[Hub]/) : Traits : Lung FEV1/FVC ratio : ← →

chr4:7,060,959-8,621,167

Best TWAS P=2.33e-12 · Best GWAS P=3.21e-15 conditioned to 0.000202

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
3	GTEx	Brain Cerebellum	AFAP1	0.47	0.19	lasso	4	0.19	2.8e-06	-5.8	7.0	2.3e-12	-0.58	0.14	0.74	TRUE
2	GTEx	Brain Cerebellar Hemisphere	AFAP1-AS1	0.33	0.16	lasso	7	0.16	5.9e-05	6.9	6.9	5.3e-12	-0.50	0.21	0.38	TRUE
7	The Cancer Genome Atlas	Brain Lower Grade Glioma	LOC84740	0.05	0.02	lasso	5	0.03	2.1e-04	-5.1	-5.4	7.6e-08	0.32	0.00	0.98	TRUE
6	METSIM	Adipose	AFAP1	0.05	0.03	enet	13	0.03	1.3e-05	4.8	6.4	2.0e-10	-0.50	0.49	0.46	FALSE
1	GTEx	Brain Cerebellar Hemisphere	AFAP1	0.60	0.28	lasso	11	0.34	1.1e-09	6.9	6.3	3.1e-10	-0.50	0.35	0.59	FALSE
4	GTEx	Whole Blood	AFAP1	0.45	0.48	enet	44	0.50	1.3e-52	4.8	5.3	1.1e-07	-0.42	1.00	0.00	FALSE
5	GTEx	Whole Blood	AFAP1-AS1	0.36	0.33	lasso	8	0.33	2.6e-31	4.8	5.2	1.7e-07	-0.44	0.99	0.01	FALSE