[Hub]/) : Traits : Lung FVC :

chr8:21,416,204-23,240,950

Best TWAS P=4.24e-11 · Best GWAS P=4.25e-11 conditioned to 1

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex PDLIM2 0.08 0.06 enet 11 0.06 8.9e-08 -5.7 5.5 4.1e-08 -0.88 0.10 0.90 FALSE
2 GTEx Adipose Subcutaneous BIN3 0.11 0.10 enet 11 0.10 1.4e-08 -5.7 -5.7 1.4e-08 0.86 0.05 0.95 FALSE
3 GTEx Adipose Subcutaneous CCAR2 0.15 0.14 enet 26 0.13 6.9e-11 -5.9 -5.8 8.8e-09 0.92 0.04 0.96 FALSE
4 GTEx Adipose Visceral Omentum BIN3 0.09 0.10 lasso 2 0.06 5.5e-04 -5.7 -5.8 6.0e-09 0.89 0.03 0.95 FALSE
5 GTEx Adipose Visceral Omentum CCAR2 0.22 0.03 lasso 3 0.01 1.0e-01 -6.1 -5.8 8.4e-09 0.89 0.05 0.70 FALSE
6 GTEx Artery Aorta BIN3 0.11 0.07 lasso 3 0.06 2.1e-04 -6.6 -6.5 7.2e-11 0.99 0.01 0.99 FALSE
7 GTEx Artery Tibial BIN3 0.13 0.09 lasso 2 0.08 1.0e-06 -6.6 -6.6 4.9e-11 1.00 0.00 1.00 FALSE
8 GTEx Breast Mammary Tissue (Male) BIN3 0.22 0.00 lasso 4 -0.01 6.5e-01 -5.3 -5.4 5.1e-08 0.80 0.05 0.48 FALSE
9 GTEx Breast Mammary Tissue (Female) BIN3 0.03 0.00 lasso 2 0.02 7.6e-02 -6.4 -6.3 3.4e-10 0.92 0.02 0.58 FALSE
10 GTEx Cells EBV-transformed lymphocytes CCAR2 0.20 0.05 lasso 3 0.03 3.1e-02 -6.1 -6.1 1.4e-09 0.93 0.05 0.83 FALSE
11 GTEx Cells Transformed fibroblasts BIN3 0.26 0.12 lasso 7 0.16 2.4e-12 -6.6 -6.1 1.2e-09 0.90 0.00 1.00 FALSE
12 GTEx Cells Transformed fibroblasts C8orf58 0.36 0.42 lasso 7 0.47 3.6e-39 -5.7 -5.9 2.8e-09 0.91 0.17 0.83 FALSE
13 GTEx Cells Transformed fibroblasts RP11-582J16.5 0.11 0.10 lasso 4 0.09 2.0e-07 -5.4 5.3 1.3e-07 -0.84 0.34 0.66 FALSE
14 GTEx Colon Transverse BIN3 0.17 0.12 lasso 1 0.09 4.8e-05 -6.3 -6.3 2.3e-10 0.96 0.01 0.98 FALSE
15 GTEx Esophagus Mucosa BIN3 0.13 0.09 lasso 3 0.10 5.4e-07 -6.3 -6.6 5.7e-11 0.97 0.00 1.00 FALSE
16 GTEx Esophagus Muscularis BIN3 0.10 0.01 lasso 3 0.01 9.3e-02 2.6 -5.6 2.8e-08 0.75 0.01 0.94 FALSE
17 GTEx Lung BIN3 0.21 0.12 enet 25 0.14 7.9e-11 -5.9 -6.5 7.1e-11 0.86 0.02 0.98 FALSE
18 GTEx Lung CCAR2 0.11 0.07 enet 11 0.08 2.0e-06 -6.4 -6.4 1.9e-10 0.96 0.02 0.98 FALSE
19 GTEx Muscle Skeletal CCAR2 0.06 0.02 enet 7 0.01 2.7e-02 -5.9 -6.2 5.7e-10 0.95 0.02 0.98 FALSE
20 GTEx Nerve Tibial CCAR2 0.09 0.08 lasso 4 0.08 3.7e-06 -6.1 -5.8 6.9e-09 0.91 0.06 0.94 FALSE
21 GTEx Nerve Tibial C8orf58 0.14 0.10 lasso 6 0.11 2.7e-08 -5.9 -6.2 4.5e-10 0.94 0.10 0.90 FALSE
22 GTEx Ovary BIN3 0.38 0.24 lasso 5 0.30 4.0e-08 -5.5 -5.4 7.1e-08 0.83 0.03 0.96 FALSE
23 GTEx Skin Not Sun Exposed Suprapubic BIN3 0.09 0.09 lasso 2 0.08 2.5e-05 -6.2 -6.3 3.0e-10 0.90 0.05 0.93 FALSE
24 GTEx Skin Not Sun Exposed Suprapubic CCAR2 0.11 0.08 lasso 4 0.05 8.8e-04 -5.5 -6.0 2.0e-09 0.87 0.05 0.95 FALSE
25 GTEx Skin Sun Exposed Lower leg BIN3 0.13 0.14 lasso 4 0.16 7.6e-13 -6.6 -6.4 1.6e-10 0.98 0.00 1.00 FALSE
26 GTEx Skin Sun Exposed Lower leg CCAR2 0.11 0.09 lasso 5 0.10 1.7e-08 -5.3 -5.7 1.1e-08 0.88 0.10 0.90 FALSE
27 GTEx Stomach BIN3 0.17 0.00 enet 9 0.02 3.4e-02 -6.6 -5.2 1.5e-07 0.88 0.01 0.96 FALSE
28 GTEx Stomach PIWIL2 0.17 0.06 lasso 7 0.04 4.0e-03 -4.5 6.0 1.6e-09 -0.28 0.14 0.28 FALSE
29 GTEx Testis POLR3D 0.21 0.11 enet 11 0.13 1.6e-06 -5.2 -5.4 5.6e-08 -0.01 0.80 0.17 FALSE
30 GTEx Thyroid BIN3 0.17 0.12 lasso 4 0.12 2.1e-09 -6.6 -6.6 4.6e-11 0.98 0.00 1.00 FALSE
31 GTEx Thyroid CCAR2 0.17 0.12 lasso 5 0.12 9.5e-10 -5.6 -6.0 1.5e-09 0.91 0.06 0.94 FALSE
32 GTEx Thyroid C8orf58 0.07 0.03 lasso 2 0.03 3.0e-03 -5.9 -5.9 3.8e-09 0.88 0.03 0.96 FALSE
33 GTEx Whole Blood C8orf58 0.05 0.03 lasso 4 0.02 5.5e-03 -6.4 -6.3 2.4e-10 0.96 0.02 0.94 FALSE
34 METSIM Adipose BIN3 0.07 0.06 enet 12 0.06 5.6e-09 -6.6 -5.4 5.6e-08 0.91 0.00 1.00 FALSE
35 METSIM Adipose C8orf58 0.04 0.02 enet 13 0.02 1.1e-03 -5.9 -6.4 2.0e-10 0.88 0.04 0.96 FALSE
36 ROSMAP Brain Pre-frontal Cortex BIN3 0.27 0.38 lasso 2 0.38 7.2e-52 -6.6 -6.6 4.2e-11 1.00 0.00 1.00 TRUE
37 ROSMAP Brain Pre-frontal Cortex CCAR2 0.11 0.08 lasso 6 0.07 1.8e-09 -5.7 5.8 6.6e-09 -0.91 0.15 0.85 FALSE
38 ROSMAP Brain Pre-frontal Cortex C8orf58 0.15 0.18 lasso 5 0.18 7.6e-23 -5.9 -6.2 5.4e-10 0.92 0.11 0.89 FALSE
39 ROSMAP Brain Pre-frontal Cortex CTD-3247F14.2 0.10 0.12 lasso 3 0.12 1.5e-14 -5.2 -5.7 1.2e-08 0.83 0.10 0.90 FALSE
40 The Cancer Genome Atlas Bladder Urothelial Carcinoma C8orf58 0.04 0.05 blup 69 0.04 1.7e-04 -5.9 -6.0 1.6e-09 0.92 0.04 0.94 FALSE
41 The Cancer Genome Atlas Breast Invasive Carcinoma C8orf58 0.04 0.04 blup 71 0.05 1.7e-10 -5.8 -5.9 3.8e-09 0.86 0.10 0.90 FALSE
42 The Cancer Genome Atlas Colon Adenocarcinoma C8orf58 0.11 0.03 blup 69 0.04 2.5e-03 -5.3 -6.0 2.4e-09 0.86 0.06 0.88 FALSE
43 The Cancer Genome Atlas Colon Adenocarcinoma FLJ14107 0.05 0.04 blup 66 0.04 1.8e-03 -5.9 -6.0 2.4e-09 0.91 0.04 0.65 FALSE
44 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma C8orf58 0.04 0.01 blup 69 0.02 2.9e-03 -4.3 -5.9 3.0e-09 0.88 0.06 0.84 FALSE
45 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma PIWIL2 0.05 0.05 blup 73 0.06 2.1e-07 -5.3 -5.8 8.6e-09 0.01 0.01 0.99 FALSE
46 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma C8orf58 0.04 0.03 blup 69 0.04 3.2e-05 -5.8 -5.8 6.5e-09 0.88 0.02 0.98 FALSE
47 The Cancer Genome Atlas Brain Lower Grade Glioma C8orf58 0.11 0.18 lasso 4 0.17 4.9e-19 -5.8 -5.9 4.2e-09 0.90 0.09 0.91 FALSE
48 The Cancer Genome Atlas Lung Adenocarcinoma BIN3 0.04 0.03 lasso 4 0.04 3.6e-05 -5.9 -6.1 1.4e-09 0.88 0.03 0.96 FALSE
49 The Cancer Genome Atlas Lung Adenocarcinoma C8orf58 0.05 0.06 lasso 3 0.05 2.1e-06 -5.9 -6.0 2.0e-09 0.92 0.04 0.96 FALSE
50 The Cancer Genome Atlas Lung Squamous Cell Carcinoma C8orf58 0.02 0.01 blup 69 0.02 4.9e-03 -5.6 -6.3 2.8e-10 0.94 0.01 0.92 FALSE
51 The Cancer Genome Atlas Lung Squamous Cell Carcinoma POLR3D 0.02 0.02 blup 39 0.01 1.1e-02 -5.3 -5.8 8.6e-09 -0.03 0.00 0.82 TRUE
52 The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma C8orf58 0.05 0.06 lasso 4 0.03 2.1e-03 -5.6 -6.0 2.2e-09 0.84 0.08 0.61 FALSE
53 The Cancer Genome Atlas Prostate Adenocarcinoma BIN3 0.02 0.01 blup 97 0.01 3.4e-02 -5.9 -5.7 1.2e-08 0.88 0.09 0.72 FALSE
54 The Cancer Genome Atlas Prostate Adenocarcinoma C8orf58 0.07 0.11 lasso 2 0.10 5.6e-11 -5.6 -5.8 7.9e-09 0.88 0.15 0.85 FALSE
55 The Cancer Genome Atlas Soft Tissue Sarcoma BIN3 0.05 0.02 blup 96 0.02 2.0e-02 -6.2 -5.8 6.1e-09 0.89 0.02 0.79 FALSE
56 The Cancer Genome Atlas Thyroid Carcinoma BIN3 0.07 0.04 lasso 5 0.05 2.5e-05 -6.3 -6.2 4.7e-10 0.95 0.02 0.98 FALSE
57 The Cancer Genome Atlas Thyroid Carcinoma C8orf58 0.06 0.09 blup 69 0.09 4.8e-09 -5.6 -6.3 2.3e-10 0.89 0.13 0.87 FALSE