Hub : Genes

RASL11B

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0470	0.0230	5.0e-03	0.010	0.011	0.020	0.013	0.018	1.9e-02	0.01600	0.00160	0.00800	2.3e-03
2	GTEx	Lung	0.0831	0.0392	7.0e-03	-0.001	NA	-0.004	NA	-0.004	4.3e-01	NA	0.93000	NA	9.4e-01
3	GTEx	Nerve Tibial	0.1305	0.0444	3.3e-06	0.064	NA	0.051	NA	0.082	2.7e-05	NA	0.00016	NA	2.0e-06
4	ROSMAP	Brain Pre-frontal Cortex	0.0482	0.0184	3.3e-04	0.048	0.025	0.035	0.027	0.040	6.8e-07	0.00031	0.00002	0.00017	6.2e-06

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	0.8	1.2	2.3	0.6	1.3	1.5	0.6
Bipolar Disorder or Schizophrenia	0.3	0.8	1.2	-0.4	1.1	-0.8	-1.1
Depressed Affect (Nagel 2018)	0.4	0.8	1.8	0.6	1.0	0.5	1.3
Depression (Nagel 2018)	0.2	0.3	0.4	-0.1	0.5	-0.6	0.7
Intelligence (Savage-Jansen 2018)	0.2	0.7	2.1	-0.0	-0.7	1.4	0.4
Neuroticism (Nagel 2018)	0.3	0.8	2.8	0.0	-0.0	0.6	1.7
Schizophrenia (2018)	1.2	2.5	5.3	-1.0	0.5	-2.3	-1.9
Schizophrenia vs Biploar Disorder	0.6	0.7	1.8	0.1	-0.9	-0.5	-1.4
Worry (Nagel 2018)	0.2	0.5	1.0	-0.6	-0.8	-1.0	0.1
Alzheimer’s Disease (in mother)	0.2	0.3	0.9	-0.4	0.9	-0.2	-0.1
Alzheimer’s Disease (in father)	0.3	0.3	0.8	-0.2	0.4	-0.9	-0.4
Alzheimer’s Disease (including proxy)	0.1	0.1	0.3	0.3	0.5	0.0	0.1
Crohns Disease (2017)	2.0	4.5	15.3	0.2	-3.9	-1.6	-0.3
Irritable Bowel Disease (IBD)	1.3	3.1	9.4	1.1	-3.1	-0.9	-1.0
Ulcerative Colitis (UC)	0.6	1.2	2.2	1.3	-1.0	0.2	-1.5
Major Depression (MDD)	0.4	0.4	1.6	-0.2	-0.2	-1.2	-0.4
Reaction Time	0.3	0.6	2.0	0.0	-1.4	0.4	0.6
Verbal and Numeric Reasoning (VNR)	0.0	0.1	0.2	-0.3	-0.1	0.3	0.4
Breast Cancer	1.3	3.2	6.8	-1.3	2.6	-1.9	0.8
Ovarian Cancer	1.6	2.1	7.6	-2.8	0.8	-0.3	-0.3
Prostate Cancer	0.9	1.3	2.4	-1.2	-1.6	-1.1	-0.0
Age at First Birth	0.7	1.0	1.2	1.1	-1.1	1.1	0.6
Bipolar Disorder (2011)	0.7	0.6	1.9	1.4	0.4	0.7	-0.0
Body Mass Index (BMI) (2010)	2.2	3.0	5.7	-1.1	-2.2	-2.4	-0.6
Coronary Artery Disease (CAD)	1.2	1.4	3.0	-0.0	0.2	1.6	-1.7
Crohns Disease (2012)	1.0	1.6	3.3	-0.2	-1.8	-1.8	-0.1
Mean Putamen Volume	1.4	1.6	2.6	0.8	1.1	1.4	1.6
Fasting Glucose	1.2	1.4	5.1	0.6	-2.3	0.0	0.4
HbA1C	0.2	0.2	0.4	-0.1	0.5	-0.2	0.7
HDL Cholesterol	0.7	1.1	3.3	0.0	0.8	1.8	-0.8
LDL Cholesterol	0.2	0.4	0.6	-0.6	0.6	-0.3	-0.8
Lupus	0.3	0.5	1.3	-0.7	-1.1	0.2	-0.3
Neuroticism (2016)	0.2	0.2	0.6	-0.3	0.8	0.2	0.4
Primary Biliary Cirrhosis	0.3	0.4	0.7	-0.8	-0.4	-0.3	-0.8
Rheumatoid Arthritis	0.3	0.4	0.7	0.1	-0.8	-0.8	0.5
Schizophrenia (2014)	0.5	1.1	2.0	-0.4	-0.3	-1.4	-1.4
Triglycerides	0.9	1.5	3.2	0.0	-1.3	-1.1	1.8
Type 2 Diabetes (T2D) (2012)	1.3	1.5	4.8	-0.6	-2.2	-0.1	0.9
Ulcerative Colitis	0.8	1.1	2.6	1.1	-0.7	0.6	-1.6
Blood Eosinophil Count	0.8	5.9	10.1	-3.2	-1.2	-2.4	-2.5
Blood Platelet Count	0.2	2.7	8.5	0.3	1.4	2.9	-0.5
Blood Red Count	0.5	4.6	12.2	-0.9	0.4	-3.5	-2.3
Blood White Count	0.5	3.5	8.1	-0.9	-1.8	-2.9	-1.3
Heel T-Score	0.4	3.4	6.6	2.5	-0.6	2.6	-0.7
BMI	2.4	13.7	26.2	-3.9	-2.4	-5.1	-2.8
Height	0.1	2.8	7.6	-1.3	0.5	2.8	1.2
Waist Hip Ratio (WHR)	0.3	1.5	3.2	-1.8	1.6	0.2	-0.5
Systolic Blood Pressure	0.1	0.3	0.8	-0.3	0.2	-0.7	-0.9
Smoking Status	0.5	1.3	3.1	-0.0	-1.4	-0.3	-1.8
Allergy or Eczema	1.0	2.6	5.6	-0.7	-1.7	-2.4	-1.2
Cardiovascular Disease	1.8	5.9	11.4	-2.3	-0.5	-2.6	-3.4
Hypothyroidism (self reported)	0.3	0.8	1.2	1.0	0.2	1.1	-0.9
Respiratory disease	0.8	1.7	3.9	-2.0	-0.8	-1.5	-0.0
Type 2 Diabetes (T2D) (2018)	1.4	2.7	5.6	-2.2	-0.0	-2.4	-0.6
Lung FEV1/FVC ratio	3.2	16.4	38.2	-4.1	-1.3	-3.0	-6.2
Lung FVC	0.2	1.0	1.7	-1.0	1.3	-0.3	-1.2
Neuroticism	0.4	1.0	3.8	0.3	-0.2	0.0	2.0
Chronotype (morning person)	1.5	3.4	12.0	-0.7	0.9	-3.5	0.5
Hair Pigment	0.0	1.0	1.7	1.3	-0.1	0.9	1.1
Tanning	0.1	0.9	2.3	0.3	0.7	-0.9	-1.5
Hand grip strength (left)	0.7	1.9	4.5	0.3	-0.7	2.1	1.6
Number of treatments/medications taken	1.6	2.9	4.3	-2.0	1.3	-1.1	-2.1
Average weekly spirits intake	0.9	1.1	2.8	-1.0	1.7	-0.1	-0.6
Sensitivity / hurt feelings	1.4	2.3	4.8	-1.1	0.1	2.2	1.9
Frequency of depressed mood in last 2 weeks	0.6	0.8	1.6	-0.5	1.2	-1.2	0.1
Hearing difficulty/problems: Yes	0.4	0.6	1.8	-0.8	0.1	-0.4	-1.3
Relative age of first facial hair	1.0	2.1	5.7	-0.3	-2.4	-0.4	1.5
Other serious medical condition/disability diagnosed by doctor	0.2	0.3	0.9	-0.4	1.0	-0.1	0.4
Ever used hormone-replacement therapy (HRT)	0.4	0.5	1.0	-0.1	0.6	1.0	-0.8
Ever had hysterectomy (womb removed)	0.3	0.4	0.9	-0.1	0.4	0.7	-0.9
Systolic blood pressure, automated reading	0.3	0.8	2.1	-0.3	-1.0	0.2	-1.4
Eye problems/disorders: Diabetes related eye disease	1.2	1.3	3.0	-0.5	1.7	-0.9	-1.1
Angina	0.6	0.8	1.8	-1.3	0.1	-1.0	-0.7
Medication for hormone replacement therapy	1.1	1.3	4.3	2.1	-0.2	0.3	0.7
Vitamin and mineral supplements	0.0	0.0	0.1	-0.1	0.3	0.1	-0.3
Supplements: Zinc	0.5	0.5	1.2	1.1	-0.1	-0.9	0.1
Medication: Co-codamol	0.6	0.7	1.5	0.0	1.1	-0.0	-1.2
Medication: Metformin	1.4	2.0	5.4	-0.9	1.1	-2.3	-0.7
Diabetes (father)	1.2	1.5	2.6	-1.3	-1.3	-1.6	-0.4
Diabetes (mother)	2.1	2.6	7.4	-1.6	-0.5	-2.7	-0.6
Severe depression (siblings)	0.6	0.7	2.1	1.4	0.3	-0.3	0.8
Pack years adult smoking proportion	0.2	0.3	0.7	-0.3	0.3	0.9	0.3
Impedance of leg (right)	1.8	8.7	16.2	2.6	2.8	4.0	2.0
Leg fat-free mass (left)	1.1	5.9	8.2	-2.9	-2.1	-2.4	-2.3
Trunk fat percentage	0.3	1.3	2.2	-1.2	0.1	-1.5	-1.2
Hand grip strength (right)	0.4	1.0	2.6	-0.3	-1.1	1.6	0.3
Townsend deprivation index at recruitment	0.2	0.3	0.9	0.9	0.4	-0.3	0.4
Current tobacco smoking	0.4	0.7	1.5	0.4	-1.2	1.0	-0.5
Average weekly fortified wine intake	1.8	2.1	5.0	-2.2	-0.0	-1.7	0.6
Maternal smoking around birth	1.3	1.8	5.0	0.4	-0.4	2.2	1.4
Fed-up feelings	0.9	1.6	4.0	0.6	1.4	-0.2	2.0
Frequency of unenthusiasm / disinterest in last 2 weeks	0.1	0.2	0.4	-0.5	0.3	-0.6	0.3
Relative age voice broke	0.5	0.8	1.5	0.1	-1.1	0.7	1.2
Taking other prescription medications	0.6	0.9	1.7	-1.2	0.7	-1.3	-0.5
Age when periods started (menarche)	0.1	0.2	0.6	0.8	0.5	0.1	0.0
Bilateral oophorectomy (both ovaries removed)	1.3	1.5	2.7	1.6	0.8	1.4	0.9
Heel bone mineral density (BMD) T-score, automated (left)	0.7	1.5	2.2	1.2	-0.2	1.4	-1.5
Tinnitus: Yes, but not now, but have in the past	0.1	0.1	0.2	-0.3	0.4	0.3	-0.1
Qualifications: CSEs or equivalent	0.5	0.6	1.1	0.8	0.6	1.0	0.8
Serious illness, injury or assault to yourself	0.0	0.1	0.2	0.2	-0.4	0.0	0.1
High blood pressure	1.1	3.1	6.6	-1.5	1.0	-1.5	-2.6
Hayfever, allergic rhinitis or eczema	0.8	1.8	4.4	-0.4	-0.7	-2.1	-1.5
Multivitamins +/- minerals	0.2	0.3	0.6	-0.7	-0.8	0.0	0.2
Stomach or abdominal pain in last month	0.6	0.8	1.9	-0.5	-0.9	-1.4	-0.3
Supplements: Glucosamine	0.1	0.2	0.3	0.1	0.5	0.5	0.4
Diverticular disease/diverticulitis (self-reported)	1.9	2.3	3.8	-2.0	-1.8	-1.3	-0.7
Medication: Atenolol	2.5	3.1	7.3	-2.7	1.3	-1.0	-1.4
Medication: Levothyroxine sodium	0.6	1.0	1.5	-0.7	-1.1	-1.0	-1.2
Sitting height	0.1	0.9	2.2	-0.9	-0.7	1.5	0.3
Chronic bronchitis/emphysema (father)	0.4	0.4	1.2	-1.1	-0.1	-0.7	0.0
High blood pressure (mother)	5.7	8.0	13.5	-2.5	-3.3	-3.7	-1.2
Body mass index (BMI)	1.3	5.4	10.7	-2.3	-0.8	-3.3	-2.2
Impedance of leg (left)	1.5	7.2	13.4	2.2	2.5	3.7	2.1
Leg predicted mass (left)	1.1	6.1	8.5	-2.9	-2.2	-2.3	-2.4
Trunk fat mass	0.6	2.8	4.1	-2.0	-0.5	-1.9	-1.7
Waist circumference	0.9	3.4	6.6	-2.3	0.0	-2.6	-1.4
Number of incorrect matches in round	2.0	3.3	8.5	2.9	1.2	1.7	0.7
Past tobacco smoking	0.4	0.8	2.0	-1.4	0.3	0.2	0.9
Alcohol usually taken with meals	1.8	2.9	6.4	2.5	-0.3	0.2	2.2
Nervous feelings	2.1	3.9	5.9	-2.4	-2.1	-1.6	-1.6
Frequency of tenseness / restlessness in last 2 weeks	1.7	2.7	5.1	-2.0	-0.3	-2.3	-1.3
Hearing difficulty/problems with background noise	0.3	0.5	2.0	0.2	-1.4	0.1	0.1
Hair/balding pattern: Pattern 2	0.2	0.3	0.8	-0.6	0.2	-0.9	0.1
Had menopause	1.1	1.4	3.8	1.1	1.9	0.6	0.2
Had other major operations	1.4	1.8	2.7	1.5	1.1	1.6	0.9
Forced vital capacity (FVC)	0.3	1.2	3.0	-0.9	0.9	1.7	-0.6
Heel bone mineral density (BMD) T-score, automated (right)	0.6	1.4	2.8	1.5	-0.3	1.7	-0.5
Ever unenthusiastic/disinterested for a whole week	1.6	2.0	5.1	0.4	0.4	1.6	2.3
Qualifications: None of the above	0.6	1.2	2.6	-1.3	1.6	-0.8	0.3
Financial difficulties in last 2 years	0.5	0.7	2.1	-0.0	-0.4	-1.5	-0.8
Mouth/teeth dental problems	2.3	3.5	9.2	0.2	3.0	-0.5	-2.1
Heart attack	0.2	0.3	1.1	0.2	-0.1	-1.1	0.1
Allergy	0.7	1.7	4.9	1.0	0.0	2.2	1.0
Pain all over the body in last month	1.0	1.1	2.1	-0.2	-1.4	-0.6	-1.4
Diabetes (self-reported)	0.5	0.7	1.3	-0.9	0.6	-1.1	-0.7
Hayfever/allergic rhinitis (self-reported)	0.1	0.1	0.2	0.4	0.4	0.0	0.3
Medication: Ramipril	0.2	0.3	0.7	0.5	0.3	0.3	-0.8
Medication: Simvastatin	1.3	1.9	3.5	-1.3	0.8	-1.4	-1.9
Fluid intelligence score	0.6	1.2	3.2	-0.6	-1.8	-0.7	-0.9
Illnesses of siblings	1.6	2.3	6.0	2.4	0.2	1.5	0.8
Neuroticism score	0.3	0.5	0.8	-0.9	-0.6	-0.5	0.9
Weight	0.8	3.8	6.2	-2.5	-1.1	-2.0	-1.9
Impedance of arm (right)	2.1	9.8	15.6	3.5	1.1	3.9	3.2
Arm fat percentage (right)	0.6	2.5	5.3	-1.3	-0.4	-2.3	-1.7
Trunk fat-free mass	1.0	5.9	9.1	-3.0	-2.3	-2.0	-2.2
Hip circumference	0.5	2.3	3.8	-1.3	-1.3	-1.9	-1.4
Time employed in main current job	0.7	0.9	2.1	-0.9	1.4	-0.7	-0.4
Alcohol intake versus 10 years previously	1.9	2.8	6.4	-1.4	-2.5	-0.5	-1.6
Father’s age at death	0.3	0.4	0.9	0.9	-0.5	-0.8	0.1
Worrier / anxious feelings	0.2	0.4	0.7	-0.3	0.8	-0.5	0.9
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.7	1.4	-0.4	1.0	-1.2	0.5
Falls in the last year	0.4	0.5	1.3	-0.5	-0.4	-1.1	-0.5
Hair/balding pattern: Pattern 3	0.2	0.3	0.6	0.3	0.5	0.3	-0.8
Number of live births	2.5	3.6	6.4	2.5	1.9	0.9	1.8
Forced expiratory volume in 1-second (FEV1)	0.6	2.0	4.0	-2.0	0.2	0.5	-1.9
Pulse rate	2.2	3.7	6.1	-1.0	-1.7	-2.2	-2.5
Happiness	0.1	0.2	0.6	0.8	0.1	-0.1	-0.2
Noisy workplace	0.6	0.7	1.6	-0.5	-0.4	-1.2	0.9
Qualifications: A levels/AS levels or equivalent	0.5	1.1	2.8	1.7	-0.7	-0.0	1.0
Serious illness, injury or assault of a close relative in last 2 years	1.7	2.0	4.7	-2.2	1.4	-1.0	-0.5
Mouth/teeth dental problems: Dentures	1.2	2.0	6.7	-0.9	-2.6	0.2	0.4
Asthma	0.7	1.4	1.9	-1.4	1.3	-1.4	0.6
Medication: Ibuprofen (e.g. Nurofen)	1.2	1.5	3.8	-0.9	1.0	0.6	-1.9
Medication: Cholesterol lowering	0.8	1.3	2.0	-1.3	0.2	-1.4	-1.2
Depression (self-reported)	0.8	0.9	2.8	0.3	0.0	-0.9	-1.7
Medication: Lansoprazole	0.4	0.4	0.6	0.2	-0.7	-0.7	-0.8
Prospective memory result	0.3	0.3	1.2	0.3	1.1	-0.2	-0.0
Lung cancer (father)	0.9	1.1	2.1	-0.8	1.1	1.4	-0.6
Illnesses of mother	2.1	2.5	6.1	1.4	1.4	2.5	0.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.4	2.8	-1.7	0.6	0.3	-1.6
Pulse wave Arterial Stiffness index	0.4	0.4	1.4	-1.2	-0.1	-0.3	-0.5
Impedance of arm (left)	1.8	8.5	16.8	3.1	1.2	4.1	2.5
Arm fat mass (right)	1.1	4.5	6.3	-2.3	-1.1	-2.5	-2.3
Trunk predicted mass	1.1	6.0	9.2	-3.0	-2.3	-2.0	-2.3
Standing height	0.2	2.0	6.9	-0.7	-0.5	2.6	0.6
Length of working week for main job	0.5	0.6	2.0	0.4	0.1	-0.0	1.4
Exposure to tobacco smoke at home	1.0	1.2	2.2	-0.3	-1.5	-1.3	-0.7
Breastfed as a baby	1.5	1.8	4.9	1.2	2.2	-0.7	0.7
Tense / ‘highly strung’	1.6	2.7	4.8	-1.3	-0.9	-1.8	-2.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.7	1.0	2.3	0.9	0.8	0.5	-1.5
Hair/balding pattern: Pattern 4	0.1	0.1	0.3	0.2	-0.1	-0.4	-0.6
Birth weight of first child	0.2	0.4	1.2	0.2	-1.1	-0.2	0.6
Peak expiratory flow (PEF)	0.6	1.5	2.4	-1.4	0.2	1.2	-1.6
Pulse wave reflection index	0.7	0.8	1.5	0.6	1.1	0.4	1.2
Ever highly irritable/argumentative for 2 days	2.3	2.8	7.5	0.3	-1.8	0.6	2.7
Loud music exposure frequency	0.9	1.0	2.4	-0.7	-0.1	-1.0	-1.6
Qualifications: O levels/GCSEs or equivalent	0.2	0.4	0.9	1.0	0.1	0.7	0.0
Mouth/teeth dental problems: Bleeding gums	0.6	0.8	1.3	-1.1	-0.7	-1.0	0.8
Blood clot in the leg (DVT)	1.7	2.2	4.6	-1.4	0.4	-1.5	-2.1
Medication: Paracetamol	0.8	1.4	2.3	-1.0	1.4	-0.6	-1.5
Headache pain in last month	0.5	0.9	2.1	-0.8	-0.8	-1.4	0.4
Medication for cholesterol, blood pressure or diabetes	1.1	1.9	3.1	1.4	0.3	1.5	1.8
Glaucoma (self-reported)	1.0	1.1	2.2	-0.8	1.5	-1.1	-0.8
Gout (self-reported)	2.1	2.9	5.3	-2.1	-0.9	-2.3	-1.0
Hypothyroidism/myxoedema (self-reported)	0.2	0.5	1.2	0.8	-0.1	0.1	-1.1
Medication: Amlodipine	0.6	0.9	3.2	-0.5	0.1	0.3	-1.8
Medication: Ventolin 100micrograms inhaler	1.0	1.3	4.4	0.5	-0.2	-2.1	0.7
Birth weight	0.4	0.9	2.1	-0.1	-1.5	1.2	-0.4
Chronic bronchitis/emphysema (mother)	0.2	0.2	0.3	0.5	0.5	-0.1	0.4
High blood pressure (siblings)	2.4	3.4	10.5	-3.2	0.1	-1.5	-1.0
Forced vital capacity (FVC), Best measure	0.2	0.7	1.5	-0.9	0.5	1.2	-0.4
Body fat percentage	0.4	1.5	2.6	-1.2	0.1	-1.6	-1.4
Leg fat percentage (right)	0.5	2.0	2.6	-1.6	0.6	-1.6	-1.5
Arm fat-free mass (right)	1.3	6.8	10.8	-3.3	-1.9	-2.5	-2.6
Exposure to tobacco smoke outside home	2.6	3.5	6.9	0.6	-2.3	-2.6	-1.2
Comparative body size at age 10	0.7	2.0	4.4	-1.7	0.7	-0.3	-2.1
Number of full brothers	2.7	3.4	9.4	-3.1	-1.1	-0.5	-1.6
Worry too long after embarrassment	0.8	1.3	4.0	-1.0	-2.0	-0.1	-0.2
Seen a psychiatrist for nerves, anxiety, tension or depression	1.0	1.4	2.8	1.7	0.0	1.5	0.6
Wheeze or whistling in the chest in last year	2.1	3.8	9.4	-2.3	-0.4	-3.1	0.7
Number of children fathered	0.8	0.9	1.8	-1.2	-0.1	-0.6	1.4
Reason for reducing amount of alcohol drunk: Health precaution	1.3	1.5	4.5	-1.1	0.1	2.1	-0.7
Age at first live birth	0.3	0.5	1.2	0.7	-0.3	-0.3	1.1
Pulse wave peak to peak time	0.4	0.5	1.1	1.1	0.2	0.5	0.7
Health satisfaction	0.3	0.4	1.0	-0.0	-0.4	0.5	-1.0
Shortness of breath walking on level ground	1.7	2.0	5.8	-0.2	-1.4	-2.4	0.6
Qualifications: College or University degree	0.3	0.8	1.1	0.9	-0.6	-1.0	1.0
Eye problems/disorders: None of the above	0.8	0.9	2.0	0.1	-1.2	-0.3	1.4
Mouth/teeth dental problems: Loose teeth	1.2	1.4	2.0	1.2	-1.4	0.8	1.3
Emphysema/chronic bronchitis	0.6	0.7	1.6	1.0	-0.1	-0.2	1.3
Medication for pain relief, constipation, heartburn	1.2	2.1	4.5	1.0	-1.4	0.9	2.1
Neck or shoulder pain in last month	0.8	1.1	2.6	0.3	1.3	-1.6	0.3
Medication: Blood pressure	1.0	1.7	3.2	-1.5	0.0	-1.8	-1.1
Angina (self-reported)	0.6	0.7	1.7	-1.3	-0.1	-0.9	-0.6
Migraine (self-reported)	0.5	0.6	1.3	0.2	1.1	1.0	-0.2
Medication: Ibuprofen	0.9	1.0	2.6	-0.7	1.0	-0.2	-1.6
Medication: Allopurinol	0.2	0.3	0.5	-0.3	-0.5	-0.6	0.7
Medication: Omeprazole	0.7	0.8	2.2	-1.0	-0.3	-1.5	0.1
Medication: Seretide 50 evohaler	0.2	0.2	0.6	0.1	0.3	0.8	0.3
Mean time to correctly identify matches	0.1	0.1	0.3	-0.4	0.3	0.6	0.0
Heart disease (mother)	0.2	0.2	0.5	0.2	-0.7	-0.4	0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.4	1.5	-0.4	-0.3	-1.2	0.2
Whole body fat mass	0.7	3.0	4.1	-2.0	-0.5	-1.9	-1.9
Leg fat mass (right)	0.9	3.4	4.8	-2.2	-0.3	-2.0	-2.1
Arm predicted mass (right)	1.3	6.4	10.6	-3.2	-1.9	-2.4	-2.5
Pulse rate, automated reading	0.6	1.9	2.9	-0.9	-1.0	-1.7	-1.7
Alcohol intake frequency.	0.5	1.1	1.7	-1.0	-1.3	-0.8	-1.1
Comparative height size at age 10	0.6	3.1	7.0	-0.6	-2.1	2.6	-0.9
Number of full sisters	0.8	0.9	1.7	-0.3	-1.2	-0.7	1.3
Suffer from ‘nerves’	1.7	2.6	4.9	-1.4	-1.3	-2.2	-1.4
Overall health rating	0.9	1.8	6.6	-0.0	0.3	-2.6	-0.9
Chest pain or discomfort	0.5	0.7	1.5	-0.1	1.2	-1.1	-0.1
Had major operations	1.0	1.2	2.1	-1.4	-0.1	-1.5	-0.9
Age at last live birth	0.4	0.6	1.2	-0.4	-0.1	-1.1	1.1
Family relationship satisfaction	0.8	1.0	3.1	-0.5	-1.8	-0.2	-0.7
Leg pain on walking	1.3	1.7	4.6	-1.3	0.2	-2.1	-0.6
Qualifications: NVQ or HND or HNC or equivalent	1.2	1.5	2.4	-1.5	-1.3	-1.3	-0.3
Commuting to job workplace: Car/motor vehicle	0.3	0.3	0.8	0.9	-0.3	-0.5	0.3
Illness, injury, bereavement, stress in last 2 years	0.4	0.4	0.7	0.2	-0.6	0.9	0.8
Medication: Aspirin	0.1	0.2	0.4	-0.5	0.0	-0.1	-0.6
Supplements: Vitamin C	0.7	0.8	1.6	0.5	1.2	-1.1	0.3
Knee pain experienced in last month	0.1	0.2	0.5	0.7	0.1	-0.1	0.4
Hypertension (Self-reported)	1.0	2.7	6.7	-1.6	0.7	-1.0	-2.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.7	2.0	3.2	-0.5	-1.4	-1.8	-1.6
Illnesses of father: Heart disease	0.3	0.4	1.0	-0.6	-0.5	1.0	-0.1
Illnesses of siblings: Diabetes	0.4	0.5	1.2	-0.5	0.6	0.3	1.1
Smoking status: Previous	0.2	0.3	0.6	0.8	0.6	-0.2	-0.5
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.8	2.2	-1.5	-0.5	0.7	-0.4
Whole body fat-free mass	1.1	6.5	9.4	-3.1	-2.4	-2.3	-2.4
Leg fat-free mass (right)	1.3	6.7	8.5	-2.9	-2.4	-2.6	-2.4
Arm fat percentage (left)	0.8	3.0	5.3	-1.6	-0.5	-2.3	-2.0
Average weekly red wine intake	1.2	1.7	6.0	0.6	2.4	0.3	0.7
Handedness (chirality/laterality): Left-handed	1.1	1.3	1.6	1.1	-1.0	1.2	1.3
Mood swings	0.4	0.7	2.2	0.7	1.5	-0.0	0.2
Loneliness, isolation	0.5	0.7	1.2	-1.1	0.8	-0.7	-0.8
Long-standing illness, disability or infirmity	0.7	1.1	2.2	0.3	1.4	-1.5	-0.5
Ever had bowel cancer screening	0.6	0.7	1.3	0.7	1.2	1.0	-0.3
Diabetes diagnosed by doctor	0.8	1.4	2.9	-1.0	0.7	-1.7	-1.1
Ever had stillbirth, spontaneous miscarriage or termination	1.2	1.3	3.1	0.8	0.8	-1.7	1.1
Friendships satisfaction	0.8	1.0	1.8	-0.3	-1.3	1.1	0.8
Qualifications: nursing, teaching	0.2	0.2	0.6	0.6	0.1	0.8	-0.1
Commuting to job workplace: Walk	0.8	0.8	1.6	-0.4	-1.3	-1.3	-0.0
Eye problems/disorders: Cataract	0.4	0.5	1.9	0.1	-0.0	-0.3	-1.4
Mouth/teeth dental problems: Mouth ulcers	1.5	2.5	6.0	1.4	-1.1	0.8	2.4
Medication for cholesterol	1.2	1.8	3.3	-0.3	-1.2	-1.5	1.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.0	1.2	1.8	1.3	1.0	1.3	0.6
Back pain experienced in last month	0.2	0.4	0.6	0.8	0.5	-0.7	0.4
Mineral and other dietary supplements	0.6	0.9	1.8	-0.9	-1.3	-0.9	0.2
Breast cancer (self-reported)	1.6	1.9	4.0	2.0	-0.1	1.6	1.0
Asthma (self-reported)	0.6	1.2	1.7	-1.2	1.2	-1.3	0.6
Osteoporosis (self-reported)	0.2	0.3	0.8	0.9	0.6	0.1	0.1
Osteoarthritis (self-reported)	0.3	0.4	0.8	0.1	0.6	-0.6	-0.9
Medication: Aspirin	0.2	0.2	0.3	-0.6	-0.4	-0.6	-0.2
Medication: Gliclazide	4.0	4.6	12.0	-2.3	-0.6	-3.5	-0.9
Illnesses of father: None of the above (group 1)	1.9	2.4	5.3	2.3	-0.5	1.5	1.3
Smoking status: Current	0.4	0.7	1.7	0.5	-1.3	0.5	-0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.6	3.3	5.0	-1.4	2.1	1.3	-2.2
Whole body water mass	1.2	6.8	9.8	-3.1	-2.4	-2.4	-2.4
Leg predicted mass (right)	1.2	6.3	8.1	-2.9	-2.4	-2.5	-2.3
Arm fat mass (left)	1.0	4.1	5.9	-2.2	-1.0	-2.4	-2.2
Number of self-reported non-cancer illnesses	1.8	3.1	3.6	-1.7	1.8	-1.9	-1.6
Average weekly champagne plus white wine intake	1.0	1.4	2.2	1.4	-1.5	-1.1	-0.3
Miserableness	0.6	1.0	2.2	0.4	0.7	1.1	1.5
Guilty feelings	0.6	0.8	2.9	0.2	0.3	0.5	1.7
Wears glasses or contact lenses	0.6	0.6	1.4	-0.1	-0.5	0.9	1.2
Ever taken oral contraceptive pill	1.5	1.7	5.1	-0.4	-2.3	-1.1	-0.6
Hearing aid user	0.4	0.5	1.3	0.3	-0.4	1.1	-0.5
Mother’s age at death	1.2	1.6	3.8	2.0	1.1	0.6	-0.9
Financial situation satisfaction	0.7	0.9	2.2	1.2	-1.5	-0.1	0.1
Tinnitus: Yes, now most or all of the time	0.9	1.1	2.1	-0.0	-1.5	1.3	0.7
Commuting to job workplace: Public transport	0.2	0.2	0.4	0.6	0.3	0.5	-0.1
Eye problems/disorders: Glaucoma	1.0	1.2	4.1	-0.8	2.0	-0.2	-0.3
Medication: Blood pressure	1.7	3.2	4.6	-2.0	1.9	0.8	-2.1
Pain type(s) experienced in last month: Hip pain	0.4	0.5	1.2	0.4	1.1	-0.7	0.3
Supplements: Fish oil (including cod liver oil)	0.5	0.6	1.8	0.4	0.2	0.7	-1.4
High cholesterol (Self-reported)	1.8	3.1	5.7	-2.2	1.3	-0.3	-2.4
Medication: Bendroflumethiazide	2.0	3.0	5.8	-2.4	-0.1	-2.1	-1.5
Medication: Paracetamol	1.3	2.0	3.4	-1.2	1.8	-0.6	-1.7
Medication: Lisinopril	0.2	0.3	0.8	-0.2	0.9	-0.5	0.1
Medication: Atorvastatin	1.2	1.5	3.2	0.1	1.4	1.8	0.8
Illnesses of father: High blood pressure	1.2	1.5	4.6	-2.2	0.4	-0.8	-0.8
Alcohol drinker status: Never	0.6	0.8	1.7	0.5	0.8	0.7	1.3
Ever smoked	1.0	1.8	5.6	2.4	-0.5	0.8	-0.8
Basal metabolic rate	1.1	6.2	8.8	-3.0	-2.2	-2.3	-2.4
Leg fat percentage (left)	0.8	2.8	4.4	-1.9	0.3	-2.1	-1.7
Arm fat-free mass (left)	1.2	5.9	9.1	-3.0	-1.8	-2.3	-2.5
Number of operations (self-reported)	0.3	0.5	0.9	0.9	-0.0	-0.4	1.0
Average weekly beer plus cider intake	0.7	1.0	3.1	-0.2	0.5	1.8	0.8
Irritability	0.3	0.5	0.8	0.9	0.4	0.9	0.7
Risk taking	0.4	0.6	1.3	1.1	-0.9	-0.2	0.5
Ever had prostate specific antigen (PSA) test	1.5	1.7	4.8	2.2	-0.2	0.3	1.4
Fractured/broken bones in last 5 years	0.8	1.1	1.8	1.3	-0.6	-1.2	0.9
Age started oral contraceptive pill	0.1	0.1	0.2	-0.4	-0.2	-0.2	-0.4
Diastolic blood pressure, automated reading	0.3	1.0	2.2	0.7	-0.4	-1.5	-1.0
Ever depressed for a whole week	0.4	0.5	0.9	0.1	0.9	0.7	0.9
Unable to work because of sickness or disability	0.4	0.5	0.8	0.5	-0.2	-0.9	-0.8
Commuting to job workplace: Cycle	0.5	0.6	0.9	-0.7	-0.5	0.9	1.0
Myopia	0.7	1.0	2.3	-1.2	0.5	-1.5	0.2
Vascular/heart problems diagnosed by doctor	0.9	2.5	5.9	1.6	-0.6	1.0	2.4
Cholesterol lowering medication	1.0	1.5	4.1	-0.4	1.1	2.0	-0.8
Medication: Omeprazole (e.g. Zanprol)	1.1	1.3	3.4	-0.5	-1.2	-1.8	0.3
Pain experienced in last month	0.8	1.4	4.5	-0.1	0.8	2.1	0.5
Supplements: Calcium	0.2	0.2	0.4	0.7	0.0	-0.3	-0.4
Basal cell carcinoma (self-reported)	0.5	0.6	1.8	0.1	-1.3	0.6	-0.4
Heart attack/myocardial infarction (self-reported)	0.2	0.3	0.9	0.4	-0.2	-0.9	0.2
Deep venous thrombosis (DVT) (self-reported)	1.9	2.4	5.0	-1.3	0.9	-1.5	-2.2
Heart disease (siblings)	1.1	1.3	3.2	-1.8	-0.0	-0.9	-1.2
Alcohol drinker status: Previous	0.6	0.7	1.9	1.4	-0.8	-0.5	0.1
Pack years of smoking	0.2	0.3	0.5	-0.0	0.4	0.6	0.7
Impedance of whole body	2.1	10.7	19.8	3.3	2.1	4.4	2.8
Leg fat mass (left)	1.0	4.1	5.8	-2.4	-0.3	-2.3	-2.2
Arm predicted mass (left)	1.3	6.7	10.1	-3.2	-2.0	-2.5	-2.6