Hub : Genes

POLR3D

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Testis 0.2140 0.0620 1.7e-04 0.110 NA 0.134 NA 0.123 1.4e-05 NA 1.6e-06 NA 4.1e-06
2 METSIM Adipose 0.1465 0.0326 2.5e-09 0.091 0.076 0.088 0.083 0.087 1.4e-13 1.6e-11 4.7e-13 1.8e-12 5.2e-13
3 ROSMAP Brain Pre-frontal Cortex 0.1749 0.0413 6.7e-09 0.100 0.078 0.082 0.088 0.104 9.3e-13 2.8e-10 9.4e-11 2.1e-11 3.0e-13
4 TCGA Cervical Squamous Cell Carcinoma 0.1000 0.0450 9.7e-04 0.092 0.090 0.089 NA 0.073 2.9e-05 3.4e-05 3.8e-05 NA 1.8e-04
5 TCGA Lung Adenocarcinoma 0.0399 0.0208 8.1e-03 -0.001 0.008 0.001 NA 0.004 3.9e-01 3.9e-02 2.2e-01 NA 1.0e-01
6 TCGA Lung Squamous Cell Carcinoma 0.0225 0.0128 8.6e-03 0.024 0.013 0.007 NA 0.006 8.2e-04 1.1e-02 4.2e-02 NA 6.0e-02
7 TCGA Prostate Adenocarcinoma 0.0362 0.0188 8.4e-03 0.017 0.011 0.024 NA 0.024 6.0e-03 2.1e-02 1.4e-03 NA 1.3e-03
8 TCGA Thyroid Carcinoma 0.0810 0.0330 2.4e-05 0.018 0.051 0.047 NA 0.041 6.1e-03 9.8e-06 2.3e-05 NA 7.3e-05

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8
Bipolar Disorder (2018) 0.2 0.2 0.9 1.0 -0.9 0.5 0.0 0.0 0.0 0.0 0.0
Bipolar Disorder or Schizophrenia 0.3 0.7 3.7 1.9 -1.0 1.1 0.0 0.0 0.0 0.2 0.0
Depressed Affect (Nagel 2018) 1.0 2.1 6.8 -1.8 1.0 -0.6 -0.4 -0.4 -2.6 -1.7 -1.5
Depression (Nagel 2018) 0.3 0.4 1.3 0.1 0.3 -0.5 -0.3 1.1 -0.4 -0.9 -0.8
Intelligence (Savage-Jansen 2018) 0.2 0.5 1.0 -0.7 1.0 -0.8 -0.8 -0.4 -0.9 0.2 0.4
Neuroticism (Nagel 2018) 1.0 2.3 8.2 -2.1 1.1 -1.4 -0.5 -0.5 -2.9 -0.9 -1.2
Schizophrenia (2018) 0.3 0.6 2.6 1.6 -0.3 0.9 0.3 0.4 1.0 -0.4 0.2
Schizophrenia vs Biploar Disorder 0.1 0.2 0.8 0.8 0.0 0.9 0.0 0.0 0.0 0.0 0.0
Worry (Nagel 2018) 0.4 0.9 2.6 -1.3 0.6 -1.0 -0.7 0.8 -1.6 -0.2 -0.6
Alzheimer’s Disease (in mother) 2.3 2.7 6.0 2.3 -1.1 0.8 1.1 0.2 2.4 2.2 1.5
Alzheimer’s Disease (in father) 0.4 0.4 1.4 0.4 -1.2 0.4 -0.1 0.5 0.7 -0.6 -0.8
Alzheimer’s Disease (including proxy) 2.2 3.1 6.9 2.4 -1.8 1.2 1.1 1.1 2.6 1.8 1.5
Crohns Disease (2017) 0.6 1.3 2.7 1.0 -0.2 1.3 1.3 1.6 0.9 1.1 0.9
Irritable Bowel Disease (IBD) 0.3 0.7 1.9 0.2 0.0 1.0 1.1 0.9 0.2 1.4 1.0
Ulcerative Colitis (UC) 0.4 0.7 1.7 -0.2 0.1 0.9 0.8 0.7 -0.3 1.3 1.3
Major Depression (MDD) 2.1 2.6 8.4 2.9 -1.7 2.5 0.0 0.0 0.0 1.8 0.0
Reaction Time 0.5 1.0 2.2 1.0 -0.9 0.8 1.4 -1.5 0.6 -0.2 0.9
Verbal and Numeric Reasoning (VNR) 0.1 0.3 0.6 -0.6 0.7 -0.5 -0.4 -0.3 -0.5 0.4 0.8
Breast Cancer 0.7 1.6 2.6 -0.7 1.6 -0.9 -1.6 -1.5 -1.3 -1.5 -0.8
Ovarian Cancer 0.3 0.4 1.2 0.8 0.6 0.1 -0.2 1.1 0.6 0.5 0.8
Prostate Cancer 1.4 2.0 4.2 -1.2 1.0 -2.1 -1.7 -0.9 -1.2 -0.9 -1.8
Age at First Birth 1.6 2.3 7.8 0.8 -0.5 1.3 1.0 2.8 1.4 1.4 1.8
Bipolar Disorder (2011) 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Body Mass Index (BMI) (2010) 0.1 0.1 0.4 -0.1 -0.3 -0.3 0.3 0.6 0.0 -0.5 0.3
Coronary Artery Disease (CAD) 0.2 0.3 1.2 1.0 -0.2 1.1 0.0 0.0 0.0 0.0 0.0
Crohns Disease (2012) 0.1 0.2 0.6 0.5 -0.8 0.8 0.0 0.0 0.0 0.0 0.0
Mean Putamen Volume 0.4 0.5 1.6 0.8 -1.3 0.7 0.5 0.1 0.4 -0.6 0.5
Fasting Glucose 0.7 0.8 2.1 -0.6 1.3 -0.4 -1.4 0.0 -1.3 -0.8 -0.1
HbA1C 0.3 0.4 1.2 -0.1 0.7 -0.4 -1.1 0.9 -0.2 -0.6 -0.2
HDL Cholesterol 0.2 0.3 1.3 0.2 0.6 0.0 -0.6 0.1 0.0 1.1 0.6
LDL Cholesterol 0.7 1.2 3.0 -1.7 0.1 -1.3 -0.9 -1.1 0.0 -1.0 -1.2
Lupus 2.0 3.0 3.8 -1.8 1.8 -1.7 -1.9 -1.7 -1.8 -1.1 -2.0
Neuroticism (2016) 0.1 0.2 0.8 -0.0 -0.4 0.3 0.4 0.4 -0.5 -0.9 -0.2
Primary Biliary Cirrhosis 0.4 0.6 1.3 -1.0 0.4 -0.4 0.2 -0.8 -1.1 -1.2 -0.8
Rheumatoid Arthritis 0.3 0.4 1.5 0.3 -0.1 0.6 0.5 -0.6 0.6 0.7 1.2
Schizophrenia (2014) 0.5 1.1 4.4 2.1 -0.5 0.8 0.6 0.7 1.2 -0.1 0.9
Triglycerides 0.6 1.0 2.0 -1.4 1.1 -1.4 -1.0 -0.3 0.0 -0.9 -0.7
Type 2 Diabetes (T2D) (2012) 0.1 0.1 0.4 -0.5 0.0 -0.6 0.0 0.0 0.0 0.0 0.0
Ulcerative Colitis 0.3 0.4 1.7 -1.0 0.7 0.1 0.0 0.0 0.0 1.3 0.0
Blood Eosinophil Count 1.3 9.9 18.0 4.0 -2.9 2.5 2.3 2.0 4.2 2.8 3.7
Blood Platelet Count 0.2 1.9 4.7 -1.9 -0.6 -1.1 -2.0 0.2 -0.8 -0.9 -2.2
Blood Red Count 0.1 0.9 3.1 -0.8 1.8 -0.7 -1.1 -0.7 -1.0 -0.0 -0.5
Blood White Count 0.2 1.8 6.6 0.5 -2.1 1.6 -0.4 0.4 0.2 -2.6 -0.7
Heel T-Score 0.1 1.1 3.8 -1.9 0.6 -0.9 -0.2 -0.1 -1.5 -0.7 -0.9
BMI 0.2 1.1 2.5 0.9 -0.8 1.6 0.9 1.5 1.1 -0.3 -0.3
Height 0.1 1.2 3.8 0.2 -1.7 0.6 1.9 0.7 -0.2 0.4 1.3
Waist Hip Ratio (WHR) 1.1 4.8 13.2 2.4 -3.6 3.0 2.1 -0.7 2.1 -1.1 0.8
Systolic Blood Pressure 0.3 1.5 6.0 -0.2 0.8 0.0 -2.5 -1.2 -0.3 -1.5 -1.3
Smoking Status 2.1 5.1 11.7 1.8 -3.3 2.5 3.4 1.7 1.2 0.5 2.0
Allergy or Eczema 0.4 1.0 4.1 0.4 -0.4 -1.4 -2.0 -0.6 0.5 -0.6 0.5
Cardiovascular Disease 0.2 0.8 2.1 0.1 0.1 0.3 -1.2 0.5 0.5 -1.4 -1.4
Hypothyroidism (self reported) 0.6 1.5 4.2 -0.8 1.5 -1.6 -1.1 -2.0 -0.6 0.7 0.0
Respiratory disease 0.7 1.6 4.2 -1.1 0.7 -2.0 -1.4 -2.0 -0.5 0.5 -0.8
Type 2 Diabetes (T2D) (2018) 1.6 3.0 6.2 2.1 -2.0 1.6 1.0 2.5 2.3 0.5 0.1
Lung FEV1/FVC ratio 0.4 1.9 3.9 -1.1 1.4 -0.3 -1.3 0.0 -1.8 -2.0 -1.7
Lung FVC 3.4 17.1 33.1 -5.4 2.8 -4.8 -3.2 -3.0 -5.8 -3.0 -3.8
Neuroticism 0.8 1.9 6.4 -1.8 1.2 -1.1 -0.6 -0.8 -2.5 -0.6 -1.3
Chronotype (morning person) 0.2 0.5 1.9 -0.8 0.6 -0.9 -1.4 -0.5 -0.3 -0.1 -0.4
Hair Pigment 0.1 1.7 4.8 -1.2 1.3 -1.5 -2.2 -1.0 -0.6 -0.4 -1.5
Tanning 0.1 0.9 1.9 0.0 -0.3 1.1 1.4 1.1 -0.2 1.3 1.0
Hand grip strength (left) 0.1 0.2 0.4 -0.5 -0.2 0.0 0.6 0.1 -0.7 0.2 0.6
Number of treatments/medications taken 0.6 1.1 4.0 -0.9 -0.5 -0.0 -1.0 0.8 -0.2 -2.0 -1.6
Average weekly spirits intake 0.4 0.5 1.1 -1.0 -0.3 -0.0 0.8 -0.2 -0.9 0.2 -1.0
Sensitivity / hurt feelings 0.2 0.3 1.4 -0.3 -0.5 -0.3 0.2 -0.1 -1.2 -0.8 -0.1
Frequency of depressed mood in last 2 weeks 0.8 1.1 2.3 -1.0 1.1 -0.4 -0.8 -0.2 -1.4 -1.5 -1.4
Hearing difficulty/problems: Yes 0.3 0.5 1.5 -0.8 1.2 -0.8 -0.1 -0.2 -0.9 0.3 -0.2
Relative age of first facial hair 0.4 0.9 2.7 0.8 -1.6 1.6 0.1 0.2 0.9 0.2 0.3
Other serious medical condition/disability diagnosed by doctor 2.3 3.0 4.3 -1.8 1.2 -1.8 -1.9 -1.3 -1.4 -2.0 -2.1
Ever used hormone-replacement therapy (HRT) 2.9 3.7 7.1 2.6 -1.1 1.2 0.2 1.6 2.5 1.9 2.7
Ever had hysterectomy (womb removed) 0.2 0.2 0.5 0.3 -0.7 -0.6 0.2 -0.2 0.4 -0.4 0.0
Systolic blood pressure, automated reading 0.4 1.1 3.6 0.3 0.0 0.3 -1.9 -0.1 -0.2 -1.8 -1.3
Eye problems/disorders: Diabetes related eye disease 1.6 1.7 6.0 -0.8 0.1 -0.7 -0.7 -1.1 -0.5 -2.5 -2.2
Angina 0.9 1.2 3.7 0.7 -1.9 1.3 1.4 0.3 0.8 -0.2 1.0
Medication for hormone replacement therapy 0.2 0.3 1.1 0.3 0.2 -0.5 -0.4 -0.2 0.2 -1.0 -0.5
Vitamin and mineral supplements 0.5 0.7 1.4 -0.3 -1.2 -1.0 0.7 -1.1 -0.4 -0.4 -1.2
Supplements: Zinc 4.1 4.4 9.6 -2.2 3.1 -2.2 -2.6 -1.2 -2.2 -0.7 -1.7
Medication: Co-codamol 3.7 4.2 6.1 -2.0 1.6 -1.8 -2.4 -2.0 -1.6 -2.5 -2.4
Medication: Metformin 1.7 2.4 5.5 1.9 -1.8 1.2 0.5 2.3 2.4 0.6 -0.2
Diabetes (father) 0.8 1.0 3.1 0.4 0.3 -0.9 -1.0 -1.8 0.4 -0.8 -1.4
Diabetes (mother) 0.2 0.3 1.0 -0.4 0.2 -0.4 0.6 -1.0 -0.6 0.3 -0.2
Severe depression (siblings) 1.2 1.4 4.0 -1.0 0.9 -1.0 -1.9 2.0 -0.4 0.7 -0.3
Pack years adult smoking proportion 3.1 4.7 8.5 2.0 -2.1 2.9 2.6 1.8 2.1 1.6 1.7
Impedance of leg (right) 0.0 0.1 0.3 0.1 0.1 0.2 -0.2 -0.2 -0.2 0.5 0.3
Leg fat-free mass (left) 0.5 2.5 6.1 1.0 -1.8 1.9 1.7 2.5 1.5 0.3 0.4
Trunk fat percentage 0.1 0.3 1.2 0.4 0.5 -0.1 -0.2 0.7 0.7 -0.3 -1.1
Hand grip strength (right) 0.2 0.5 1.5 -0.1 -1.0 0.7 0.8 0.5 0.2 0.3 1.2
Townsend deprivation index at recruitment 2.2 3.0 7.5 2.7 -2.0 2.1 1.3 0.1 2.1 0.1 1.5
Current tobacco smoking 1.2 1.9 5.3 1.3 -2.3 1.3 1.9 0.2 1.1 0.6 1.1
Average weekly fortified wine intake 0.1 0.1 0.4 -0.5 -0.7 -0.1 -0.1 0.3 0.0 0.1 -0.6
Maternal smoking around birth 3.1 4.4 10.1 -2.3 1.1 -2.0 -1.2 -1.9 -2.2 -2.1 -3.2
Fed-up feelings 0.8 1.5 3.0 -0.7 1.5 -0.5 -0.7 -1.3 -1.4 -1.7 -1.2
Frequency of unenthusiasm / disinterest in last 2 weeks 0.6 0.8 2.0 0.9 -0.7 1.3 0.7 1.4 0.7 -0.7 -0.0
Relative age voice broke 0.6 0.9 1.9 0.8 -1.4 0.6 0.4 0.4 1.4 1.1 0.8
Taking other prescription medications 1.1 1.7 4.6 -1.3 0.9 -2.1 -2.0 0.7 -0.4 -0.5 -1.1
Age when periods started (menarche) 2.9 7.0 12.3 3.0 -3.2 3.5 3.1 1.2 2.5 1.3 2.4
Bilateral oophorectomy (both ovaries removed) 0.8 0.9 4.2 0.5 -2.0 0.8 1.0 0.9 0.8 -0.3 -0.1
Heel bone mineral density (BMD) T-score, automated (left) 0.1 0.2 0.6 -0.8 0.1 -0.0 -0.8 0.0 -0.6 -0.4 -0.4
Tinnitus: Yes, but not now, but have in the past 0.7 0.8 3.3 0.4 0.6 -0.4 -0.8 1.2 0.6 1.8 0.0
Qualifications: CSEs or equivalent 0.2 0.3 0.7 -0.2 0.3 -0.6 0.3 -0.7 -0.9 0.0 -0.5
Serious illness, injury or assault to yourself 0.4 0.5 1.1 -0.7 0.1 -0.5 -0.4 -1.1 -0.5 -0.5 -1.1
High blood pressure 0.4 1.0 2.3 1.0 -0.7 1.2 -0.4 1.4 1.5 -0.7 -0.8
Hayfever, allergic rhinitis or eczema 0.3 0.6 1.1 0.8 -0.4 -0.8 -1.0 -1.1 0.7 -0.1 0.9
Multivitamins +/- minerals 2.2 2.8 5.6 1.5 -0.9 2.4 1.6 1.5 1.3 1.6 2.3
Stomach or abdominal pain in last month 1.0 1.3 3.0 -1.1 0.6 -0.9 -0.7 -1.7 -1.1 -1.5 -1.0
Supplements: Glucosamine 0.4 0.5 1.5 -0.7 0.7 -0.2 -1.2 -0.5 -0.8 -0.8 0.1
Diverticular disease/diverticulitis (self-reported) 0.6 0.7 1.9 -0.3 -0.1 -0.9 -1.0 -0.5 -0.4 -1.2 -1.4
Medication: Atenolol 0.2 0.3 0.6 0.5 -0.4 0.7 0.1 -0.8 0.1 -0.7 0.7
Medication: Levothyroxine sodium 1.2 2.0 4.9 -1.7 1.5 -2.2 -1.6 -1.0 -1.0 0.6 -1.0
Sitting height 0.1 0.6 1.4 0.0 -0.8 0.1 1.0 0.9 0.3 0.8 1.2
Chronic bronchitis/emphysema (father) 0.2 0.3 0.7 -0.5 -0.1 0.8 0.8 -0.1 -0.5 -0.5 0.0
High blood pressure (mother) 0.3 0.4 1.4 0.2 -1.2 0.4 0.8 0.7 0.5 0.7 0.0
Body mass index (BMI) 0.1 0.4 1.1 0.5 -0.3 0.7 0.3 1.1 0.8 -0.2 -0.7
Impedance of leg (left) 0.2 0.8 1.6 -0.8 0.8 -0.8 -0.9 -1.3 -1.1 -0.4 -0.5
Leg predicted mass (left) 0.5 2.5 6.4 1.0 -1.9 1.9 1.8 2.5 1.5 0.3 0.5
Trunk fat mass 0.1 0.6 2.0 0.7 -0.4 0.7 0.5 1.4 1.0 0.0 -0.6
Waist circumference 0.6 2.2 4.2 1.6 -2.1 2.0 1.9 0.9 1.7 -0.2 0.2
Number of incorrect matches in round 0.6 0.9 2.0 1.1 -0.6 0.5 0.7 1.4 1.1 1.3 0.6
Past tobacco smoking 0.7 1.2 3.1 -0.8 1.0 -1.0 -1.2 -1.8 -0.5 -0.7 -1.3
Alcohol usually taken with meals 0.2 0.4 0.9 -0.4 0.8 -0.6 -0.9 0.3 -0.5 -0.1 0.7
Nervous feelings 0.2 0.4 0.9 -0.8 -0.1 -0.9 0.5 -0.8 -0.8 0.2 -0.7
Frequency of tenseness / restlessness in last 2 weeks 0.9 1.4 5.7 0.8 -0.5 1.5 -0.2 2.4 0.9 0.9 0.9
Hearing difficulty/problems with background noise 0.2 0.4 0.7 -0.8 0.6 -0.5 -0.8 -0.1 -0.8 -0.4 -0.4
Hair/balding pattern: Pattern 2 1.0 1.3 3.8 1.3 -0.4 1.3 -0.0 1.9 1.5 0.4 0.3
Had menopause 0.0 0.1 0.2 -0.1 0.1 0.2 -0.1 -0.3 -0.4 -0.2 -0.2
Had other major operations 0.9 1.1 4.3 0.3 0.7 -1.2 -2.1 -1.3 0.6 0.5 -0.6
Forced vital capacity (FVC) 0.4 1.5 5.8 -2.2 -0.2 -0.7 0.6 -0.2 -2.4 -0.3 -0.5
Heel bone mineral density (BMD) T-score, automated (right) 0.0 0.1 0.2 -0.2 -0.2 0.3 0.1 -0.1 -0.5 -0.4 -0.1
Ever unenthusiastic/disinterested for a whole week 1.2 1.4 3.5 1.2 -1.2 1.9 -0.0 1.2 1.4 0.3 1.1
Qualifications: None of the above 0.8 1.6 4.6 -0.9 0.9 -0.7 -1.6 -2.2 -0.8 -1.1 -1.4
Financial difficulties in last 2 years 1.8 2.4 7.2 -0.7 2.7 -1.6 -2.6 -1.0 -0.3 0.1 -1.0
Mouth/teeth dental problems 1.0 1.5 3.0 -1.7 1.4 -1.3 -1.3 0.5 -1.1 0.2 -1.4
Heart attack 1.1 1.5 3.4 1.6 -1.3 1.8 0.3 0.3 1.5 -0.9 1.0
Allergy 0.3 0.8 2.9 -0.2 -0.3 1.4 1.7 0.9 -0.5 0.1 -0.6
Pain all over the body in last month 0.3 0.3 1.7 -0.3 1.3 -0.6 -0.1 0.4 -0.1 0.4 -0.3
Diabetes (self-reported) 0.8 1.3 4.1 1.2 -0.7 1.0 0.3 2.0 1.7 0.0 -0.1
Hayfever/allergic rhinitis (self-reported) 0.3 0.4 1.1 -0.2 0.5 -0.9 -0.6 -1.0 -0.6 -0.3 -0.3
Medication: Ramipril 1.2 1.5 2.8 1.4 -0.8 1.4 1.7 1.0 1.3 0.9 1.2
Medication: Simvastatin 0.3 0.4 1.6 0.4 -1.3 0.1 0.9 0.3 0.7 0.2 0.2
Fluid intelligence score 0.7 1.4 4.1 -1.2 2.0 -1.2 -1.5 0.5 -1.2 -0.2 0.0
Illnesses of siblings 1.3 1.8 3.2 -1.3 1.8 -1.1 -1.3 -1.1 -1.7 -1.3 -0.9
Neuroticism score 0.6 1.2 4.6 -1.5 0.9 -0.8 -0.1 -0.6 -2.1 -0.4 -0.9
Weight 0.3 1.5 3.4 0.8 -1.5 1.5 1.4 1.9 1.1 -0.2 -0.1
Impedance of arm (right) 0.3 1.3 3.8 -0.2 1.5 -1.9 -0.6 -1.7 -0.5 0.5 -0.6
Arm fat percentage (right) 0.1 0.3 0.8 0.4 0.7 -0.4 0.0 0.5 0.6 0.3 -0.9
Trunk fat-free mass 0.8 4.8 9.8 0.8 -3.1 3.0 2.9 2.8 1.0 0.4 1.1
Hip circumference 0.4 1.6 4.2 1.3 -1.0 1.1 1.6 2.0 1.4 0.5 0.6
Time employed in main current job 0.7 0.8 1.4 -1.0 1.1 -0.6 -0.3 1.1 -1.2 0.1 -1.1
Alcohol intake versus 10 years previously 0.2 0.3 0.7 -0.8 0.1 -0.5 0.0 0.5 -0.5 0.4 -0.7
Father’s age at death 0.2 0.3 1.1 -0.0 -0.5 -0.3 -0.1 -0.7 -0.4 -1.0 -0.2
Worrier / anxious feelings 0.2 0.3 1.0 -0.2 -0.1 -1.0 -0.2 0.8 -1.0 0.1 -0.1
Frequency of tiredness / lethargy in last 2 weeks 0.4 0.7 2.5 -0.3 1.0 -0.3 -0.6 -0.1 -0.6 -1.6 -1.2
Falls in the last year 0.4 0.5 1.3 -0.8 0.1 -0.4 0.0 -1.2 -0.9 -0.8 -0.8
Hair/balding pattern: Pattern 3 0.4 0.6 3.7 0.2 -0.1 0.2 0.6 -1.9 0.3 0.5 0.6
Number of live births 0.5 0.7 3.3 -0.3 -0.3 -0.1 -0.1 -0.5 -0.5 -1.1 -1.8
Forced expiratory volume in 1-second (FEV1) 0.6 1.9 7.4 -2.3 0.1 -0.5 0.5 -0.8 -2.7 -0.7 -1.1
Pulse rate 0.1 0.1 0.4 0.3 0.2 -0.1 -0.3 0.3 0.6 0.0 -0.6
Happiness 0.1 0.2 0.5 0.0 0.6 0.4 0.7 -0.3 -0.4 0.1 -0.1
Noisy workplace 0.6 0.7 2.1 0.5 -0.8 0.8 1.4 0.6 0.8 0.7 0.7
Qualifications: A levels/AS levels or equivalent 0.1 0.3 1.8 0.2 0.4 0.1 0.4 0.3 -0.1 0.4 1.4
Serious illness, injury or assault of a close relative in last 2 years 0.4 0.5 1.1 1.1 -0.7 0.6 0.6 0.2 0.9 0.3 0.7
Mouth/teeth dental problems: Dentures 0.9 1.6 2.7 1.6 -1.7 1.1 1.4 0.7 1.1 0.4 1.4
Asthma 0.8 1.6 3.6 -1.3 0.6 -1.9 -1.9 -1.2 -0.7 -0.3 -1.5
Medication: Ibuprofen (e.g. Nurofen) 1.3 1.6 5.9 -0.4 -0.6 0.6 1.5 1.7 0.1 2.4 0.7
Medication: Cholesterol lowering 0.6 0.9 2.2 0.8 -1.5 0.5 0.5 1.3 1.3 -0.4 -0.2
Depression (self-reported) 0.1 0.1 0.6 -0.2 0.2 -0.3 0.0 -0.8 0.3 -0.1 -0.2
Medication: Lansoprazole 2.7 3.1 8.1 -2.1 -0.5 -2.1 -0.6 -1.0 -1.8 -1.7 -2.8
Prospective memory result 0.2 0.2 0.7 0.4 -0.3 0.2 0.9 0.5 0.1 0.5 0.1
Lung cancer (father) 1.0 1.1 3.4 -0.6 0.3 -1.4 -1.1 -1.8 -0.3 -0.1 -1.4
Illnesses of mother 0.6 0.8 2.2 -0.9 1.1 -0.8 -1.5 -0.1 -0.6 -0.9 -0.5
Forced expiratory volume in 1-second (FEV1), Best measure 1.1 3.4 11.1 -2.7 0.3 -0.9 0.0 -1.4 -3.3 -1.9 -1.7
Pulse wave Arterial Stiffness index 5.6 6.5 9.0 2.7 -2.2 2.5 2.9 2.5 2.7 1.6 3.0
Impedance of arm (left) 0.2 1.1 3.6 -0.3 1.5 -1.9 -0.7 -1.4 -0.6 0.3 -0.4
Arm fat mass (right) 0.1 0.6 1.6 0.8 -0.3 0.6 0.5 1.3 1.2 0.2 -0.4
Trunk predicted mass 0.8 4.6 9.3 0.8 -3.1 2.9 2.9 2.7 1.0 0.4 1.2
Standing height 0.3 2.7 7.0 0.4 -2.6 1.6 2.4 2.0 0.5 0.3 1.4
Length of working week for main job 0.8 0.9 2.7 -1.7 0.4 -0.6 -1.1 0.4 -1.7 -0.1 -0.2
Exposure to tobacco smoke at home 0.3 0.3 0.7 0.2 0.5 -0.5 -0.9 0.8 0.0 -0.6 -0.5
Breastfed as a baby 0.6 0.7 1.9 -1.3 -0.1 -0.2 0.3 0.8 -1.2 -0.4 -1.4
Tense / ‘highly strung’ 0.4 0.6 1.4 -0.9 0.7 -0.4 -0.5 -0.1 -1.2 -1.2 -0.5
Seen doctor (GP) for nerves, anxiety, tension or depression 0.5 0.7 2.5 -0.2 1.6 -1.1 -1.0 -0.8 -0.2 0.2 -0.4
Hair/balding pattern: Pattern 4 0.4 0.9 2.7 -1.1 0.3 -0.7 -0.4 -0.0 -1.2 -1.6 -1.0
Birth weight of first child 0.1 0.1 0.5 0.0 0.7 -0.1 -0.5 0.2 0.2 -0.2 0.1
Peak expiratory flow (PEF) 1.4 3.2 9.1 -2.9 1.1 -1.6 -0.5 -1.2 -3.0 -0.5 -1.6
Pulse wave reflection index 1.7 2.1 4.8 1.3 -1.3 1.7 2.2 1.5 1.3 0.8 1.1
Ever highly irritable/argumentative for 2 days 3.2 3.8 9.6 1.4 -2.4 3.1 2.1 1.9 1.9 0.2 1.1
Loud music exposure frequency 0.2 0.3 1.2 -0.1 -0.1 0.3 0.1 -0.5 0.2 1.1 0.7
Qualifications: O levels/GCSEs or equivalent 0.5 0.7 1.2 0.5 -0.3 1.1 1.0 0.9 0.7 0.9 1.0
Mouth/teeth dental problems: Bleeding gums 0.1 0.2 0.6 0.3 0.2 -0.0 -0.5 -0.8 -0.1 -0.1 -0.6
Blood clot in the leg (DVT) 0.5 0.6 2.7 0.4 -0.6 0.5 -0.3 1.6 1.1 0.2 0.5
Medication: Paracetamol 0.6 1.1 4.4 -1.0 -0.0 -0.6 -0.3 -0.5 -1.1 -1.1 -2.1
Headache pain in last month 0.4 0.7 1.7 -1.0 1.3 -0.6 -0.4 -0.8 -0.5 -0.1 -1.1
Medication for cholesterol, blood pressure or diabetes 0.2 0.4 1.3 -0.2 1.1 -0.3 -0.7 -0.6 -0.3 0.6 0.5
Glaucoma (self-reported) 1.4 1.6 3.3 -0.7 1.6 -1.8 -1.7 -1.2 -1.1 -0.7 -0.6
Gout (self-reported) 0.5 0.7 1.6 -0.2 -0.9 0.9 1.2 1.3 -0.3 0.2 0.6
Hypothyroidism/myxoedema (self-reported) 0.7 1.3 2.7 -1.1 1.4 -1.6 -1.5 -1.1 -0.6 0.7 -0.7
Medication: Amlodipine 0.6 0.9 1.9 0.7 -1.4 1.1 0.6 1.2 0.8 -0.8 0.3
Medication: Ventolin 100micrograms inhaler 0.8 1.1 1.8 1.0 -1.3 0.7 1.2 0.6 1.2 1.1 0.9
Birth weight 0.3 0.7 3.0 0.4 0.2 1.2 0.8 0.1 0.3 0.2 1.7
Chronic bronchitis/emphysema (mother) 1.0 1.1 4.1 0.2 -0.1 -1.0 -0.3 -2.0 -0.3 -1.5 -1.2
High blood pressure (siblings) 0.5 0.7 2.9 0.5 -1.7 0.9 0.8 0.3 0.6 -0.0 0.0
Forced vital capacity (FVC), Best measure 0.8 2.8 8.9 -2.6 0.1 -1.2 -0.0 -1.3 -3.0 -1.5 -1.1
Body fat percentage 0.1 0.4 1.5 0.4 0.4 0.0 -0.2 1.0 0.7 -0.2 -1.2
Leg fat percentage (right) 0.2 0.9 2.7 1.0 -0.4 1.1 0.4 1.6 1.3 0.4 -0.4
Arm fat-free mass (right) 0.6 3.2 7.6 0.5 -2.4 2.5 2.0 2.8 1.1 -0.0 0.7
Exposure to tobacco smoke outside home 0.4 0.5 2.0 0.5 -0.1 0.3 -0.6 0.7 1.0 1.4 0.3
Comparative body size at age 10 0.9 2.6 4.3 -2.0 2.0 -1.8 -2.1 -1.1 -1.8 -0.4 -0.2
Number of full brothers 0.8 1.0 4.3 -0.4 0.7 -0.3 -1.1 1.2 0.6 2.1 0.5
Worry too long after embarrassment 0.5 0.9 2.7 -1.5 0.2 -0.6 0.7 -0.4 -1.6 0.3 -0.9
Seen a psychiatrist for nerves, anxiety, tension or depression 0.1 0.1 0.4 0.3 -0.6 0.2 -0.4 -0.2 0.5 -0.4 0.2
Wheeze or whistling in the chest in last year 0.4 0.7 2.2 1.3 -0.5 0.2 -0.9 -0.3 1.5 -0.4 0.4
Number of children fathered 0.6 0.6 1.9 0.5 0.9 -0.2 1.4 0.4 0.0 0.8 1.1
Reason for reducing amount of alcohol drunk: Health precaution 1.3 1.5 5.2 -0.7 0.2 -0.4 -1.5 0.7 -0.0 -2.3 -1.9
Age at first live birth 0.5 0.9 3.5 0.3 0.4 -0.1 0.4 1.6 0.2 1.9 1.0
Pulse wave peak to peak time 4.4 5.2 7.4 -2.4 1.9 -2.3 -2.7 -2.1 -2.3 -1.5 -2.7
Health satisfaction 0.9 1.1 3.4 0.1 -1.4 0.7 0.3 -0.9 -0.0 -1.8 -1.5
Shortness of breath walking on level ground 1.5 1.8 6.2 0.6 -2.5 1.8 2.0 0.3 0.2 -0.9 -0.2
Qualifications: College or University degree 0.9 2.9 6.5 1.4 -2.1 1.3 1.4 1.8 1.3 1.4 2.6
Eye problems/disorders: None of the above 4.9 5.7 8.3 2.3 -2.0 2.9 2.7 1.9 2.1 2.6 2.3
Mouth/teeth dental problems: Loose teeth 0.2 0.2 0.7 -0.1 0.3 -0.6 0.1 -0.8 0.1 -0.4 -0.4
Emphysema/chronic bronchitis 1.3 1.5 3.3 1.1 -0.3 0.3 0.7 0.2 1.8 1.8 1.8
Medication for pain relief, constipation, heartburn 0.3 0.6 1.6 1.1 -0.4 0.3 0.4 -1.1 0.5 0.0 1.3
Neck or shoulder pain in last month 5.0 7.1 11.0 -3.0 2.6 -2.5 -2.4 -2.4 -3.3 -2.3 -2.7
Medication: Blood pressure 0.1 0.3 0.7 -0.0 -0.6 0.4 0.5 0.6 0.2 -0.5 -0.8
Angina (self-reported) 0.7 1.0 3.0 0.5 -1.7 1.3 1.2 -0.1 0.6 -0.6 0.8
Migraine (self-reported) 0.2 0.2 1.1 0.1 0.3 0.2 0.7 0.3 -0.1 -0.2 1.0
Medication: Ibuprofen 1.5 1.8 4.8 -0.0 -1.2 1.0 1.6 2.0 0.5 2.2 0.7
Medication: Allopurinol 0.5 0.7 2.8 -1.1 -0.1 0.3 0.7 1.7 -1.0 -0.2 -0.2
Medication: Omeprazole 3.0 3.6 7.6 -1.9 1.5 -1.9 -2.2 -0.5 -1.8 -2.8 -1.9
Medication: Seretide 50 evohaler 1.4 1.6 3.0 1.5 -0.8 0.7 1.7 -0.6 1.6 1.6 1.0
Mean time to correctly identify matches 0.6 1.1 2.0 1.3 -1.4 0.9 1.4 -0.9 0.7 -0.8 0.6
Heart disease (mother) 3.4 4.1 7.4 -2.7 1.8 -2.3 -2.1 -0.4 -2.4 -2.1 -1.6
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.4 1.6 7.6 0.4 0.3 0.3 1.3 2.8 0.6 1.3 1.2
Whole body fat mass 0.1 0.5 1.8 0.5 -0.3 0.5 0.3 1.3 1.0 -0.1 -0.9
Leg fat mass (right) 0.3 1.1 3.6 0.9 -0.6 1.1 0.7 1.9 1.4 0.3 -0.4
Arm predicted mass (right) 0.6 3.0 6.7 0.6 -2.3 2.4 2.0 2.6 1.0 0.2 0.8
Pulse rate, automated reading 0.9 3.0 5.9 -1.2 1.9 -2.4 -2.4 -1.4 -0.8 -1.0 -1.8
Alcohol intake frequency. 0.4 1.0 2.3 1.3 -1.1 0.6 1.1 0.2 1.5 1.2 0.3
Comparative height size at age 10 0.1 0.8 2.4 -0.7 -1.6 0.3 1.3 1.1 -0.3 -0.9 0.1
Number of full sisters 0.7 0.9 2.6 1.2 -0.7 0.8 1.6 -0.3 0.8 0.7 1.0
Suffer from ‘nerves’ 0.2 0.3 1.2 -0.6 0.2 -0.2 0.4 0.2 -0.4 1.1 0.4
Overall health rating 0.4 0.9 2.7 1.3 -1.1 1.0 0.7 -0.1 1.7 -0.3 -0.3
Chest pain or discomfort 1.5 2.1 4.1 -1.2 2.0 -1.5 -1.0 -1.5 -1.8 -1.5 -0.5
Had major operations 1.1 1.3 5.0 -1.5 -0.4 -0.2 -0.0 -0.9 -1.3 -2.2 -0.9
Age at last live birth 0.7 1.0 4.2 0.0 0.2 -0.2 -0.2 2.0 0.3 2.0 0.3
Family relationship satisfaction 0.3 0.4 0.9 1.0 -0.4 0.8 0.5 0.5 0.7 -0.1 0.1
Leg pain on walking 5.1 6.4 11.5 -3.3 1.4 -2.2 -1.9 -1.0 -3.1 -2.7 -3.4
Qualifications: NVQ or HND or HNC or equivalent 0.8 0.9 2.8 1.3 -0.4 0.6 0.8 0.4 1.1 0.8 1.7
Commuting to job workplace: Car/motor vehicle 0.7 0.8 1.4 -0.6 1.2 -1.1 -0.9 -1.1 -0.0 -0.2 -0.9
Illness, injury, bereavement, stress in last 2 years 1.1 1.3 3.6 0.3 -1.9 1.7 1.5 1.0 -0.0 -0.3 0.7
Medication: Aspirin 0.7 0.9 2.3 0.8 -1.1 1.5 1.3 1.0 0.6 -0.0 0.5
Supplements: Vitamin C 1.0 1.2 2.5 -1.2 1.6 -0.7 -1.5 0.7 -0.9 -1.0 -0.7
Knee pain experienced in last month 4.2 6.5 8.6 -2.7 2.2 -2.7 -2.5 -2.7 -2.9 -2.1 -2.5
Hypertension (Self-reported) 0.3 0.9 2.2 0.6 -0.4 0.7 -0.8 0.9 0.8 -1.5 -1.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 4.2 4.9 7.9 -2.2 1.9 -2.8 -2.4 -0.7 -2.2 -2.2 -2.5
Illnesses of father: Heart disease 0.3 0.4 1.1 0.3 0.4 0.2 0.5 -1.0 -0.5 0.5 1.0
Illnesses of siblings: Diabetes 0.5 0.6 2.9 1.0 -1.7 -0.0 0.6 0.5 0.7 0.0 -0.5
Smoking status: Previous 0.8 1.2 2.9 0.7 -0.8 1.3 1.4 1.7 0.5 0.6 1.1
Forced expiratory volume in 1-second (FEV1), predicted 0.1 0.3 0.8 0.4 -0.9 -0.1 -0.1 -0.7 0.7 0.4 0.0
Whole body fat-free mass 0.6 3.2 6.6 0.8 -2.4 2.4 2.3 2.6 1.1 0.2 0.8
Leg fat-free mass (right) 0.3 1.4 3.6 0.5 -1.5 1.4 1.4 1.9 1.0 -0.2 0.2
Arm fat percentage (left) 0.1 0.3 0.7 0.5 0.6 -0.2 0.0 0.9 0.8 0.2 -0.8
Average weekly red wine intake 0.1 0.2 0.6 -0.2 -0.7 0.1 -0.4 0.7 -0.2 -0.3 -0.3
Handedness (chirality/laterality): Left-handed 0.7 0.8 2.5 0.8 -0.9 0.6 -0.0 -0.7 0.6 -1.6 -1.2
Mood swings 0.4 0.7 1.9 -0.9 1.2 -0.2 -0.9 -0.0 -1.4 -0.6 -0.1
Loneliness, isolation 0.1 0.2 0.4 -0.4 0.6 0.0 -0.2 -0.4 -0.7 -0.3 -0.3
Long-standing illness, disability or infirmity 0.3 0.5 0.8 0.6 -0.4 0.7 -0.7 0.9 0.9 0.4 0.8
Ever had bowel cancer screening 1.1 1.3 2.8 -1.1 1.3 -1.2 -1.7 1.3 -0.9 -0.4 -0.2
Diabetes diagnosed by doctor 1.0 1.7 4.4 1.9 -1.0 1.3 0.7 1.5 2.1 0.1 -0.0
Ever had stillbirth, spontaneous miscarriage or termination 0.8 0.8 4.4 0.3 -0.6 0.6 0.4 2.1 0.6 0.8 -0.0
Friendships satisfaction 0.2 0.3 0.8 -0.1 -0.9 0.0 0.6 0.4 0.0 -0.2 -0.9
Qualifications: nursing, teaching 0.7 1.0 3.0 0.7 -0.9 1.2 0.9 1.7 0.6 0.7 1.0
Commuting to job workplace: Walk 0.1 0.1 0.2 -0.3 -0.1 -0.4 -0.5 -0.1 -0.3 -0.3 0.2
Eye problems/disorders: Cataract 2.2 2.5 6.1 -1.3 1.8 -2.1 -2.5 -0.3 -1.1 -1.5 -1.2
Mouth/teeth dental problems: Mouth ulcers 0.5 0.9 5.2 -0.0 0.1 -0.1 -0.5 -2.3 -0.2 -1.2 -0.1
Medication for cholesterol 0.1 0.2 0.7 -0.2 -0.2 0.0 0.9 0.0 -0.3 0.5 0.5
Medication: Laxatives (e.g. Dulcolax, Senokot) 2.4 2.8 5.7 -2.4 1.2 -2.1 -2.0 0.1 -1.6 -0.5 -2.0
Back pain experienced in last month 0.9 1.3 2.5 -1.0 0.3 -1.1 -1.0 -1.6 -1.3 -1.1 -1.3
Mineral and other dietary supplements 0.3 0.4 1.4 -0.4 -0.6 -1.0 -0.4 -0.6 0.1 0.1 -1.2
Breast cancer (self-reported) 0.1 0.1 0.3 -0.1 -0.1 -0.1 0.2 0.2 -0.4 0.1 0.6
Asthma (self-reported) 0.7 1.4 3.7 -1.1 0.5 -1.6 -1.9 -1.1 -0.4 -0.2 -1.3
Osteoporosis (self-reported) 0.4 0.5 2.2 -0.0 0.3 -0.7 -1.5 -0.5 0.4 -0.6 -0.8
Osteoarthritis (self-reported) 1.2 1.5 2.8 -1.2 1.7 -1.3 -1.4 -1.6 -1.0 -0.8 -0.3
Medication: Aspirin 0.9 1.2 2.9 0.9 -1.3 1.7 1.3 1.2 0.9 -0.0 0.6
Medication: Gliclazide 1.1 1.2 5.7 1.0 0.1 0.1 0.3 2.4 1.3 0.9 0.5
Illnesses of father: None of the above (group 1) 0.2 0.2 0.7 -0.4 0.4 -0.6 -0.8 0.1 -0.3 -0.1 -0.2
Smoking status: Current 1.1 1.8 5.0 1.2 -2.2 1.2 2.0 0.1 1.1 0.7 1.0
Forced expiratory volume in 1-second (FEV1), predicted percentage 2.3 4.9 11.4 -3.0 1.6 -1.8 -1.4 -1.4 -3.4 -2.0 -2.2
Whole body water mass 0.6 3.4 6.5 0.9 -2.5 2.4 2.3 2.5 1.2 0.4 0.9
Leg predicted mass (right) 0.3 1.4 3.5 0.5 -1.5 1.4 1.5 1.9 1.0 -0.1 0.2
Arm fat mass (left) 0.2 0.6 2.6 0.7 -0.1 0.5 0.5 1.6 1.1 0.4 -0.4
Number of self-reported non-cancer illnesses 0.2 0.4 1.1 -0.5 0.0 -0.5 -1.0 0.6 -0.1 -1.1 -0.4
Average weekly champagne plus white wine intake 0.2 0.3 0.7 0.3 -0.8 0.8 0.8 0.1 0.4 0.1 -0.1
Miserableness 1.0 1.7 7.7 -1.7 0.9 0.1 1.1 -0.0 -2.8 -1.0 -0.7
Guilty feelings 0.6 0.9 2.0 -0.9 1.4 -1.2 -1.0 -0.4 -1.2 0.2 -0.4
Wears glasses or contact lenses 0.3 0.4 1.3 -0.7 0.1 -0.7 0.3 0.3 -1.1 0.6 0.4
Ever taken oral contraceptive pill 0.6 0.7 1.9 -1.0 1.0 -1.0 -1.4 0.1 -0.7 0.5 -0.4
Hearing aid user 1.1 1.2 3.6 -0.9 -0.4 -0.1 -0.3 -1.2 -0.6 -1.8 -1.9
Mother’s age at death 0.4 0.5 1.2 -0.9 1.1 -0.8 -0.1 -0.7 -0.8 0.6 -0.1
Financial situation satisfaction 0.4 0.5 1.4 -0.2 0.6 0.0 -0.7 -1.2 -0.4 -1.1 -0.7
Tinnitus: Yes, now most or all of the time 0.4 0.5 2.1 -0.1 0.6 0.2 0.9 -1.4 -0.4 -0.1 0.5
Commuting to job workplace: Public transport 0.3 0.3 1.1 0.0 1.0 0.8 -0.4 0.0 -0.3 0.3 0.7
Eye problems/disorders: Glaucoma 1.2 1.4 3.6 -0.9 1.8 -1.9 -1.4 -1.0 -0.9 0.2 -0.2
Medication: Blood pressure 0.4 0.7 1.9 -0.1 0.3 -0.0 -1.1 -1.1 -0.0 -1.4 -1.0
Pain type(s) experienced in last month: Hip pain 4.4 5.5 7.7 -2.8 2.4 -2.7 -2.7 -0.9 -2.7 -1.4 -2.5
Supplements: Fish oil (including cod liver oil) 0.5 0.7 2.5 0.6 0.8 0.8 -0.0 0.8 0.3 0.7 1.6
High cholesterol (Self-reported) 0.4 0.7 2.1 -0.5 -1.5 0.3 0.7 1.2 0.2 -0.3 -0.8
Medication: Bendroflumethiazide 4.2 6.4 8.1 -2.3 2.5 -2.3 -2.8 -2.5 -2.4 -2.9 -2.5
Medication: Paracetamol 0.2 0.4 1.7 -0.5 -0.4 0.1 0.5 -0.1 -0.7 -0.4 -1.3
Medication: Lisinopril 0.4 0.5 2.0 0.0 0.5 -0.7 -1.0 1.4 0.1 0.7 -0.1
Medication: Atorvastatin 0.8 1.0 1.8 -1.0 1.4 -1.2 -1.1 1.1 -0.6 -0.1 -0.8
Illnesses of father: High blood pressure 0.2 0.2 0.5 -0.3 0.7 0.2 -0.1 0.7 -0.4 0.7 -0.1
Alcohol drinker status: Never 2.7 3.3 6.8 2.3 -1.9 1.9 1.6 0.3 2.6 1.3 1.6
Ever smoked 0.9 1.5 6.0 0.4 -1.0 0.7 1.0 2.5 0.2 1.1 1.6
Basal metabolic rate 0.6 3.1 6.7 0.9 -2.3 2.3 2.2 2.6 1.2 0.2 0.7
Leg fat percentage (left) 0.1 0.3 1.0 0.3 0.2 0.4 -0.2 1.0 0.6 -0.2 -1.0
Arm fat-free mass (left) 0.6 2.8 6.0 0.6 -2.3 2.3 2.0 2.5 1.0 -0.0 0.5
Number of operations (self-reported) 0.7 1.1 4.8 -0.3 -0.5 -0.8 -1.0 -1.3 -0.1 -2.2 -0.7
Average weekly beer plus cider intake 0.4 0.6 3.2 -0.2 0.8 -0.5 -0.3 -1.8 -0.1 -0.1 -0.9
Irritability 2.6 4.4 13.5 -2.0 2.1 -1.8 -1.4 -3.7 -2.4 -0.6 -1.3
Risk taking 1.2 1.7 3.9 0.8 -0.7 1.4 1.2 2.0 1.7 1.3 0.9
Ever had prostate specific antigen (PSA) test 0.7 0.8 2.4 0.3 -0.7 0.5 1.5 1.6 0.1 0.9 0.1
Fractured/broken bones in last 5 years 0.3 0.4 1.2 -0.8 0.0 -0.6 -0.2 -0.8 -1.1 -0.8 -0.0
Age started oral contraceptive pill 0.5 0.6 1.8 -0.1 -1.3 0.1 0.4 1.1 -0.0 0.7 1.1
Diastolic blood pressure, automated reading 0.3 1.1 5.4 0.4 1.0 -0.3 -2.3 0.4 0.4 -0.8 -1.0
Ever depressed for a whole week 2.6 3.2 7.6 1.5 -1.8 2.8 0.8 2.3 1.6 1.0 1.7
Unable to work because of sickness or disability 0.4 0.5 2.2 0.5 0.4 -0.4 -0.9 -0.7 0.2 -1.5 -0.3
Commuting to job workplace: Cycle 0.6 0.7 2.4 -0.4 -1.0 0.4 0.2 -0.5 -1.2 -1.6 0.1
Myopia 0.4 0.6 2.1 0.0 1.4 -0.2 -0.8 -0.5 -0.3 1.1 0.3
Vascular/heart problems diagnosed by doctor 0.3 0.8 1.9 -0.6 0.5 -0.9 0.6 -1.3 -1.4 0.6 0.6
Cholesterol lowering medication 0.3 0.4 1.6 -0.2 -1.1 0.3 0.5 1.3 -0.0 0.5 0.2
Medication: Omeprazole (e.g. Zanprol) 2.9 3.6 7.2 -1.8 1.6 -2.1 -1.8 -1.0 -1.8 -2.7 -1.9
Pain experienced in last month 3.8 6.3 10.2 3.2 -2.3 3.2 2.4 2.3 2.5 0.9 2.6
Supplements: Calcium 1.3 1.5 6.4 -0.5 1.6 -0.9 -2.5 -0.4 0.0 -1.2 -0.5
Basal cell carcinoma (self-reported) 0.3 0.4 1.6 -0.2 0.5 -1.2 -0.2 -0.1 -0.6 -0.8 0.0
Heart attack/myocardial infarction (self-reported) 0.8 1.1 2.4 1.3 -1.1 1.5 0.0 0.2 1.2 -1.1 0.7
Deep venous thrombosis (DVT) (self-reported) 0.3 0.4 1.6 0.4 -0.6 0.5 -0.2 1.3 0.9 -0.0 0.5
Heart disease (siblings) 0.5 0.6 2.1 0.2 -1.4 1.1 0.8 0.2 0.4 -0.6 0.4
Alcohol drinker status: Previous 0.4 0.4 1.3 1.1 -0.3 0.1 -0.2 -1.0 0.6 -0.8 -0.2
Pack years of smoking 2.7 3.9 6.5 1.8 -1.9 2.5 2.5 1.9 1.9 1.5 1.4
Impedance of whole body 0.2 1.0 2.3 -0.7 1.4 -1.5 -1.0 -1.2 -0.9 0.1 -0.4
Leg fat mass (left) 0.2 0.7 2.7 0.5 -0.4 0.8 0.4 1.6 1.1 0.0 -0.8
Arm predicted mass (left) 0.5 2.7 6.2 0.6 -2.1 2.4 1.9 2.5 0.8 -0.0 0.7