Hub : Genes

FAM47E-STBD1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Cells Transformed fibroblasts	0.0900	0.0400	6.6e-03	0.035	NA	0.038	NA	0.039	1.1e-03	NA	7.6e-04	NA	5.9e-04
2	GTEx	Esophagus Gastroesophageal Junction	0.2190	0.0810	6.2e-04	0.108	NA	0.034	NA	0.068	1.1e-04	NA	2.2e-02	NA	1.8e-03
3	GTEx	Esophagus Mucosa	0.1070	0.0410	1.1e-03	0.104	NA	0.079	NA	0.091	2.0e-07	NA	6.1e-06	NA	1.2e-06
4	GTEx	Esophagus Muscularis	0.1150	0.0420	5.6e-04	0.065	NA	0.040	NA	0.079	8.9e-05	NA	1.8e-03	NA	1.6e-05
5	GTEx	Heart Atrial Appendage	0.1090	0.0500	6.6e-03	0.024	NA	-0.006	NA	0.000	2.8e-02	NA	9.5e-01	NA	3.0e-01
6	GTEx	Heart Left Ventricle	0.1350	0.0609	2.2e-03	0.008	NA	0.038	NA	0.041	1.2e-01	NA	4.0e-03	NA	2.9e-03
7	GTEx	Nerve Tibial	0.0979	0.0345	3.1e-04	0.027	NA	0.062	NA	0.060	4.8e-03	NA	3.4e-05	NA	4.7e-05
8	GTEx	Stomach	0.1310	0.0510	1.9e-03	0.044	NA	0.017	NA	0.041	3.6e-03	NA	5.2e-02	NA	4.6e-03
9	GTEx	Testis	0.3780	0.0750	4.5e-07	0.358	NA	0.269	NA	0.333	1.0e-16	NA	2.3e-12	NA	1.9e-15
10	GTEx	Thyroid	0.1260	0.0400	9.9e-06	0.114	NA	0.077	NA	0.091	4.7e-09	NA	1.7e-06	NA	2.0e-07
11	METSIM	Adipose	0.0431	0.0206	7.9e-03	0.016	0.006	0.008	0.008	0.011	1.6e-03	0.038	2.2e-02	0.022	7.1e-03

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11
Bipolar Disorder (2018)	0.4	0.6	2.4	0.1	-0.3	-0.0	0.3	1.3	-0.4	-0.5	0.0	-1.5	0.3	1.5
Bipolar Disorder or Schizophrenia	1.3	3.1	6.9	1.9	0.7	1.9	2.1	2.6	1.7	0.8	1.7	-1.7	2.1	0.9
Depressed Affect (Nagel 2018)	0.5	1.1	5.0	-1.3	-2.2	-1.0	-1.2	-0.8	0.3	0.1	-1.1	0.5	-0.9	-0.4
Depression (Nagel 2018)	0.2	0.3	0.9	-0.5	0.2	0.6	0.0	0.2	-0.6	-0.2	-0.7	0.9	0.6	-0.6
Intelligence (Savage-Jansen 2018)	0.3	0.9	1.9	-1.2	-1.4	-1.3	-1.2	0.0	0.6	-0.2	-1.1	0.2	-1.3	-0.2
Neuroticism (Nagel 2018)	0.6	1.3	4.7	-1.4	-2.2	-1.4	-1.4	-0.8	-0.4	-0.3	-1.1	0.5	-1.3	-0.2
Schizophrenia (2018)	2.0	4.1	6.4	2.4	1.1	2.5	2.5	2.3	2.5	1.4	2.2	-1.0	2.4	-0.1
Schizophrenia vs Biploar Disorder	1.0	1.4	3.4	1.2	0.3	1.6	1.2	0.2	1.8	1.6	1.1	-0.1	1.4	-0.7
Worry (Nagel 2018)	0.3	0.6	1.4	-0.6	-0.9	-1.1	-1.0	-0.7	-0.6	-0.4	-0.3	0.8	-1.2	-0.7
Alzheimer’s Disease (in mother)	1.4	1.7	4.1	-0.9	0.2	-1.4	-1.2	0.8	-1.3	-2.0	-0.8	1.8	-1.5	-1.2
Alzheimer’s Disease (in father)	0.5	0.6	2.4	0.4	0.9	0.2	0.2	-0.4	0.1	0.7	0.5	1.3	-0.1	-1.5
Alzheimer’s Disease (including proxy)	3.1	4.5	10.1	-2.1	0.1	-2.4	-1.5	-0.5	-2.0	-2.4	-2.0	3.2	-2.6	-2.5
Crohns Disease (2017)	1.1	2.5	5.0	-1.8	-1.7	-1.3	-1.8	-0.6	-1.5	-2.2	-2.1	1.3	-1.4	-0.8
Irritable Bowel Disease (IBD)	0.2	0.4	1.3	-0.3	-1.2	-0.1	-0.2	-0.5	-0.6	-1.1	-0.7	0.5	-0.0	-0.3
Ulcerative Colitis (UC)	0.4	0.7	1.6	1.2	-0.1	0.9	1.3	-0.3	0.7	0.4	1.1	-0.6	1.1	0.3
Major Depression (MDD)	0.3	0.4	1.7	-0.4	0.2	-0.2	-0.2	-0.1	-1.3	-0.8	-0.5	-0.8	0.1	0.5
Reaction Time	1.2	2.3	7.9	1.2	-1.3	1.3	1.2	2.8	1.6	2.2	1.2	0.8	1.1	-0.8
Verbal and Numeric Reasoning (VNR)	0.6	1.5	3.2	-1.7	-1.5	-1.4	-1.5	-0.6	-0.1	-1.2	-1.8	0.3	-1.2	0.6
Breast Cancer	1.5	3.6	6.6	-2.3	-0.6	-2.1	-2.3	-0.6	-2.6	-2.4	-2.2	1.3	-1.9	1.0
Ovarian Cancer	1.0	1.3	4.6	1.0	0.9	0.5	0.8	0.7	0.9	-0.6	1.0	-2.0	0.6	2.1
Prostate Cancer	0.2	0.3	1.1	0.3	0.3	1.1	0.5	0.7	-0.0	-0.3	0.2	-0.6	0.9	0.6
Age at First Birth	1.2	1.8	3.2	1.5	0.3	1.8	1.8	1.0	1.4	1.0	1.3	-0.6	1.7	-1.3
Bipolar Disorder (2011)	0.6	0.6	1.7	-0.7	-1.3	-1.0	-0.7	0.9	0.3	0.0	-0.6	-0.6	-0.8	0.3
Body Mass Index (BMI) (2010)	1.2	1.7	3.9	-1.5	-0.8	-2.0	-1.5	-0.8	-1.0	-0.8	-1.2	-1.3	-1.7	1.1
Coronary Artery Disease (CAD)	0.1	0.1	0.8	0.0	0.1	-0.2	-0.2	0.3	-0.0	-0.0	0.0	0.5	-0.4	-0.9
Crohns Disease (2012)	1.4	2.3	4.3	-1.8	-0.8	-1.1	-1.8	-0.5	-1.8	-2.0	-2.1	1.8	-1.2	-1.1
Mean Putamen Volume	1.1	1.3	6.9	0.4	2.0	0.3	0.4	2.6	1.0	0.1	0.3	-1.1	0.3	0.8
Fasting Glucose	0.6	0.7	3.4	0.2	0.6	-0.2	0.0	-0.6	-0.3	-1.3	0.2	-1.8	-0.0	1.3
HbA1C	2.3	2.5	7.8	-1.5	-0.4	-2.8	-2.0	0.4	-1.1	-2.1	-0.7	0.8	-2.5	-0.6
HDL Cholesterol	0.5	0.9	3.8	-0.2	-1.7	0.5	0.2	1.9	0.4	0.8	-0.3	1.0	0.6	-0.5
LDL Cholesterol	0.7	1.0	3.4	-0.6	-1.0	0.7	-0.3	-0.1	-1.8	0.9	-0.8	1.2	0.3	-1.7
Lupus	0.1	0.2	0.5	0.5	-0.4	0.2	0.4	-0.6	-0.4	0.1	0.6	0.6	0.1	-0.7
Neuroticism (2016)	0.5	0.8	3.6	-0.5	-1.9	-0.7	-0.4	-0.1	-1.4	0.2	-0.3	-1.0	-0.2	0.9
Primary Biliary Cirrhosis	0.9	1.3	6.1	-1.3	0.9	-0.7	-1.1	-0.9	-0.5	-2.5	-1.5	-0.8	-0.7	0.4
Rheumatoid Arthritis	0.2	0.2	0.8	-0.2	0.9	0.1	0.0	-0.2	0.2	-0.3	-0.4	-0.9	0.3	0.6
Schizophrenia (2014)	1.4	3.2	6.2	2.3	0.8	2.4	2.5	1.1	1.4	1.2	2.2	-1.3	2.4	0.1
Triglycerides	0.3	0.5	2.3	0.4	0.8	0.3	0.4	-0.1	-0.4	-0.5	0.3	-1.0	0.5	1.5
Type 2 Diabetes (T2D) (2012)	1.2	1.3	6.1	0.5	1.2	-0.6	0.2	1.8	0.5	-1.0	0.7	-1.2	-0.2	2.5
Ulcerative Colitis	0.3	0.4	1.3	0.7	0.1	0.7	0.8	-1.1	-0.5	-0.1	0.5	-0.3	0.7	-0.7
Blood Eosinophil Count	0.1	0.6	2.5	-0.3	0.3	-0.8	-0.4	1.2	0.7	-0.1	-0.0	-1.1	-0.6	1.6
Blood Platelet Count	0.3	3.1	7.0	1.9	1.7	0.1	1.4	2.5	2.1	1.0	2.6	-1.3	0.2	2.3
Blood Red Count	5.5	53.5	108.2	9.0	3.7	10.4	9.8	0.8	4.8	7.7	7.7	-5.8	10.3	2.7
Blood White Count	0.0	0.3	2.6	0.0	0.3	0.1	0.2	-1.6	-0.7	0.2	0.1	-0.3	0.1	0.4
Heel T-Score	0.1	0.7	2.9	0.5	1.1	-0.9	0.1	-0.2	0.4	-0.5	1.1	-0.5	-0.7	1.7
BMI	0.7	4.3	11.4	-1.1	1.7	-2.6	-1.4	-1.4	0.1	-3.4	-0.8	-2.4	-1.9	3.3
Height	0.5	8.7	27.1	-3.5	-5.2	-2.6	-3.4	-1.1	-2.4	-1.6	-3.3	2.5	-2.7	-2.0
Waist Hip Ratio (WHR)	0.5	2.3	4.3	-1.6	-1.5	-1.9	-1.8	0.8	-1.8	-0.5	-1.3	1.7	-2.1	-1.0
Systolic Blood Pressure	2.4	11.8	20.4	-4.3	-3.3	-3.9	-4.5	-0.6	-2.6	-1.9	-4.0	3.0	-4.3	-3.3
Smoking Status	2.6	6.1	11.5	-3.4	-2.2	-3.0	-3.4	-0.8	-1.7	-1.6	-3.0	1.9	-3.2	-1.3
Allergy or Eczema	0.1	0.3	1.5	-0.1	0.3	-0.1	-0.3	0.5	0.5	-0.8	-0.2	1.2	-0.4	-0.6
Cardiovascular Disease	1.9	6.4	14.6	-3.2	-1.1	-3.8	-3.4	0.7	-0.9	-3.2	-2.9	0.2	-3.5	0.6
Hypothyroidism (self reported)	0.1	0.3	1.0	0.5	0.5	-0.5	0.2	0.0	-0.9	-0.3	0.9	0.1	-0.3	1.0
Respiratory disease	0.4	0.9	2.5	-0.7	-0.5	-1.5	-1.2	0.3	1.1	-1.1	-0.5	-0.0	-1.6	-0.4
Type 2 Diabetes (T2D) (2018)	1.3	2.5	6.2	-1.0	0.8	-1.9	-1.1	1.7	-1.1	-2.5	-0.7	-1.4	-1.6	2.4
Lung FEV1/FVC ratio	1.5	7.4	26.9	2.3	2.2	2.7	2.7	5.2	2.4	1.1	2.0	-2.5	2.8	2.1
Lung FVC	1.7	8.5	14.7	-3.3	-3.4	-3.8	-3.6	-2.4	0.2	-1.1	-2.9	2.7	-3.8	-2.4
Neuroticism	1.1	2.8	9.2	-2.0	-3.0	-1.6	-2.0	-1.1	-0.9	0.2	-1.8	1.2	-1.7	-1.1
Chronotype (morning person)	0.3	0.8	3.6	0.8	0.6	0.2	0.8	0.9	0.5	-0.2	1.0	-1.9	0.4	0.9
Hair Pigment	0.1	4.0	12.0	-2.2	-0.3	-2.2	-2.3	1.3	-1.2	-3.5	-2.8	0.0	-2.1	1.3
Tanning	0.1	1.1	4.4	-0.5	-1.6	0.5	-0.6	-2.1	-1.3	0.0	-0.5	0.3	0.1	-1.4
Hand grip strength (left)	0.2	0.6	5.2	-0.2	-0.3	-0.6	-0.3	-2.3	-0.4	0.1	0.1	0.4	-0.6	-0.7
Number of treatments/medications taken	1.3	2.3	6.1	-1.9	-0.4	-1.4	-1.8	1.2	0.1	-2.5	-2.0	-0.6	-1.3	1.5
Average weekly spirits intake	0.6	0.7	1.6	-0.9	0.1	-1.0	-1.0	-1.1	-0.3	-1.3	-0.8	0.3	-1.0	-0.3
Sensitivity / hurt feelings	0.1	0.2	0.9	0.2	-0.4	0.4	0.4	-0.6	-0.3	0.3	0.3	-0.9	0.5	0.6
Frequency of depressed mood in last 2 weeks	0.4	0.6	1.9	-0.3	-0.4	0.8	0.2	-0.9	-0.8	0.1	-0.5	1.1	0.6	-1.4
Hearing difficulty/problems: Yes	0.3	0.5	3.5	-0.5	-0.6	-0.0	-0.4	0.0	-0.0	1.9	-0.3	0.8	-0.1	-0.7
Relative age of first facial hair	0.7	1.4	3.7	-1.3	0.4	-0.9	-1.3	-1.9	-1.5	-1.3	-1.3	0.7	-0.9	-0.6
Other serious medical condition/disability diagnosed by doctor	1.7	2.3	5.4	1.6	-0.6	1.5	1.8	0.7	1.3	0.2	1.5	-1.8	1.9	2.3
Ever used hormone-replacement therapy (HRT)	0.3	0.4	1.6	-0.9	1.3	-0.2	-0.7	0.5	-0.3	0.2	-0.9	0.2	-0.2	0.2
Ever had hysterectomy (womb removed)	2.4	2.7	5.4	-2.3	0.3	-2.1	-2.3	0.1	-1.8	-1.7	-2.1	-0.0	-2.2	-0.0
Systolic blood pressure, automated reading	2.3	6.8	12.7	-3.6	-1.7	-3.0	-3.6	-0.7	-2.4	-1.4	-3.5	2.1	-3.2	-1.6
Eye problems/disorders: Diabetes related eye disease	0.5	0.5	3.1	-0.1	1.8	0.4	0.2	1.2	-0.1	0.6	-0.3	0.2	0.4	-0.4
Angina	0.8	1.1	2.7	-1.7	0.7	-1.1	-1.4	0.4	-0.9	-1.0	-1.4	-0.4	-1.1	-0.6
Medication for hormone replacement therapy	3.1	3.5	6.2	2.3	1.8	1.1	2.1	1.7	1.9	1.1	2.5	-2.1	1.4	2.0
Vitamin and mineral supplements	0.6	0.8	3.5	0.1	-1.9	-0.2	0.1	1.5	0.3	0.3	0.0	-1.1	0.0	1.2
Supplements: Zinc	0.9	1.0	3.1	-1.0	1.0	-0.9	-0.8	-0.3	-1.8	-1.3	-1.0	1.1	-0.8	-0.1
Medication: Co-codamol	0.8	0.9	3.7	-0.7	1.4	0.2	-0.3	-1.9	-1.1	-1.1	-0.8	-0.9	0.4	0.5
Medication: Metformin	1.4	1.9	4.0	-1.7	0.7	-1.7	-1.7	1.0	-1.0	-2.0	-1.6	0.3	-1.6	0.9
Diabetes (father)	1.7	2.1	7.3	-1.9	0.6	-1.6	-1.7	0.4	-0.5	-2.7	-1.8	0.8	-1.4	-0.2
Diabetes (mother)	0.9	1.1	2.1	-0.9	1.2	-1.2	-1.1	0.5	-1.5	-1.3	-1.0	0.5	-1.1	0.8
Severe depression (siblings)	1.0	1.1	4.7	0.7	2.2	1.5	1.0	-0.9	-0.4	0.4	0.5	-0.8	1.4	0.3
Pack years adult smoking proportion	0.7	1.0	3.2	-1.4	-1.8	-0.6	-1.1	-1.2	-0.4	-0.1	-1.3	0.4	-0.6	-0.8
Impedance of leg (right)	0.9	4.5	9.9	2.5	0.1	3.1	2.5	1.7	0.2	3.0	2.0	0.4	2.6	-1.8
Leg fat-free mass (left)	1.1	5.7	11.7	-2.7	-2.0	-3.4	-2.9	-2.2	-0.4	-3.2	-2.2	0.2	-3.1	1.0
Trunk fat percentage	0.3	1.1	4.7	-0.5	0.6	-0.4	-0.4	-0.4	-0.3	-1.8	-0.8	-1.4	-0.1	2.2
Hand grip strength (right)	0.2	0.5	1.9	-0.3	0.0	-1.3	-0.7	-1.4	-0.1	-0.6	0.2	0.2	-1.1	-0.3
Townsend deprivation index at recruitment	2.0	2.7	5.6	-2.2	-0.7	-2.2	-2.2	-0.4	-0.6	-2.4	-1.9	0.6	-2.0	0.7
Current tobacco smoking	2.2	3.6	6.2	-2.5	-1.7	-2.3	-2.5	-0.8	-1.9	-2.0	-2.1	1.0	-2.2	-0.7
Average weekly fortified wine intake	0.4	0.5	1.9	0.3	-1.4	-0.1	0.0	-0.1	1.3	0.6	0.4	0.7	-0.2	-0.6
Maternal smoking around birth	0.2	0.3	1.0	-1.0	0.0	-0.5	-0.8	-0.4	-0.5	-0.1	-1.0	-0.3	-0.5	-0.3
Fed-up feelings	0.8	1.5	6.7	-1.4	-2.6	-0.8	-1.1	-1.2	0.4	0.2	-1.5	0.7	-0.7	-1.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.6	0.8	3.1	0.8	0.3	1.7	1.3	0.4	-0.4	0.5	0.3	0.3	1.8	-0.3
Relative age voice broke	1.2	1.8	8.5	-1.3	-2.9	0.0	-0.9	-1.0	-0.8	0.1	-1.8	1.4	-0.1	-1.3
Taking other prescription medications	0.5	0.8	3.0	-0.2	-0.2	-0.3	-0.2	1.1	-0.1	-1.7	-0.4	-1.3	-0.0	1.7
Age when periods started (menarche)	0.4	1.1	2.9	0.2	-1.7	0.8	0.3	1.4	0.4	1.5	-0.0	1.0	0.5	-1.6
Bilateral oophorectomy (both ovaries removed)	1.0	1.1	3.1	-0.8	1.5	-1.4	-1.0	-0.1	-1.1	-1.8	-0.5	-0.2	-1.3	0.5
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.4	1.9	-0.6	-0.2	-0.3	-0.6	-1.4	-0.5	-0.4	-0.7	0.2	-0.3	-0.4
Tinnitus: Yes, but not now, but have in the past	0.5	0.5	2.2	-0.1	0.2	-0.9	-0.2	0.8	0.6	-0.5	0.2	-1.5	-0.7	0.8
Qualifications: CSEs or equivalent	0.9	1.2	1.9	-1.3	-1.0	-1.2	-1.3	-0.1	-1.0	-1.2	-1.4	0.6	-1.3	-0.6
Serious illness, injury or assault to yourself	0.6	0.7	2.0	-0.4	0.6	-0.9	-0.6	0.6	1.4	-1.4	-0.4	-0.3	-0.8	0.6
High blood pressure	2.5	6.9	16.0	-3.5	-0.9	-3.3	-3.5	0.1	-0.8	-4.0	-3.4	-0.8	-3.0	1.3
Hayfever, allergic rhinitis or eczema	0.1	0.3	1.5	0.6	-0.2	0.5	0.4	0.1	0.6	-0.1	0.3	1.2	0.3	-0.7
Multivitamins +/- minerals	1.6	2.1	7.4	-1.1	0.3	-1.1	-1.2	-2.7	-1.1	-1.6	-0.9	1.8	-1.2	-1.5
Stomach or abdominal pain in last month	0.1	0.1	0.6	-0.1	-0.8	-0.2	-0.1	-0.7	-0.2	-0.2	-0.3	0.1	-0.2	0.1
Supplements: Glucosamine	0.6	0.8	6.2	0.6	2.5	0.4	0.5	-1.0	-0.1	0.1	0.8	0.4	0.3	-0.4
Diverticular disease/diverticulitis (self-reported)	0.8	1.0	5.2	1.1	-0.4	0.6	0.9	0.5	2.3	0.5	1.2	-0.5	0.6	0.4
Medication: Atenolol	0.7	0.9	5.0	0.4	-0.1	0.8	0.5	2.2	-0.0	-0.1	0.2	-1.4	0.8	0.7
Medication: Levothyroxine sodium	0.2	0.4	0.9	-0.6	0.4	-1.0	-0.8	0.2	0.7	-0.2	-0.3	0.9	-0.9	0.3
Sitting height	0.6	4.4	9.6	-2.0	-3.1	-2.4	-2.2	-2.9	-1.3	-2.1	-1.9	-0.1	-2.2	0.6
Chronic bronchitis/emphysema (father)	0.8	1.0	2.6	-1.3	-0.1	-0.7	-1.0	-1.1	-1.2	-1.2	-1.6	0.6	-0.4	0.3
High blood pressure (mother)	0.3	0.4	0.7	-0.3	0.8	-0.7	-0.4	-0.7	-0.8	-0.7	-0.3	-0.7	-0.6	0.2
Body mass index (BMI)	0.7	3.1	10.3	-1.6	1.2	-2.0	-1.6	-0.7	0.1	-3.2	-1.5	-1.1	-1.6	2.7
Impedance of leg (left)	1.1	5.1	10.8	2.7	0.5	3.3	2.8	2.2	0.6	3.0	2.3	-0.2	2.9	-1.3
Leg predicted mass (left)	1.1	5.7	11.8	-2.6	-2.0	-3.4	-2.9	-2.3	-0.4	-3.2	-2.2	0.3	-3.1	1.0
Trunk fat mass	0.4	1.9	6.3	-1.2	0.1	-1.3	-1.2	-0.8	-0.2	-2.5	-1.3	-1.2	-1.0	2.3
Waist circumference	0.7	2.6	6.1	-1.8	-0.6	-2.2	-1.9	-0.3	-0.3	-2.5	-1.6	-0.3	-1.9	1.9
Number of incorrect matches in round	0.8	1.3	4.3	1.1	1.2	1.3	1.1	2.1	0.5	1.0	1.2	0.3	1.2	-0.5
Past tobacco smoking	2.1	3.9	6.5	2.5	1.0	2.5	2.5	1.1	2.3	1.8	2.3	-1.1	2.5	0.5
Alcohol usually taken with meals	1.3	2.1	6.6	1.5	1.8	0.5	1.3	-0.9	0.2	-1.0	1.6	-2.0	0.7	2.6
Nervous feelings	0.2	0.4	1.4	-0.5	-1.2	-0.4	-0.6	-0.5	-0.9	-0.4	-0.6	-0.4	-0.5	0.0
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.5	1.2	-0.7	-0.6	0.3	-0.3	0.3	-1.0	-1.0	-1.1	0.8	0.3	-0.5
Hearing difficulty/problems with background noise	0.9	1.5	3.4	-1.8	-0.9	-1.7	-1.8	-0.2	-0.8	-0.5	-1.5	0.4	-1.6	-0.4
Hair/balding pattern: Pattern 2	1.6	2.1	4.1	-1.8	-1.4	-0.3	-1.3	-1.6	-1.8	-0.8	-2.0	1.4	-0.5	-1.8
Had menopause	0.5	0.6	1.3	-1.0	0.4	-0.6	-1.0	0.5	-0.7	-1.1	-0.9	0.3	-0.6	0.9
Had other major operations	0.6	0.8	4.0	-0.4	1.8	-0.3	-0.2	-0.6	0.2	-2.0	-0.3	-0.3	-0.1	0.4
Forced vital capacity (FVC)	1.4	5.6	14.5	-2.4	-3.8	-2.9	-2.7	-2.1	0.6	-0.4	-2.0	1.8	-3.0	-2.0
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.3	1.3	-0.4	-0.5	-0.5	-0.4	-1.2	-0.7	-0.5	-0.4	0.1	-0.3	0.2
Ever unenthusiastic/disinterested for a whole week	0.3	0.4	1.4	0.2	0.8	0.7	0.4	-1.2	0.6	0.7	0.0	0.2	0.7	-0.5
Qualifications: None of the above	0.5	1.1	3.8	-1.2	-0.7	0.1	-1.0	1.1	-1.9	0.6	-1.5	1.1	-0.1	-0.8
Financial difficulties in last 2 years	0.2	0.3	1.4	0.1	-0.7	-0.2	-0.0	-1.2	-0.3	-0.4	0.3	-0.2	-0.1	-0.7
Mouth/teeth dental problems	0.6	0.9	2.2	0.8	-1.1	0.7	0.8	1.0	0.9	-0.0	0.4	-1.4	0.8	1.5
Heart attack	1.3	1.7	4.4	-1.6	-2.1	-0.9	-1.3	0.8	-1.4	-0.7	-1.6	1.3	-0.8	-1.0
Allergy	0.3	0.8	2.5	0.4	1.0	0.3	0.6	-0.6	-0.6	0.7	0.5	-1.5	0.6	1.6
Pain all over the body in last month	0.4	0.5	0.9	-1.0	-0.0	-0.6	-0.8	0.8	0.9	-0.2	-0.9	0.7	-0.6	-0.3
Diabetes (self-reported)	1.0	1.6	3.6	-1.3	1.1	-1.2	-1.2	0.7	-1.5	-1.9	-1.4	-0.4	-1.1	1.3
Hayfever/allergic rhinitis (self-reported)	0.2	0.2	0.5	0.4	-0.7	-0.3	0.2	0.4	0.7	0.1	0.6	-0.4	-0.2	0.6
Medication: Ramipril	0.8	1.0	3.5	-1.0	-1.3	-0.3	-0.9	1.9	-0.5	0.7	-1.0	1.0	-0.6	-0.7
Medication: Simvastatin	0.8	1.1	8.2	-0.6	-0.2	-1.0	-0.6	2.9	0.3	-0.9	-0.2	-0.9	-0.8	0.6
Fluid intelligence score	1.0	2.1	3.5	-1.4	-0.8	-1.8	-1.4	-1.8	-1.4	-1.9	-1.4	-0.6	-1.4	1.5
Illnesses of siblings	1.2	1.7	3.8	1.9	-0.4	1.7	1.9	-0.5	0.5	1.1	1.8	-0.4	1.7	-0.7
Neuroticism score	0.4	0.9	1.6	-1.3	-1.2	-1.2	-1.2	-0.8	0.0	-0.6	-1.0	0.1	-1.1	-0.2
Weight	0.8	3.7	10.4	-2.1	-0.8	-2.5	-2.2	-1.1	-0.2	-3.2	-2.0	-0.5	-2.2	1.9
Impedance of arm (right)	0.5	2.5	7.7	1.5	-0.6	2.3	1.6	0.6	-0.7	2.8	1.1	0.5	1.9	-1.6
Arm fat percentage (right)	0.7	2.8	8.8	-1.6	1.1	-1.7	-1.5	-0.5	-0.5	-3.0	-1.7	-1.2	-1.3	2.5
Trunk fat-free mass	0.7	4.2	9.8	-2.0	-2.2	-3.1	-2.5	-1.6	0.5	-2.7	-1.4	0.1	-2.9	1.1
Hip circumference	0.4	1.9	4.2	-1.6	-0.7	-1.7	-1.5	-0.8	0.8	-2.0	-1.5	-0.6	-1.4	1.7
Time employed in main current job	0.3	0.4	1.0	-0.3	0.9	0.4	-0.2	0.4	-1.0	0.7	-0.5	0.1	0.2	-0.9
Alcohol intake versus 10 years previously	3.0	4.5	7.4	2.5	1.0	2.5	2.7	0.6	0.8	2.1	2.1	-2.3	2.7	2.5
Father’s age at death	1.5	2.0	4.8	1.5	1.7	0.6	1.3	0.8	1.0	-0.1	1.8	-2.0	0.9	2.2
Worrier / anxious feelings	1.6	3.0	5.0	-2.2	-1.4	-1.8	-2.2	-1.4	-1.3	-1.5	-2.1	1.2	-1.9	-1.9
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.8	1.9	-1.1	-1.2	-0.4	-0.9	-0.6	-0.2	-0.9	-1.4	1.0	-0.4	-1.0
Falls in the last year	0.9	1.2	3.8	-1.3	0.3	-1.2	-1.2	-0.9	-1.0	-1.9	-1.2	-0.3	-1.1	0.2
Hair/balding pattern: Pattern 3	0.7	1.0	3.2	1.0	0.4	0.1	0.7	1.3	0.3	-0.0	1.1	-1.7	0.2	1.8
Number of live births	0.5	0.7	2.8	-0.7	-1.7	-0.6	-0.7	-1.1	-1.2	0.2	-0.6	-0.4	-0.5	0.1
Forced expiratory volume in 1-second (FEV1)	0.9	2.9	6.0	-1.8	-2.3	-2.4	-2.1	-0.8	0.9	-0.6	-1.5	1.2	-2.5	-1.3
Pulse rate	0.2	0.4	0.9	-0.9	-1.0	-0.3	-0.5	-0.9	0.4	-0.1	-0.8	0.5	-0.1	-0.0
Happiness	0.9	1.1	3.8	-0.2	0.2	-0.1	-0.2	-1.9	-1.1	0.7	-0.1	1.8	-0.2	-1.9
Noisy workplace	0.6	0.7	3.0	0.0	0.5	-0.0	0.0	1.7	1.1	-0.1	0.1	-1.7	0.0	0.7
Qualifications: A levels/AS levels or equivalent	0.1	0.2	0.7	-0.0	-0.8	0.3	0.1	0.3	0.5	0.6	-0.0	0.4	0.2	-0.6
Serious illness, injury or assault of a close relative in last 2 years	1.7	1.9	4.8	1.6	1.5	2.2	1.8	-1.1	-0.7	0.9	1.1	-0.2	2.1	0.2
Mouth/teeth dental problems: Dentures	1.0	1.7	3.7	-1.7	-0.5	-1.5	-1.6	0.0	-0.2	-0.9	-1.3	1.9	-1.5	-1.4
Asthma	0.3	0.6	1.3	-0.6	-1.0	-1.1	-1.0	0.1	0.4	-1.0	-0.5	0.1	-1.1	-0.2
Medication: Ibuprofen (e.g. Nurofen)	1.1	1.4	7.1	1.2	1.3	0.1	0.8	-2.7	0.8	-0.5	1.4	-1.0	0.3	1.1
Medication: Cholesterol lowering	1.0	1.5	4.0	-1.4	-0.2	-2.0	-1.7	1.1	-0.8	-1.1	-0.9	-0.1	-1.9	-0.3
Depression (self-reported)	0.4	0.5	2.1	-0.4	0.8	0.3	-0.1	-0.6	0.8	-0.6	-0.7	1.5	0.3	-0.7
Medication: Lansoprazole	1.4	1.6	4.5	-1.1	-0.8	-1.4	-1.3	1.1	1.5	0.0	-1.1	2.1	-1.5	-1.0
Prospective memory result	1.0	1.3	5.2	0.2	1.5	1.0	0.3	2.3	1.8	0.0	-0.0	0.8	0.7	-1.1
Lung cancer (father)	0.5	0.5	2.5	-0.4	-0.3	-0.5	-0.4	0.2	-1.2	-1.6	-0.6	-0.7	-0.4	0.7
Illnesses of mother	3.6	4.4	10.3	2.3	-0.5	3.2	2.5	-0.4	1.9	3.1	1.9	0.2	2.9	-0.9
Forced expiratory volume in 1-second (FEV1), Best measure	0.9	2.7	4.9	-1.9	-2.0	-2.0	-2.1	-0.8	0.3	-0.4	-1.8	1.4	-2.2	-1.8
Pulse wave Arterial Stiffness index	0.9	1.0	2.3	1.0	-1.0	1.4	1.2	0.7	0.6	0.8	1.1	-0.8	1.5	0.1
Impedance of arm (left)	0.6	2.9	8.5	1.7	-0.7	2.5	1.8	0.2	-0.9	2.9	1.1	0.5	2.2	-1.6
Arm fat mass (right)	0.8	3.4	10.3	-1.7	0.5	-2.2	-1.8	-0.9	-0.4	-3.2	-1.7	-1.3	-1.7	2.8
Trunk predicted mass	0.7	4.2	9.9	-2.1	-2.1	-3.1	-2.5	-1.6	0.5	-2.7	-1.5	0.2	-2.9	1.1
Standing height	0.3	3.4	20.3	-1.4	-4.5	-1.5	-1.7	-1.2	-0.6	-0.2	-1.1	1.3	-1.7	-1.5
Length of working week for main job	2.8	3.1	7.1	-2.3	0.1	-2.7	-2.5	-0.5	-0.8	-1.6	-1.9	1.1	-2.5	-0.6
Exposure to tobacco smoke at home	0.6	0.7	2.7	0.1	0.4	1.0	0.5	1.6	0.7	0.8	0.1	-1.2	1.0	0.1
Breastfed as a baby	0.5	0.6	3.1	0.0	1.1	-0.1	0.0	0.7	-0.0	-1.0	0.0	-1.7	-0.1	0.8
Tense / ‘highly strung’	0.3	0.5	2.4	-0.5	-0.2	-0.8	-0.7	-0.0	-0.8	-1.6	-0.5	-0.2	-0.8	0.6
Seen doctor (GP) for nerves, anxiety, tension or depression	0.5	0.8	4.6	-0.4	1.2	-0.7	-0.4	-1.0	-0.6	-2.2	-0.4	0.2	-0.5	0.1
Hair/balding pattern: Pattern 4	0.6	1.4	3.9	1.2	-0.4	1.0	1.2	1.2	2.0	1.9	1.2	0.1	1.0	0.0
Birth weight of first child	0.9	1.6	4.3	0.6	-2.1	1.3	0.8	-1.6	-1.2	1.9	0.3	0.9	1.2	-0.9
Peak expiratory flow (PEF)	0.4	0.8	1.8	-0.6	1.1	-0.9	-0.7	0.6	1.4	-0.5	-0.6	1.1	-1.0	-1.1
Pulse wave reflection index	0.9	1.1	2.7	1.2	0.4	1.6	1.4	0.8	-0.1	1.2	1.0	-0.3	1.6	-0.4
Ever highly irritable/argumentative for 2 days	0.3	0.3	1.0	-0.7	-0.8	-0.5	-0.6	-0.3	-0.3	-1.0	-0.7	-0.4	-0.4	0.2
Loud music exposure frequency	1.0	1.1	3.1	0.8	0.5	1.7	1.1	0.7	1.0	1.1	0.3	-1.2	1.8	0.1
Qualifications: O levels/GCSEs or equivalent	0.4	0.7	3.6	0.6	0.0	0.4	0.5	-1.9	-1.1	0.5	0.9	0.3	0.4	-0.9
Mouth/teeth dental problems: Bleeding gums	1.7	2.2	4.4	1.6	2.1	1.8	1.7	1.1	1.0	1.6	1.3	-0.9	1.8	0.1
Blood clot in the leg (DVT)	2.0	2.6	5.7	-2.4	-1.1	-1.6	-2.1	0.2	-1.5	-1.8	-2.3	0.6	-1.5	-1.2
Medication: Paracetamol	0.2	0.4	1.3	-0.9	-0.0	0.1	-0.5	0.5	1.0	-0.8	-1.1	-0.4	0.1	-0.1
Headache pain in last month	0.3	0.5	2.5	0.5	-0.5	0.8	0.6	-0.1	1.6	0.3	0.4	-0.2	0.8	-0.3
Medication for cholesterol, blood pressure or diabetes	1.0	1.7	3.2	1.8	1.2	1.7	1.8	-0.6	0.7	1.1	1.6	0.0	1.7	0.3
Glaucoma (self-reported)	0.2	0.3	1.1	-0.4	0.1	-1.0	-0.6	-0.2	0.2	-0.4	-0.1	-0.3	-0.9	0.2
Gout (self-reported)	0.6	0.9	2.7	0.4	1.3	-0.8	-0.0	-0.3	0.1	-1.4	0.6	-1.3	-0.5	1.6
Hypothyroidism/myxoedema (self-reported)	0.2	0.4	1.5	-0.2	0.2	-1.2	-0.6	0.5	-0.1	-0.7	0.2	0.5	-1.1	0.8
Medication: Amlodipine	0.7	1.0	2.6	-1.0	-1.0	-1.0	-1.0	1.6	1.2	-1.2	-0.8	-0.3	-1.0	0.0
Medication: Ventolin 100micrograms inhaler	0.8	1.0	2.1	-1.3	0.1	-1.4	-1.4	-0.3	-0.0	-1.2	-1.3	0.1	-1.4	0.3
Birth weight	0.7	1.5	4.4	-0.9	-2.1	-0.8	-1.0	-1.3	-0.6	-1.4	-1.1	-1.7	-0.8	0.9
Chronic bronchitis/emphysema (mother)	0.4	0.5	1.0	-0.9	-0.4	-0.7	-0.8	0.4	-0.1	-0.8	-1.0	1.0	-0.6	-0.4
High blood pressure (siblings)	0.9	1.3	2.9	-1.7	0.7	-1.3	-1.6	0.1	-0.7	-0.7	-1.6	0.7	-1.4	-0.8
Forced vital capacity (FVC), Best measure	1.5	5.4	9.2	-2.7	-3.0	-2.6	-2.8	-1.9	-0.2	-0.6	-2.5	2.1	-2.8	-2.4
Body fat percentage	0.3	1.4	5.4	-0.6	1.1	-0.6	-0.5	-0.4	-0.3	-2.1	-0.9	-1.4	-0.3	2.3
Leg fat percentage (right)	0.6	2.3	8.7	-1.1	1.6	-1.5	-1.1	-0.3	-0.3	-2.9	-1.1	-1.2	-1.1	2.4
Arm fat-free mass (right)	0.6	2.9	6.4	-1.6	-1.6	-2.5	-1.9	-1.6	0.4	-2.5	-1.2	0.1	-2.2	1.2
Exposure to tobacco smoke outside home	1.7	2.3	8.8	-1.6	1.1	-1.1	-1.3	-1.6	-1.7	-3.0	-1.9	0.1	-0.8	0.6
Comparative body size at age 10	0.6	1.6	10.6	-0.5	0.6	-0.7	-0.5	-3.3	-0.9	-1.4	-0.2	1.3	-0.6	-0.7
Number of full brothers	0.3	0.4	1.8	0.4	0.8	0.0	0.3	0.2	0.1	0.5	0.5	-0.8	0.3	1.4
Worry too long after embarrassment	0.1	0.2	1.1	-0.2	-0.0	-0.3	-0.2	0.7	1.1	-0.2	-0.1	-0.5	-0.2	0.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.3	1.0	-0.6	1.0	0.2	-0.3	-0.1	-0.1	-1.0	-0.7	0.7	0.1	-0.2
Wheeze or whistling in the chest in last year	0.3	0.6	1.6	-1.1	-0.7	-0.7	-0.9	-0.1	-0.6	-1.0	-1.3	-0.4	-0.6	0.3
Number of children fathered	0.5	0.6	1.4	0.6	1.1	1.0	0.8	1.2	0.8	0.2	0.4	-0.1	0.9	-0.3
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.5	2.2	-0.6	-0.7	-0.6	-0.5	0.8	0.3	-0.1	-0.6	-1.5	-0.5	0.5
Age at first live birth	0.2	0.4	0.7	0.7	0.7	0.7	0.7	0.6	0.8	0.3	0.7	-0.5	0.5	-0.7
Pulse wave peak to peak time	0.9	1.0	2.8	-1.0	0.6	-1.6	-1.3	-0.8	-0.4	-0.9	-1.0	0.7	-1.7	-0.0
Health satisfaction	0.6	0.8	2.5	-0.3	0.5	1.1	0.1	1.2	-0.0	0.6	-0.6	1.4	0.9	-1.6
Shortness of breath walking on level ground	0.2	0.3	1.2	-0.2	-0.5	0.1	-0.0	0.1	1.1	-0.4	-0.2	0.9	0.1	-0.5
Qualifications: College or University degree	0.2	0.5	3.2	0.2	0.7	-0.6	-0.1	-0.8	1.8	-0.4	0.2	-0.5	-0.4	0.6
Eye problems/disorders: None of the above	0.5	0.6	1.3	0.7	1.0	1.1	0.8	0.3	-0.2	-0.2	0.3	-0.9	1.1	0.8
Mouth/teeth dental problems: Loose teeth	1.0	1.2	4.1	0.1	1.8	-0.3	0.1	2.0	1.1	0.0	0.1	-1.1	0.0	1.7
Emphysema/chronic bronchitis	1.2	1.4	3.8	-1.2	-0.9	-1.3	-1.4	0.4	0.8	-0.0	-1.1	1.2	-1.5	-2.0
Medication for pain relief, constipation, heartburn	0.6	1.0	2.9	-0.0	-1.7	0.4	0.1	-0.5	-1.0	1.6	-0.1	1.5	0.1	-1.4
Neck or shoulder pain in last month	0.9	1.2	2.8	1.2	0.2	1.3	1.2	-0.9	0.9	0.3	1.0	-1.7	1.4	1.2
Medication: Blood pressure	1.1	2.0	4.1	-2.0	-1.5	-1.6	-2.0	0.4	-0.3	-1.6	-2.0	-0.2	-1.6	-0.1
Angina (self-reported)	0.7	0.9	2.3	-1.5	0.8	-0.9	-1.2	0.4	-1.0	-1.0	-1.3	-0.5	-0.9	-0.2
Migraine (self-reported)	0.5	0.7	1.9	0.9	1.4	1.3	0.9	-0.6	-0.1	0.4	0.8	0.3	1.0	-0.4
Medication: Ibuprofen	0.8	0.9	6.4	0.6	0.4	-0.2	0.3	-2.5	0.9	-0.8	0.8	-0.8	0.0	0.8
Medication: Allopurinol	1.0	1.4	3.7	-0.6	0.9	-1.6	-0.9	-0.1	-0.6	-1.8	-0.3	-1.4	-1.2	1.9
Medication: Omeprazole	1.0	1.2	4.0	0.7	1.1	0.3	0.5	1.6	0.7	-0.3	0.7	-2.0	0.3	1.7
Medication: Seretide 50 evohaler	0.7	0.8	2.0	-1.1	-0.8	-0.6	-1.1	1.4	0.1	-1.0	-1.2	-0.3	-0.7	0.9
Mean time to correctly identify matches	0.6	1.2	4.4	1.0	-0.5	1.1	1.0	2.1	1.5	1.2	0.9	0.2	1.0	-0.2
Heart disease (mother)	2.5	3.1	5.6	-2.4	0.2	-2.2	-2.4	-0.5	-1.9	-2.1	-2.2	0.3	-2.2	-0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.8	1.0	5.2	-0.2	0.8	-0.5	-0.3	-1.0	-0.5	0.4	0.1	1.8	-0.6	-2.3
Whole body fat mass	0.5	2.2	7.9	-1.4	0.3	-1.5	-1.3	-1.0	-0.4	-2.8	-1.4	-0.9	-1.1	2.2
Leg fat mass (right)	0.9	3.6	11.8	-1.9	0.5	-2.4	-2.0	-1.0	-0.4	-3.4	-1.9	-0.8	-1.9	2.2
Arm predicted mass (right)	0.6	3.1	6.8	-1.8	-1.7	-2.6	-2.1	-1.4	0.3	-2.5	-1.4	0.1	-2.3	1.2
Pulse rate, automated reading	0.6	2.0	4.4	-1.8	-1.2	-1.8	-1.7	-1.1	-0.5	-2.1	-1.6	-0.0	-1.5	1.1
Alcohol intake frequency.	2.2	5.2	9.3	2.9	0.9	2.3	2.8	1.1	2.8	2.0	3.1	-1.7	2.5	1.7
Comparative height size at age 10	1.0	5.5	8.0	-2.8	-2.6	-2.4	-2.8	-2.2	-1.9	-1.3	-2.5	2.5	-2.5	-1.8
Number of full sisters	1.7	2.1	4.0	-1.6	-1.0	-2.0	-1.9	-1.2	-1.0	-1.0	-1.4	1.1	-2.0	-1.1
Suffer from ‘nerves’	0.3	0.5	1.5	0.6	0.9	-0.1	0.5	0.1	0.5	-0.5	0.7	-1.2	0.1	1.1
Overall health rating	0.3	0.6	2.6	-0.2	-0.4	0.6	0.2	1.6	1.4	0.7	-0.6	-0.3	0.7	-0.2
Chest pain or discomfort	0.3	0.4	1.4	0.4	-0.3	1.2	0.6	-0.3	-0.3	0.3	0.1	0.8	0.9	-0.8
Had major operations	0.4	0.5	3.0	-0.5	1.7	0.2	-0.2	1.0	-0.2	-0.3	-0.7	0.1	0.1	-0.6
Age at last live birth	0.1	0.1	0.5	-0.1	-0.5	-0.3	-0.2	-0.3	0.1	-0.6	-0.1	0.0	-0.4	-0.7
Family relationship satisfaction	0.8	1.0	2.6	1.0	-0.2	1.6	1.2	0.1	0.0	1.6	0.7	0.3	1.5	-0.9
Leg pain on walking	0.8	1.1	3.3	0.1	-1.3	1.8	0.7	-0.7	-0.5	1.2	-0.4	0.3	1.7	-0.9
Qualifications: NVQ or HND or HNC or equivalent	0.6	0.8	2.2	0.8	1.5	1.1	1.0	-1.3	0.5	0.1	0.8	-0.0	1.0	0.1
Commuting to job workplace: Car/motor vehicle	1.0	1.1	2.6	-0.8	1.0	-1.6	-1.1	-0.9	0.3	-1.4	-0.3	1.2	-1.6	-0.7
Illness, injury, bereavement, stress in last 2 years	0.8	1.0	1.8	-1.4	-1.2	-1.3	-1.3	-0.8	-0.0	-0.7	-1.1	0.2	-1.3	0.2
Medication: Aspirin	1.0	1.4	3.3	-0.6	1.4	-1.2	-0.8	0.4	0.4	-1.8	-0.4	-1.8	-0.9	1.7
Supplements: Vitamin C	0.2	0.3	1.4	-0.2	1.2	0.0	-0.2	0.5	-0.5	-0.5	-0.1	0.8	-0.0	-0.1
Knee pain experienced in last month	0.5	0.8	1.4	1.0	0.6	0.8	1.1	-0.7	-0.0	-0.2	0.9	-1.1	1.0	1.2
Hypertension (Self-reported)	1.8	5.1	12.4	-3.0	-0.5	-2.9	-3.0	0.3	-0.6	-3.5	-3.0	-0.8	-2.6	1.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.2	1.4	3.3	-1.1	0.5	-1.6	-1.5	0.1	-0.8	-1.2	-0.9	1.6	-1.8	-0.6
Illnesses of father: Heart disease	7.5	10.3	18.5	-4.2	-2.8	-4.3	-4.3	-1.6	-1.7	-2.4	-3.7	2.2	-4.3	-1.6
Illnesses of siblings: Diabetes	1.4	1.8	3.3	-1.8	1.2	-1.4	-1.7	1.7	0.4	-1.4	-1.7	-0.4	-1.3	0.6
Smoking status: Previous	1.0	1.5	3.0	-1.7	-0.2	-1.6	-1.7	0.6	-0.9	-1.0	-1.6	0.8	-1.7	-0.4
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.4	1.5	0.2	-0.9	-0.1	0.2	-1.2	-0.9	-0.9	0.2	0.0	0.0	0.6
Whole body fat-free mass	0.8	4.9	10.8	-2.3	-2.1	-3.3	-2.6	-1.9	0.2	-3.0	-1.8	0.2	-3.0	1.1
Leg fat-free mass (right)	1.0	5.3	11.6	-2.6	-1.9	-3.4	-2.8	-2.1	-0.3	-3.1	-2.1	0.1	-3.0	1.1
Arm fat percentage (left)	0.6	2.6	8.2	-1.4	1.0	-1.6	-1.4	-0.7	-0.5	-2.9	-1.6	-1.2	-1.2	2.5
Average weekly red wine intake	0.1	0.2	0.6	0.3	0.8	-0.0	0.2	0.2	0.6	-0.5	0.3	-0.8	-0.0	0.6
Handedness (chirality/laterality): Left-handed	0.5	0.5	2.7	-0.5	0.6	-0.0	-0.3	-0.6	-0.9	-1.7	-0.7	-0.9	-0.2	-0.3
Mood swings	0.2	0.4	2.6	-0.1	-1.6	-0.4	-0.1	0.4	0.6	0.8	0.2	0.4	-0.3	-0.4
Loneliness, isolation	0.8	1.0	3.5	-0.9	-1.9	0.3	-0.4	-1.6	-1.3	0.5	-1.0	0.6	0.2	-1.0
Long-standing illness, disability or infirmity	0.3	0.5	1.3	-0.6	0.3	-0.3	-0.5	0.9	0.8	-1.1	-0.6	-0.3	-0.1	1.1
Ever had bowel cancer screening	0.2	0.3	0.7	-0.5	0.6	-0.4	-0.4	0.6	0.1	-0.9	-0.4	-0.6	-0.4	-0.2
Diabetes diagnosed by doctor	1.2	2.0	4.3	-1.7	0.8	-1.4	-1.5	1.3	-1.5	-2.1	-1.6	0.4	-1.4	0.9
Ever had stillbirth, spontaneous miscarriage or termination	3.0	3.2	6.6	-2.3	-1.5	-1.6	-2.2	1.0	-0.4	-1.6	-2.6	2.2	-1.7	-1.5
Friendships satisfaction	1.1	1.4	2.3	1.5	1.0	1.5	1.4	-1.1	-0.7	1.3	1.3	0.1	1.5	-0.4
Qualifications: nursing, teaching	0.3	0.4	2.4	0.1	0.6	-0.3	-0.1	-0.2	1.5	-0.8	0.3	0.8	-0.4	-0.8
Commuting to job workplace: Walk	0.5	0.5	1.4	0.0	-0.7	1.2	0.4	0.6	0.1	0.6	-0.6	-0.8	1.2	0.8
Eye problems/disorders: Cataract	0.6	0.7	2.2	0.6	-0.4	0.6	0.7	0.9	0.3	0.4	0.6	-1.5	0.6	1.5
Mouth/teeth dental problems: Mouth ulcers	0.4	0.6	3.7	-0.1	0.3	-0.9	-0.3	-1.9	-1.0	-0.7	0.2	0.1	-0.8	0.4
Medication for cholesterol	2.0	3.1	11.3	-1.2	-1.0	-0.9	-1.2	-3.4	-1.8	-0.1	-1.2	2.4	-1.1	-2.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.5	0.5	1.8	-0.0	0.6	-0.2	0.1	-1.3	-1.3	-0.9	-0.2	0.9	-0.1	-0.7
Back pain experienced in last month	0.2	0.3	0.8	-0.6	0.3	0.2	-0.3	0.7	0.5	-0.9	-0.9	-0.1	0.2	0.1
Mineral and other dietary supplements	0.2	0.2	0.9	-0.4	-0.9	-0.6	-0.5	0.1	0.3	-0.4	-0.4	-0.3	-0.6	-0.2
Breast cancer (self-reported)	1.4	1.6	4.9	1.1	1.9	2.2	1.5	0.5	0.0	1.0	0.6	-0.6	2.0	-0.1
Asthma (self-reported)	0.3	0.6	1.3	-0.8	-1.0	-1.1	-1.0	0.0	0.1	-0.9	-0.7	0.1	-1.1	-0.3
Osteoporosis (self-reported)	0.5	0.6	2.3	0.6	0.7	0.7	0.7	0.3	1.2	-0.4	0.3	-0.7	0.8	1.5
Osteoarthritis (self-reported)	0.5	0.6	1.1	-1.0	-0.3	-1.0	-1.0	0.5	0.9	-0.5	-1.0	0.3	-1.0	0.6
Medication: Aspirin	0.9	1.1	2.5	-0.8	1.1	-1.2	-0.9	0.6	0.2	-1.6	-0.6	-1.4	-1.0	1.5
Medication: Gliclazide	2.5	2.8	8.0	-2.0	-0.3	-2.0	-2.0	0.9	-0.6	-2.8	-2.0	0.5	-2.1	-0.5
Illnesses of father: None of the above (group 1)	7.4	9.2	16.1	4.0	0.0	3.5	3.9	1.6	2.9	4.0	3.9	-1.9	3.4	0.7
Smoking status: Current	1.9	3.0	4.8	-2.2	-1.8	-1.9	-2.2	-0.9	-1.9	-1.7	-2.0	0.9	-1.9	-0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.7	1.5	3.2	-1.4	0.2	-1.7	-1.6	0.7	0.4	-0.6	-1.1	1.4	-1.8	-1.4
Whole body water mass	0.8	4.7	10.5	-2.3	-2.0	-3.2	-2.6	-1.7	0.1	-3.0	-1.7	0.1	-3.0	1.2
Leg predicted mass (right)	1.0	5.3	11.6	-2.6	-2.0	-3.4	-2.8	-2.1	-0.3	-3.1	-2.1	0.1	-3.0	1.1
Arm fat mass (left)	0.8	3.3	10.1	-1.7	0.6	-2.1	-1.7	-0.9	-0.3	-3.2	-1.6	-1.2	-1.7	2.8
Number of self-reported non-cancer illnesses	1.2	2.0	5.4	-1.7	-0.2	-2.0	-1.8	0.9	-0.2	-2.3	-1.5	-0.1	-1.8	0.7
Average weekly champagne plus white wine intake	0.8	1.0	3.5	-0.8	-1.0	-1.9	-1.2	-0.2	-0.5	-1.1	-0.4	0.1	-1.8	-0.2
Miserableness	0.9	1.6	3.4	-1.5	-1.9	-1.4	-1.5	-1.5	0.4	0.1	-1.2	0.8	-1.4	-1.1
Guilty feelings	0.3	0.5	2.1	-1.1	-0.1	-0.3	-0.8	0.1	-0.8	-0.5	-1.5	-0.3	-0.3	0.2
Wears glasses or contact lenses	1.6	1.8	5.1	1.3	1.9	0.4	1.1	1.0	0.4	0.3	1.5	-2.1	0.7	2.3
Ever taken oral contraceptive pill	2.1	2.3	10.3	0.7	0.3	-0.3	0.4	3.1	3.2	0.1	0.8	-1.5	-0.2	1.2
Hearing aid user	0.3	0.3	1.1	-0.4	0.5	0.3	-0.3	0.0	-1.1	0.0	-0.8	0.8	0.2	-0.4
Mother’s age at death	0.2	0.3	0.8	0.7	-0.2	-0.3	0.4	0.9	0.8	0.1	0.8	0.4	-0.3	-0.5
Financial situation satisfaction	1.6	2.0	3.9	1.6	-0.4	1.9	1.7	1.3	0.3	2.0	1.5	0.2	1.7	-1.1
Tinnitus: Yes, now most or all of the time	0.2	0.3	1.5	0.3	-1.2	-0.3	-0.0	0.5	0.4	0.5	0.4	0.4	-0.2	0.6
Commuting to job workplace: Public transport	0.4	0.5	2.4	-0.0	-0.1	0.2	0.1	-0.1	-0.1	-0.6	-0.4	-1.5	0.3	1.5
Eye problems/disorders: Glaucoma	0.1	0.2	0.7	-0.2	0.3	-0.8	-0.3	-0.1	-0.3	-0.3	0.2	-0.4	-0.6	0.5
Medication: Blood pressure	0.9	1.6	3.3	-1.3	0.3	-1.2	-1.3	1.8	0.0	-1.8	-1.3	-1.2	-1.1	1.6
Pain type(s) experienced in last month: Hip pain	0.5	0.6	3.1	-0.2	-1.8	-0.3	-0.3	0.7	1.2	0.2	-0.1	1.2	-0.3	-0.0
Supplements: Fish oil (including cod liver oil)	0.5	0.6	2.3	0.2	0.4	1.5	0.7	-0.9	-0.7	0.6	-0.1	0.3	1.3	-0.3
High cholesterol (Self-reported)	0.7	1.2	7.6	-0.2	0.3	-0.9	-0.3	2.8	0.3	-0.3	0.0	-1.4	-0.6	1.5
Medication: Bendroflumethiazide	1.6	2.4	4.5	-2.0	-0.8	-1.6	-1.8	-0.6	-1.0	-2.1	-2.1	-1.3	-1.2	1.7
Medication: Paracetamol	0.3	0.5	2.2	-0.7	-0.2	0.1	-0.4	1.3	1.5	-0.3	-0.7	-0.8	0.1	0.2
Medication: Lisinopril	0.5	0.7	2.2	-1.0	-1.5	-0.9	-1.0	-0.3	-0.2	-0.4	-1.1	0.5	-0.8	0.2
Medication: Atorvastatin	1.4	1.8	4.0	-2.0	-1.2	-1.3	-1.8	0.0	-1.2	-0.4	-2.0	1.1	-1.4	-0.6
Illnesses of father: High blood pressure	2.7	3.4	7.6	-2.2	-0.2	-1.8	-2.1	-2.8	-2.2	-1.5	-2.2	0.7	-1.9	-1.0
Alcohol drinker status: Never	0.8	0.9	2.6	0.7	0.1	1.6	1.2	-0.1	0.7	0.9	0.7	-1.0	1.6	0.2
Ever smoked	2.8	5.0	8.7	-2.7	-1.7	-2.9	-2.8	-2.0	-2.5	-2.0	-2.4	0.4	-2.8	-0.2
Basal metabolic rate	0.9	4.7	10.2	-2.3	-1.7	-3.2	-2.6	-1.8	0.0	-3.2	-1.8	-0.1	-2.9	1.5
Leg fat percentage (left)	0.7	2.7	9.5	-0.8	1.9	-1.3	-0.8	0.2	0.0	-3.0	-0.8	-1.8	-0.8	3.1
Arm fat-free mass (left)	0.7	3.5	8.4	-1.9	-1.3	-2.8	-2.2	-1.1	0.1	-2.9	-1.4	-0.2	-2.5	1.3
Number of operations (self-reported)	0.6	0.9	3.5	-0.9	1.4	-0.6	-0.7	-0.9	-1.3	-1.9	-0.7	0.4	-0.5	-0.3
Average weekly beer plus cider intake	0.9	1.3	4.5	-1.4	-1.1	-0.4	-1.1	-0.0	-0.7	0.2	-1.8	1.0	-0.5	-2.1
Irritability	1.6	2.8	5.4	-1.8	-2.3	-2.3	-1.9	-1.7	-0.7	-1.5	-1.6	0.4	-2.1	0.6
Risk taking	0.7	1.0	2.2	-1.2	-0.5	-0.5	-1.1	-1.1	-0.5	-0.6	-1.2	1.5	-0.7	-1.2
Ever had prostate specific antigen (PSA) test	0.3	0.3	1.1	0.6	0.4	0.6	0.7	0.6	1.1	-0.4	0.5	-0.2	0.5	-0.3
Fractured/broken bones in last 5 years	0.8	1.0	2.4	-1.5	0.8	-0.4	-1.3	-0.8	-1.1	-1.1	-1.6	0.5	-0.6	-0.8
Age started oral contraceptive pill	1.0	1.3	6.1	0.9	2.5	1.1	0.8	0.9	1.1	1.2	0.8	0.6	0.8	-0.6
Diastolic blood pressure, automated reading	1.0	3.1	5.8	-2.4	-1.8	-1.6	-2.3	-1.1	-1.7	-0.8	-2.4	1.1	-1.8	-1.5
Ever depressed for a whole week	0.5	0.7	2.9	-0.7	1.1	-0.2	-0.6	-1.7	-1.0	-0.6	-0.8	-0.2	-0.2	-0.4
Unable to work because of sickness or disability	0.5	0.6	2.2	-0.6	0.4	-0.4	-0.5	0.2	-0.9	-1.5	-0.8	-0.8	-0.2	1.3
Commuting to job workplace: Cycle	1.1	1.3	3.2	1.2	1.3	1.8	1.3	0.9	0.3	1.3	0.9	-0.1	1.6	0.3
Myopia	0.3	0.4	1.3	-0.0	1.1	-0.7	-0.1	-1.0	0.2	-0.5	0.3	-0.6	-0.5	1.1
Vascular/heart problems diagnosed by doctor	2.6	7.1	14.5	3.8	1.0	3.2	3.7	-0.7	1.1	3.7	3.7	-0.0	3.1	-0.3
Cholesterol lowering medication	0.5	0.8	6.7	-0.1	0.1	0.2	0.1	2.6	-0.2	-0.3	-0.1	-0.5	0.4	1.0
Medication: Omeprazole (e.g. Zanprol)	1.7	2.0	4.6	1.5	1.2	1.0	1.4	1.4	1.1	0.5	1.5	-2.1	1.1	2.0
Pain experienced in last month	0.4	0.6	1.9	-0.3	-0.6	-0.7	-0.5	-0.1	-1.0	0.4	-0.1	1.4	-0.9	-1.2
Supplements: Calcium	0.4	0.5	3.0	0.5	0.3	0.4	0.4	0.4	0.0	-0.1	0.4	-0.8	0.6	1.7
Basal cell carcinoma (self-reported)	1.5	1.8	5.4	-1.3	0.9	-1.9	-1.5	-0.8	-1.1	-2.3	-1.0	0.2	-1.8	0.1
Heart attack/myocardial infarction (self-reported)	1.3	1.7	4.4	-1.6	-2.1	-1.0	-1.4	0.9	-1.4	-0.8	-1.6	1.2	-0.9	-0.8
Deep venous thrombosis (DVT) (self-reported)	2.1	2.8	5.9	-2.4	-1.0	-1.7	-2.2	0.3	-1.5	-1.9	-2.3	0.6	-1.7	-1.1
Heart disease (siblings)	0.2	0.2	1.3	0.1	-0.1	0.5	0.0	0.5	0.5	0.4	0.0	-0.0	0.3	1.1
Alcohol drinker status: Previous	0.8	0.9	2.6	-1.2	-1.6	-1.1	-1.2	-0.1	-0.5	-0.7	-1.0	0.6	-1.0	-0.4
Pack years of smoking	1.0	1.5	4.1	-1.7	-2.0	-1.0	-1.4	-1.3	-0.7	-0.4	-1.6	0.7	-0.8	-0.8
Impedance of whole body	0.9	4.6	11.0	2.4	-0.3	3.3	2.6	1.1	-0.5	3.3	1.8	0.3	2.9	-1.7
Leg fat mass (left)	0.9	3.4	12.0	-1.7	0.8	-2.1	-1.7	-0.7	-0.1	-3.5	-1.6	-1.1	-1.7	2.7
Arm predicted mass (left)	0.7	3.7	8.7	-2.0	-1.6	-2.8	-2.3	-1.1	0.1	-3.0	-1.5	-0.2	-2.6	1.5