[Hub]/) : Traits : Lung FVC : ← →

chr8:21,416,204-23,240,950

Best TWAS P=4.24e-11 · Best GWAS P=4.25e-11 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	PDLIM2	0.08	0.06	enet	11	0.06	8.9e-08	-5.7	5.5	4.1e-08	-0.88	0.10	0.90	FALSE
2	GTEx	Adipose Subcutaneous	BIN3	0.11	0.10	enet	11	0.10	1.4e-08	-5.7	-5.7	1.4e-08	0.86	0.05	0.95	FALSE
3	GTEx	Adipose Subcutaneous	CCAR2	0.15	0.14	enet	26	0.13	6.9e-11	-5.9	-5.8	8.8e-09	0.92	0.04	0.96	FALSE
4	GTEx	Adipose Visceral Omentum	BIN3	0.09	0.10	lasso	2	0.06	5.5e-04	-5.7	-5.8	6.0e-09	0.89	0.03	0.95	FALSE
5	GTEx	Adipose Visceral Omentum	CCAR2	0.22	0.03	lasso	3	0.01	1.0e-01	-6.1	-5.8	8.4e-09	0.89	0.05	0.70	FALSE
6	GTEx	Artery Aorta	BIN3	0.11	0.07	lasso	3	0.06	2.1e-04	-6.6	-6.5	7.2e-11	0.99	0.01	0.99	FALSE
7	GTEx	Artery Tibial	BIN3	0.13	0.09	lasso	2	0.08	1.0e-06	-6.6	-6.6	4.9e-11	1.00	0.00	1.00	FALSE
8	GTEx	Breast Mammary Tissue (Male)	BIN3	0.22	0.00	lasso	4	-0.01	6.5e-01	-5.3	-5.4	5.1e-08	0.80	0.05	0.48	FALSE
9	GTEx	Breast Mammary Tissue (Female)	BIN3	0.03	0.00	lasso	2	0.02	7.6e-02	-6.4	-6.3	3.4e-10	0.92	0.02	0.58	FALSE
10	GTEx	Cells EBV-transformed lymphocytes	CCAR2	0.20	0.05	lasso	3	0.03	3.1e-02	-6.1	-6.1	1.4e-09	0.93	0.05	0.83	FALSE
11	GTEx	Cells Transformed fibroblasts	BIN3	0.26	0.12	lasso	7	0.16	2.4e-12	-6.6	-6.1	1.2e-09	0.90	0.00	1.00	FALSE
12	GTEx	Cells Transformed fibroblasts	C8orf58	0.36	0.42	lasso	7	0.47	3.6e-39	-5.7	-5.9	2.8e-09	0.91	0.17	0.83	FALSE
13	GTEx	Cells Transformed fibroblasts	RP11-582J16.5	0.11	0.10	lasso	4	0.09	2.0e-07	-5.4	5.3	1.3e-07	-0.84	0.34	0.66	FALSE
14	GTEx	Colon Transverse	BIN3	0.17	0.12	lasso	1	0.09	4.8e-05	-6.3	-6.3	2.3e-10	0.96	0.01	0.98	FALSE
15	GTEx	Esophagus Mucosa	BIN3	0.13	0.09	lasso	3	0.10	5.4e-07	-6.3	-6.6	5.7e-11	0.97	0.00	1.00	FALSE
16	GTEx	Esophagus Muscularis	BIN3	0.10	0.01	lasso	3	0.01	9.3e-02	2.6	-5.6	2.8e-08	0.75	0.01	0.94	FALSE
17	GTEx	Lung	BIN3	0.21	0.12	enet	25	0.14	7.9e-11	-5.9	-6.5	7.1e-11	0.86	0.02	0.98	FALSE
18	GTEx	Lung	CCAR2	0.11	0.07	enet	11	0.08	2.0e-06	-6.4	-6.4	1.9e-10	0.96	0.02	0.98	FALSE
19	GTEx	Muscle Skeletal	CCAR2	0.06	0.02	enet	7	0.01	2.7e-02	-5.9	-6.2	5.7e-10	0.95	0.02	0.98	FALSE
20	GTEx	Nerve Tibial	CCAR2	0.09	0.08	lasso	4	0.08	3.7e-06	-6.1	-5.8	6.9e-09	0.91	0.06	0.94	FALSE
21	GTEx	Nerve Tibial	C8orf58	0.14	0.10	lasso	6	0.11	2.7e-08	-5.9	-6.2	4.5e-10	0.94	0.10	0.90	FALSE
22	GTEx	Ovary	BIN3	0.38	0.24	lasso	5	0.30	4.0e-08	-5.5	-5.4	7.1e-08	0.83	0.03	0.96	FALSE
23	GTEx	Skin Not Sun Exposed Suprapubic	BIN3	0.09	0.09	lasso	2	0.08	2.5e-05	-6.2	-6.3	3.0e-10	0.90	0.05	0.93	FALSE
24	GTEx	Skin Not Sun Exposed Suprapubic	CCAR2	0.11	0.08	lasso	4	0.05	8.8e-04	-5.5	-6.0	2.0e-09	0.87	0.05	0.95	FALSE
25	GTEx	Skin Sun Exposed Lower leg	BIN3	0.13	0.14	lasso	4	0.16	7.6e-13	-6.6	-6.4	1.6e-10	0.98	0.00	1.00	FALSE
26	GTEx	Skin Sun Exposed Lower leg	CCAR2	0.11	0.09	lasso	5	0.10	1.7e-08	-5.3	-5.7	1.1e-08	0.88	0.10	0.90	FALSE
27	GTEx	Stomach	BIN3	0.17	0.00	enet	9	0.02	3.4e-02	-6.6	-5.2	1.5e-07	0.88	0.01	0.96	FALSE
28	GTEx	Stomach	PIWIL2	0.17	0.06	lasso	7	0.04	4.0e-03	-4.5	6.0	1.6e-09	-0.28	0.14	0.28	FALSE
29	GTEx	Testis	POLR3D	0.21	0.11	enet	11	0.13	1.6e-06	-5.2	-5.4	5.6e-08	-0.01	0.80	0.17	FALSE
30	GTEx	Thyroid	BIN3	0.17	0.12	lasso	4	0.12	2.1e-09	-6.6	-6.6	4.6e-11	0.98	0.00	1.00	FALSE
31	GTEx	Thyroid	CCAR2	0.17	0.12	lasso	5	0.12	9.5e-10	-5.6	-6.0	1.5e-09	0.91	0.06	0.94	FALSE
32	GTEx	Thyroid	C8orf58	0.07	0.03	lasso	2	0.03	3.0e-03	-5.9	-5.9	3.8e-09	0.88	0.03	0.96	FALSE
33	GTEx	Whole Blood	C8orf58	0.05	0.03	lasso	4	0.02	5.5e-03	-6.4	-6.3	2.4e-10	0.96	0.02	0.94	FALSE
34	METSIM	Adipose	BIN3	0.07	0.06	enet	12	0.06	5.6e-09	-6.6	-5.4	5.6e-08	0.91	0.00	1.00	FALSE
35	METSIM	Adipose	C8orf58	0.04	0.02	enet	13	0.02	1.1e-03	-5.9	-6.4	2.0e-10	0.88	0.04	0.96	FALSE
36	ROSMAP	Brain Pre-frontal Cortex	BIN3	0.27	0.38	lasso	2	0.38	7.2e-52	-6.6	-6.6	4.2e-11	1.00	0.00	1.00	TRUE
37	ROSMAP	Brain Pre-frontal Cortex	CCAR2	0.11	0.08	lasso	6	0.07	1.8e-09	-5.7	5.8	6.6e-09	-0.91	0.15	0.85	FALSE
38	ROSMAP	Brain Pre-frontal Cortex	C8orf58	0.15	0.18	lasso	5	0.18	7.6e-23	-5.9	-6.2	5.4e-10	0.92	0.11	0.89	FALSE
39	ROSMAP	Brain Pre-frontal Cortex	CTD-3247F14.2	0.10	0.12	lasso	3	0.12	1.5e-14	-5.2	-5.7	1.2e-08	0.83	0.10	0.90	FALSE
40	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	C8orf58	0.04	0.05	blup	69	0.04	1.7e-04	-5.9	-6.0	1.6e-09	0.92	0.04	0.94	FALSE
41	The Cancer Genome Atlas	Breast Invasive Carcinoma	C8orf58	0.04	0.04	blup	71	0.05	1.7e-10	-5.8	-5.9	3.8e-09	0.86	0.10	0.90	FALSE
42	The Cancer Genome Atlas	Colon Adenocarcinoma	C8orf58	0.11	0.03	blup	69	0.04	2.5e-03	-5.3	-6.0	2.4e-09	0.86	0.06	0.88	FALSE
43	The Cancer Genome Atlas	Colon Adenocarcinoma	FLJ14107	0.05	0.04	blup	66	0.04	1.8e-03	-5.9	-6.0	2.4e-09	0.91	0.04	0.65	FALSE
44	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	C8orf58	0.04	0.01	blup	69	0.02	2.9e-03	-4.3	-5.9	3.0e-09	0.88	0.06	0.84	FALSE
45	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	PIWIL2	0.05	0.05	blup	73	0.06	2.1e-07	-5.3	-5.8	8.6e-09	0.01	0.01	0.99	FALSE
46	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	C8orf58	0.04	0.03	blup	69	0.04	3.2e-05	-5.8	-5.8	6.5e-09	0.88	0.02	0.98	FALSE
47	The Cancer Genome Atlas	Brain Lower Grade Glioma	C8orf58	0.11	0.18	lasso	4	0.17	4.9e-19	-5.8	-5.9	4.2e-09	0.90	0.09	0.91	FALSE
48	The Cancer Genome Atlas	Lung Adenocarcinoma	BIN3	0.04	0.03	lasso	4	0.04	3.6e-05	-5.9	-6.1	1.4e-09	0.88	0.03	0.96	FALSE
49	The Cancer Genome Atlas	Lung Adenocarcinoma	C8orf58	0.05	0.06	lasso	3	0.05	2.1e-06	-5.9	-6.0	2.0e-09	0.92	0.04	0.96	FALSE
50	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	C8orf58	0.02	0.01	blup	69	0.02	4.9e-03	-5.6	-6.3	2.8e-10	0.94	0.01	0.92	FALSE
51	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	POLR3D	0.02	0.02	blup	39	0.01	1.1e-02	-5.3	-5.8	8.6e-09	-0.03	0.00	0.82	TRUE
52	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	C8orf58	0.05	0.06	lasso	4	0.03	2.1e-03	-5.6	-6.0	2.2e-09	0.84	0.08	0.61	FALSE
53	The Cancer Genome Atlas	Prostate Adenocarcinoma	BIN3	0.02	0.01	blup	97	0.01	3.4e-02	-5.9	-5.7	1.2e-08	0.88	0.09	0.72	FALSE
54	The Cancer Genome Atlas	Prostate Adenocarcinoma	C8orf58	0.07	0.11	lasso	2	0.10	5.6e-11	-5.6	-5.8	7.9e-09	0.88	0.15	0.85	FALSE
55	The Cancer Genome Atlas	Soft Tissue Sarcoma	BIN3	0.05	0.02	blup	96	0.02	2.0e-02	-6.2	-5.8	6.1e-09	0.89	0.02	0.79	FALSE
56	The Cancer Genome Atlas	Thyroid Carcinoma	BIN3	0.07	0.04	lasso	5	0.05	2.5e-05	-6.3	-6.2	4.7e-10	0.95	0.02	0.98	FALSE
57	The Cancer Genome Atlas	Thyroid Carcinoma	C8orf58	0.06	0.09	blup	69	0.09	4.8e-09	-5.6	-6.3	2.3e-10	0.89	0.13	0.87	FALSE