Best TWAS P=3.91e-08 · Best GWAS P=7.29e-09 conditioned to 0.0413
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 3 | GTEx | Lung | SLC2A9 | 0.06 | 0.00 | lasso | 5 | 0.00 | 5.7e-01 | -5.7 | -5.5 | 3.9e-08 | 0.87 | 0.03 | 0.92 | TRUE |
| 2 | GTEx | Cells Transformed fibroblasts | WDR1 | 0.09 | 0.03 | lasso | 4 | 0.03 | 2.1e-03 | -4.5 | 5.4 | 5.3e-08 | -0.74 | 0.19 | 0.36 | FALSE |
| 1 | GTEx | Cells EBV-transformed lymphocytes | SLC2A9 | 0.25 | 0.18 | lasso | 6 | 0.18 | 2.0e-06 | -5.7 | -5.4 | 5.6e-08 | 0.96 | 0.03 | 0.97 | FALSE |
| 6 | The Cancer Genome Atlas | Thyroid Carcinoma | WDR1 | 0.12 | 0.05 | blup | 111 | 0.06 | 2.4e-06 | -4.6 | 5.3 | 1.3e-07 | -0.88 | 0.07 | 0.93 | FALSE |
| 5 | GTEx | Whole Blood | RP11-448G15.3 | 0.09 | 0.02 | lasso | 5 | 0.00 | 3.0e-01 | 5.3 | -5.1 | 2.7e-07 | 0.46 | 0.10 | 0.48 | FALSE |
| 4 | GTEx | Lung | RP11-448G15.3 | 0.10 | 0.03 | enet | 12 | 0.02 | 1.1e-02 | 5.3 | -5.1 | 3.0e-07 | 0.49 | 0.10 | 0.69 | FALSE |