Best TWAS P=2.56e-53 · Best GWAS P=1.73e-45 conditioned to 1.53e-06
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | EEFSEC | 0.07 | 0.04 | blup | 496 | 0.04 | 1.2e-05 | 11.48 | -12.6 | 1.4e-36 | -0.78 | 0.05 | 0.95 | FALSE |
| 2 | CommonMind | Brain Pre-frontal Cortex | RUVBL1 | 0.04 | 0.00 | bslmm | 434 | 0.03 | 3.6e-04 | 2.62 | -8.8 | 2.1e-18 | -0.57 | 0.08 | 0.20 | FALSE |
| 3 | GTEx | Adipose Subcutaneous | EEFSEC | 0.07 | 0.03 | enet | 12 | 0.06 | 2.4e-05 | 12.98 | -13.9 | 6.4e-44 | -0.72 | 0.10 | 0.88 | FALSE |
| 4 | GTEx | Artery Aorta | RAB7A | 0.13 | 0.00 | enet | 21 | 0.08 | 5.6e-05 | 0.69 | 5.1 | 3.1e-07 | 0.25 | 0.09 | 0.04 | FALSE |
| 5 | GTEx | Cells Transformed fibroblasts | SEC61A1 | 0.13 | 0.18 | lasso | 2 | 0.17 | 1.0e-12 | 9.53 | 9.7 | 4.3e-22 | 0.48 | 1.00 | 0.00 | FALSE |
| 6 | GTEx | Cells Transformed fibroblasts | EEFSEC | 0.08 | 0.08 | lasso | 2 | 0.06 | 2.4e-05 | 12.57 | -12.6 | 3.1e-36 | -0.53 | 0.70 | 0.09 | FALSE |
| 7 | GTEx | Cells Transformed fibroblasts | RUVBL1 | 0.07 | 0.04 | lasso | 3 | 0.02 | 2.5e-02 | 13.52 | 13.5 | 3.0e-41 | 0.96 | 0.06 | 0.93 | FALSE |
| 8 | GTEx | Esophagus Muscularis | EEFSEC | 0.07 | 0.08 | lasso | 5 | 0.07 | 4.4e-05 | 12.98 | -12.9 | 4.2e-38 | -0.53 | 0.26 | 0.64 | FALSE |
| 9 | GTEx | Lung | EEFSEC | 0.11 | 0.02 | enet | 41 | 0.06 | 2.3e-05 | -0.97 | -7.9 | 3.6e-15 | -0.40 | 0.13 | 0.68 | FALSE |
| 10 | GTEx | Muscle Skeletal | EEFSEC | 0.05 | 0.01 | lasso | 5 | 0.02 | 4.3e-03 | 3.29 | -8.6 | 9.8e-18 | -0.16 | 0.70 | 0.01 | FALSE |
| 11 | GTEx | Nerve Tibial | EEFSEC | 0.07 | 0.06 | lasso | 2 | 0.06 | 4.5e-05 | 13.04 | -12.9 | 4.1e-38 | -0.53 | 0.80 | 0.16 | FALSE |
| 12 | GTEx | Testis | RUVBL1 | 0.31 | 0.30 | lasso | 12 | 0.30 | 1.2e-13 | 13.89 | 14.2 | 8.1e-46 | 0.96 | 0.04 | 0.96 | FALSE |
| 13 | GTEx | Thyroid | SEC61A1 | 0.14 | 0.07 | lasso | 6 | 0.05 | 1.2e-04 | 9.49 | 9.5 | 2.5e-21 | 0.49 | 0.90 | 0.03 | FALSE |
| 14 | GTEx | Thyroid | RPN1 | 0.16 | 0.04 | lasso | 3 | 0.08 | 1.0e-06 | 1.43 | 6.4 | 1.6e-10 | 0.41 | 0.92 | 0.06 | FALSE |
| 15 | METSIM | Adipose | ABTB1 | 0.11 | 0.08 | lasso | 4 | 0.08 | 1.2e-11 | 5.23 | 5.4 | 7.3e-08 | -0.10 | 1.00 | 0.00 | TRUE |
| 16 | METSIM | Adipose | RPN1 | 0.07 | 0.05 | blup | 362 | 0.05 | 2.3e-08 | -0.79 | 5.6 | 2.0e-08 | 0.36 | 1.00 | 0.00 | FALSE |
| 17 | NTR | Blood | RPN1 | 0.03 | 0.00 | bslmm | 335 | 0.01 | 8.5e-04 | 1.52 | 6.4 | 2.0e-10 | 0.43 | 0.04 | 0.15 | FALSE |
| 18 | YFS | Blood | ABTB1 | 0.26 | 0.15 | enet | 48 | 0.18 | 6.7e-58 | 5.23 | 5.5 | 3.3e-08 | -0.11 | 1.00 | 0.00 | FALSE |
| 19 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | EEFSEC | 0.04 | 0.02 | blup | 115 | 0.02 | 6.7e-03 | 13.96 | -12.7 | 3.4e-37 | -0.95 | 0.01 | 0.94 | FALSE |
| 20 | The Cancer Genome Atlas | Glioblastoma Multiforme | EEFSEC | 0.09 | 0.07 | lasso | 10 | 0.05 | 1.7e-02 | 13.97 | -14.3 | 2.4e-46 | -0.95 | 0.04 | 0.70 | FALSE |
| 21 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | TPRA1 | 0.02 | 0.01 | blup | 29 | 0.01 | 1.7e-02 | -4.41 | 5.7 | 1.0e-08 | -0.13 | 0.02 | 0.56 | TRUE |
| 22 | The Cancer Genome Atlas | Brain Lower Grade Glioma | EEFSEC | 0.07 | 0.05 | blup | 115 | 0.07 | 1.6e-08 | 13.04 | -14.5 | 1.6e-47 | -0.76 | 0.21 | 0.79 | FALSE |
| 23 | The Cancer Genome Atlas | Lung Adenocarcinoma | RUVBL1 | 0.02 | 0.02 | lasso | 3 | 0.02 | 1.5e-03 | 8.19 | 10.4 | 1.9e-25 | 0.78 | 0.04 | 0.59 | FALSE |
| 24 | The Cancer Genome Atlas | Thyroid Carcinoma | EEFSEC | 0.08 | 0.03 | blup | 116 | 0.04 | 1.8e-04 | 13.97 | -15.4 | 2.6e-53 | -0.84 | 0.03 | 0.97 | TRUE |