[Hub]/) : Traits : Lung FEV1/FVC ratio : ← →

chr2:85,678,425-87,126,250

Best TWAS P=3.97e-09 · Best GWAS P=9.27e-09 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
33	GTEx	Testis	IMMT	0.42	0.47	enet	28	0.48	9.9e-24	5.7	-5.9	4.0e-09	-0.99	0.02	0.98	TRUE
28	GTEx	Small Intestine Terminal Ileum	RP11-301O19.1	0.25	0.15	enet	39	0.09	5.9e-03	5.7	5.8	5.0e-09	0.71	0.03	0.83	FALSE
27	GTEx	Skin Sun Exposed Lower leg	RP11-301O19.1	0.16	0.18	enet	27	0.15	2.7e-12	5.7	5.8	5.9e-09	0.97	0.02	0.98	FALSE
34	GTEx	Testis	RP11-301O19.1	0.41	0.38	lasso	16	0.35	2.4e-16	5.7	5.7	9.5e-09	0.99	0.02	0.98	FALSE
4	GTEx	Artery Coronary	RP11-301O19.1	0.14	0.16	lasso	2	0.09	6.3e-04	5.7	5.7	1.0e-08	1.00	0.02	0.96	FALSE
45	The Cancer Genome Atlas	Testicular Germ Cell Tumors	IMMT	0.12	0.11	blup	81	0.06	2.6e-03	5.5	-5.7	1.1e-08	-0.98	0.03	0.90	FALSE
9	GTEx	Brain Cortex	RP11-301O19.1	0.14	0.23	lasso	1	0.21	1.9e-06	5.7	5.7	1.2e-08	1.00	0.03	0.95	FALSE
13	GTEx	Breast Mammary Tissue (Female)	IMMT	0.05	-0.01	lasso	1	0.01	1.2e-01	5.7	-5.7	1.2e-08	-1.00	0.03	0.35	FALSE
7	GTEx	Brain Cerebellum	RP11-301O19.1	0.14	0.15	lasso	6	0.14	6.1e-05	5.7	-5.7	1.3e-08	-1.00	0.03	0.94	FALSE
12	GTEx	Brain Nucleus accumbens basal ganglia	RP11-301O19.1	0.35	0.40	lasso	9	0.40	1.2e-11	5.7	-5.7	1.4e-08	-0.99	0.02	0.98	FALSE
15	GTEx	Cells Transformed fibroblasts	RP11-301O19.1	0.15	0.21	lasso	10	0.19	1.8e-14	5.7	5.7	1.4e-08	0.99	0.02	0.98	FALSE
24	GTEx	Pancreas	RP11-301O19.1	0.28	0.29	enet	16	0.28	2.6e-12	5.7	5.7	1.4e-08	0.99	0.02	0.98	FALSE
38	YFS	Blood	IMMT	0.14	0.27	enet	26	0.26	2.1e-86	5.7	-5.7	1.4e-08	-1.00	0.02	0.98	FALSE
1	GTEx	Adipose Subcutaneous	RP11-301O19.1	0.13	0.12	lasso	10	0.12	2.9e-10	5.7	5.7	1.5e-08	0.99	0.02	0.98	FALSE
10	GTEx	Brain Frontal Cortex BA9	RP11-301O19.1	0.19	0.18	lasso	1	0.18	1.7e-05	5.7	-5.7	1.5e-08	-0.99	0.03	0.96	FALSE
41	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	MRPL35	0.04	0.02	blup	61	0.02	2.9e-02	5.6	5.7	1.5e-08	0.97	0.02	0.80	FALSE
2	GTEx	Adrenal Gland	MRPL35	0.19	0.10	enet	9	0.14	1.0e-05	-3.8	5.6	1.7e-08	0.72	0.21	0.56	FALSE
14	GTEx	Cells Transformed fibroblasts	IMMT	0.12	0.16	lasso	2	0.14	1.6e-10	5.7	-5.6	1.7e-08	-1.00	0.02	0.98	FALSE
18	GTEx	Esophagus Mucosa	RP11-301O19.1	0.09	0.08	enet	18	0.05	1.8e-04	5.7	5.6	1.7e-08	0.99	0.02	0.98	FALSE
23	GTEx	Nerve Tibial	RP11-301O19.1	0.23	0.36	lasso	11	0.35	7.2e-26	5.7	5.6	1.7e-08	1.00	0.02	0.98	FALSE
5	GTEx	Artery Tibial	RP11-301O19.1	0.10	0.07	enet	21	0.05	8.5e-05	5.7	5.6	1.9e-08	0.98	0.02	0.98	FALSE
32	GTEx	Stomach	RP11-301O19.1	0.17	0.15	lasso	14	0.12	2.4e-06	5.7	5.6	1.9e-08	0.99	0.02	0.98	FALSE
30	GTEx	Spleen	RP11-301O19.1	0.21	0.18	enet	24	0.18	1.7e-05	5.7	5.6	2.0e-08	0.96	0.02	0.97	FALSE
11	GTEx	Brain Hypothalamus	RP11-301O19.1	0.39	0.37	lasso	24	0.41	1.1e-10	5.7	-5.6	2.2e-08	-0.99	0.02	0.97	FALSE
22	GTEx	Nerve Tibial	IMMT	0.14	0.19	lasso	4	0.18	1.4e-12	5.7	-5.6	2.2e-08	-0.99	0.02	0.98	FALSE
25	GTEx	Pituitary	RP11-301O19.1	0.30	0.36	enet	27	0.25	6.5e-07	5.7	5.5	3.6e-08	0.96	0.03	0.97	FALSE
29	GTEx	Spleen	IMMT	0.12	0.09	enet	21	0.06	1.5e-02	5.7	-5.5	4.2e-08	-0.99	0.03	0.91	FALSE
26	GTEx	Skin Not Sun Exposed Suprapubic	RP11-301O19.1	0.18	0.20	enet	20	0.18	2.2e-10	5.7	5.4	5.4e-08	0.98	0.02	0.98	FALSE
35	GTEx	Thyroid	RP11-301O19.1	0.16	0.22	enet	21	0.20	1.2e-15	5.7	5.4	7.9e-08	0.99	0.02	0.98	FALSE
16	GTEx	Colon Sigmoid	IMMT	0.30	0.36	enet	25	0.33	1.8e-12	5.7	-5.4	8.0e-08	-0.99	0.02	0.98	FALSE
37	GTEx	Whole Blood	RP11-301O19.1	0.04	0.05	enet	20	0.04	5.4e-05	5.7	5.3	8.9e-08	0.97	0.02	0.97	FALSE
42	The Cancer Genome Atlas	Lung Adenocarcinoma	IMMT	0.04	0.03	lasso	4	0.03	1.4e-04	5.7	-5.3	9.0e-08	-0.99	0.03	0.97	FALSE
8	GTEx	Brain Cortex	IMMT	0.15	0.12	lasso	3	0.11	6.2e-04	5.7	-5.3	9.1e-08	-0.99	0.04	0.78	FALSE
39	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	IMMT	0.05	0.04	blup	81	0.03	6.4e-04	5.7	-5.3	9.9e-08	-0.94	0.03	0.97	FALSE
20	GTEx	Heart Left Ventricle	MRPL35	0.10	0.08	enet	12	0.10	9.4e-06	-3.8	5.3	1.1e-07	0.61	0.12	0.78	FALSE
17	GTEx	Esophagus Mucosa	IMMT	0.20	0.26	enet	23	0.24	7.5e-16	-4.7	-5.3	1.2e-07	-0.98	0.02	0.98	FALSE
46	The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	LOC90784	0.16	0.04	enet	5	0.06	8.5e-03	5.1	5.3	1.2e-07	0.90	0.00	0.74	FALSE
21	GTEx	Lung	IMMT	0.18	0.20	enet	23	0.20	4.0e-15	5.7	-5.3	1.3e-07	-0.96	0.02	0.98	FALSE
43	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	IMMT	0.09	0.11	lasso	3	0.10	3.8e-05	5.2	-5.2	1.5e-07	-0.96	0.03	0.96	FALSE
6	GTEx	Brain Cerebellar Hemisphere	RP11-301O19.1	0.15	0.09	enet	10	0.04	3.0e-02	-2.8	5.2	1.6e-07	0.85	0.04	0.80	FALSE
36	GTEx	Vagina	IMMT	0.25	0.15	lasso	10	0.13	6.8e-04	5.3	-5.2	1.6e-07	-0.94	0.04	0.75	FALSE
40	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	LOC90784	0.09	0.08	enet	15	0.10	2.5e-11	5.0	5.2	1.7e-07	0.78	0.00	0.99	FALSE
19	GTEx	Esophagus Muscularis	IMMT	0.31	0.40	enet	30	0.42	1.5e-27	-4.7	-5.2	2.2e-07	-0.96	0.03	0.97	FALSE
44	The Cancer Genome Atlas	Stomach Adenocarcinoma	IMMT	0.10	0.06	lasso	4	0.08	1.5e-06	-3.5	-5.2	2.3e-07	-0.84	0.05	0.94	FALSE
31	GTEx	Stomach	IMMT	0.33	0.02	lasso	5	0.03	2.2e-02	5.7	-5.2	2.4e-07	-0.92	0.04	0.79	FALSE
3	GTEx	Artery Aorta	RP11-301O19.1	0.09	0.05	lasso	7	0.05	9.1e-04	-4.7	5.2	2.5e-07	0.94	0.04	0.96	FALSE