[Hub]/) : Traits : Lung FEV1/FVC ratio : ← →

chr3:126,695,780-129,224,131

Best TWAS P=2.56e-53 · Best GWAS P=1.73e-45 conditioned to 1.53e-06

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
24	The Cancer Genome Atlas	Thyroid Carcinoma	EEFSEC	0.08	0.03	blup	116	0.04	1.8e-04	13.97	-15.4	2.6e-53	-0.84	0.03	0.97	TRUE
21	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	TPRA1	0.02	0.01	blup	29	0.01	1.7e-02	-4.41	5.7	1.0e-08	-0.13	0.02	0.56	TRUE
15	METSIM	Adipose	ABTB1	0.11	0.08	lasso	4	0.08	1.2e-11	5.23	5.4	7.3e-08	-0.10	1.00	0.00	TRUE
22	The Cancer Genome Atlas	Brain Lower Grade Glioma	EEFSEC	0.07	0.05	blup	115	0.07	1.6e-08	13.04	-14.5	1.6e-47	-0.76	0.21	0.79	FALSE
20	The Cancer Genome Atlas	Glioblastoma Multiforme	EEFSEC	0.09	0.07	lasso	10	0.05	1.7e-02	13.97	-14.3	2.4e-46	-0.95	0.04	0.70	FALSE
12	GTEx	Testis	RUVBL1	0.31	0.30	lasso	12	0.30	1.2e-13	13.89	14.2	8.1e-46	0.96	0.04	0.96	FALSE
3	GTEx	Adipose Subcutaneous	EEFSEC	0.07	0.03	enet	12	0.06	2.4e-05	12.98	-13.9	6.4e-44	-0.72	0.10	0.88	FALSE
7	GTEx	Cells Transformed fibroblasts	RUVBL1	0.07	0.04	lasso	3	0.02	2.5e-02	13.52	13.5	3.0e-41	0.96	0.06	0.93	FALSE
11	GTEx	Nerve Tibial	EEFSEC	0.07	0.06	lasso	2	0.06	4.5e-05	13.04	-12.9	4.1e-38	-0.53	0.80	0.16	FALSE
8	GTEx	Esophagus Muscularis	EEFSEC	0.07	0.08	lasso	5	0.07	4.4e-05	12.98	-12.9	4.2e-38	-0.53	0.26	0.64	FALSE
19	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	EEFSEC	0.04	0.02	blup	115	0.02	6.7e-03	13.96	-12.7	3.4e-37	-0.95	0.01	0.94	FALSE
1	CommonMind	Brain Pre-frontal Cortex	EEFSEC	0.07	0.04	blup	496	0.04	1.2e-05	11.48	-12.6	1.4e-36	-0.78	0.05	0.95	FALSE
6	GTEx	Cells Transformed fibroblasts	EEFSEC	0.08	0.08	lasso	2	0.06	2.4e-05	12.57	-12.6	3.1e-36	-0.53	0.70	0.09	FALSE
23	The Cancer Genome Atlas	Lung Adenocarcinoma	RUVBL1	0.02	0.02	lasso	3	0.02	1.5e-03	8.19	10.4	1.9e-25	0.78	0.04	0.59	FALSE
5	GTEx	Cells Transformed fibroblasts	SEC61A1	0.13	0.18	lasso	2	0.17	1.0e-12	9.53	9.7	4.3e-22	0.48	1.00	0.00	FALSE
13	GTEx	Thyroid	SEC61A1	0.14	0.07	lasso	6	0.05	1.2e-04	9.49	9.5	2.5e-21	0.49	0.90	0.03	FALSE
2	CommonMind	Brain Pre-frontal Cortex	RUVBL1	0.04	0.00	bslmm	434	0.03	3.6e-04	2.62	-8.8	2.1e-18	-0.57	0.08	0.20	FALSE
10	GTEx	Muscle Skeletal	EEFSEC	0.05	0.01	lasso	5	0.02	4.3e-03	3.29	-8.6	9.8e-18	-0.16	0.70	0.01	FALSE
9	GTEx	Lung	EEFSEC	0.11	0.02	enet	41	0.06	2.3e-05	-0.97	-7.9	3.6e-15	-0.40	0.13	0.68	FALSE
14	GTEx	Thyroid	RPN1	0.16	0.04	lasso	3	0.08	1.0e-06	1.43	6.4	1.6e-10	0.41	0.92	0.06	FALSE
17	NTR	Blood	RPN1	0.03	0.00	bslmm	335	0.01	8.5e-04	1.52	6.4	2.0e-10	0.43	0.04	0.15	FALSE
16	METSIM	Adipose	RPN1	0.07	0.05	blup	362	0.05	2.3e-08	-0.79	5.6	2.0e-08	0.36	1.00	0.00	FALSE
18	YFS	Blood	ABTB1	0.26	0.15	enet	48	0.18	6.7e-58	5.23	5.5	3.3e-08	-0.11	1.00	0.00	FALSE
4	GTEx	Artery Aorta	RAB7A	0.13	0.00	enet	21	0.08	5.6e-05	0.69	5.1	3.1e-07	0.25	0.09	0.04	FALSE