[Hub]/) : Traits : Lung FEV1/FVC ratio : ← →

chr4:152,543,783-155,397,517

Best TWAS P=3.05e-13 · Best GWAS P=5.86e-16 conditioned to 1.52e-05

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
47	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	SFRP2	0.03	0.03	enet	5	0.04	5.1e-05	-7.9	-7.3	3.1e-13	0.88	0.01	0.88	TRUE
24	GTEx	Pancreas	ARFIP1	0.14	0.06	lasso	3	0.06	1.1e-03	6.2	6.7	1.8e-11	0.05	0.02	0.98	TRUE
38	YFS	Blood	SFRP2	0.03	0.02	lasso	9	0.01	1.6e-05	-7.8	-7.2	7.8e-13	0.88	0.03	0.97	FALSE
35	NTR	Blood	RNF175	0.03	0.03	lasso	9	0.03	4.0e-09	-6.9	7.0	2.3e-12	-0.79	0.14	0.86	FALSE
50	The Cancer Genome Atlas	Thyroid Carcinoma	ARFIP1	0.05	0.09	blup	86	0.08	2.1e-08	-5.9	6.5	9.7e-11	0.07	0.09	0.91	FALSE
48	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	TLR2	0.03	0.02	enet	9	0.02	4.0e-03	-6.9	6.5	1.1e-10	-0.81	0.01	0.94	FALSE
37	YFS	Blood	ARFIP1	0.09	0.15	enet	26	0.16	3.2e-48	5.8	6.4	1.2e-10	0.03	0.11	0.89	FALSE
21	GTEx	Lung	ARFIP1	0.20	0.12	lasso	6	0.13	2.2e-10	-5.9	6.4	1.8e-10	0.07	0.06	0.94	FALSE
4	GTEx	Adipose Visceral Omentum	ARFIP1	0.19	0.09	lasso	5	0.11	2.7e-06	-5.9	6.4	2.0e-10	0.07	0.06	0.94	FALSE
12	GTEx	Cells EBV-transformed lymphocytes	ARFIP1	0.28	0.11	lasso	8	0.18	1.6e-06	5.8	6.4	2.0e-10	0.05	0.03	0.97	FALSE
46	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	ARFIP1	0.08	0.05	lasso	6	0.08	4.9e-09	5.8	6.3	2.5e-10	0.05	0.10	0.90	FALSE
33	METSIM	Adipose	ARFIP1	0.17	0.22	enet	27	0.24	2.3e-36	6.1	6.3	3.3e-10	0.07	0.01	0.99	FALSE
31	GTEx	Thyroid	ARFIP1	0.16	0.17	lasso	4	0.18	4.6e-14	-5.9	6.2	5.5e-10	0.08	0.04	0.96	FALSE
7	GTEx	Artery Coronary	ARFIP1	0.17	0.10	lasso	1	0.08	8.4e-04	-6.2	6.2	5.7e-10	0.06	0.04	0.94	FALSE
25	GTEx	Pituitary	ARFIP1	0.27	-0.01	enet	16	-0.01	6.5e-01	-6.2	6.2	5.7e-10	0.07	0.04	0.53	FALSE
22	GTEx	Nerve Tibial	ARFIP1	0.33	0.39	lasso	5	0.42	3.5e-32	-6.2	6.2	5.9e-10	0.08	0.04	0.96	FALSE
26	GTEx	Skin Not Sun Exposed Suprapubic	ARFIP1	0.14	0.05	enet	13	0.11	9.1e-07	-6.2	6.2	7.9e-10	0.04	0.04	0.96	FALSE
18	GTEx	Esophagus Muscularis	ARFIP1	0.26	0.24	lasso	7	0.24	5.7e-15	-6.2	6.1	8.5e-10	0.09	0.04	0.96	FALSE
27	GTEx	Skin Sun Exposed Lower leg	ARFIP1	0.09	0.04	lasso	6	0.04	2.0e-04	-5.9	6.1	9.9e-10	0.06	0.07	0.93	FALSE
6	GTEx	Artery Aorta	ARFIP1	0.30	0.17	lasso	13	0.16	2.1e-09	-5.9	6.1	1.2e-09	0.09	0.06	0.94	FALSE
9	GTEx	Brain Caudate basal ganglia	ARFIP1	0.25	0.03	lasso	5	0.09	1.4e-03	5.8	6.1	1.2e-09	0.00	0.03	0.80	FALSE
2	CommonMind	Brain Pre-frontal Cortex	TIGD4	0.09	0.07	lasso	3	0.07	5.9e-09	5.9	6.1	1.3e-09	0.03	0.02	0.98	FALSE
45	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	ARFIP1	0.02	0.03	enet	4	0.02	2.6e-03	5.8	6.0	1.4e-09	0.02	0.03	0.75	FALSE
5	GTEx	Adrenal Gland	ARFIP1	0.13	0.09	lasso	10	0.06	2.6e-03	-5.8	6.0	1.6e-09	0.09	0.05	0.87	FALSE
32	GTEx	Whole Blood	ARFIP1	0.16	0.21	lasso	4	0.22	4.1e-20	5.8	6.0	1.9e-09	0.02	0.10	0.90	FALSE
28	GTEx	Spleen	ARFIP1	0.28	0.25	enet	23	0.31	1.1e-08	-5.8	6.0	2.3e-09	0.08	0.07	0.93	FALSE
15	GTEx	Colon Sigmoid	ARFIP1	0.19	0.15	enet	13	0.14	9.8e-06	-5.9	6.0	2.5e-09	0.08	0.06	0.93	FALSE
40	The Cancer Genome Atlas	Breast Invasive Carcinoma	ARFIP1	0.04	0.03	blup	86	0.03	3.4e-07	-6.2	6.0	2.7e-09	0.06	0.03	0.97	FALSE
10	GTEx	Breast Mammary Tissue	ARFIP1	0.17	0.19	lasso	6	0.19	5.3e-10	-5.9	5.9	3.9e-09	0.09	0.07	0.93	FALSE
8	GTEx	Artery Tibial	ARFIP1	0.22	0.18	lasso	3	0.17	1.8e-13	-5.9	5.9	4.0e-09	0.09	0.06	0.94	FALSE
23	GTEx	Ovary	ARFIP1	0.28	0.16	lasso	5	0.09	2.8e-03	-5.4	5.8	4.9e-09	0.06	0.05	0.90	FALSE
13	GTEx	Cells Transformed fibroblasts	RNF175	0.09	0.01	lasso	2	0.00	2.5e-01	-6.8	5.8	5.8e-09	-0.67	0.07	0.52	FALSE
34	NTR	Blood	ARFIP1	0.05	0.08	lasso	2	0.08	2.6e-24	5.8	5.8	6.2e-09	0.02	0.11	0.89	FALSE
29	GTEx	Stomach	ARFIP1	0.19	0.13	lasso	1	0.10	1.7e-05	-5.8	5.8	6.8e-09	0.09	0.08	0.89	FALSE
49	The Cancer Genome Atlas	Prostate Adenocarcinoma	ARFIP1	0.02	0.01	lasso	4	0.02	4.4e-03	-5.7	5.8	7.5e-09	0.09	0.04	0.69	FALSE
20	GTEx	Liver	ARFIP1	0.18	0.06	lasso	10	0.06	8.2e-03	-5.9	5.8	8.3e-09	0.09	0.05	0.87	FALSE
44	The Cancer Genome Atlas	Glioblastoma Multiforme	TLR2	0.20	0.07	blup	65	0.10	5.8e-04	-6.9	5.8	9.1e-09	-0.72	0.01	0.91	FALSE
17	GTEx	Esophagus Mucosa	ARFIP1	0.10	0.07	lasso	3	0.06	9.5e-05	-5.7	5.7	1.0e-08	0.08	0.07	0.93	FALSE
16	GTEx	Colon Transverse	ARFIP1	0.34	0.25	lasso	9	0.21	4.0e-10	-6.2	5.7	1.2e-08	0.07	0.03	0.97	FALSE
41	The Cancer Genome Atlas	Breast Invasive Carcinoma	FHDC1	0.03	0.00	blup	80	0.01	4.0e-04	6.2	5.7	1.2e-08	0.04	0.01	0.93	FALSE
36	ROSMAP	Brain Pre-frontal Cortex	ARFIP1	0.05	0.03	blup	429	0.03	2.3e-05	5.8	5.7	1.3e-08	0.03	0.04	0.96	FALSE
1	CommonMind	Brain Pre-frontal Cortex	ARFIP1	0.10	0.06	blup	431	0.06	5.5e-08	-6.2	5.7	1.4e-08	0.05	0.05	0.95	FALSE
14	GTEx	Cells Transformed fibroblasts	ARFIP1	0.17	0.15	lasso	9	0.13	9.5e-10	-6.0	5.6	1.8e-08	0.09	0.06	0.94	FALSE
19	GTEx	Heart Atrial Appendage	ARFIP1	0.22	0.09	lasso	10	0.06	7.9e-04	-5.8	5.6	1.8e-08	0.11	0.05	0.90	FALSE
39	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	ARFIP1	0.03	0.01	blup	86	0.02	1.1e-02	-5.7	5.6	1.9e-08	0.09	0.05	0.49	FALSE
30	GTEx	Testis	FBXW7	0.15	0.02	lasso	11	0.01	1.2e-01	-5.9	5.5	3.4e-08	0.09	0.05	0.66	FALSE
43	The Cancer Genome Atlas	Breast Invasive Carcinoma	TIGD4	0.02	0.00	blup	46	0.00	7.4e-02	4.3	5.4	6.2e-08	0.00	0.01	0.29	FALSE
42	The Cancer Genome Atlas	Breast Invasive Carcinoma	RNF175	0.03	0.01	lasso	5	0.01	8.1e-03	-6.1	5.3	1.2e-07	-0.37	0.34	0.03	FALSE
3	GTEx	Adipose Subcutaneous	ARFIP1	0.22	0.12	enet	34	0.16	2.7e-13	-5.9	5.2	2.7e-07	0.04	0.07	0.93	FALSE
11	GTEx	Breast Mammary Tissue (Female)	ARFIP1	0.21	0.16	lasso	8	0.11	4.6e-04	-5.9	5.1	3.0e-07	0.08	0.07	0.81	FALSE