Best TWAS P=2.33e-12 · Best GWAS P=3.21e-15 conditioned to 0.000202
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Brain Cerebellar Hemisphere | AFAP1 | 0.60 | 0.28 | lasso | 11 | 0.34 | 1.1e-09 | 6.9 | 6.3 | 3.1e-10 | -0.50 | 0.35 | 0.59 | FALSE |
| 2 | GTEx | Brain Cerebellar Hemisphere | AFAP1-AS1 | 0.33 | 0.16 | lasso | 7 | 0.16 | 5.9e-05 | 6.9 | 6.9 | 5.3e-12 | -0.50 | 0.21 | 0.38 | TRUE |
| 3 | GTEx | Brain Cerebellum | AFAP1 | 0.47 | 0.19 | lasso | 4 | 0.19 | 2.8e-06 | -5.8 | 7.0 | 2.3e-12 | -0.58 | 0.14 | 0.74 | TRUE |
| 4 | GTEx | Whole Blood | AFAP1 | 0.45 | 0.48 | enet | 44 | 0.50 | 1.3e-52 | 4.8 | 5.3 | 1.1e-07 | -0.42 | 1.00 | 0.00 | FALSE |
| 5 | GTEx | Whole Blood | AFAP1-AS1 | 0.36 | 0.33 | lasso | 8 | 0.33 | 2.6e-31 | 4.8 | 5.2 | 1.7e-07 | -0.44 | 0.99 | 0.01 | FALSE |
| 6 | METSIM | Adipose | AFAP1 | 0.05 | 0.03 | enet | 13 | 0.03 | 1.3e-05 | 4.8 | 6.4 | 2.0e-10 | -0.50 | 0.49 | 0.46 | FALSE |
| 7 | The Cancer Genome Atlas | Brain Lower Grade Glioma | LOC84740 | 0.05 | 0.02 | lasso | 5 | 0.03 | 2.1e-04 | -5.1 | -5.4 | 7.6e-08 | 0.32 | 0.00 | 0.98 | TRUE |