TWAS
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About
Usage
Models
Genes
Traits
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Traits
:
Lung FEV1/FVC ratio
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chr4:76,342,004-77,927,345
Best TWAS P=1.24e-08 · Best GWAS P=1.14e-07 conditioned to 0.00659
76.4M
76.6M
76.8M
77M
77.2M
77.4M
77.6M
77.8M
78M
0
2
4
6
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
1
GTEx
Colon Sigmoid
NUP54
0.27
0.18
enet
42
0.22
3.1e-08
3.9
5.7
1.2e-08
0.53
0.05
0.94
TRUE
2
GTEx
Heart Atrial Appendage
FAM47E-STBD1
0.11
0.02
lasso
4
0.00
3.0e-01
5.1
5.2
2.1e-07
0.73
0.03
0.70
FALSE
3
The Cancer Genome Atlas
Pheochromocytoma and Paraganglioma
NUP54
0.09
0.07
lasso
2
0.08
4.0e-04
5.0
5.1
2.8e-07
0.91
0.01
0.86
FALSE