[Hub]/) : Traits : Lung FEV1/FVC ratio : ← →

chr2:60,546,132-62,460,013

Best TWAS P=9.9e-16 · Best GWAS P=1.69e-12 conditioned to 0.113

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
27	GTEx	Cells EBV-transformed lymphocytes	AHSA2	0.33	0.13	lasso	3	0.25	1.4e-08	6.5	-8.0	9.9e-16	-0.75	0.04	0.83	TRUE
86	The Cancer Genome Atlas	Glioblastoma Multiforme	AHSA2	0.21	0.13	blup	38	0.18	4.4e-06	5.6	-7.5	7.5e-14	-0.80	0.10	0.79	FALSE
34	GTEx	Esophagus Mucosa	AHSA2	0.23	0.12	enet	28	0.18	4.5e-12	4.8	-7.5	7.8e-14	-0.73	0.15	0.85	FALSE
44	GTEx	Muscle Skeletal	AHSA2	0.08	0.06	lasso	4	0.09	2.5e-09	7.1	-7.4	1.2e-13	-0.88	0.00	1.00	FALSE
42	GTEx	Liver	AHSA2	0.33	0.19	lasso	6	0.29	1.2e-08	6.5	-7.4	1.8e-13	-0.82	0.05	0.95	FALSE
39	GTEx	Heart Atrial Appendage	AHSA2	0.24	0.19	enet	19	0.18	1.3e-08	5.6	-7.4	1.9e-13	-0.74	0.09	0.91	FALSE
80	The Cancer Genome Atlas	Breast Invasive Carcinoma	AHSA2	0.10	0.13	blup	38	0.18	6.7e-35	5.5	-7.3	3.3e-13	-0.81	0.05	0.95	FALSE
57	GTEx	Skin Sun Exposed Lower leg	AHSA2	0.16	0.14	lasso	8	0.23	1.4e-18	-6.0	-7.1	9.1e-13	-0.59	0.41	0.59	FALSE
107	The Cancer Genome Atlas	Stomach Adenocarcinoma	AHSA2	0.15	0.04	blup	39	0.09	8.4e-07	5.9	-7.1	1.4e-12	-0.87	0.10	0.90	FALSE
29	GTEx	Colon Sigmoid	AHSA2	0.42	0.29	enet	17	0.43	1.1e-16	4.8	-7.0	2.9e-12	-0.82	0.03	0.97	FALSE
70	GTEx	Whole Blood	AHSA2	0.19	0.27	lasso	9	0.32	3.7e-30	5.6	-7.0	3.7e-12	-0.77	0.69	0.31	FALSE
15	GTEx	Brain Cerebellum	AHSA2	0.43	0.36	lasso	5	0.40	4.2e-13	6.5	-6.9	4.3e-12	-0.79	0.02	0.98	FALSE
13	GTEx	Brain Cerebellar Hemisphere	KIAA1841	0.16	0.08	enet	10	0.09	2.7e-03	-6.0	-6.9	4.6e-12	-0.66	0.15	0.54	FALSE
2	CommonMind	Brain Pre-frontal Cortex	KIAA1841	0.05	0.05	enet	15	0.06	1.2e-07	-5.7	-6.9	5.1e-12	-0.72	0.20	0.80	FALSE
56	GTEx	Skin Not Sun Exposed Suprapubic	AHSA2	0.25	0.23	enet	13	0.28	2.1e-15	-6.2	-6.9	5.6e-12	-0.54	0.40	0.60	FALSE
90	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	AHSA2	0.13	0.05	enet	8	0.09	5.8e-06	5.6	-6.9	5.6e-12	-0.65	0.05	0.90	FALSE
36	GTEx	Esophagus Muscularis	AHSA2	0.44	0.39	enet	24	0.46	7.4e-31	6.5	-6.9	6.2e-12	-0.80	0.08	0.92	FALSE
81	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	AHSA2	0.11	0.12	enet	6	0.11	4.9e-06	5.2	-6.9	6.6e-12	-0.76	0.09	0.88	FALSE
102	The Cancer Genome Atlas	Rectum Adenocarcinoma	AHSA2	0.12	0.13	lasso	2	0.07	1.1e-02	-6.2	-6.8	1.3e-11	-0.45	0.01	0.61	FALSE
111	The Cancer Genome Atlas	Thyroid Carcinoma	AHSA2	0.27	0.32	enet	11	0.34	1.3e-33	5.9	-6.7	1.7e-11	-0.75	0.03	0.97	FALSE
77	YFS	Blood	AHSA2	0.50	0.46	enet	32	0.62	3.1e-265	4.8	-6.7	2.0e-11	-0.57	1.00	0.00	FALSE
91	The Cancer Genome Atlas	Brain Lower Grade Glioma	AHSA2	0.54	0.35	lasso	8	0.46	2.7e-57	4.8	-6.7	2.2e-11	-0.76	0.26	0.74	FALSE
6	GTEx	Adipose Visceral Omentum	AHSA2	0.36	0.27	lasso	7	0.36	1.1e-19	6.5	-6.7	2.8e-11	-0.84	0.03	0.97	FALSE
50	GTEx	Pancreas	AHSA2	0.30	0.17	lasso	8	0.26	1.3e-11	5.8	-6.6	3.4e-11	-0.85	0.02	0.98	FALSE
25	GTEx	Breast Mammary Tissue (Female)	AHSA2	0.24	0.13	lasso	7	0.15	3.2e-05	5.1	-6.6	3.8e-11	-0.72	0.12	0.65	FALSE
35	GTEx	Esophagus Muscularis	KIAA1841	0.06	0.10	enet	10	0.10	9.0e-07	-6.5	-6.6	3.8e-11	-0.59	0.20	0.79	FALSE
54	GTEx	Prostate	AHSA2	0.49	0.41	lasso	7	0.51	8.2e-15	6.5	-6.6	4.3e-11	-0.81	0.06	0.94	FALSE
16	GTEx	Brain Cerebellum	RP11-493E12.2	0.30	0.01	enet	27	0.10	6.5e-04	-6.2	6.6	4.4e-11	0.55	0.05	0.47	FALSE
46	GTEx	Nerve Tibial	AHSA2	0.45	0.44	enet	15	0.56	4.8e-47	5.6	-6.6	4.7e-11	-0.82	0.83	0.17	FALSE
53	GTEx	Pituitary	AC016747.3	0.23	0.19	enet	12	0.20	1.0e-05	-5.9	-6.5	6.0e-11	-0.63	0.22	0.71	FALSE
49	GTEx	Ovary	RP11-493E12.2	0.14	0.12	lasso	7	0.13	5.0e-04	-6.4	6.5	7.1e-11	0.52	0.13	0.69	FALSE
10	GTEx	Artery Aorta	AHSA2	0.40	0.33	enet	17	0.43	1.4e-25	4.8	-6.5	8.6e-11	-0.78	0.15	0.85	FALSE
32	GTEx	Esophagus Gastroesophageal Junction	AHSA2	0.47	0.52	enet	25	0.59	7.0e-26	4.7	-6.5	9.4e-11	-0.79	0.61	0.39	FALSE
55	GTEx	Prostate	RP11-493E12.2	0.15	0.16	lasso	4	0.09	3.4e-03	-6.5	6.5	1.0e-10	0.45	0.13	0.59	FALSE
14	GTEx	Brain Cerebellar Hemisphere	AHSA2	0.35	0.22	enet	12	0.38	7.8e-11	-4.7	-6.4	1.2e-10	-0.68	0.15	0.84	FALSE
4	GTEx	Adipose Subcutaneous	AHSA2	0.27	0.31	enet	13	0.39	5.5e-34	4.8	-6.4	1.3e-10	-0.77	0.99	0.01	FALSE
28	GTEx	Cells Transformed fibroblasts	AHSA2	0.32	0.33	enet	16	0.36	1.2e-27	6.5	-6.4	1.3e-10	-0.78	0.10	0.90	FALSE
105	The Cancer Genome Atlas	Soft Tissue Sarcoma	C2orf74	0.30	0.42	enet	11	0.48	1.2e-31	4.8	6.4	1.4e-10	0.75	0.59	0.41	FALSE
88	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	AHSA2	0.06	0.05	blup	39	0.06	8.9e-08	-5.7	-6.4	1.7e-10	-0.60	0.05	0.95	FALSE
73	METSIM	Adipose	AHSA2	0.26	0.27	enet	19	0.28	5.6e-43	5.6	-6.4	1.9e-10	-0.70	0.97	0.03	FALSE
65	GTEx	Thyroid	AHSA2	0.34	0.37	lasso	10	0.42	8.2e-35	4.8	-6.3	2.1e-10	-0.76	0.80	0.20	FALSE
41	GTEx	Heart Left Ventricle	AHSA2	0.13	0.08	lasso	8	0.07	1.2e-04	4.8	-6.3	2.2e-10	-0.74	0.06	0.94	FALSE
52	GTEx	Pituitary	AHSA2	0.48	0.45	lasso	5	0.50	1.1e-14	5.6	-6.3	3.0e-10	-0.72	0.41	0.59	FALSE
76	ROSMAP	Brain Pre-frontal Cortex	AHSA2	0.46	0.57	enet	23	0.65	3.2e-111	4.8	-6.3	3.2e-10	-0.76	0.98	0.02	FALSE
24	GTEx	Breast Mammary Tissue	AHSA2	0.20	0.20	lasso	6	0.20	1.7e-10	4.8	-6.3	3.8e-10	-0.73	0.80	0.20	FALSE
100	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	AHSA2	0.20	0.11	blup	39	0.22	3.5e-09	5.1	-6.3	3.9e-10	-0.69	0.08	0.92	FALSE
63	GTEx	Testis	AHSA2	0.51	0.49	enet	13	0.57	1.7e-30	4.7	-6.2	4.0e-10	-0.80	0.72	0.28	FALSE
101	The Cancer Genome Atlas	Prostate Adenocarcinoma	AHSA2	0.17	0.25	blup	39	0.27	7.6e-28	4.8	-6.2	5.1e-10	-0.74	0.90	0.10	FALSE
98	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	AHSA2	0.16	0.20	blup	39	0.22	2.0e-09	5.0	-6.2	5.2e-10	-0.64	0.24	0.76	FALSE
21	GTEx	Brain Nucleus accumbens basal ganglia	AHSA2	0.44	0.34	enet	13	0.39	1.7e-11	5.6	-6.2	5.7e-10	-0.70	0.28	0.71	FALSE
93	The Cancer Genome Atlas	Lung Adenocarcinoma	AHSA2	0.09	0.12	lasso	5	0.16	7.6e-19	5.9	-6.2	7.9e-10	-0.64	0.10	0.90	FALSE
12	GTEx	Artery Tibial	AHSA2	0.39	0.36	lasso	4	0.47	8.4e-41	6.5	-6.1	8.2e-10	-0.79	0.15	0.85	FALSE
74	ROSMAP	Brain Pre-frontal Cortex	XPO1	0.03	0.02	blup	310	0.02	3.4e-03	-6.3	6.1	8.2e-10	0.51	0.14	0.70	FALSE
43	GTEx	Lung	AHSA2	0.36	0.35	lasso	9	0.40	2.8e-32	4.8	-6.1	8.4e-10	-0.76	0.98	0.02	FALSE
31	GTEx	Colon Transverse	AHSA2	0.24	0.25	lasso	10	0.32	7.8e-16	5.2	-6.1	1.0e-09	-0.76	0.54	0.46	FALSE
47	GTEx	Nerve Tibial	RP11-493E12.2	0.05	0.06	lasso	6	0.04	7.0e-04	-5.7	6.1	1.0e-09	0.52	0.26	0.73	FALSE
62	GTEx	Stomach	AHSA2	0.22	0.17	enet	21	0.24	1.0e-11	4.7	-6.0	1.6e-09	-0.67	0.95	0.05	FALSE
18	GTEx	Brain Hippocampus	AHSA2	0.34	0.40	enet	17	0.35	5.9e-09	4.7	-6.0	1.7e-09	-0.74	0.10	0.90	FALSE
3	CommonMind	Brain Pre-frontal Cortex	XPO1	0.06	0.03	bslmm	313	0.03	1.4e-04	-6.3	6.0	1.9e-09	0.55	0.20	0.79	FALSE
19	GTEx	Brain Hippocampus	RP11-493E12.2	0.14	0.08	lasso	7	0.09	3.9e-03	-4.3	6.0	1.9e-09	0.60	0.08	0.42	FALSE
67	GTEx	Thyroid	RP11-493E12.2	0.05	0.06	lasso	5	0.05	9.3e-05	5.2	6.0	2.1e-09	0.77	0.49	0.39	FALSE
104	The Cancer Genome Atlas	Soft Tissue Sarcoma	AHSA2	0.15	0.15	blup	37	0.18	8.3e-11	4.8	-6.0	2.1e-09	-0.72	0.54	0.46	FALSE
5	GTEx	Adipose Subcutaneous	RP11-493E12.2	0.05	0.02	lasso	4	0.03	1.3e-03	-5.8	6.0	2.3e-09	0.51	0.20	0.77	FALSE
92	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	AHSA2	0.21	0.10	blup	38	0.13	9.4e-07	5.9	-5.9	2.8e-09	-0.76	0.08	0.92	FALSE
79	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	AHSA2	0.09	0.10	blup	38	0.14	1.0e-11	5.9	-5.9	3.1e-09	-0.68	0.14	0.86	FALSE
11	GTEx	Artery Coronary	AHSA2	0.42	0.19	lasso	6	0.22	4.0e-08	4.8	-5.9	3.3e-09	-0.66	0.69	0.30	FALSE
48	GTEx	Ovary	AHSA2	0.56	0.51	lasso	5	0.47	5.2e-13	4.7	-5.9	3.3e-09	-0.72	0.08	0.92	FALSE
38	GTEx	Esophagus Muscularis	RP11-493E12.2	0.05	0.09	lasso	3	0.06	2.0e-04	-5.8	5.9	3.9e-09	0.52	0.19	0.75	FALSE
40	GTEx	Heart Atrial Appendage	AC016747.3	0.15	0.08	lasso	8	0.16	1.9e-07	5.2	-5.9	4.0e-09	-0.67	0.56	0.44	FALSE
97	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	AHSA2	0.10	0.06	blup	39	0.08	3.2e-06	4.8	-5.9	4.5e-09	-0.60	0.34	0.62	FALSE
94	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	AHSA2	0.10	0.12	blup	38	0.12	2.6e-13	4.8	-5.8	5.3e-09	-0.74	0.50	0.50	FALSE
7	GTEx	Adipose Visceral Omentum	AC016747.3	0.14	0.13	enet	15	0.16	7.6e-09	5.0	-5.8	6.1e-09	-0.72	0.41	0.59	FALSE
78	YFS	Blood	PEX13	0.01	0.00	blup	334	0.01	6.7e-03	-3.2	5.8	7.0e-09	0.51	0.14	0.17	FALSE
60	GTEx	Spleen	AHSA2	0.39	0.24	enet	13	0.35	6.3e-10	6.5	-5.8	7.2e-09	-0.77	0.02	0.98	FALSE
85	The Cancer Genome Atlas	Esophageal Carcinoma	C2orf74	0.17	0.30	lasso	11	0.32	4.7e-11	5.6	5.8	7.2e-09	0.61	0.14	0.86	FALSE
59	GTEx	Small Intestine Terminal Ileum	AHSA2	0.48	0.16	lasso	7	0.17	1.1e-04	4.8	-5.8	7.6e-09	-0.68	0.10	0.66	FALSE
45	GTEx	Nerve Tibial	KIAA1841	0.06	0.01	lasso	4	0.02	1.5e-02	-4.3	-5.7	9.7e-09	-0.53	0.18	0.65	FALSE
23	GTEx	Brain Putamen basal ganglia	AHSA2	0.32	0.39	enet	14	0.36	2.6e-09	5.6	-5.7	1.0e-08	-0.72	0.14	0.85	FALSE
9	GTEx	Adrenal Gland	AC016747.3	0.26	0.23	enet	14	0.13	1.9e-05	4.8	-5.7	1.1e-08	-0.60	0.83	0.11	FALSE
17	GTEx	Brain Frontal Cortex BA9	AHSA2	0.38	0.40	lasso	4	0.48	2.1e-14	5.6	-5.7	1.5e-08	-0.70	0.40	0.60	FALSE
58	GTEx	Skin Sun Exposed Lower leg	AC016747.3	0.06	0.06	enet	6	0.04	5.4e-04	5.9	-5.7	1.6e-08	-0.71	0.59	0.37	FALSE
20	GTEx	Brain Hypothalamus	AHSA2	0.23	0.34	lasso	4	0.35	4.1e-09	5.6	-5.6	2.5e-08	-0.63	0.18	0.81	FALSE
66	GTEx	Thyroid	AC016747.3	0.15	0.15	lasso	1	0.12	1.9e-09	5.5	-5.5	3.1e-08	-0.72	0.97	0.03	FALSE
106	The Cancer Genome Atlas	Skin Cutaneous Melanoma	C2orf74	0.45	0.39	enet	10	0.39	2.1e-11	5.6	5.5	3.3e-08	0.64	0.22	0.78	FALSE
71	GTEx	Whole Blood	AC016747.3	0.07	0.08	lasso	6	0.08	3.9e-08	-5.0	-5.5	4.1e-08	-0.57	0.88	0.12	FALSE
72	GTEx	Whole Blood	RP11-493E12.2	0.04	0.02	lasso	6	0.01	1.8e-02	-6.1	5.5	4.9e-08	0.29	0.18	0.70	FALSE
83	The Cancer Genome Atlas	Colon Adenocarcinoma	AHSA2	0.10	0.11	enet	10	0.11	4.1e-07	-4.7	-5.5	4.9e-08	-0.54	0.11	0.88	FALSE
89	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	AHSA2	0.16	0.15	enet	20	0.20	3.7e-22	4.8	-5.5	4.9e-08	-0.72	0.61	0.39	FALSE
26	GTEx	Breast Mammary Tissue (Female)	AC016747.3	0.18	0.13	enet	9	0.10	8.4e-04	4.8	-5.4	5.4e-08	-0.66	0.33	0.42	FALSE
96	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	KIAA1841	0.05	0.02	blup	61	0.02	4.5e-03	-6.2	-5.4	5.4e-08	-0.47	0.00	0.93	FALSE
95	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	C2orf74	0.11	0.17	enet	9	0.20	8.0e-22	4.8	5.4	5.5e-08	0.60	0.84	0.16	FALSE
61	GTEx	Spleen	AC016747.3	0.37	0.26	enet	19	0.30	2.8e-08	5.5	-5.4	6.3e-08	-0.63	0.50	0.43	FALSE
108	The Cancer Genome Atlas	Stomach Adenocarcinoma	C2orf74	0.15	0.24	enet	9	0.25	4.3e-18	5.0	5.4	6.4e-08	0.65	0.59	0.41	FALSE
103	The Cancer Genome Atlas	Rectum Adenocarcinoma	C2orf74	0.44	0.28	enet	16	0.29	1.4e-07	5.1	5.4	7.7e-08	0.57	0.37	0.51	FALSE
110	The Cancer Genome Atlas	Testicular Germ Cell Tumors	C2orf74	0.39	0.46	enet	12	0.51	8.3e-21	4.8	5.4	7.7e-08	0.67	0.79	0.21	FALSE
51	GTEx	Pancreas	AC016747.3	0.10	0.08	enet	11	0.09	1.2e-04	-4.5	-5.4	7.9e-08	-0.58	0.50	0.44	FALSE
1	CommonMind	Brain Pre-frontal Cortex	AHSA2	0.41	0.31	enet	27	0.41	2.2e-53	6.5	-5.3	8.6e-08	-0.78	0.12	0.88	FALSE
30	GTEx	Colon Sigmoid	AC016747.3	0.14	0.16	lasso	4	0.12	4.5e-05	5.5	-5.3	8.8e-08	-0.67	0.24	0.56	FALSE
87	The Cancer Genome Atlas	Glioblastoma Multiforme	C2orf74	0.18	0.31	lasso	6	0.29	1.6e-09	4.7	5.3	9.3e-08	0.64	0.47	0.53	FALSE
109	The Cancer Genome Atlas	Testicular Germ Cell Tumors	AHSA2	0.25	0.20	enet	12	0.22	2.1e-08	5.1	-5.3	1.0e-07	-0.56	0.48	0.51	FALSE
69	GTEx	Vagina	AC016747.3	0.28	0.19	lasso	9	0.17	9.7e-05	5.1	-5.3	1.2e-07	-0.66	0.09	0.77	FALSE
75	ROSMAP	Brain Pre-frontal Cortex	KIAA1841	0.14	0.13	lasso	3	0.13	6.2e-16	5.4	5.3	1.2e-07	0.71	0.99	0.01	FALSE
99	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	C2orf74	0.51	0.50	lasso	5	0.54	1.8e-26	5.0	5.3	1.2e-07	0.64	0.78	0.22	FALSE
64	GTEx	Testis	AC016747.3	0.48	0.63	lasso	7	0.63	3.3e-35	-4.7	-5.3	1.3e-07	-0.46	0.98	0.02	FALSE
82	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	C2orf74	0.19	0.22	lasso	4	0.23	1.9e-11	5.0	5.2	1.6e-07	0.60	0.60	0.40	FALSE
68	GTEx	Uterus	AHSA2	0.37	0.15	lasso	7	0.19	1.2e-04	4.7	-5.2	1.9e-07	-0.67	0.03	0.72	FALSE
33	GTEx	Esophagus Gastroesophageal Junction	RP11-493E12.2	0.15	0.08	lasso	4	0.04	1.5e-02	5.0	5.2	2.4e-07	0.63	0.12	0.44	FALSE
22	GTEx	Brain Putamen basal ganglia	KIAA1841	0.16	0.16	lasso	1	0.13	6.3e-04	5.2	-5.2	2.5e-07	-0.56	0.16	0.37	FALSE
37	GTEx	Esophagus Muscularis	AC016747.3	0.15	0.21	enet	8	0.23	7.1e-14	4.8	-5.2	2.5e-07	-0.65	0.98	0.02	FALSE
84	The Cancer Genome Atlas	Esophageal Carcinoma	AHSA2	0.16	0.27	lasso	3	0.26	1.0e-08	5.1	-5.2	2.5e-07	-0.58	0.48	0.52	FALSE
8	GTEx	Adrenal Gland	AHSA2	0.14	0.12	lasso	2	0.17	9.0e-07	4.8	-5.1	3.1e-07	-0.62	0.75	0.22	FALSE