5.5	3.3e-08	-0.52	0.99	0.00	FALSE
64	The Cancer Genome Atlas	Brain Lower Grade Glioma	OXER1	0.05	0.03	lasso	4	0.04	4.6e-05	5.95	-5.5	3.4e-08	-0.36	0.85	0.10	FALSE
53	YFS	Blood	COX7A2L	0.11	0.12	bslmm	551	0.12	3.0e-38	-4.61	-5.5	4.3e-08	-0.60	1.00	0.00	FALSE
38	GTEx	Skin Sun Exposed Lower leg	HAAO	0.22	0.10	enet	19	0.11	2.3e-09	5.34	-5.5	5.0e-08	-0.27	1.00	0.00	FALSE
56	The Cancer Genome Atlas	Breast Invasive Carcinoma	HAAO	0.02	0.01	blup	59	0.03	4.7e-07	-2.74	-5.4	6.3e-08	-0.28	0.36	0.64	FALSE
41	GTEx	Spleen	FTOP1	0.27	-0.01	lasso	13	0.01	2.2e-01	6.09	5.4	6.6e-08	0.26	0.10	0.06	FALSE
28	GTEx	Nerve Tibial	ZFP36L2	0.06	0.00	lasso	8	0.01	3.5e-02	6.82	-5.4	6.7e-08	0.06	0.08	0.72	FALSE
72	The Cancer Genome Atlas	Thyroid Carcinoma	COX7A2L	0.23	0.28	lasso	5	0.30	6.2e-30	-4.99	-5.4	6.8e-08	-0.62	1.00	0.00	FALSE
29	GTEx	Nerve Tibial	OXER1	0.31	0.03	lasso	8	0.05	3.5e-04	3.35	-5.4	7.6e-08	-0.26	0.77	0.01	FALSE
55	YFS	Blood	THADA	0.01	0.00	blup	724	0.00	1.1e-02	-0.96	-5.4	8.5e-08	-0.27	0.08	0.05	FALSE
33	GTEx	Pituitary	COX7A2L	0.45	0.18	lasso	8	0.18	2.2e-05	-4.99	-5.3	8.6e-08	-0.56	0.30	0.21	FALSE
65	The Cancer Genome Atlas	Lung Adenocarcinoma	COX7A2L	0.06	0.04	lasso	2	0.04	9.5e-06	4.69	-5.3	8.6e-08	-0.63	0.28	0.17	FALSE
70	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	OXER1	0.04	0.01	blup	52	0.01	6.8e-02	3.81	-5.3	9.9e-08	-0.35	0.02	0.71	FALSE
5	GTEx	Artery Aorta	FTOP1	0.17	0.04	lasso	6	0.02	3.5e-02	5.47	5.3	1.2e-07	0.31	0.19	0.04	FALSE
13	GTEx	Brain Putamen basal ganglia	HAAO	0.18	0.28	lasso	2	0.25	1.2e-06	5.47	-5.2	2.4e-07	-0.31	0.24	0.08	FALSE
37	GTEx	Skin Sun Exposed Lower leg	COX7A2L	0.24	0.24	lasso	4	0.26	1.4e-21	-4.27	-5.2	2.5e-07	-0.53	1.00	0.00	FALSE
40	GTEx	Spleen	COX7A2L	0.30	0.22	enet	10	0.25	4.7e-07	-4.61	-5.1	2.9e-07	-0.53	0.67	0.20	FALSE
43	GTEx	Thyroid	COX7A2L	0.52	0.55	lasso	7	0.55	1.8e-49	-4.61	-5.1	3.0e-07	-0.54	1.00	0.00	FALSE