TWAS
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Traits
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Traits
:
Lung FEV1/FVC ratio
:
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→
chr4:53,038,557-54,427,925
Best TWAS P=6.34e-10 · Best GWAS P=2.95e-10 conditioned to 0.00113
53M
53.2M
53.4M
53.6M
53.8M
54M
54.2M
54.4M
0
2
4
6
8
10
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
1
ROSMAP
Brain Pre-frontal Cortex
RASL11B
0.05
0.05
lasso
3
0.04
6.2e-06
5.8
-6.2
6.3e-10
-0.6
0.05
0.95
TRUE