TWAS
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Models
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Traits
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Traits
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Lung FEV1/FVC ratio
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chr3:10,904,692-12,457,119
Best TWAS P=9.8e-10 · Best GWAS P=4.82e-19 conditioned to 3.94e-14
11M
11.2M
11.4M
11.6M
11.8M
12M
12.2M
12.4M
0
5
10
15
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
2
ROSMAP
Brain Pre-frontal Cortex
VGLL4
0.05
0.03
blup
422
0.04
3.7e-06
5.0
6.1
9.8e-10
-0.27
0.95
0.00
TRUE
1
CommonMind
Brain Pre-frontal Cortex
VGLL4
0.04
0.02
blup
511
0.02
7.8e-04
4.4
6.0
2.5e-09
-0.04
0.62
0.01
FALSE