[Hub]/) : Traits : Lung FEV1/FVC ratio : ← →

chr5:12,225-1,390,349

Best TWAS P=2.3e-19 · Best GWAS P=2.21e-21 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
8	GTEx	Colon Sigmoid	AC026740.1	0.13	0.06	lasso	3	0.03	3.8e-02	-9.5	9.0	2.3e-19	-0.98	0.02	0.89	TRUE
21	GTEx	Testis	CEP72	0.36	0.24	lasso	5	0.25	2.2e-11	-9.5	8.8	1.2e-18	-0.93	0.00	1.00	FALSE
11	GTEx	Esophagus Muscularis	AC026740.1	0.12	0.10	lasso	6	0.08	1.1e-05	-8.7	8.7	2.6e-18	-0.82	0.02	0.96	FALSE
16	GTEx	Prostate	EXOC3	0.23	0.13	lasso	14	0.06	1.1e-02	-8.1	8.4	5.3e-17	-0.86	0.02	0.92	FALSE
5	GTEx	Artery Tibial	AC026740.1	0.08	0.06	lasso	3	0.05	1.0e-04	-8.8	8.3	9.4e-17	-0.89	0.02	0.97	FALSE
27	METSIM	Adipose	TPPP	0.04	0.00	blup	355	0.01	1.2e-02	-8.8	8.1	6.0e-16	-0.71	0.03	0.96	FALSE
9	GTEx	Esophagus Mucosa	AC026740.1	0.17	0.07	lasso	5	0.07	2.2e-05	-8.7	8.1	6.8e-16	-0.90	0.03	0.97	FALSE
17	GTEx	Skin Not Sun Exposed Suprapubic	AC026740.1	0.15	0.10	lasso	5	0.20	1.9e-11	-8.7	8.1	8.4e-16	-0.86	0.01	0.99	FALSE
24	GTEx	Thyroid	AC026740.1	0.20	0.10	lasso	4	0.10	7.8e-08	-8.8	7.8	7.4e-15	-0.90	0.06	0.94	FALSE
4	GTEx	Adipose Visceral Omentum	AC026740.1	0.12	0.05	enet	14	0.12	1.5e-06	-8.0	7.6	3.4e-14	-0.80	0.03	0.95	FALSE
28	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	SLC9A3	0.18	-0.01	blup	61	0.05	2.2e-03	-8.8	-7.5	8.7e-14	0.57	0.00	0.69	FALSE
1	CommonMind	Brain Pre-frontal Cortex	TPPP	0.04	0.00	blup	361	0.02	1.9e-03	6.2	7.3	2.5e-13	-0.64	0.02	0.72	FALSE
23	GTEx	Thyroid	CEP72	0.17	0.07	lasso	3	0.04	3.4e-04	-5.9	7.2	5.7e-13	-0.71	0.08	0.81	FALSE
2	GTEx	Adipose Subcutaneous	CEP72	0.16	0.07	lasso	4	0.08	5.8e-07	-5.9	7.2	7.7e-13	-0.73	0.05	0.95	FALSE
14	GTEx	Ovary	SLC9A3	0.24	0.04	enet	34	0.06	1.8e-02	-8.1	-7.1	9.3e-13	0.70	0.02	0.85	FALSE
13	GTEx	Nerve Tibial	CEP72	0.25	0.18	lasso	6	0.18	1.1e-12	-5.9	7.0	2.0e-12	-0.66	0.44	0.56	FALSE
22	GTEx	Testis	AC026740.1	0.19	0.04	enet	8	0.06	1.3e-03	-8.7	7.0	2.1e-12	-0.80	0.04	0.92	FALSE
30	The Cancer Genome Atlas	Thyroid Carcinoma	CEP72	0.15	0.13	blup	63	0.15	1.0e-14	-8.2	7.0	2.5e-12	-0.79	0.53	0.47	FALSE
31	The Cancer Genome Atlas	Thyroid Carcinoma	TPPP	0.04	0.04	lasso	1	0.02	5.1e-03	-6.9	6.9	4.3e-12	-0.67	0.03	0.60	FALSE
15	GTEx	Ovary	CTD-2228K2.7	0.29	0.03	enet	26	0.08	4.8e-03	-8.1	-6.5	6.4e-11	0.68	0.03	0.82	FALSE
29	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	SLC9A3	0.09	0.03	blup	63	0.04	2.0e-05	-8.8	-6.4	1.3e-10	0.73	0.00	1.00	FALSE
20	GTEx	Stomach	AC026740.1	0.13	0.01	lasso	4	0.03	1.5e-02	-8.0	6.2	7.7e-10	-0.76	0.04	0.72	FALSE
25	GTEx	Whole Blood	AC026740.1	0.08	0.04	enet	9	0.08	1.8e-07	2.0	6.1	8.1e-10	-0.74	0.12	0.88	FALSE
10	GTEx	Esophagus Muscularis	CEP72	0.13	0.10	lasso	6	0.10	1.0e-06	-5.9	6.1	1.2e-09	-0.56	0.14	0.85	FALSE
3	GTEx	Adipose Subcutaneous	AC026740.1	0.13	0.04	lasso	5	0.07	1.0e-06	2.1	5.8	7.3e-09	-0.65	0.48	0.52	FALSE
7	GTEx	Brain Frontal Cortex BA9	AC026740.1	0.17	0.02	enet	13	0.06	9.5e-03	2.5	5.6	2.3e-08	-0.70	0.04	0.53	FALSE
26	METSIM	Adipose	CEP72	0.04	0.04	lasso	5	0.03	1.5e-05	5.0	5.5	4.9e-08	-0.48	0.91	0.05	FALSE
6	GTEx	Brain Frontal Cortex BA9	CTD-2228K2.7	0.40	0.07	lasso	9	0.26	1.8e-07	-4.9	-5.4	7.8e-08	0.39	0.04	0.68	FALSE
19	GTEx	Spleen	SLC9A3	0.25	-0.01	enet	30	0.23	1.5e-06	-3.1	-5.3	9.9e-08	0.52	0.04	0.38	FALSE
18	GTEx	Skin Sun Exposed Lower leg	SLC9A3	0.61	0.09	enet	29	0.40	1.5e-35	-4.9	-5.3	1.3e-07	0.45	1.00	0.00	FALSE
12	GTEx	Lung	AC026740.1	0.17	0.07	lasso	6	0.09	1.0e-07	1.9	5.2	2.0e-07	-0.64	0.27	0.73	FALSE