TWAS hub - VGLL4

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0410	0.0180	1.5e-03	0.019	0.023	0.006	0.022	0.019	0.00200	7.8e-04	6.0e-02	9.5e-04	1.8e-03
2	GTEx	Artery Aorta	0.1490	0.0620	1.3e-03	-0.002	NA	0.005	NA	-0.002	0.46000	NA	1.7e-01	NA	4.6e-01
3	GTEx	Spleen	0.3440	0.1260	5.7e-03	-0.012	NA	0.020	NA	0.003	0.92000	NA	9.9e-02	NA	2.6e-01
4	GTEx	Testis	0.1830	0.0790	9.3e-03	-0.006	NA	-0.006	NA	-0.005	0.84000	NA	8.8e-01	NA	6.9e-01
5	ROSMAP	Brain Pre-frontal Cortex	0.0531	0.0199	5.7e-05	0.034	0.042	0.015	0.039	0.028	0.00003	3.7e-06	4.2e-03	9.0e-06	1.3e-04
6	YFS	Blood	0.0472	0.0139	2.0e-07	0.007	0.023	0.020	0.023	0.013	0.00170	3.9e-08	2.7e-07	4.7e-08	2.2e-05
7	TCGA	Prostate Adenocarcinoma	0.0640	0.0277	5.6e-04	0.007	0.017	0.004	NA	0.005	0.05400	5.4e-03	1.0e-01	NA	8.3e-02

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	3	4	5	6	7
Relative age of first facial hair	9.0	18.5	39.4	-6.1	-2.5	-5.2	-6.3	-2.6	3.5
Comparative body size at age 10	8.8	24.4	58.1	7.6	3.7	6.8	5.5	3.7	-3.0
Systolic Blood Pressure	6.4	32.1	78.0	-8.8	-4.2	-7.5	-6.0	-5.7	2.0
Medication for cholesterol	5.9	9.0	18.2	4.1	0.5	4.2	2.6	4.3	-1.7
Systolic blood pressure, automated reading	5.5	15.9	36.7	-6.1	-3.5	-5.1	-4.9	-3.4	1.2
Heel T-Score	5.0	40.1	88.0	7.5	9.4	5.4	9.0	3.1	-4.1
Hearing difficulty/problems with background noise	5.0	8.0	23.5	-3.7	-1.8	-1.8	-4.8	-0.3	3.4
Hair/balding pattern: Pattern 4	4.5	10.9	20.2	3.7	3.1	3.3	4.5	2.7	-3.8
Hypertension (Self-reported)	4.2	11.6	28.4	-5.3	-3.0	-4.4	-3.7	-2.9	1.4
Medication: Blood pressure	4.2	8.0	17.0	-4.1	-1.8	-3.7	-2.4	-4.1	-0.2
Cardiovascular Disease	3.9	12.8	29.2	-5.4	-2.3	-3.6	-4.1	-4.0	3.0
High blood pressure	3.7	10.4	24.1	-4.9	-2.8	-4.0	-3.4	-3.2	1.5
Vascular/heart problems diagnosed by doctor	3.6	9.8	21.6	4.7	2.6	3.8	3.5	3.4	-1.4
Sitting height	3.2	22.8	50.3	-5.2	-5.5	-2.4	-6.0	-3.1	7.1
Heel bone mineral density (BMD) T-score, automated (right)	3.2	7.3	16.9	3.2	2.9	4.1	3.0	2.3	-1.0
Illnesses of mother	3.2	3.9	9.0	2.5	1.1	3.0	2.2	2.3	-1.0
Lung FEV1/FVC ratio	3.1	15.6	37.3	6.0	3.4	3.9	6.1	-0.4	3.1
Medication: Bendroflumethiazide	3.1	4.8	14.7	-3.1	-0.7	-2.6	-1.2	-3.8	-0.6
Medication for hormone replacement therapy	3.0	3.4	7.2	-2.7	-0.2	-2.0	-2.6	-0.8	2.2
Medication: Atenolol	3.0	3.7	9.0	-3.0	-2.5	-1.6	-2.6	-0.8	0.7
Happiness	3.0	3.6	8.7	-2.7	-1.9	-3.0	-2.1	-1.2	0.4
Hearing difficulty/problems: Yes	2.9	4.4	12.5	-1.9	-0.7	-0.5	-3.5	1.3	3.5
Birth weight of first child	2.8	5.1	11.1	2.9	0.5	3.3	3.1	-0.1	2.6
Pain type(s) experienced in last month: Hip pain	2.8	3.5	7.6	-2.0	-1.4	-2.1	-1.5	-2.8	2.0
High blood pressure (mother)	2.7	3.9	9.8	-2.9	0.9	-3.1	-2.2	-1.8	0.4
Depression (self-reported)	2.7	3.3	9.5	-3.0	0.1	-3.1	-1.7	-1.3	0.4
Type 2 Diabetes (T2D) (2012)	2.6	3.0	7.5	-1.8	-0.0	-1.5	-2.7	-1.0	2.6
Noisy workplace	2.6	3.2	11.6	-1.6	-3.4	-0.7	-2.1	-1.0	1.6
Health satisfaction	2.6	3.3	7.7	-2.8	-1.6	-2.5	-1.3	-2.2	0.4
Overall health rating	2.6	5.6	17.3	-4.2	-1.2	-2.7	-2.4	-2.1	1.6
Tinnitus: Yes, now most or all of the time	2.6	3.0	8.2	-2.9	-0.4	-2.8	-1.9	-1.0	-0.6
Migraine (self-reported)	2.5	3.0	8.8	-1.4	-3.0	-2.2	-1.0	-1.6	1.4
Waist Hip Ratio (WHR)	2.4	10.7	35.0	3.5	3.5	2.1	5.9	0.8	-3.1
Neuroticism	2.4	5.7	17.3	-3.6	-2.1	-4.2	-2.1	-0.7	0.8
Number of treatments/medications taken	2.4	4.3	10.3	-2.7	-0.0	-3.2	-1.5	-2.9	1.5
Serious illness, injury or assault to yourself	2.3	2.8	6.1	-2.1	0.7	-1.7	-1.6	-2.5	1.8
Birth weight	2.3	4.9	11.3	2.8	3.4	2.2	3.1	-0.9	0.3
Depression (Nagel 2018)	2.2	3.3	10.5	-2.8	-0.4	-3.2	-1.5	-1.5	-0.5
HDL Cholesterol	2.2	3.7	9.5	3.1	0.7	2.8	1.6	1.1	-2.1
Average weekly spirits intake	2.2	2.8	5.7	2.1	0.6	1.6	2.0	1.4	-2.4
Qualifications: CSEs or equivalent	2.2	2.9	10.2	-2.6	-0.5	-3.2	-1.3	-1.1	0.6
Leg pain on walking	2.2	2.8	7.6	-1.7	-1.5	-1.5	-2.1	-0.2	2.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.2	2.5	7.6	-1.7	-2.3	0.3	-1.4	0.4	2.8
Length of working week for main job	2.1	2.3	5.4	1.2	0.4	2.2	1.9	2.3	-0.8
Medication for pain relief, constipation, heartburn	2.1	3.5	10.7	1.9	1.2	3.3	1.1	2.7	-0.7
Irritability	2.1	3.6	7.8	-2.8	-1.5	-2.1	-2.5	-0.1	2.1
Ever used hormone-replacement therapy (HRT)	2.0	2.5	7.4	-2.1	-1.2	-0.4	-1.9	-1.0	2.7
Current tobacco smoking	2.0	3.2	7.7	2.5	2.0	1.2	2.8	0.1	-1.8
Heel bone mineral density (BMD) T-score, automated (left)	2.0	4.6	9.9	2.3	3.1	3.1	2.1	1.6	-0.6
Smoking status: Current	2.0	3.2	8.3	2.6	1.9	1.4	2.9	0.2	-1.3
Financial situation satisfaction	2.0	2.5	7.7	-2.0	-1.0	-2.8	-1.8	-0.5	-1.1
Worry (Nagel 2018)	1.9	4.0	14.9	-2.9	-1.3	-3.9	-0.8	-1.4	-0.5
Frequency of depressed mood in last 2 weeks	1.9	2.7	8.0	-2.7	-0.6	-2.8	-1.5	-0.8	-0.3
Hair/balding pattern: Pattern 2	1.9	2.4	4.9	2.0	2.2	0.8	1.6	1.6	-1.4
Mood swings	1.9	3.4	8.8	-3.0	-1.4	-2.1	-2.1	0.2	2.1
Neuroticism (Nagel 2018)	1.8	4.3	15.6	-3.1	-0.8	-4.0	-1.6	-1.0	0.8
Fed-up feelings	1.8	3.3	10.1	-3.2	-2.2	-1.9	-1.7	0.3	1.3
Forced vital capacity (FVC)	1.8	6.9	12.9	-2.6	-2.0	-2.5	-2.6	-3.5	3.6
Fluid intelligence score	1.8	3.8	8.1	2.7	2.8	1.4	1.6	0.7	-2.6
Medication: Blood pressure	1.8	3.1	9.2	-3.0	-1.9	-2.3	-1.3	-1.3	-0.5
Knee pain experienced in last month	1.8	2.9	11.7	-1.1	0.0	-1.8	-1.8	-0.7	3.4
Mean Putamen Volume	1.7	1.9	8.5	-1.2	-0.2	-1.8	-0.1	-2.9	0.7
Impedance of leg (right)	1.7	8.1	26.6	-2.1	-0.3	-5.2	0.1	-5.0	-0.9
Average weekly red wine intake	1.7	2.5	6.4	1.5	2.5	1.8	1.4	1.3	-1.4
Cholesterol lowering medication	1.7	2.6	9.4	1.4	1.6	-0.7	1.8	-3.1	-0.6
Chronic bronchitis/emphysema (mother)	1.6	1.9	4.7	2.2	0.6	1.6	1.2	1.5	-1.4
Ulcerative Colitis (UC)	1.5	2.8	8.3	-1.1	-1.6	-1.2	-1.7	-1.9	2.9
Age at First Birth	1.5	2.2	3.9	1.7	1.3	1.9	2.0	1.5	-0.9
Frequency of unenthusiasm / disinterest in last 2 weeks	1.5	1.9	6.4	-2.5	-0.6	-2.0	-1.6	-0.7	0.3
Diverticular disease/diverticulitis (self-reported)	1.5	1.7	5.1	-1.8	-0.3	-0.4	-1.5	-1.2	2.3
Impedance of leg (left)	1.5	7.5	25.6	-2.0	0.0	-5.1	0.4	-4.6	-1.1
Medication: Paracetamol	1.5	2.5	10.9	-1.3	-0.1	-3.3	-1.0	-1.7	1.2
Glaucoma (self-reported)	1.5	1.8	5.5	2.3	0.3	0.8	1.8	0.2	-1.7
Qualifications: nursing, teaching	1.5	2.4	6.6	1.7	2.6	0.9	2.2	-0.0	-1.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.5	1.8	5.1	-1.8	-0.6	-2.3	-0.7	-1.1	1.3
Hearing aid user	1.5	1.7	5.3	-0.7	-1.7	-0.5	-2.3	1.1	1.3
Eye problems/disorders: Glaucoma	1.5	1.8	5.8	2.4	0.0	1.3	1.7	1.0	-1.1
Number of operations (self-reported)	1.5	2.2	6.3	-0.8	0.6	0.9	-2.5	1.1	2.5
Basal cell carcinoma (self-reported)	1.5	1.8	3.5	-1.6	-0.7	-1.2	-1.9	-1.9	0.9
Diabetes (mother)	1.4	1.8	5.4	-1.1	-1.3	-2.3	-0.8	-0.7	1.8
Impedance of arm (left)	1.4	6.7	28.0	-0.7	1.6	-3.6	1.2	-5.3	-0.9
Forced vital capacity (FVC), Best measure	1.4	5.1	11.5	-2.1	-1.4	-2.4	-2.0	-3.4	2.8
Impedance of whole body	1.4	7.3	27.2	-1.1	1.1	-4.3	1.2	-5.2	-1.2
Depressed Affect (Nagel 2018)	1.3	2.7	7.1	-2.4	-1.1	-2.7	-1.6	-0.7	1.3
BMI	1.3	7.5	18.3	4.3	-0.2	4.3	1.4	3.6	-0.8
Ever had hysterectomy (womb removed)	1.3	1.5	3.9	-1.7	-1.0	-0.3	-1.5	-0.6	2.0
Bilateral oophorectomy (both ovaries removed)	1.3	1.5	5.2	-1.4	-0.1	-0.7	-0.9	-2.3	1.5
Had other major operations	1.3	1.6	6.5	-1.7	0.8	-0.5	-2.6	-0.3	0.8
Impedance of arm (right)	1.3	6.0	24.3	0.1	2.0	-3.0	1.9	-4.9	-1.1
Qualifications: O levels/GCSEs or equivalent	1.3	2.1	5.2	1.5	2.3	1.5	0.9	1.2	-1.6
Suffer from ‘nerves’	1.3	2.0	7.3	-1.8	0.6	-2.7	-0.1	-0.5	-1.7
Osteoarthritis (self-reported)	1.3	1.7	4.0	-1.8	-0.9	-1.4	-1.4	-0.2	2.0
Medication: Gliclazide	1.3	1.5	4.0	-2.0	-1.6	-1.3	-1.3	0.1	0.6
Illnesses of father: High blood pressure	1.3	1.6	6.2	0.1	0.6	1.4	-1.7	2.5	-0.0
Age started oral contraceptive pill	1.3	1.6	5.5	1.9	0.0	1.2	2.3	-0.3	-1.0
Heart disease (siblings)	1.3	1.6	4.1	-2.0	1.3	-0.9	0.1	-2.0	0.6
Alzheimer’s Disease (in mother)	1.2	1.4	3.9	-0.7	-1.2	-1.3	-1.3	-1.0	2.0
Lung FVC	1.2	5.9	12.9	-2.5	-1.2	-2.3	-3.1	-2.4	3.6
Multivitamins +/- minerals	1.2	1.5	5.2	-1.9	-0.2	-1.2	-2.3	0.2	-0.0
Neuroticism score	1.2	2.5	7.3	-2.5	-1.5	-2.7	-1.0	0.2	1.0
Frequency of tiredness / lethargy in last 2 weeks	1.2	1.9	5.2	-2.3	0.0	-1.4	-1.6	-1.4	1.4
Forced expiratory volume in 1-second (FEV1)	1.2	4.0	16.6	-0.7	-0.9	-0.9	-0.9	-2.8	4.1
Exposure to tobacco smoke outside home	1.2	1.7	5.5	-2.3	-1.1	-0.9	-1.6	-0.2	1.2
Worry too long after embarrassment	1.2	2.1	7.8	-1.8	0.7	-2.8	-1.4	-0.7	-0.9
Qualifications: NVQ or HND or HNC or equivalent	1.2	1.4	6.2	-0.1	-2.5	-0.7	-0.7	-0.4	1.6
Smoking status: Previous	1.2	1.8	2.8	-1.7	-1.7	-1.5	-1.3	-0.9	1.6
Medication: Atorvastatin	1.2	1.5	4.6	2.1	0.8	0.7	2.1	-0.2	-0.4
Deep venous thrombosis (DVT) (self-reported)	1.2	1.6	3.1	1.4	1.4	1.8	1.6	0.5	1.1
Irritable Bowel Disease (IBD)	1.1	2.7	8.6	-1.4	-0.9	-1.2	-1.0	-2.9	2.3
LDL Cholesterol	1.1	1.8	6.6	1.4	0.1	1.4	2.6	1.4	-0.4
Number of incorrect matches in round	1.1	1.9	5.4	2.3	1.4	1.4	1.4	1.3	-0.1
Hip circumference	1.1	4.9	11.8	-2.2	-3.1	-1.7	-3.4	-1.1	2.1
Mouth/teeth dental problems: Dentures	1.1	1.9	4.1	-1.4	0.5	-2.0	1.1	-1.9	-1.6
Forced expiratory volume in 1-second (FEV1), Best measure	1.1	3.4	11.0	-0.2	-0.1	-1.3	-0.4	-3.3	3.3
Peak expiratory flow (PEF)	1.1	2.5	7.2	-0.4	-1.4	-1.6	-0.9	-2.2	2.7
Eye problems/disorders: None of the above	1.1	1.3	3.5	-1.9	0.1	-1.2	-1.7	-0.3	1.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.1	1.3	5.5	-0.8	-1.2	-2.4	0.2	-1.2	0.1
Medication: Aspirin	1.1	1.4	6.6	0.3	-0.9	-0.5	0.8	-2.6	-1.2
Mother’s age at death	1.1	1.4	3.9	0.6	1.9	2.0	0.1	0.2	1.3
Pain experienced in last month	1.1	1.9	7.6	1.3	1.4	-0.1	1.0	1.0	-2.8
Intelligence (Savage-Jansen 2018)	1.0	3.2	10.6	2.5	3.2	0.9	1.6	1.0	-1.0
Ulcerative Colitis	1.0	1.5	7.0	-0.7	-1.1	0.0	-1.2	-0.6	2.7
Height	1.0	19.2	63.4	-2.9	-3.5	-3.4	-1.7	-6.0	8.0
Eye problems/disorders: Diabetes related eye disease	1.0	1.1	3.8	2.0	0.0	0.9	1.7	0.2	-0.4
Vitamin and mineral supplements	1.0	1.3	3.7	1.6	0.9	1.2	1.9	0.7	0.1
Supplements: Glucosamine	1.0	1.3	4.1	-1.2	0.3	0.0	-1.7	-0.5	2.0
Allergy	1.0	2.4	7.6	-1.0	-1.9	-1.4	-1.5	-2.8	0.8
Pain all over the body in last month	1.0	1.1	3.9	-2.0	0.3	-1.0	-1.3	-0.4	0.8
Illnesses of siblings	1.0	1.4	5.6	1.6	-1.0	0.1	0.6	2.4	-0.7
Worrier / anxious feelings	1.0	2.0	5.8	-2.4	-1.5	-1.9	-0.7	-1.1	-0.1
Loud music exposure frequency	1.0	1.1	3.0	0.6	1.3	-1.2	0.8	-0.7	-1.7
Shortness of breath walking on level ground	1.0	1.2	2.5	-1.6	-1.0	-1.2	-1.4	-0.1	-1.0
Comparative height size at age 10	1.0	5.4	21.7	-1.4	-2.2	-1.6	-0.9	-4.7	2.5
Asthma (self-reported)	1.0	2.0	10.0	0.7	0.0	0.1	0.7	3.2	-1.7
High cholesterol (Self-reported)	1.0	1.8	6.9	1.9	1.1	0.9	2.6	-0.3	0.1
Medication: Omeprazole (e.g. Zanprol)	1.0	1.2	2.7	-0.6	-1.5	-0.0	-0.4	1.6	1.6
Supplements: Calcium	1.0	1.1	3.2	-0.9	-1.6	0.1	-1.8	0.7	0.6
Respiratory disease	0.9	1.9	9.9	-0.4	0.1	-0.5	-1.0	3.2	-1.5
Diabetes (father)	0.9	1.2	3.3	-1.6	0.5	-1.8	-1.2	-0.3	0.7
Body mass index (BMI)	0.9	3.9	12.4	2.4	0.0	2.8	0.6	3.5	-1.0
Asthma	0.9	1.8	8.5	0.7	-0.1	-0.1	0.4	2.9	-1.9
Prospective memory result	0.9	1.1	3.0	0.5	-1.1	-1.3	1.3	-0.2	1.7
Blood clot in the leg (DVT)	0.9	1.1	2.2	1.1	1.2	1.5	1.3	0.7	0.9
Gout (self-reported)	0.9	1.2	4.0	0.3	-0.4	0.3	-0.5	2.0	2.0
Qualifications: College or University degree	0.9	2.8	6.2	2.5	1.8	1.8	1.6	1.6	-1.3
Number of self-reported non-cancer illnesses	0.9	1.6	4.4	-1.9	-0.6	-2.1	-0.4	-0.9	1.5
Miserableness	0.9	1.6	3.9	-1.7	-1.3	-2.0	-1.2	0.6	0.9
Medication: Paracetamol	0.9	1.4	6.3	-1.1	0.5	-2.5	-0.6	-1.1	0.7
Medication: Lisinopril	0.9	1.2	4.0	-1.5	-2.0	-1.0	-0.7	-0.5	0.3
Risk taking	0.9	1.4	3.3	1.5	0.7	1.8	1.8	-0.2	-0.1
Fasting Glucose	0.8	0.9	3.1	-1.3	-1.0	-0.0	-0.3	-1.8	-0.7
Schizophrenia (2014)	0.8	1.7	4.0	-2.0	0.2	0.7	-1.4	-1.2	2.0
Hypothyroidism (self reported)	0.8	1.8	4.2	-2.0	-1.3	-2.0	0.2	-0.4	1.6
Hand grip strength (left)	0.8	2.0	6.6	-1.2	-2.6	-1.9	-0.7	-1.4	-0.4
Medication: Levothyroxine sodium	0.8	1.4	4.7	-1.6	-0.7	-1.1	-0.3	-0.7	2.2
Nervous feelings	0.8	1.5	6.1	-1.3	-1.4	-2.5	-0.3	0.3	-0.6
Tense / ‘highly strung’	0.8	1.3	4.2	-2.0	-0.0	-2.0	-0.8	-0.1	0.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.8	1.2	3.3	-1.3	-0.8	-1.8	-0.3	-1.5	0.4
Medication: Ibuprofen	0.8	0.9	2.2	-0.0	1.5	-1.4	0.2	-1.4	-0.7
Medication: Omeprazole	0.8	1.0	3.3	-0.8	-1.2	-0.2	0.2	1.1	1.8
Chest pain or discomfort	0.8	1.2	4.2	-0.0	0.8	-0.0	-1.3	2.0	1.3
Illness, injury, bereavement, stress in last 2 years	0.8	0.9	2.9	0.9	-1.1	0.7	0.2	1.1	-1.7
Medication: Aspirin	0.8	1.0	4.7	0.6	-0.6	-0.3	1.0	-2.2	-0.9
Mineral and other dietary supplements	0.8	1.1	4.2	1.2	0.5	0.7	2.0	-0.7	-1.1
Average weekly champagne plus white wine intake	0.8	1.1	4.1	1.6	0.7	2.0	0.8	0.4	0.2
Supplements: Fish oil (including cod liver oil)	0.8	1.0	3.2	-1.3	-1.1	-0.7	-1.8	0.7	0.4
Fractured/broken bones in last 5 years	0.8	1.1	4.2	-0.9	-0.5	-0.8	-0.5	-2.0	1.2
Alzheimer’s Disease (in father)	0.7	0.8	2.1	-0.0	0.9	-0.7	0.3	-1.4	-1.4
Body Mass Index (BMI) (2010)	0.7	1.0	3.5	-1.0	-1.9	-0.4	-0.7	-0.5	1.1
Arm fat percentage (right)	0.7	2.9	7.5	2.7	0.8	1.9	1.8	1.5	-1.7
Trunk fat-free mass	0.7	4.1	12.5	0.0	-3.1	1.6	-1.8	0.7	3.5
Time employed in main current job	0.7	0.8	2.2	1.2	0.9	-0.7	1.5	-0.4	0.2
Trunk predicted mass	0.7	4.2	12.9	0.0	-3.2	1.6	-1.8	0.7	3.6
Standing height	0.7	6.6	20.3	-1.4	-2.9	-1.5	-0.7	-4.5	3.6
Mouth/teeth dental problems: Bleeding gums	0.7	1.0	3.8	-0.2	0.3	-0.0	-1.9	1.5	0.8
Medication: Amlodipine	0.7	1.0	3.4	-1.8	-0.3	-0.7	-0.9	-1.3	0.8
High blood pressure (siblings)	0.7	1.0	3.2	-1.2	0.7	-0.4	-1.1	-1.8	0.7
Age at first live birth	0.7	1.2	2.8	1.7	0.2	1.3	1.3	0.3	-1.5
Medication: Allopurinol	0.7	0.9	3.1	-0.5	-0.3	-1.3	-0.9	0.6	1.8
Long-standing illness, disability or infirmity	0.7	1.1	2.5	-1.6	-0.3	-1.4	-0.8	-1.4	0.8
Friendships satisfaction	0.7	0.9	4.3	-0.6	-0.1	-2.1	-1.1	-0.1	0.7
Average weekly beer plus cider intake	0.7	1.0	2.2	-1.3	0.2	-1.4	-1.0	0.1	1.5
Unable to work because of sickness or disability	0.7	0.9	3.0	-1.7	-0.5	-1.3	-1.1	-0.7	0.0
Crohns Disease (2017)	0.6	1.4	7.2	-1.2	-0.1	-0.8	-0.0	-2.7	0.5
Verbal and Numeric Reasoning (VNR)	0.6	1.5	7.9	1.1	2.8	0.1	0.1	-0.4	-1.0
Other serious medical condition/disability diagnosed by doctor	0.6	0.8	2.1	-1.2	0.1	-1.4	-0.3	-1.3	0.5
Average weekly fortified wine intake	0.6	0.7	1.5	1.1	1.1	0.1	0.6	1.2	-0.7
Maternal smoking around birth	0.6	0.9	3.5	1.1	1.9	0.4	0.7	-1.0	-0.6
Relative age voice broke	0.6	0.9	2.1	-1.4	0.1	-1.2	-1.5	-0.4	-0.9
Tinnitus: Yes, but not now, but have in the past	0.6	0.6	2.1	1.4	0.9	-0.0	1.1	0.6	-0.1
Frequency of tenseness / restlessness in last 2 weeks	0.6	0.9	2.4	-1.6	0.6	-1.1	-0.5	0.6	-1.2
Medication: Lansoprazole	0.6	0.7	2.8	-1.0	0.0	-0.2	-0.5	-1.7	1.0
Lung cancer (father)	0.6	0.7	1.8	1.3	-0.1	0.5	1.3	0.3	1.1
Pulse wave Arterial Stiffness index	0.6	0.7	2.8	-0.0	0.2	-1.7	1.0	-0.7	-0.8
Medication for cholesterol, blood pressure or diabetes	0.6	1.0	2.8	1.7	1.1	1.6	0.6	0.7	-0.2
Arm fat-free mass (right)	0.6	3.1	7.7	-0.0	-2.8	1.8	-1.6	1.4	2.5
Pulse wave peak to peak time	0.6	0.7	3.1	0.2	-0.1	1.8	-0.7	0.5	0.8
Arm predicted mass (right)	0.6	3.2	7.8	-0.2	-2.8	1.9	-1.7	1.4	2.5
Had major operations	0.6	0.7	2.2	0.1	-0.7	-0.2	-1.4	0.0	1.5
Family relationship satisfaction	0.6	0.8	1.7	-0.4	0.6	-1.3	-0.8	-1.2	0.9
Commuting to job workplace: Car/motor vehicle	0.6	0.7	1.4	1.1	1.2	0.7	0.8	-0.4	-1.0
Whole body fat-free mass	0.6	3.3	9.4	0.3	-2.6	1.9	-1.4	0.8	3.1
Arm fat percentage (left)	0.6	2.2	5.6	2.4	0.6	1.7	1.5	1.4	-1.5
Loneliness, isolation	0.6	0.8	3.6	-0.8	-0.4	-1.9	-0.7	-0.4	0.8
Ever had stillbirth, spontaneous miscarriage or termination	0.6	0.6	1.7	-0.6	-0.5	-1.3	0.8	-0.5	1.2
Eye problems/disorders: Cataract	0.6	0.7	2.2	-0.7	-0.4	-0.9	-0.3	-1.5	1.2
Whole body water mass	0.6	3.3	9.2	0.4	-2.6	2.0	-1.4	0.8	3.0
Arm fat-free mass (left)	0.6	2.9	6.7	0.4	-2.6	1.9	-1.3	1.4	2.5
Arm predicted mass (left)	0.6	3.2	7.6	0.2	-2.8	1.9	-1.7	1.6	2.4
Alzheimer’s Disease (including proxy)	0.5	0.7	3.0	-0.4	-0.5	-0.9	-0.5	-1.7	0.5
Reaction Time	0.5	0.9	2.5	0.3	0.4	-0.1	1.6	1.3	-1.4
HbA1C	0.5	0.5	2.2	-1.0	-1.5	-0.7	0.2	-0.1	0.2
Triglycerides	0.5	0.8	2.9	-1.7	-0.8	-1.4	0.0	-0.3	0.1
Smoking Status	0.5	1.1	3.3	1.8	0.8	1.0	1.5	0.2	-0.6
Past tobacco smoking	0.5	0.9	2.4	0.4	1.6	1.0	0.4	0.8	-1.4
Mouth/teeth dental problems	0.5	0.8	2.6	1.1	-0.7	1.6	0.4	-0.2	1.2
Medication: Ramipril	0.5	0.6	1.3	-0.8	1.1	-0.8	0.2	-0.8	-1.1
Medication: Simvastatin	0.5	0.7	2.0	0.2	0.8	-1.4	0.6	-1.3	-0.6
Qualifications: A levels/AS levels or equivalent	0.5	1.2	2.8	1.3	1.2	0.1	1.4	-1.7	-0.6
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.6	1.6	-0.2	0.9	-1.2	-0.5	-1.3	-0.1
Arm fat mass (right)	0.5	2.2	5.2	2.3	0.1	2.1	1.0	1.9	-0.9
Pulse wave reflection index	0.5	0.6	1.3	-0.2	1.1	-1.1	0.6	-0.8	-0.8
Medication: Ventolin 100micrograms inhaler	0.5	0.7	2.0	0.2	-0.2	-0.5	0.6	1.4	-1.4
Mouth/teeth dental problems: Loose teeth	0.5	0.6	2.8	-0.2	0.8	0.5	-0.4	1.7	-0.2
Illnesses of father: Heart disease	0.5	0.6	1.7	1.1	0.6	0.3	1.3	-0.8	-0.6
Forced expiratory volume in 1-second (FEV1), predicted	0.5	1.0	1.8	-1.0	-1.4	-0.5	-0.6	-1.2	1.3
Handedness (chirality/laterality): Left-handed	0.5	0.6	1.6	-1.0	-0.6	-1.2	-1.2	-0.5	-0.0
Commuting to job workplace: Walk	0.5	0.6	1.3	-0.9	-0.3	0.9	-0.9	-1.2	0.6
Mouth/teeth dental problems: Mouth ulcers	0.5	0.9	2.3	0.5	1.0	-0.4	1.2	0.9	-1.5
Back pain experienced in last month	0.5	0.7	2.0	-1.4	-1.2	0.6	-0.7	-0.6	0.7
Breast cancer (self-reported)	0.5	0.6	2.6	-0.6	1.0	-1.6	0.2	-0.7	0.0
Illnesses of father: None of the above (group 1)	0.5	0.6	2.4	0.0	-0.6	-1.6	-0.2	-0.8	0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.1	5.8	-0.2	-0.7	-0.5	-0.7	-0.6	2.4
Basal metabolic rate	0.5	2.6	7.0	0.6	-2.3	1.9	-1.1	0.9	2.6
Diastolic blood pressure, automated reading	0.5	1.4	3.3	-1.7	-1.8	-1.4	-1.1	-0.6	0.6
Ever depressed for a whole week	0.5	0.7	2.8	-0.1	-0.4	-0.3	1.2	0.5	-1.7
Alcohol drinker status: Previous	0.5	0.5	1.3	1.0	0.8	1.1	0.8	-0.4	-0.5
Bipolar Disorder (2018)	0.4	0.7	3.7	-0.8	0.4	-0.3	0.5	-1.9	-0.1
Bipolar Disorder or Schizophrenia	0.4	1.1	3.9	-1.5	-0.0	0.4	-0.5	-2.0	0.8
Schizophrenia (2018)	0.4	0.9	1.8	-1.3	-0.3	0.8	-1.1	-1.1	1.1
Ovarian Cancer	0.4	0.6	2.3	0.6	0.8	-0.3	-0.1	1.5	0.7
Bipolar Disorder (2011)	0.4	0.4	1.4	-1.2	0.2	0.0	-0.7	-0.5	0.9
Lupus	0.4	0.6	2.2	-0.5	0.8	-0.5	0.7	0.1	-1.5
Neuroticism (2016)	0.4	0.6	1.0	-0.9	-1.0	0.7	-0.7	0.4	1.0
Blood Eosinophil Count	0.4	2.9	7.2	0.3	1.9	-1.0	2.4	2.7	-1.6
Blood Red Count	0.4	4.3	18.9	-1.4	-1.3	-2.4	-0.7	-4.3	-1.0
Blood White Count	0.4	2.7	7.4	-1.2	-1.8	-2.7	0.1	-0.3	-2.6
Hair Pigment	0.4	10.0	27.2	2.7	2.3	3.6	4.1	0.8	5.2
Sensitivity / hurt feelings	0.4	0.7	2.3	-0.0	-0.2	-0.6	-0.7	1.5	1.2
Angina	0.4	0.6	2.2	-0.3	-1.5	-1.0	-0.3	-0.5	-0.6
Medication: Metformin	0.4	0.5	2.8	-0.6	-1.7	-0.3	0.1	-0.7	-0.1
Severe depression (siblings)	0.4	0.4	1.2	-0.8	0.5	-1.1	-0.4	-0.6	-0.7
Pack years adult smoking proportion	0.4	0.7	1.9	0.6	0.2	1.4	1.4	-0.4	-0.5
Leg fat-free mass (left)	0.4	2.1	5.1	0.9	-1.7	2.2	-0.8	0.8	2.3
Taking other prescription medications	0.4	0.6	1.3	-0.9	1.0	-1.0	0.3	0.2	1.1
Age when periods started (menarche)	0.4	1.0	4.6	0.7	0.6	-0.2	1.1	0.7	-2.1
Leg predicted mass (left)	0.4	2.1	5.2	1.0	-1.6	2.1	-0.8	0.8	2.3
Had menopause	0.4	0.4	1.8	-0.3	-1.0	0.1	-0.1	0.1	-1.4
Diabetes (self-reported)	0.4	0.6	2.9	-0.1	-1.7	0.3	-0.0	-1.1	0.3
Exposure to tobacco smoke at home	0.4	0.4	1.7	-0.8	-1.3	0.2	0.0	0.6	0.4
Ever highly irritable/argumentative for 2 days	0.4	0.5	2.0	-0.4	0.3	-1.0	-0.4	0.4	-1.4
Hypothyroidism/myxoedema (self-reported)	0.4	0.9	3.9	-0.9	-0.4	-0.9	0.6	-0.2	2.0
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.5	1.5	-0.4	1.2	-0.3	1.1	0.5	-0.3
Number of children fathered	0.4	0.4	1.6	0.1	0.7	-0.3	0.9	-1.3	-0.0
Emphysema/chronic bronchitis	0.4	0.5	1.4	-1.2	0.6	-0.1	-1.0	0.5	-0.6
Neck or shoulder pain in last month	0.4	0.5	1.4	1.2	0.6	1.0	0.8	0.0	-0.6
Mean time to correctly identify matches	0.4	0.7	2.2	-0.3	0.4	-0.6	1.3	0.7	-1.5
Supplements: Vitamin C	0.4	0.5	1.0	0.7	0.8	0.6	0.7	-1.0	-0.4
Leg fat-free mass (right)	0.4	2.1	5.2	0.9	-1.5	2.3	-0.6	1.0	2.3
Osteoporosis (self-reported)	0.4	0.4	2.2	-0.3	-0.6	-0.7	-0.0	0.0	-1.5
Leg predicted mass (right)	0.4	2.1	5.3	1.0	-1.5	2.3	-0.6	1.0	2.2
Arm fat mass (left)	0.4	1.7	3.8	1.9	-0.3	1.9	0.7	1.8	-0.6
Guilty feelings	0.4	0.6	1.6	-0.6	0.4	-1.3	0.3	0.9	1.1
Commuting to job workplace: Public transport	0.4	0.4	1.4	0.7	0.9	-0.3	-0.1	1.2	-0.4
Leg fat percentage (left)	0.4	1.3	3.0	1.7	-0.7	0.7	0.8	1.5	-1.4
Ever had prostate specific antigen (PSA) test	0.4	0.5	1.2	-0.7	0.0	-0.7	-1.1	0.3	-1.0
Commuting to job workplace: Cycle	0.4	0.5	2.2	0.4	-0.5	0.5	0.0	-1.0	1.5
Pack years of smoking	0.4	0.6	1.9	0.4	-0.2	1.4	1.2	-0.7	-0.1
Major Depression (MDD)	0.3	0.4	1.0	0.4	-0.1	-0.6	1.0	-0.6	-0.9
Breast Cancer	0.3	0.7	1.9	0.9	1.4	-0.2	0.1	-0.6	-1.2
Prostate Cancer	0.3	0.5	1.3	1.1	0.4	0.3	0.9	0.6	-0.8
Coronary Artery Disease (CAD)	0.3	0.4	1.2	-0.7	-0.2	-0.4	-1.1	-0.8	0.1
Crohns Disease (2012)	0.3	0.4	1.4	-0.9	-0.6	0.2	0.3	-1.2	-0.3
Allergy or Eczema	0.3	0.7	3.5	-0.6	1.9	-0.5	0.6	-0.2	-0.3
Type 2 Diabetes (T2D) (2018)	0.3	0.5	2.7	0.3	-1.6	0.4	0.7	0.3	-0.4
Supplements: Zinc	0.3	0.3	1.2	-0.1	0.1	-0.2	-0.8	0.1	1.1
Hayfever, allergic rhinitis or eczema	0.3	0.6	2.8	-0.0	1.7	0.7	0.7	0.7	-0.1
Chronic bronchitis/emphysema (father)	0.3	0.3	1.5	-0.4	-0.1	1.2	0.6	0.3	0.0
Waist circumference	0.3	1.1	3.1	1.8	-0.2	1.3	1.2	1.3	-0.3
Ever unenthusiastic/disinterested for a whole week	0.3	0.4	1.0	-1.0	-0.5	-1.0	0.1	0.6	-0.4
Qualifications: None of the above	0.3	0.5	1.6	-1.1	-0.3	-0.5	-0.2	-1.3	0.8
Weight	0.3	1.4	3.4	1.4	-1.6	1.8	-0.0	1.2	0.9
Falls in the last year	0.3	0.4	1.6	0.1	1.3	-0.2	0.2	-0.5	1.1
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.4	0.9	0.2	0.8	0.5	0.1	-0.9	1.0
Breastfed as a baby	0.3	0.3	1.2	-0.1	0.3	-0.1	-0.7	-0.8	1.1
Body fat percentage	0.3	1.2	3.5	1.9	-0.0	0.7	1.4	0.3	-1.6
Leg fat percentage (right)	0.3	1.1	2.6	1.6	-0.9	0.5	0.6	1.2	-1.4
Number of full brothers	0.3	0.4	1.2	-1.1	-0.2	-1.1	-0.3	0.2	0.2
Wheeze or whistling in the chest in last year	0.3	0.6	1.9	1.0	1.1	-0.0	0.4	1.4	0.4
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.4	0.8	-0.1	-0.9	-0.8	0.5	-0.4	-0.8
Angina (self-reported)	0.3	0.5	1.5	-0.2	-1.2	-1.1	-0.2	-0.2	-0.6
Medication: Seretide 50 evohaler	0.3	0.3	1.7	0.2	-0.6	-0.3	0.1	1.3	-0.5
Leg fat mass (right)	0.3	1.1	2.8	1.7	-0.8	1.4	0.5	1.4	-0.2
Pulse rate, automated reading	0.3	1.0	1.9	1.4	0.1	0.7	1.4	-1.4	0.9
Number of full sisters	0.3	0.4	1.3	0.3	0.4	-0.5	-0.3	-0.9	1.1
Illnesses of siblings: Diabetes	0.3	0.4	1.4	-0.6	0.5	-0.1	0.1	-1.2	-0.8
Ever had bowel cancer screening	0.3	0.3	0.9	-0.6	-1.0	-0.8	-0.6	0.1	0.3
Diabetes diagnosed by doctor	0.3	0.5	2.5	0.4	-1.6	0.4	0.4	-0.6	-0.1
Leg fat mass (left)	0.3	1.2	2.9	1.7	-0.7	1.5	0.5	1.6	-0.3
Primary Biliary Cirrhosis	0.2	0.3	0.8	-0.7	-0.7	-0.3	-0.6	0.9	-0.2
Blood Platelet Count	0.2	2.5	7.7	-0.7	-0.5	-1.8	0.4	2.8	-2.4
Chronotype (morning person)	0.2	0.4	1.8	-0.6	1.3	-0.0	-0.1	-0.6	0.5
Trunk fat percentage	0.2	1.0	2.5	1.5	0.1	0.4	1.4	-0.3	-1.6
Hand grip strength (right)	0.2	0.6	3.1	-0.0	-1.8	-0.8	-0.7	-0.2	-0.2
Trunk fat mass	0.2	0.8	2.4	1.6	-0.8	1.0	0.9	0.1	-0.7
Alcohol usually taken with meals	0.2	0.2	0.7	-0.2	0.8	0.6	-0.7	-0.2	-0.3
Financial difficulties in last 2 years	0.2	0.3	1.6	-0.5	0.1	-0.5	-0.4	-0.2	-1.3
Hayfever/allergic rhinitis (self-reported)	0.2	0.3	1.0	0.4	0.2	0.4	0.5	1.0	0.5
Father’s age at death	0.2	0.3	1.1	0.3	0.6	-0.2	-0.1	1.1	-0.7
Hair/balding pattern: Pattern 3	0.2	0.3	1.3	0.2	-0.8	0.5	0.4	0.2	-1.1
Number of live births	0.2	0.3	0.9	-0.4	0.9	-1.0	0.1	-0.2	-0.6
Medication: Cholesterol lowering	0.2	0.3	0.6	0.2	-0.8	-0.6	0.8	0.1	0.5
Heart disease (mother)	0.2	0.3	0.6	-0.7	-0.8	-0.2	-0.4	-0.5	-0.7
Whole body fat mass	0.2	1.0	3.1	1.8	-0.7	1.4	0.9	0.6	-0.7
Alcohol drinker status: Never	0.2	0.2	0.9	-0.3	-0.1	-0.3	-0.6	0.4	-0.9
Myopia	0.2	0.3	0.6	-0.6	0.6	-0.0	-0.8	-0.6	0.6
Heart attack/myocardial infarction (self-reported)	0.2	0.3	0.8	0.3	-0.8	-0.2	0.5	-0.4	-0.9
Schizophrenia vs Biploar Disorder	0.1	0.2	0.5	-0.7	-0.6	-0.0	-0.6	0.2	0.2
Rheumatoid Arthritis	0.1	0.2	0.6	-0.4	-0.0	-0.3	-0.5	-0.8	-0.5
Tanning	0.1	0.8	4.4	0.6	-0.2	0.6	0.6	2.1	-0.4
Medication: Co-codamol	0.1	0.1	0.4	0.0	0.6	-0.5	0.6	-0.2	0.1
Townsend deprivation index at recruitment	0.1	0.2	0.7	0.2	-0.2	0.5	-0.0	0.3	-0.9
Stomach or abdominal pain in last month	0.1	0.2	0.6	0.2	-0.8	0.5	0.5	0.1	-0.3
Heart attack	0.1	0.1	0.4	0.3	-0.6	-0.2	0.3	-0.3	-0.6
Alcohol intake versus 10 years previously	0.1	0.2	0.5	0.2	0.7	-0.1	-0.2	0.7	0.3
Pulse rate	0.1	0.1	0.5	-0.0	-0.7	-0.1	-0.2	0.1	0.1
Alcohol intake frequency.	0.1	0.3	0.6	-0.5	0.6	0.8	-0.4	-0.1	-0.7
Age at last live birth	0.1	0.2	0.7	0.8	0.3	0.5	0.5	-0.2	-0.2
Wears glasses or contact lenses	0.1	0.1	0.5	0.2	0.7	0.0	-0.3	-0.4	-0.4
Ever taken oral contraceptive pill	0.1	0.1	0.2	-0.3	-0.3	0.5	-0.1	-0.1	-0.2
Ever smoked	0.1	0.2	0.7	0.4	-0.1	-0.4	0.8	-0.5	0.4
Headache pain in last month	0.0	0.1	0.2	0.1	0.1	-0.4	0.1	-0.4	0.5

Hub : Genes

VGLL4

Models

Trait associations