[Hub]/) : Traits : Lung FEV1/FVC ratio :

chr4:7,060,959-8,621,167

Best TWAS P=2.33e-12 · Best GWAS P=3.21e-15 conditioned to 0.000202

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 GTEx Brain Cerebellar Hemisphere AFAP1 0.60 0.28 lasso 11 0.34 1.1e-09 6.9 6.3 3.1e-10 -0.50 0.35 0.59 FALSE
2 GTEx Brain Cerebellar Hemisphere AFAP1-AS1 0.33 0.16 lasso 7 0.16 5.9e-05 6.9 6.9 5.3e-12 -0.50 0.21 0.38 TRUE
3 GTEx Brain Cerebellum AFAP1 0.47 0.19 lasso 4 0.19 2.8e-06 -5.8 7.0 2.3e-12 -0.58 0.14 0.74 TRUE
4 GTEx Whole Blood AFAP1 0.45 0.48 enet 44 0.50 1.3e-52 4.8 5.3 1.1e-07 -0.42 1.00 0.00 FALSE
5 GTEx Whole Blood AFAP1-AS1 0.36 0.33 lasso 8 0.33 2.6e-31 4.8 5.2 1.7e-07 -0.44 0.99 0.01 FALSE
6 METSIM Adipose AFAP1 0.05 0.03 enet 13 0.03 1.3e-05 4.8 6.4 2.0e-10 -0.50 0.49 0.46 FALSE
7 The Cancer Genome Atlas Brain Lower Grade Glioma LOC84740 0.05 0.02 lasso 5 0.03 2.1e-04 -5.1 -5.4 7.6e-08 0.32 0.00 0.98 TRUE