[Hub]/) : Traits : Lung FEV1/FVC ratio :

chr3:72,238,172-74,372,906

Best TWAS P=2.39e-16 · Best GWAS P=1.62e-15 conditioned to 6.22e-13

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 GTEx Artery Aorta PDZRN3 0.51 0.21 enet 12 0.25 8.7e-14 -7.6 8.0 1.3e-15 0.07 0.04 0.96 FALSE
2 GTEx Artery Coronary PDZRN3 0.27 0.14 lasso 7 0.09 7.4e-04 -7.6 7.3 2.6e-13 0.07 0.08 0.82 FALSE
3 GTEx Artery Tibial PDZRN3 0.39 0.28 enet 11 0.27 3.5e-21 -7.7 7.9 2.2e-15 0.11 0.02 0.98 FALSE
4 GTEx Esophagus Gastroesophageal Junction PDZRN3 0.25 0.12 lasso 9 0.18 3.6e-07 -7.6 7.7 1.7e-14 0.11 0.11 0.87 FALSE
5 GTEx Esophagus Muscularis PDZRN3 0.32 0.21 enet 16 0.26 3.7e-16 -7.7 7.3 2.0e-13 0.09 0.03 0.97 FALSE
6 GTEx Heart Atrial Appendage PDZRN3 0.45 0.26 lasso 8 0.24 4.0e-11 -7.6 7.7 1.2e-14 0.10 0.04 0.96 FALSE
7 GTEx Heart Left Ventricle PDZRN3 0.42 0.24 lasso 10 0.21 1.3e-11 -7.3 8.2 2.4e-16 0.08 0.32 0.68 TRUE
8 GTEx Vagina GXYLT2 0.35 0.00 enet 21 0.13 5.8e-04 -2.8 5.3 1.3e-07 0.02 0.01 0.01 TRUE