[Hub]/) : Traits : Lung FEV1/FVC ratio : ← →

chr3:56,341,514-58,613,378

Best TWAS P=2.11e-25 · Best GWAS P=5.84e-26 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
3	GTEx	Esophagus Muscularis	SLMAP	0.06	0.05	lasso	4	0.05	5.2e-04	10.53	10.4	2.1e-25	0.97	0.02	0.96	TRUE
12	The Cancer Genome Atlas	Glioblastoma Multiforme	CCDC66	0.19	0.02	enet	14	0.12	1.7e-04	-3.55	5.4	6.9e-08	-0.05	0.00	0.24	TRUE
10	The Cancer Genome Atlas	Breast Invasive Carcinoma	SLMAP	0.01	0.01	blup	86	0.01	9.1e-03	10.42	9.8	1.8e-22	0.96	0.02	0.84	FALSE
8	ROSMAP	Brain Pre-frontal Cortex	DNAH12	0.04	0.00	blup	448	0.02	1.0e-03	6.51	7.6	2.2e-14	0.42	0.18	0.09	FALSE
6	METSIM	Adipose	DNAH12	0.03	0.03	lasso	3	0.02	1.4e-03	7.19	7.2	6.2e-13	0.67	0.61	0.22	FALSE
15	The Cancer Genome Atlas	Thyroid Carcinoma	PDE12	0.04	0.02	blup	39	0.02	2.7e-03	6.71	6.5	9.1e-11	0.61	0.03	0.87	FALSE
1	CommonMind	Brain Pre-frontal Cortex	DNAH12	0.07	0.07	lasso	3	0.07	2.1e-09	6.79	6.4	1.4e-10	0.56	1.00	0.00	FALSE
14	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	PDE12	0.05	0.02	lasso	2	0.02	1.2e-02	7.14	6.2	4.7e-10	0.64	0.01	0.88	FALSE
13	The Cancer Genome Atlas	Brain Lower Grade Glioma	SPATA12	0.04	0.02	blup	70	0.03	4.4e-04	6.37	-5.9	3.1e-09	-0.35	0.01	0.91	FALSE
7	ROSMAP	Brain Pre-frontal Cortex	ARF4	0.12	0.15	lasso	7	0.16	1.4e-19	-4.96	-5.7	1.3e-08	-0.32	1.00	0.00	FALSE
9	The Cancer Genome Atlas	Breast Invasive Carcinoma	ASB14	0.05	0.03	enet	7	0.03	3.7e-07	-4.70	-5.5	3.5e-08	-0.24	0.99	0.00	FALSE
4	GTEx	Muscle Skeletal	RP11-755B10.4	0.08	0.03	lasso	6	0.06	2.5e-06	-3.80	-5.5	3.9e-08	-0.40	0.94	0.02	FALSE
2	GTEx	Colon Sigmoid	RP11-755B10.4	0.20	0.17	lasso	5	0.16	3.3e-06	-3.86	-5.5	4.4e-08	-0.31	0.52	0.18	FALSE
11	The Cancer Genome Atlas	Esophageal Carcinoma	FAM116A	0.13	0.05	lasso	2	0.09	7.7e-04	5.25	5.4	6.8e-08	0.56	0.02	0.18	FALSE
5	METSIM	Adipose	APPL1	0.04	0.00	blup	416	0.02	2.1e-04	-0.81	-5.2	1.9e-07	-0.22	0.08	0.04	FALSE