Best TWAS P=2.39e-16 · Best GWAS P=1.62e-15 conditioned to 6.22e-13
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Aorta | PDZRN3 | 0.51 | 0.21 | enet | 12 | 0.25 | 8.7e-14 | -7.6 | 8.0 | 1.3e-15 | 0.07 | 0.04 | 0.96 | FALSE |
| 2 | GTEx | Artery Coronary | PDZRN3 | 0.27 | 0.14 | lasso | 7 | 0.09 | 7.4e-04 | -7.6 | 7.3 | 2.6e-13 | 0.07 | 0.08 | 0.82 | FALSE |
| 3 | GTEx | Artery Tibial | PDZRN3 | 0.39 | 0.28 | enet | 11 | 0.27 | 3.5e-21 | -7.7 | 7.9 | 2.2e-15 | 0.11 | 0.02 | 0.98 | FALSE |
| 4 | GTEx | Esophagus Gastroesophageal Junction | PDZRN3 | 0.25 | 0.12 | lasso | 9 | 0.18 | 3.6e-07 | -7.6 | 7.7 | 1.7e-14 | 0.11 | 0.11 | 0.87 | FALSE |
| 5 | GTEx | Esophagus Muscularis | PDZRN3 | 0.32 | 0.21 | enet | 16 | 0.26 | 3.7e-16 | -7.7 | 7.3 | 2.0e-13 | 0.09 | 0.03 | 0.97 | FALSE |
| 6 | GTEx | Heart Atrial Appendage | PDZRN3 | 0.45 | 0.26 | lasso | 8 | 0.24 | 4.0e-11 | -7.6 | 7.7 | 1.2e-14 | 0.10 | 0.04 | 0.96 | FALSE |
| 7 | GTEx | Heart Left Ventricle | PDZRN3 | 0.42 | 0.24 | lasso | 10 | 0.21 | 1.3e-11 | -7.3 | 8.2 | 2.4e-16 | 0.08 | 0.32 | 0.68 | TRUE |
| 8 | GTEx | Vagina | GXYLT2 | 0.35 | 0.00 | enet | 21 | 0.13 | 5.8e-04 | -2.8 | 5.3 | 1.3e-07 | 0.02 | 0.01 | 0.01 | TRUE |