Best TWAS P=2.15e-09 · Best GWAS P=2.14e-08 conditioned to 0.827
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | FASTK | 0.08 | 0.05 | lasso | 2 | 0.05 | 2.3e-06 | -5.1 | -5.2 | 1.7e-07 | -0.54 | 0.06 | 0.93 | FALSE |
| 2 | GTEx | Artery Tibial | FASTK | 0.13 | 0.08 | lasso | 3 | 0.07 | 3.6e-06 | -5.1 | -5.2 | 2.4e-07 | -0.55 | 0.05 | 0.94 | FALSE |
| 3 | GTEx | Brain Cerebellum | ABCB8 | 0.25 | 0.25 | lasso | 2 | 0.25 | 4.5e-08 | -5.1 | 5.6 | 2.7e-08 | 0.28 | 0.04 | 0.93 | FALSE |
| 4 | GTEx | Nerve Tibial | CDK5 | 0.09 | 0.00 | lasso | 5 | 0.00 | 1.7e-01 | 5.3 | -5.8 | 5.8e-09 | -0.67 | 0.04 | 0.50 | FALSE |
| 5 | GTEx | Skin Sun Exposed Lower leg | FASTK | 0.14 | 0.06 | lasso | 6 | 0.04 | 2.4e-04 | -5.1 | -5.3 | 1.4e-07 | -0.40 | 0.06 | 0.93 | FALSE |
| 6 | METSIM | Adipose | AOC1 | 0.17 | 0.08 | enet | 26 | 0.11 | 3.2e-16 | 4.5 | 5.7 | 1.4e-08 | -0.01 | 0.42 | 0.57 | TRUE |
| 7 | The Cancer Genome Atlas | Colon Adenocarcinoma | TMUB1 | 0.06 | 0.02 | enet | 6 | 0.04 | 3.9e-03 | 5.6 | -6.0 | 2.1e-09 | -0.93 | 0.00 | 0.95 | TRUE |
| 8 | The Cancer Genome Atlas | Lung Adenocarcinoma | ABCB8 | 0.07 | 0.04 | enet | 11 | 0.05 | 1.3e-06 | -5.1 | 5.3 | 1.1e-07 | 0.17 | 0.00 | 0.98 | FALSE |
| 9 | The Cancer Genome Atlas | Stomach Adenocarcinoma | FASTK | 0.05 | 0.01 | blup | 51 | 0.03 | 3.7e-03 | -4.5 | -5.7 | 1.1e-08 | -0.50 | 0.03 | 0.54 | FALSE |
| 10 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | TMEM176A | 0.15 | 0.00 | lasso | 10 | 0.02 | 5.7e-02 | 4.9 | 5.2 | 2.0e-07 | -0.01 | 0.01 | 0.29 | FALSE |
| 11 | The Cancer Genome Atlas | Thyroid Carcinoma | ATG9B | 0.05 | 0.04 | enet | 7 | 0.05 | 2.9e-05 | -4.5 | 5.2 | 2.1e-07 | 0.30 | 0.01 | 0.92 | FALSE |