Best TWAS P=2.6e-28 · Best GWAS P=1.1e-32 conditioned to 4.54e-06
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Tibial | RP11-435O5.5 | 0.09 | 0.04 | lasso | 2 | 0.02 | 7.3e-03 | 5.2 | -5.2 | 1.8e-07 | -0.44 | 0.25 | 0.06 | FALSE |
| 2 | GTEx | Liver | PTCH1 | 0.25 | 0.06 | enet | 11 | 0.03 | 4.9e-02 | 11.7 | 11.0 | 2.6e-28 | 0.91 | 0.01 | 0.94 | TRUE |
| 3 | GTEx | Spleen | PTCH1 | 0.33 | 0.08 | lasso | 8 | 0.18 | 1.9e-05 | -1.3 | 7.9 | 2.1e-15 | 0.64 | 0.05 | 0.73 | FALSE |
| 4 | NTR | Blood | PTCH1 | 0.04 | 0.02 | blup | 433 | 0.02 | 4.1e-08 | 11.2 | 7.0 | 2.7e-12 | 0.64 | 0.02 | 0.98 | FALSE |
| 5 | YFS | Blood | PTCH1 | 0.09 | 0.05 | lasso | 8 | 0.05 | 1.2e-15 | 11.1 | 10.6 | 2.3e-26 | 0.95 | 0.02 | 0.98 | FALSE |
| 6 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | PTCH1 | 0.04 | 0.00 | blup | 56 | 0.02 | 1.6e-03 | 11.1 | 8.4 | 3.0e-17 | 0.72 | 0.02 | 0.23 | FALSE |